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Showing 1 to 10 of 10 entries
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Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging.

Analytical chemistry

Cobice DF, Livingstone DE, Mackay CL, Goodwin RJ, Smith LB, Walker BR, Andrew R.
PMID: 27676129
Anal Chem. 2016 Nov 01;88(21):10362-10367. doi: 10.1021/acs.analchem.6b02242. Epub 2016 Oct 14.

Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can also be produced within tissues to act in intracrine and paracrine fashions. Because of this, circulating...

Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis.

Journal of personalized medicine

D'Cruz LG, McEleney KG, Tan KBC, Shukla P, Gardiner PV, Connolly P, Conway C, Cobice D, Gibson DS.
PMID: 32993083
J Pers Med. 2020 Sep 26;10(4). doi: 10.3390/jpm10040149.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes loss of joint function and significantly reduces quality of life. Plasma metabolite concentrations of disease-modifying anti-rheumatic drugs (DMARDs) can influence treatment efficacy and toxicity. This study explored the...

Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.

The British journal of nutrition

Conway MC, McSorley EM, Mulhern MS, Spence T, Weslowska M, Strain JJ, van Wijngaarden E, Davidson PW, Myers GJ, Wahlberg KE, Shamlaye CF, Cobice DF, Hyland BW, Pineda D, Broberg K, Yeates AJ.
PMID: 33526157
Br J Nutr. 2021 Dec 14;126(11):1687-1697. doi: 10.1017/S0007114521000441. Epub 2021 Feb 02.

Optimal maternal long-chain PUFA (LCPUFA) status is essential for the developing fetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS SNP have been associated with increased maternal...

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD.

Wellcome open research

Lyall MJ, Cartier J, Richards JA, Cobice D, Thomson JP, Meehan RR, Anderton SM, Drake AJ.
PMID: 29707653
Wellcome Open Res. 2017 Aug 22;2:67. doi: 10.12688/wellcomeopenres.12199.1. eCollection 2017.

No abstract available.

Assessing the Oxidative Degradation of N-Methylpyrrolidone (NMP) in Microelectronic Fabrication Processes by Using a Multiplatform Analytical Approach.

Journal of analytical methods in chemistry

Lennon G, Willox S, Ramdas R, Funston SJ, Klun M, Pieh R, Fairlie S, Dobbin S, Cobice DF.
PMID: 32190404
J Anal Methods Chem. 2020 Mar 04;2020:8265054. doi: 10.1155/2020/8265054. eCollection 2020.

During the construction of recording head devices, corrosion of metal features and subsequent deposition of corrosion by-products have been observed. Previous studies have determined that the use of N-methylpyrrolidone (NMP) may be a contributing factor. In this study, we...

On-tissue chemical derivatization in mass spectrometry imaging.

Mass spectrometry reviews

Harkin C, Smith KW, Cruickshank FL, Logan Mackay C, Flinders B, Heeren RMA, Moore T, Brockbank S, Cobice DF.
PMID: 33433028
Mass Spectrom Rev. 2021 Jan 12; doi: 10.1002/mas.21680. Epub 2021 Jan 12.

Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable tool for a wide range of applications. Matrix-assisted laser desorption/ionization (MALDI) is at the forefront of MSI ionization due to its wide availability and increasing improvement in...

Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging.

ACS omega

Smith KW, Flinders B, Thompson PD, Cruickshank FL, Mackay CL, Heeren RMA, Cobice DF.
PMID: 32548531
ACS Omega. 2020 May 27;5(22):13430-13437. doi: 10.1021/acsomega.0c01697. eCollection 2020 Jun 09.

Vitamin D plays a key role in the maintenance of calcium/phosphate homeostasis and elicits biological effects that are relevant to immune function and metabolism. It is predominantly formed through UV exposure in the skin by conversion of 7-dehydrocholsterol (vitamin...

Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.

The British journal of nutrition

Conway MC, McSorley EM, Mulhern MS, Spence T, Weslowska M, Strain JJ, van Wijngaarden E, Davidson PW, Myers GJ, Wahlberg KE, Shamlaye CF, Cobice DF, Hyland BW, Pineda D, Broberg K, Yeates AJ.
PMID: 33526157
Br J Nutr. 2021 Dec 14;126(11):1687-1697. doi: 10.1017/S0007114521000441. Epub 2021 Feb 02.

Optimal maternal long-chain PUFA (LCPUFA) status is essential for the developing fetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS SNP have been associated with increased maternal...

Sleep, a Governor of Morbidity in PTSD: A Systematic Review of Biological Markers in PTSD-Related Sleep Disturbances.

Nature and science of sleep

Maguire DG, Ruddock MW, Milanak ME, Moore T, Cobice D, Armour C.
PMID: 32801980
Nat Sci Sleep. 2020 Jul 31;12:545-562. doi: 10.2147/NSS.S260734. eCollection 2020.

BACKGROUND: Sleep disturbances (SD) are the most impactful and commonly reported symptoms in post-traumatic stress disorder (PTSD). Yet, they are often resistant to primary PTSD therapies. Research has identified two distinct SDs highly prevalent in PTSD; insomnia and nightmares....

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.

Molecular therapy. Nucleic acids

Schiroli D, Gómara MJ, Maurizi E, Atkinson SD, Mairs L, Christie KA, Cobice DF, McCrudden CM, Nesbit MA, Haro I, Moore T.
PMID: 31476668
Mol Ther Nucleic Acids. 2019 Sep 06;17:891-906. doi: 10.1016/j.omtn.2019.07.017. Epub 2019 Aug 01.

Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas...

Showing 1 to 10 of 10 entries