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Showing 1 to 12 of 192 entries
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Ig Constant Region Effects on Variable Region Structure and Function.

Frontiers in microbiology

Janda A, Bowen A, Greenspan NS, Casadevall A.
PMID: 26870003
Front Microbiol. 2016 Feb 04;7:22. doi: 10.3389/fmicb.2016.00022. eCollection 2016.

The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have...

Radiolabeled antibodies for therapy of infectious diseases.

Microbiology spectrum

Dadachova E, Casadevall A.
PMID: 25599011
Microbiol Spectr. 2014 Nov;2(6):0023. doi: 10.1128/microbiolspec.AID-0023-2014.

Novel approaches to treatment of infectious diseases are urgently needed. This need has resulted in renewing the interest in antibodies for therapy of infectious diseases. Radioimmunotherapy (RIT) is a cancer treatment modality, which utilizes radiolabeled monoclonal antibodies (mAbs). During...

Fungal Melanin: What do We Know About Structure?.

Frontiers in microbiology

Nosanchuk JD, Stark RE, Casadevall A.
PMID: 26733993
Front Microbiol. 2015 Dec 22;6:1463. doi: 10.3389/fmicb.2015.01463. eCollection 2015.

The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin's importance in human disease, as well as melanin's contribution to the ability of fungi to survive in diverse hostile environments, the structure...

New insights on the pathogenesis of invasive Cryptococcus neoformans infection.

Current infectious disease reports

Eisenman HC, Casadevall A, McClelland EE.
PMID: 17999881
Curr Infect Dis Rep. 2007 Nov;9(6):457-64. doi: 10.1007/s11908-007-0070-8.

Disseminated cryptococcosis begins with infection of the lungs via inhalation. This is followed by escape from the lungs and entry into the bloodstream allowing dissemination to the brain and central nervous system. We discuss the steps involved in dissemination...

Mechanistic science.

Infection and immunity

Casadevall A, Fang FC.
PMID: 19596776
Infect Immun. 2009 Sep;77(9):3517-9. doi: 10.1128/IAI.00623-09. Epub 2009 Jul 13.

No abstract available.

Descriptive science.

Infection and immunity

Casadevall A, Fang FC.
PMID: 18625736
Infect Immun. 2008 Sep;76(9):3835-6. doi: 10.1128/IAI.00743-08. Epub 2008 Jul 14.

No abstract available.

A new design for the ASM general meeting.

mBio

Miller JF, McFall-Ngai M, Casadevall A.
PMID: 21151775
mBio. 2010 Nov 23;1(5). doi: 10.1128/mBio.00240-10.

No abstract available.

Biogenesis of extracellular vesicles in yeast: Many questions with few answers.

Communicative & integrative biology

Oliveira DL, Nakayasu ES, Joffe LS, Guimarães AJ, Sobreira TJ, Nosanchuk JD, Cordero RJ, Frases S, Casadevall A, Almeida IC, Nimrichter L, Rodrigues ML.
PMID: 21331232
Commun Integr Biol. 2010 Nov;3(6):533-5. doi: 10.4161/cib.3.6.12756. Epub 2010 Nov 01.

The cellular events required for unconventional protein secretion in eukaryotic pathogens are beginning to be revealed. In fungi, extracellular release of proteins involves passage through the cell wall by mechanisms that are poorly understood. In recent years, several studies...

Safety and efficacy of 188-rhenium-labeled antibody to melanin in patients with metastatic melanoma.

Journal of skin cancer

Klein M, Lotem M, Peretz T, Zwas ST, Mizrachi S, Liberman Y, Chisin R, Schachter J, Ron IG, Iosilevsky G, Kennedy JA, Revskaya E, de Kater AW, Banaga E, Klutzaritz V, Friedmann N, Galun E, Denardo GL, Denardo SJ, Casadevall A, Dadachova E, Thornton GB.
PMID: 23365757
J Skin Cancer. 2013;2013:828329. doi: 10.1155/2013/828329. Epub 2013 Jan 10.

There is a need for effective "broad spectrum" therapies for metastatic melanoma which would be suitable for all patients. The objectives of Phase Ia/Ib studies were to evaluate the safety, pharmacokinetics, dosimetry, and antitumor activity of (188)Re-6D2, a 188-Rhenium-labeled...

Sexual dimorphism of sonic apparatus and extreme intersexual variation of sounds in Ophidion rochei (Ophidiidae): first evidence of a tight relationship between morphology and sound characteristics in Ophidiidae.

Frontiers in zoology

Kéver L, Boyle KS, Dragičević B, Dulčić J, Casadevall M, Parmentier E.
PMID: 23217241
Front Zool. 2012 Dec 06;9(1):34. doi: 10.1186/1742-9994-9-34.

BACKGROUND: Many Ophidiidae are active in dark environments and display complex sonic apparatus morphologies. However, sound recordings are scarce and little is known about acoustic communication in this family. This paper focuses on Ophidion rochei which is known to...

Fungal polysaccharides: biological activity beyond the usual structural properties.

Frontiers in microbiology

Rodrigues ML, Nimrichter L, Cordero RJ, Casadevall A.
PMID: 21886639
Front Microbiol. 2011 Aug 15;2:171. doi: 10.3389/fmicb.2011.00171. eCollection 2011.

Studies on structure and function of polysaccharides in biological systems classically involve sequence and compositional analyses, anomeric configuration, type of glycosidic linkage, and presence of substituents. Recent studies, however, indicates that other structural parameters, so far little explored, can...

Impacted science: impact is not importance.

mBio

Casadevall A, Fang FC.
PMID: 26463169
mBio. 2015 Oct 13;6(5):e01593-15. doi: 10.1128/mBio.01593-15.

The journal impact factor (IF) exerts a tremendous influence on the conduct of scientists. The obsession with IF has been compared to a medical condition, sometimes referred to as "IF mania" or "impactitis." Here, we analyze the difference between...

Showing 1 to 12 of 192 entries