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Showing 1 to 12 of 13 entries
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Rodent hair is a Poor biomarker for internal manganese exposure.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Balachandran RC, Yanko FM, Cheng P, Prince LM, Rivers CN, Morcillo P, Akinyemi AJ, Tabbassum S, Pfalzer AC, Nie LH, Aschner M, Bowman AB.
PMID: 34534608
Food Chem Toxicol. 2021 Nov;157:112555. doi: 10.1016/j.fct.2021.112555. Epub 2021 Sep 15.

Hair is used as a biomarker of manganese (Mn) exposure, yet there is limited evidence to support its utility to quantify internal vs external Mn exposure. C57BL/6 J mice and Sprague-Dawley rats were exposed in two blocks of 3...

Pulsed administration for physiological estrogen replacement in mice.

F1000Research

Corciulo C, Scheffler JM, Gustafsson KL, Drevinge C, Humeniuk P, Del Carpio Pons AM, Poutanen M, Ohlsson C, Lagerquist MK, Islander U.
PMID: 34868559
F1000Res. 2021 Aug 16;10:809. doi: 10.12688/f1000research.54501.1. eCollection 2021.

Estrogens are important regulators of body physiology and have major effects on metabolism, bone, the immune- and central nervous systems. The specific mechanisms underlying the effects of estrogens on various cells, tissues and organs are unclear and mouse models...

Signaling of the Purinergic System in the Joint.

Frontiers in pharmacology

Corciulo C, Cronstein BN.
PMID: 32038258
Front Pharmacol. 2020 Jan 24;10:1591. doi: 10.3389/fphar.2019.01591. eCollection 2019.

The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction...

Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Iskandar AR, Kolli AR, Giralt A, Neau L, Fatarova M, Kondylis A, Torres LO, Majeed S, Merg C, Corciulo M, Trivedi K, Guedj E, Frentzel S, Calvino F, Guy PA, Ivanov NV, Peitsch MC, Hoeng J.
PMID: 34563633
Food Chem Toxicol. 2021 Nov;157:112577. doi: 10.1016/j.fct.2021.112577. Epub 2021 Sep 24.

Trehalose is added in drug formulations to act as fillers or improve aerosolization performance. Its characteristics as a carrier molecule have been explored; however, the fate of trehalose in human airway tissues has not been thoroughly investigated. Here, we...

Painless foot drop: an unusual acute presentation of new onset type 1 diabetes mellitus.

Endocrinology, diabetes & metabolism case reports

Corcillo A, Kleinaki Z, Kapnisi S, Fountoulakis N, Maltese G, Thomas SM, Karalliedde J.
PMID: 33845454
Endocrinol Diabetes Metab Case Rep. 2021 Mar 16;2021. doi: 10.1530/EDM-21-0012. Epub 2021 Mar 16.

SUMMARY: A 26-year-old Caucasian female with no past medical history or family history of auto-immune disease presented to the emergency department with new onset painless left foot drop. A panel of blood tests revealed blood glucose of 49.9 mmol/L...

Invasive aspergillosis in relapsed/refractory acute myeloid leukaemia patients: Results from SEIFEM 2016-B survey.

Mycoses

Del Principe MI, Dragonetti G, Conti A, Verga L, Ballanti S, Fanci R, Candoni A, Marchesi F, Cattaneo C, Lessi F, Fracchiolla N, Spolzino A, Prezioso L, Delia M, Potenza L, Decembrino N, Castagnola C, Nadali G, Picardi M, Zama D, Orciulo E, Veggia B, Garzia M, Dargenio M, Melillo L, Manetta S, Russo D, Mancini V, Piedimonte M, Tisi MC, Toschi N, Busca A, Pagano L.
PMID: 34695256
Mycoses. 2021 Oct 25; doi: 10.1111/myc.13384. Epub 2021 Oct 25.

