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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.

Pathobiology of aging & age related diseases

de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ, Bothwell M.
PMID: 25758563
Pathobiol Aging Age Relat Dis. 2015 Mar 09;5:25796. doi: 10.3402/pba.v5.25796. eCollection 2015.

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the...

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de Laat R, Meabon JS, Wiley JC, et al. LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol Aging Age Relat Dis. 2015;5:25796doi: 10.3402/pba.v5.25796.
de Laat, R., Meabon, J. S., Wiley, J. C., Hudson, M. P., Montine, T. J., & Bothwell, M. (2015). LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiology of aging & age related diseases, 525796. https://doi.org/10.3402/pba.v5.25796
de Laat, Rian, et al. "LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor." Pathobiology of aging & age related diseases vol. 5 (2015): 25796. doi: https://doi.org/10.3402/pba.v5.25796
de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ, Bothwell M. LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol Aging Age Relat Dis. 2015 Mar 09;5:25796. doi: 10.3402/pba.v5.25796. eCollection 2015. PMID: 25758563; PMCID: PMC4355507.
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Dye-coupling between blastomeres in early embryos ofPatella vulgata (mollusca, gastropoda): Its relevance for cell determination.

Wilhelm Roux's archives of developmental biology

Dorresteijn AW, Wagemaker HA, de Laat SW, van den Biggelaar JA.
PMID: 28305513
Wilehm Roux Arch Dev Biol. 1983 Sep;192(5):262-269. doi: 10.1007/BF00848658.

During the early development of the molluscPatella, the dorsoventral axis is established after the fifth cleavage due to direct interaction between the animal micromeres and one of the vegetal macromeres. This vegetal macromere is thereby induced to become the...

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Dorresteijn AW, Wagemaker HA, de Laat SW, et al. Dye-coupling between blastomeres in early embryos ofPatella vulgata (mollusca, gastropoda): Its relevance for cell determination. Wilehm Roux Arch Dev Biol. 1983;192(5):262-269doi: 10.1007/BF00848658.
Dorresteijn, A. W., Wagemaker, H. A., de Laat, S. W., & van den Biggelaar, J. A. (1983). Dye-coupling between blastomeres in early embryos ofPatella vulgata (mollusca, gastropoda): Its relevance for cell determination. Wilhelm Roux's archives of developmental biology, 192(5), 262-269. https://doi.org/10.1007/BF00848658
Dorresteijn, Adriaan W C, et al. "Dye-coupling between blastomeres in early embryos ofPatella vulgata (mollusca, gastropoda): Its relevance for cell determination." Wilhelm Roux's archives of developmental biology vol. 192,5 (1983): 262-269. doi: https://doi.org/10.1007/BF00848658
Dorresteijn AW, Wagemaker HA, de Laat SW, van den Biggelaar JA. Dye-coupling between blastomeres in early embryos ofPatella vulgata (mollusca, gastropoda): Its relevance for cell determination. Wilehm Roux Arch Dev Biol. 1983 Sep;192(5):262-269. doi: 10.1007/BF00848658. PMID: 28305513.
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Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

Thrombosis research

van der Meijden PE, Ozaki Y, Ruf W, de Laat B, Mutch N, Diamond S, Nieuwland R, Peters TC, Heestermans M, Kremers RM, Moorlag M, Boender J, Ünlü B, Reitsma PH.
PMID: 26387733
Thromb Res. 2015 Sep;136:S3-7. doi: 10.1016/j.thromres.2015.07.034.

No abstract available.

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van der Meijden PE, Ozaki Y, Ruf W, et al. Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). Thromb Res. 2015;136:S3-7doi: 10.1016/j.thromres.2015.07.034.
van der Meijden, P. E., Ozaki, Y., Ruf, W., de Laat, B., Mutch, N., Diamond, S., Nieuwland, R., Peters, T. C., Heestermans, M., Kremers, R. M., Moorlag, M., Boender, J., Ünlü, B., & Reitsma, P. H. (2015). Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). Thrombosis research, 136S3-7. https://doi.org/10.1016/j.thromres.2015.07.034
van der Meijden, Paola E J, et al. "Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)." Thrombosis research vol. 136 (2015): S3-7. doi: https://doi.org/10.1016/j.thromres.2015.07.034
van der Meijden PE, Ozaki Y, Ruf W, de Laat B, Mutch N, Diamond S, Nieuwland R, Peters TC, Heestermans M, Kremers RM, Moorlag M, Boender J, Ünlü B, Reitsma PH. Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). Thromb Res. 2015 Sep;136:S3-7. doi: 10.1016/j.thromres.2015.07.034. PMID: 26387733.
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Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study.

Journal of aging research

van Uden IW, van Norden AG, de Laat KF, van Oudheusden LJ, Gons RA, Tendolkar I, Zwiers MP, de Leeuw FE.
PMID: 22007299
J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06.

Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of...

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van Uden IW, van Norden AG, de Laat KF, et al. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869doi: 10.4061/2011/647869.
van Uden, I. W., van Norden, A. G., de Laat, K. F., van Oudheusden, L. J., Gons, R. A., Tendolkar, I., Zwiers, M. P., & de Leeuw, F. E. (2011). Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. Journal of aging research, 2011647869. https://doi.org/10.4061/2011/647869
van Uden, I W M, et al. "Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study." Journal of aging research vol. 2011 (2011): 647869. doi: https://doi.org/10.4061/2011/647869
van Uden IW, van Norden AG, de Laat KF, van Oudheusden LJ, Gons RA, Tendolkar I, Zwiers MP, de Leeuw FE. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06. PMID: 22007299; PMCID: PMC3189594.
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Haemangioma of infancy: two case reports with an overdose of propranolol.

Case reports in dermatology

Janmohamed SR, Madern GC, de Laat PC, Oranje AP.
PMID: 21931573
Case Rep Dermatol. 2011 Jan;3(1):18-21. doi: 10.1159/000324421. Epub 2011 Feb 05.

An 8-week-old infant was treated with oral propranolol for a haemangioma of infancy. The standard dose (according to protocol) is 2 mg/kg/day but, because of a mistake by the pharmacist, the child was treated with 8 mg/kg/day without any...

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Janmohamed SR, Madern GC, de Laat PC, et al. Haemangioma of infancy: two case reports with an overdose of propranolol. Case Rep Dermatol. 2011;3(1):18-21doi: 10.1159/000324421.
Janmohamed, S. R., Madern, G. C., de Laat, P. C., & Oranje, A. P. (2011). Haemangioma of infancy: two case reports with an overdose of propranolol. Case reports in dermatology, 3(1), 18-21. https://doi.org/10.1159/000324421
Janmohamed, S R, et al. "Haemangioma of infancy: two case reports with an overdose of propranolol." Case reports in dermatology vol. 3,1 (2011): 18-21. doi: https://doi.org/10.1159/000324421
Janmohamed SR, Madern GC, de Laat PC, Oranje AP. Haemangioma of infancy: two case reports with an overdose of propranolol. Case Rep Dermatol. 2011 Jan;3(1):18-21. doi: 10.1159/000324421. Epub 2011 Feb 05. PMID: 21931573; PMCID: PMC3175358.
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Inheritance of the m.3243A>G mutation.

JIMD reports

de Laat P, Koene S, Heuvel LP, Rodenburg RJ, Janssen MC, Smeitink JA.
PMID: 23430519
JIMD Rep. 2013;8:47-50. doi: 10.1007/8904_2012_159. Epub 2012 Jul 06.

The m.3243A>G is the most prevalent pathogenic mtDNA mutation but little is known about its inheritance. We studied 34 families containing 56 mother-child relations and 82 intersibling relations to investigate its transmission. We found a significant correlation between mother...

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de Laat P, Koene S, Heuvel LP, et al. Inheritance of the m.3243A>G mutation. JIMD Rep. 2012;8:47-50doi: 10.1007/8904_2012_159.
de Laat, P., Koene, S., Heuvel, L. P., Rodenburg, R. J., Janssen, M. C., & Smeitink, J. A. (2013). Inheritance of the m.3243A>G mutation. JIMD reports, 847-50. https://doi.org/10.1007/8904_2012_159
de Laat, Paul, et al. "Inheritance of the m.3243A>G mutation." JIMD reports vol. 8 (2013): 47-50. doi: https://doi.org/10.1007/8904_2012_159
de Laat P, Koene S, Heuvel LP, Rodenburg RJ, Janssen MC, Smeitink JA. Inheritance of the m.3243A>G mutation. JIMD Rep. 2013;8:47-50. doi: 10.1007/8904_2012_159. Epub 2012 Jul 06. PMID: 23430519; PMCID: PMC3565654.
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Erratum to: Quantification of gait in mitochondrial m.3243A > G patients: a validation study.

Orphanet journal of rare diseases

Ramakers R, Koene S, Groothuis JT, de Laat P, Janssen MCH, Smeitink J.
PMID: 29078792
Orphanet J Rare Dis. 2017 Oct 27;12(1):170. doi: 10.1186/s13023-017-0688-z.

No abstract available.

