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Showing 1 to 12 of 66 entries
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Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin.

Frontiers in immunology

Sun JB, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick AR, Xiang Z.
PMID: 28951732
Front Immunol. 2017 Sep 11;8:1119. doi: 10.3389/fimmu.2017.01119. eCollection 2017.

The calcium-binding protein S100A4 has been described to promote pathological inflammation in experimental autoimmune and inflammatory disorders and in allergy and to contribute to antigen presentation and antibody response after parenteral immunization with an alum-adjuvanted antigen. In this study,...

Enzyme pattern of biliary colic: A counterintuitive picture.

World journal of hepatology

Resnick E, Shteingart S, Melamud B, Bdolah-Abram T, Zalut T, Reuben A, Lurie Y.
PMID: 28083086
World J Hepatol. 2016 Dec 28;8(36):1629-1636. doi: 10.4254/wjh.v8.i36.1629.

AIM: To evaluate the diagnostic value of serial biochemical blood tests in the diagnosis of biliary colic.METHODS: Files were reviewed of 1039 patients who were admitted to the Share'e Zedek Medical Center emergency department between the years 2012-2013, and...

An investigation of the psychological effects of the September 11, 2001, attacks on New York City: developing and implementing research in the acute postdisaster period.

CNS spectrums

Galea S, Vlahov D, Resnick H, Kilpatrick D, Bucuvalas MJ, Morgan MD, Gold J.
PMID: 15094695
CNS Spectr. 2002 Aug;7(8):585-7, 593-6. doi: 10.1017/s1092852900018198.

The September 11, 2001, attack on New York City was the largest human-made disaster in United States history. In the first few days after the attack, it became clear that the scope of the attacks (including loss of life,...

EVALUATION OF THERAPEUTIC SUBSTANCES EMPLOYED FOR THE RELIEF OF BRONCHOSPASM. V. ADRENERGIC AGENTS.

The Journal of clinical investigation

Bresnick E, Beakey JF, Levinson L, Segal MS.
PMID: 16695790
J Clin Invest. 1949 Sep;28(5):1182-9. doi: 10.1172/JCI102152.

No abstract available.

Neural and psychosocial contributions to sex differences in knee osteoarthritic pain.

Biology of sex differences

Sluka KA, Berkley KJ, O'Connor MI, Nicolella DP, Enoka RM, Boyan BD, Hart DA, Resnick E, Kwoh CK, Tosi LL, Coutts RD, Kohrt WM.
PMID: 23244577
Biol Sex Differ. 2012 Dec 17;3(1):26. doi: 10.1186/2042-6410-3-26.

People with osteoarthritis (OA) can have significant pain that interferes with function and quality of life. Women with knee OA have greater pain and greater reductions in function and quality of life than men. In many cases, OA pain...

Addressing the gaps: sex differences in osteoarthritis of the knee.

Biology of sex differences

Boyan BD, Tosi LL, Coutts RD, Enoka RM, Hart DA, Nicolella DP, Berkley KJ, Sluka KA, Kwoh CK, O'Connor MI, Kohrt WM, Resnick E.
PMID: 23374401
Biol Sex Differ. 2013 Feb 04;4(1):4. doi: 10.1186/2042-6410-4-4.

An introduction to the accompanying three papers.

S100 proteins as therapeutic targets.

Biophysical reviews

Bresnick AR.
PMID: 30382555
Biophys Rev. 2018 Dec;10(6):1617-1629. doi: 10.1007/s12551-018-0471-y. Epub 2018 Oct 31.

The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute...

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry.

Journal of the American Chemical Society

Reddi RN, Resnick E, Rogel A, Rao BV, Gabizon R, Goldenberg K, Gurwicz N, Zaidman D, Plotnikov A, Barr H, Shulman Z, London N.
PMID: 33761747
J Am Chem Soc. 2021 Apr 07;143(13):4979-4992. doi: 10.1021/jacs.0c10644. Epub 2021 Mar 24.

Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted covalent...

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M.

Cell chemical biology

Zaidman D, Gehrtz P, Filep M, Fearon D, Gabizon R, Douangamath A, Prilusky J, Duberstein S, Cohen G, Owen CD, Resnick E, Strain-Damerell C, Lukacik P, Barr H, Walsh MA, von Delft F, London N.
PMID: 34174194
Cell Chem Biol. 2021 Dec 16;28(12):1795-1806.e5. doi: 10.1016/j.chembiol.2021.05.018. Epub 2021 Jun 25.

Designing covalent inhibitors is increasingly important, although it remains challenging. Here, we present covalentizer, a computational pipeline for identifying irreversible inhibitors based on structures of targets with non-covalent binders. Through covalent docking of tailored focused libraries, we identify candidates...

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M.

Cell chemical biology

Zaidman D, Gehrtz P, Filep M, Fearon D, Gabizon R, Douangamath A, Prilusky J, Duberstein S, Cohen G, Owen CD, Resnick E, Strain-Damerell C, Lukacik P, Barr H, Walsh MA, von Delft F, London N.
PMID: 34174194
Cell Chem Biol. 2021 Dec 16;28(12):1795-1806.e5. doi: 10.1016/j.chembiol.2021.05.018. Epub 2021 Jun 25.

Designing covalent inhibitors is increasingly important, although it remains challenging. Here, we present covalentizer, a computational pipeline for identifying irreversible inhibitors based on structures of targets with non-covalent binders. Through covalent docking of tailored focused libraries, we identify candidates...

Receipt of Private Time Among Adolescents and Young Adults With and Without Special Healthcare Needs.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Klein JD, Resnick EA, Danawala S, Grilo SA, Catallozzi M, Li B, Gorzkowski J, Kaseeska K, Santelli JS.
PMID: 35033426
J Adolesc Health. 2022 Jan 12; doi: 10.1016/j.jadohealth.2021.10.014. Epub 2022 Jan 12.

PURPOSE: Private time is an opportunity for the adolescent patient to speak directly to a healthcare provider and a marker of quality preventive health care. Little is known about whether adolescents and young adults (AYAs) with special healthcare needs...

Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry.

Journal of the American Chemical Society

Reddi RN, Rogel A, Resnick E, Gabizon R, Prasad PK, Gurwicz N, Barr H, Shulman Z, London N.
PMID: 34817989
J Am Chem Soc. 2021 Dec 08;143(48):20095-20108. doi: 10.1021/jacs.1c06167. Epub 2021 Nov 24.

Chemical modifications of native proteins can affect their stability, activity, interactions, localization, and more. However, there are few nongenetic methods for the installation of chemical modifications at a specific protein site in cells. Here we report a covalent ligand...

Showing 1 to 12 of 66 entries