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Rehabilitation Research at the National Institutes of Health: Moving the Field Forward (Executive Summary).

The American journal of occupational therapy : official publication of the American Occupational Therapy Association

Frontera WR, Bean JF, Damiano D, Ehrlich-Jones L, Fried-Oken M, Jette A, Jung R, Lieber RL, Malec JF, Mueller MJ, Ottenbacher KJ, Tansey KE, Thompson A.
PMID: 28422639
Am J Occup Ther. 2017 May-Jun;71(3):7103320010P1-7103320010P12. doi: 10.5014/ajot.2017.713003.

Approximately 53 million Americans live with a disability. For decades, the National Institutes of Health (NIH) has been conducting and supporting research to discover new ways to minimize disability and enhance the quality of life of people with disabilities....

Conjugate Addition/[3,3] Sigmatropic Shift Processes for Formation of Medium-Ring Cyclic Amines - Do They Circumvent the Woodward-Hoffmann Rules?.

The Journal of organic chemistry

Painter PP, Siebert MR, Tantillo DJ.
PMID: 26168077
J Org Chem. 2015 Dec 04;80(23):11699-705. doi: 10.1021/acs.joc.5b00996. Epub 2015 Jul 24.

Herein we describe our exploration, using density functional theory calculations, of a conjugate addition-rearrangement sequence that leads to medium-ring cyclic amines. On the basis of the results of our calculations, we conclude that the rearrangement step is rate determining....

Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver.

Hepatology international

McVicker BL, Thiele GM, Tuma DJ, Casey CA.
PMID: 26201322
Hepatol Int. 2014 Sep;8:432-8. doi: 10.1007/s12072-013-9511-7. Epub 2013 Dec 29.

The consumption of alcohol is associated with many health issues including alcoholic liver disease (ALD). The natural history of ALD involves the development of steatosis, inflammation (steatohepatitis), fibrosis and cirrhosis. During the stage of steatohepatitis, the combination of inflammation...

Tuning of Photoluminescence by Cation Nanosegregation in the (CaMg)(x)(NaSc)(1-x)Si2O6 Solid Solution.

Journal of the American Chemical Society

Xia Z, Liu G, Wen J, Mei Z, Balasubramanian M, Molokeev MS, Peng L, Gu L, Miller DJ, Liu Q, Poeppelmeier KR.
PMID: 26771260
J Am Chem Soc. 2016 Feb 03;138(4):1158-61. doi: 10.1021/jacs.5b12788. Epub 2016 Jan 22.

Controlled photoluminescence tuning is important for the optimization and modification of phosphor materials. Herein we report an isostructural solid solution of (CaMg)x(NaSc)1-xSi2O6 (0 < x < 1) in which cation nanosegregation leads to the presence of two dilute Eu(2+)...

Synthesis of Benzodihydrofurans by Asymmetric C-H Insertion Reactions of Donor/Donor Rhodium Carbenes.

Chemistry (Weinheim an der Bergstrasse, Germany)

Lamb KN, Squitieri RA, Chintala SR, Kwong AJ, Balmond EI, Soldi C, Dmitrenko O, Castiñeira Reis M, Chung R, Addison JB, Fettinger JC, Hein JE, Tantillo DJ, Fox JM, Shaw JT.
PMID: 28544228
Chemistry. 2017 Sep 04;23(49):11843-11855. doi: 10.1002/chem.201701630. Epub 2017 Aug 10.

Metal carbenes appended with two electron-donating groups, known as "donor/donor" carbenes, undergo diastereo- and enantioselective rhodium-catalyzed C-H insertion reactions with ether substrates to form benzodihydrofurans. Unlike the reactions of metal carbenes with electron-withdrawing groups attached, the attenuated electrophilicity enables...

Insight into the Capacity Fading Mechanism of Amorphous Se2S5 Confined in Micro/Mesoporous Carbon Matrix in Ether-Based Electrolytes.

Nano letters

Xu GL, Ma T, Sun CJ, Luo C, Cheng L, Ren Y, Heald SM, Wang C, Curtiss L, Wen J, Miller DJ, Li T, Zuo X, Petkov V, Chen Z, Amine K.
PMID: 27022761
Nano Lett. 2016 Apr 13;16(4):2663-73. doi: 10.1021/acs.nanolett.6b00318. Epub 2016 Mar 31.

In contrast to the stable cycle performance of space confined Se-based cathodes for lithium batteries in carbonate-based electrolytes, their common capacity fading in ether-based electrolytes has been paid less attention and not yet well-addressed so far. In this work,...

Ethanol-induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity.

Hepatology communications

Rasineni K, Donohue TM, Thomes PG, Yang L, Tuma DJ, McNiven MA, Casey CA.
PMID: 29152606
Hepatol Commun. 2017 Aug;1(6):501-512. doi: 10.1002/hep4.1063. Epub 2017 Jul 10.

BACKGROUND: Lipid droplets (LDs), the organelles central to alcoholic steatosis, are broken down by lipophagy, a specialized form of autophagy. Here, we hypothesize that ethanol administration retards lipophagy by down-regulating Dynamin 2 (Dyn2), a protein that facilitates lysosome re-formation,...

Determination of Carboxypeptidase Activity in Clinical Pathogens by Gas Chromatography-Mass Spectrometry.

Analytical letters

Lough F, Perry JD, Stanforth SP, Dean JR.
PMID: 27226648
Anal Lett. 2016 May 23;49(8):1272-1277. doi: 10.1080/00032719.2015.1092153. Epub 2016 Apr 21.

A novel method for the determination of benzoic acid has been employed to identify carboxypeptidase activities in clinically relevant pathogens. Benzoic acid was determined after chemical derivatization by gas chromatography-mass spectrometry (GC-MS). N-Benzoyl amino acid substrates were evaluated for...

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury.

Allergy, asthma & immunology research

Kim SH, Naisbitt DJ.
PMID: 26540496
Allergy Asthma Immunol Res. 2016 Jan;8(1):3-11. doi: 10.4168/aair.2016.8.1.3. Epub 2015 Jul 03.

Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings....

The DSM-III and pastoral practice.

Journal of religion and health

Dean JC.
PMID: 24301693
J Relig Health. 1986 Dec;25(4):303-8. doi: 10.1007/BF01534068.

This essay provides a conceptual bridge between psychiatry and pastoral practice which may facilitate cooperative efforts. The conceptual link is the theological and psychiatric answer to the question, "What is personhood?" found in the biblical doctrine of personhood and...

Alcoholism: A conflict of models.

Journal of religion and health

Dean JC.
PMID: 24302066
J Relig Health. 1987 Dec;26(4):270-6. doi: 10.1007/BF01533878.

Adherents to the traditional model of alcoholism explain alcoholic behavior as a consequence of alcoholism. Alcoholism is identified as an unseen, unmeasured entity inherent in alcoholics. This concept parallels the thinking of Copernicus, Kepler, Galileo, and Newton, who believed...

Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment.

Molecular cancer biology

AbdelHafez EM, Diamanduros A, Negureanu L, Luy Y, Bean JH, Zielke K, Crowe B, Vasilyeva A, Clodfelter JE, Aly OM, Abuo-Rahma GE, Scarpinato KD, Salsbury FR, King SB.
PMID: 25485184
Mol Cancer Biol. 2013;1(1).

We, and others, have previously shown that mismatch repair proteins, in addition to their repair function, contribute to cell death initiation. In response to some drugs, this cell death activity is independent of the repair function of the proteins....

Showing 1 to 12 of 737 entries