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Showing 1 to 12 of 96 entries
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Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts.

BMC research notes

Vallo S, Michaelis M, Gust KM, Black PC, Rothweiler F, Kvasnicka HM, Blaheta RA, Brandt MP, Wezel F, Haferkamp A, Cinatl J.
PMID: 27677700
BMC Res Notes. 2016 Sep 27;9(1):454. doi: 10.1186/s13104-016-2256-3.

BACKGROUND: Systemic chemotherapy with gemcitabine and cisplatin is standard of care for patients with metastatic urothelial bladder cancer. However, resistance formation is common after initial response. The protein Src is known as a proto-oncogene, which is overexpressed in various...

Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics.

Translational oncology

Vallo S, Michaelis M, Rothweiler F, Bartsch G, Gust KM, Limbart DM, Rödel F, Wezel F, Haferkamp A, Cinatl J.
PMID: 26055179
Transl Oncol. 2015 Jun;8(3):210-6. doi: 10.1016/j.tranon.2015.04.002.

Combination chemotherapy with gemcitabine and cisplatin in patients with metastatic urothelial cancer of the bladder frequently results in the development of acquired drug resistance. Availability of cell culture models with acquired resistance could help to identify candidate treatments for...

Pancytopenia in Multiple Myeloma- An Enigma: Our Experience from Tertiary Care Hospital.

Journal of clinical and diagnostic research : JCDR

Sridevi HB, Rai S, Suresh PK, Somesh MS, Minal J.
PMID: 26673280
J Clin Diagn Res. 2015 Nov;9(11):EC04-6. doi: 10.7860/JCDR/2015/12788.6718. Epub 2015 Nov 01.

INTRODUCTION: Multiple myeloma is a plasma cell neoplasm that is characterized by clonal proliferation of malignant plasma cell in the bone marrow along with M-protein in the serum and/or urine. Pancytopenia as a initial presentation of multiple myeloma is...

The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders.

Journal of geriatric psychiatry and neurology

Coen RF, McCarroll K, Casey M, McNulty H, Laird E, Molloy AM, Ward M, Strain JJ, Hoey L, Hughes C, Cunningham CJ.
PMID: 27647791
J Geriatr Psychiatry Neurol. 2016 Nov;29(6):338-343. doi: 10.1177/0891988716666381. Epub 2016 Sep 21.

BACKGROUND: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited.OBJECTIVES: The Trinity, Ulster, Department of Agriculture (TUDA) study provided the opportunity to derive performance data...

Versatile use of rhomboid flaps for closure of skin defects.

The Eurasian journal of medicine

Aydin OE, Tan O, Algan S, Kuduban SD, Cinal H, Barin EZ.
PMID: 25610151
Eurasian J Med. 2011 Apr;43(1):1-8. doi: 10.5152/eajm.2011.01.

OBJECTIVE: The aim of this study is to present our clinical experience with rhomboid flaps.MATERIALS AND METHODS: Twenty-four patients who were operated on between January 2006 and October 2010 were included in the study. All defects were reconstructed using...

Testing of SNS-032 in a Panel of Human Neuroblastoma Cell Lines with Acquired Resistance to a Broad Range of Drugs.

Translational oncology

Löschmann N, Michaelis M, Rothweiler F, Zehner R, Cinatl J, Voges Y, Sharifi M, Riecken K, Meyer J, von Deimling A, Fichtner I, Ghafourian T, Westermann F, Cinatl J.
PMID: 24466371
Transl Oncol. 2013 Dec 01;6(6):685-96. doi: 10.1593/tlo.13544. eCollection 2013 Dec 01.

Novel treatment options are needed for the successful therapy of patients with high-risk neuroblastoma. Here, we investigated the cyclin-dependent kinase (CDK) inhibitor SNS-032 in a panel of 109 neuroblastoma cell lines consisting of 19 parental cell lines and 90...

Oscillations of the orbital magnetic moment due to d-band quantum well states.

Physical review letters

Dąbrowski M, Peixoto TR, Pazgan M, Winkelmann A, Cinal M, Nakagawa T, Takagi Y, Yokoyama T, Bisio F, Bauer U, Yildiz F, Przybylski M, Kirschner J.
PMID: 25148348
Phys Rev Lett. 2014 Aug 08;113(6):067203. doi: 10.1103/PhysRevLett.113.067203. Epub 2014 Aug 06.

The effect of electron confinement on the magnetocrystalline anisotropy of ultrathin bcc Fe films is explored by combining photoemission spectroscopy, x-ray magnetic circular dichroism, and magneto-optical Kerr effect measurements. Pronounced thickness-dependent variations in the magnetocrystalline anisotropy are ascribed to...

COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?.

Diagnostics (Basel, Switzerland)

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J.
PMID: 32751741
Diagnostics (Basel). 2020 Jul 30;10(8). doi: 10.3390/diagnostics10080539.

SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in...

Magnetocrystalline anisotropy in ferromagnetic films.

Physical review. B, Condensed matter

Cinal M, Edwards DM, Mathon J.
PMID: 9976653
Phys Rev B Condens Matter. 1994 Aug 01;50(6):3754-3760. doi: 10.1103/physrevb.50.3754.

No abstract available.

Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial.

medRxiv : the preprint server for health sciences

Holubovska O, Bojkova D, Elli S, Bechtel M, Boltz D, Muzzio M, Peng X, Sala F, Cosentino C, Mironenko A, Milde J, Lebed Y, Stammer H, Goy A, Guerrini M, Mueller L, Cinatl J, Margitich V, Te Velthuis AJW.
PMID: 33469600
medRxiv. 2021 Jan 21; doi: 10.1101/2021.01.05.21249237.

Pandemic SARS-CoV-2 causes a mild to severe respiratory disease called Coronavirus Disease 2019 (COVID-19). Control of SARS-CoV-2 spread will depend on vaccine-induced or naturally acquired protective herd immunity. Until then, antiviral strategies are needed to manage COVID-19, but approved...

Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle.

Epigenetics & chromatin

Ruhr I, Bierstedt J, Rhen T, Das D, Singh SK, Miller S, Crossley DA, Galli GLJ.
PMID: 34488850
Epigenetics Chromatin. 2021 Sep 06;14(1):42. doi: 10.1186/s13072-021-00414-7.

BACKGROUND: Environmental fluctuation during embryonic and fetal development can permanently alter an organism's morphology, physiology, and behaviour. This phenomenon, known as developmental plasticity, is particularly relevant to reptiles that develop in subterranean nests with variable oxygen tensions. Previous work...

Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL.

Chemistry (Weinheim an der Bergstrasse, Germany)

Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak Ł, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I.
PMID: 34714566
Chemistry. 2021 Oct 29; doi: 10.1002/chem.202103258. Epub 2021 Oct 29.

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns,...

Showing 1 to 12 of 96 entries