BACKGROUND: In patients with relapsed/refractory acute myeloid leukaemia (R/R AML) who received salvage chemotherapy, limited and not updated studies explored the incidence of invasive aspergillosis (IA) and the role of antifungal prophylaxis (AP). The aims of this multicentre retrospective...

Browning of adipose tissue and increased thermogenesis induced by Methotrexate.

FASEB bioAdvances

Verma N, Perie L, Corciulo C, Leucht P, Ramkhelawon B, Cronstein BN, Mueller E.
PMID: 34761170
FASEB Bioadv. 2021 Oct 07;3(11):877-887. doi: 10.1096/fba.2021-00058. eCollection 2021 Nov.

Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis due to its well-known anti-inflammatory role in immune cells but its impact on brown and beige adipose tissue biology has not yet been investigated. Here, we present the...

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.

Journal of inflammation (London, England)

Ruiz Castro PA, Kogel U, Lo Sasso G, Phillips BW, Sewer A, Titz B, Garcia L, Kondylis A, Guedj E, Peric D, Bornand D, Dulize R, Merg C, Corciulo M, Ivanov NV, Peitsch MC, Hoeng J.
PMID: 32855621
J Inflamm (Lond). 2020 Aug 24;17:29. doi: 10.1186/s12950-020-00260-6. eCollection 2020.

BACKGROUND: Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and including two main disease manifestations: ulcerative colitis (UC) and Crohn's disease. In...

Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes.

Purinergic signalling

Castro CM, Corciulo C, Friedman B, Li Z, Jacob S, Fenyo D, Cronstein BN.
PMID: 33973110
Purinergic Signal. 2021 Sep;17(3):439-448. doi: 10.1007/s11302-021-09788-5. Epub 2021 May 11.

Adenosine signaling plays a critical role in the maintenance of articular cartilage and may serve as a novel therapeutic for osteoarthritis (OA), a highly prevalent and morbid disease without effective therapeutics in the current market. Mice lacking adenosine A2A...

Rapid Bedside Ultrasound Evaluation of a Ruptured Abdominal Aortic Aneurysm With a Prior Repair.

Military medicine

Corcillo J, Stierwalt J, Kaelin A, Murray B.
PMID: 34966916
Mil Med. 2021 Dec 30; doi: 10.1093/milmed/usab538. Epub 2021 Dec 30.

Ruptured aortic aneurysms carry a high risk of morbidity and mortality, particularly if not rapidly identified. We present an 87-year-old male, with a history of hypertension and prior endovascular aortic repair, who presented to the Emergency Department (ED) with...

Pulsed administration for physiological estrogen replacement in mice.

F1000Research

Corciulo C, Scheffler JM, Gustafsson KL, Drevinge C, Humeniuk P, Del Carpio Pons AM, Poutanen M, Ohlsson C, Lagerquist MK, Islander U.
PMID: 34868559
F1000Res. 2021 Aug 16;10:809. doi: 10.12688/f1000research.54501.1. eCollection 2021.

Estrogens are important regulators of body physiology and have major effects on metabolism, bone, the immune- and central nervous systems. The specific mechanisms underlying the effects of estrogens on various cells, tissues and organs are unclear and mouse models...

Defective Mitochondrial Dynamics Underlie Manganese-Induced Neurotoxicity.

Molecular neurobiology

Morcillo P, Cordero H, Ijomone OM, Ayodele A, Bornhorst J, Gunther L, Macaluso FP, Bowman AB, Aschner M.
PMID: 33666854
Mol Neurobiol. 2021 Jul;58(7):3270-3289. doi: 10.1007/s12035-021-02341-w. Epub 2021 Mar 05.

Perturbations in mitochondrial dynamics have been observed in most neurodegenerative diseases. Here, we focus on manganese (Mn)-induced Parkinsonism-like neurodegeneration, a disorder associated with the preferential of Mn in the basal ganglia where the mitochondria are considered an early target....

Showing 1 to 12 of 13 entries