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Ramakers R, Koene S, Groothuis JT, et al. Erratum to: Quantification of gait in mitochondrial m.3243A > G patients: a validation study. Orphanet J Rare Dis. 2017;12(1):170doi: 10.1186/s13023-017-0688-z.
Ramakers, R., Koene, S., Groothuis, J. T., de Laat, P., Janssen, M. C. H., & Smeitink, J. (2017). Erratum to: Quantification of gait in mitochondrial m.3243A > G patients: a validation study. Orphanet journal of rare diseases, 12(1), 170. https://doi.org/10.1186/s13023-017-0688-z
Ramakers, Rob, et al. "Erratum to: Quantification of gait in mitochondrial m.3243A > G patients: a validation study." Orphanet journal of rare diseases vol. 12,1 (2017): 170. doi: https://doi.org/10.1186/s13023-017-0688-z
Ramakers R, Koene S, Groothuis JT, de Laat P, Janssen MCH, Smeitink J. Erratum to: Quantification of gait in mitochondrial m.3243A > G patients: a validation study. Orphanet J Rare Dis. 2017 Oct 27;12(1):170. doi: 10.1186/s13023-017-0688-z. PMID: 29078792; PMCID: PMC5660442.
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Prevalence of Joint Gait Patterns Defined by a Delphi Consensus Study Is Related to Gross Motor Function, Topographical Classification, Weakness, and Spasticity, in Children with Cerebral Palsy.

Frontiers in human neuroscience

Nieuwenhuys A, Papageorgiou E, Schless SH, De Laet T, Molenaers G, Desloovere K.
PMID: 28446871
Front Hum Neurosci. 2017 Apr 12;11:185. doi: 10.3389/fnhum.2017.00185. eCollection 2017.

During a Delphi consensus study, a new joint gait classification system was developed for children with cerebral palsy (CP). This system, whose reliability and content validity have previously been established, identified 49 distinct joint patterns. The present study aims...

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Nieuwenhuys A, Papageorgiou E, Schless SH, et al. Prevalence of Joint Gait Patterns Defined by a Delphi Consensus Study Is Related to Gross Motor Function, Topographical Classification, Weakness, and Spasticity, in Children with Cerebral Palsy. Front Hum Neurosci. 2017;11:185doi: 10.3389/fnhum.2017.00185.
Nieuwenhuys, A., Papageorgiou, E., Schless, S. H., De Laet, T., Molenaers, G., & Desloovere, K. (2017). Prevalence of Joint Gait Patterns Defined by a Delphi Consensus Study Is Related to Gross Motor Function, Topographical Classification, Weakness, and Spasticity, in Children with Cerebral Palsy. Frontiers in human neuroscience, 11185. https://doi.org/10.3389/fnhum.2017.00185
Nieuwenhuys, Angela, et al. "Prevalence of Joint Gait Patterns Defined by a Delphi Consensus Study Is Related to Gross Motor Function, Topographical Classification, Weakness, and Spasticity, in Children with Cerebral Palsy." Frontiers in human neuroscience vol. 11 (2017): 185. doi: https://doi.org/10.3389/fnhum.2017.00185
Nieuwenhuys A, Papageorgiou E, Schless SH, De Laet T, Molenaers G, Desloovere K. Prevalence of Joint Gait Patterns Defined by a Delphi Consensus Study Is Related to Gross Motor Function, Topographical Classification, Weakness, and Spasticity, in Children with Cerebral Palsy. Front Hum Neurosci. 2017 Apr 12;11:185. doi: 10.3389/fnhum.2017.00185. eCollection 2017. PMID: 28446871; PMCID: PMC5388743.
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Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study.

Frontiers in cardiovascular medicine

Kleinegris MF, Konings J, Daemen JW, Henskens Y, de Laat B, Spronk HMH, Ten Cate-Hoek AJ, Ten Cate H.
PMID: 28473975
Front Cardiovasc Med. 2017 Apr 20;4:23. doi: 10.3389/fcvm.2017.00023. eCollection 2017.

BACKGROUND: In peripheral arterial disease (PAD), activation of the hemostatic system may contribute to atherosclerosis progression and atherothrombotic events.OBJECTIVE: This case-control study assesses the overall coagulation status in PAD patients by evaluating coagulation markers in combination with thrombin generation...

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Kleinegris MF, Konings J, Daemen JW, et al. Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Front Cardiovasc Med. 2017;4:23doi: 10.3389/fcvm.2017.00023.
Kleinegris, M. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., Ten Cate-Hoek, A. J., & Ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in cardiovascular medicine, 423. https://doi.org/10.3389/fcvm.2017.00023
Kleinegris, Marie-Claire F, et al. "Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study." Frontiers in cardiovascular medicine vol. 4 (2017): 23. doi: https://doi.org/10.3389/fcvm.2017.00023
Kleinegris MF, Konings J, Daemen JW, Henskens Y, de Laat B, Spronk HMH, Ten Cate-Hoek AJ, Ten Cate H. Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Front Cardiovasc Med. 2017 Apr 20;4:23. doi: 10.3389/fcvm.2017.00023. eCollection 2017. PMID: 28473975; PMCID: PMC5397513.
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Bounds on entanglement dimensions and quantum graph parameters via noncommutative polynomial optimization.

Mathematical programming

Gribling S, de Laat D, Laurent M.
PMID: 30996477
Math Program. 2018;170(1):5-42. doi: 10.1007/s10107-018-1287-z. Epub 2018 May 21.

In this paper we study optimization problems related to bipartite quantum correlations using techniques from tracial noncommutative polynomial optimization. First we consider the problem of finding the minimal entanglement dimension of such correlations. We construct a hierarchy of semidefinite...

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Gribling S, de Laat D, Laurent M. Bounds on entanglement dimensions and quantum graph parameters via noncommutative polynomial optimization. Math Program. 2018;170(1):5-42doi: 10.1007/s10107-018-1287-z.
Gribling, S., de Laat, D., & Laurent, M. (2018). Bounds on entanglement dimensions and quantum graph parameters via noncommutative polynomial optimization. Mathematical programming, 170(1), 5-42. https://doi.org/10.1007/s10107-018-1287-z
Gribling, Sander, et al. "Bounds on entanglement dimensions and quantum graph parameters via noncommutative polynomial optimization." Mathematical programming vol. 170,1 (2018): 5-42. doi: https://doi.org/10.1007/s10107-018-1287-z
Gribling S, de Laat D, Laurent M. Bounds on entanglement dimensions and quantum graph parameters via noncommutative polynomial optimization. Math Program. 2018;170(1):5-42. doi: 10.1007/s10107-018-1287-z. Epub 2018 May 21. PMID: 30996477; PMCID: PMC6435212.
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Effect of early palliative care: complex intervention and complex results - Authors' reply.

The Lancet. Oncology

Vanbutsele G, Pardon K, Van Belle S, Surmont V, De Laat M, Colman R, Eecloo K, Cocquyt V, Geboes K, Deliens L.
PMID: 29726381
Lancet Oncol. 2018 May;19(5):e222. doi: 10.1016/S1470-2045(18)30265-1.

No abstract available.

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Vanbutsele G, Pardon K, Van Belle S, et al. Effect of early palliative care: complex intervention and complex results - Authors' reply. Lancet Oncol. 2018;19(5):e222doi: 10.1016/S1470-2045(18)30265-1.
Vanbutsele, G., Pardon, K., Van Belle, S., Surmont, V., De Laat, M., Colman, R., Eecloo, K., Cocquyt, V., Geboes, K., & Deliens, L. (2018). Effect of early palliative care: complex intervention and complex results - Authors' reply. The Lancet. Oncology, 19(5), e222. https://doi.org/10.1016/S1470-2045(18)30265-1
Vanbutsele, Gaëlle, et al. "Effect of early palliative care: complex intervention and complex results - Authors' reply." The Lancet. Oncology vol. 19,5 (2018): e222. doi: https://doi.org/10.1016/S1470-2045(18)30265-1
Vanbutsele G, Pardon K, Van Belle S, Surmont V, De Laat M, Colman R, Eecloo K, Cocquyt V, Geboes K, Deliens L. Effect of early palliative care: complex intervention and complex results - Authors' reply. Lancet Oncol. 2018 May;19(5):e222. doi: 10.1016/S1470-2045(18)30265-1. PMID: 29726381.
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Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease.

Clinical kidney journal

van der Vorm LN, Visser R, Huskens D, Veninga A, Adams DL, Remijn JA, Hemker HC, Rensma PL, van Horssen R, de Laat B.
PMID: 32082555
Clin Kidney J. 2019 Jun 17;13(1):72-74. doi: 10.1093/ckj/sfz076. eCollection 2020 Feb.

No abstract available.

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van der Vorm LN, Visser R, Huskens D, et al. Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease. Clin Kidney J. 2019;13(1):72-74doi: 10.1093/ckj/sfz076.
van der Vorm, L. N., Visser, R., Huskens, D., Veninga, A., Adams, D. L., Remijn, J. A., Hemker, H. C., Rensma, P. L., van Horssen, R., & de Laat, B. (2020). Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease. Clinical kidney journal, 13(1), 72-74. https://doi.org/10.1093/ckj/sfz076
van der Vorm, Lisa N, et al. "Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease." Clinical kidney journal vol. 13,1 (2020): 72-74. doi: https://doi.org/10.1093/ckj/sfz076
van der Vorm LN, Visser R, Huskens D, Veninga A, Adams DL, Remijn JA, Hemker HC, Rensma PL, van Horssen R, de Laat B. Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease. Clin Kidney J. 2019 Jun 17;13(1):72-74. doi: 10.1093/ckj/sfz076. eCollection 2020 Feb. PMID: 32082555; PMCID: PMC7025327.
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Showing 1 to 12 of 96 entries