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Showing 1 to 12 of 39 entries
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Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes.

Molecular neuropsychiatry

Anand A, McClintick JN, Murrell J, Karne H, Nurnberger JI, Edenberg HJ.
PMID: 27867936
Mol Neuropsychiatry. 2016 Oct;2(3):115-123. doi: 10.1159/000446348. Epub 2016 Jun 29.

BACKGROUND: This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD).METHOD: Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were...

The Coronary Blood Supply in the Rhesus Monkey.

Journal of anatomy

Abramson DI, Eisenberg HJ.
PMID: 17104559
J Anat. 1935 Jul;69:520-5.

No abstract available.

Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.

Behavior genetics

Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA, Dick DM.
PMID: 34117972
Behav Genet. 2021 Sep;51(5):543-558. doi: 10.1007/s10519-021-10067-7. Epub 2021 Jun 12.

Genetic predispositions and environmental influences both play an important role in adolescent externalizing behavior; however, they are not always independent. To elucidate gene-environment interplay, we examined the interrelationships between externalizing polygenic risk scores, parental knowledge, and peer substance use...

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.

The American journal of psychiatry

Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S.
PMID: 33985350
Am J Psychiatry. 2022 Jan;179(1):58-70. doi: 10.1176/appi.ajp.2020.20091390. Epub 2021 May 14.

OBJECTIVE: Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be...

Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study.

Alcoholism, clinical and experimental research

Bountress KE, Wendt F, Bustamante D, Agrawal A, Webb B, Gillespie N, Edenberg H, Sheerin C, Johnson E, Polimanti R, Amstadter A.
PMID: 34120358
Alcohol Clin Exp Res. 2021 Aug;45(8):1616-1623. doi: 10.1111/acer.14649. Epub 2021 Jun 24.

BACKGROUND: Posttraumatic stress disorder (PTSD) often co-occurs with alcohol consumption (AC) and alcohol use disorder (AUD). However, it is unknown whether the same etiologic influences that underlie PTSD co-occurring with AUD are those that underlie PTSD and AC individually.METHODS:...

A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.

Molecular psychiatry

Meyers JL, Zhang J, Chorlian DB, Pandey AK, Kamarajan C, Wang JC, Wetherill L, Lai D, Chao M, Chan G, Kinreich S, Kapoor M, Bertelsen S, McClintick J, Bauer L, Hesselbrock V, Kuperman S, Kramer J, Salvatore JE, Dick DM, Agrawal A, Foroud T, Edenberg HJ, Goate A, Porjesz B.
PMID: 32433515
Mol Psychiatry. 2021 Sep;26(9):5040-5052. doi: 10.1038/s41380-020-0777-6. Epub 2020 May 20.

Aberrant connectivity of large-scale brain networks has been observed among individuals with alcohol use disorders (AUDs) as well as in those at risk, suggesting deficits in neural communication between brain regions in the liability to develop AUD. Electroencephalographical (EEG)...

The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A.
PMID: 34750568
Neuropsychopharmacology. 2021 Nov 08; doi: 10.1038/s41386-021-01209-w. Epub 2021 Nov 08.

Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested whether a common genetic factor undergirds liability to problematic alcohol use...

Nonlinear distortion free fiber-based chirped pulse amplification with self-phase modulation up to 2pi.

Optics express

Zhu G, Edinberg J, Xu C.
PMID: 19532489
Opt Express. 2007 Mar 05;15(5):2530-4. doi: 10.1364/oe.15.002530.

We demonstrate the removal of 2pi radians of self-phase modulation (SPM) in a fiber-based chirped pulse amplification (CPA) system. Compensation of SPM distortion is achieved in the time domain by using a LiNbO(3) electro-optic phase modulator to emulate a...

Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects.

Biology open

Sarmah S, Muralidharan P, Curtis CL, McClintick JN, Buente BB, Holdgrafer DJ, Ogbeifun O, Olorungbounmi OC, Patino L, Lucas R, Gilbert S, Groninger ES, Arciero J, Edenberg HJ, Marrs JA.
PMID: 24167711
Biol Open. 2013 Aug 14;2(10):1013-21. doi: 10.1242/bio.20135546. eCollection 2013.

Fetal alcohol spectrum disorder (FASD) occurs when pregnant mothers consume alcohol, causing embryonic ethanol exposure and characteristic birth defects that include craniofacial, neural and cardiac defects. Gastrulation is a particularly sensitive developmental stage for teratogen exposure, and zebrafish is...

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls - CORRIGENDUM.

Psychological medicine

Pettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardiñas AF, Stahl E, Walters JTR, Walters R, Sullivan PF, Posthuma D, Polderman TJC.
PMID: 30334498
Psychol Med. 2019 Jan;49(2):351. doi: 10.1017/S0033291718002945. Epub 2018 Oct 18.

No abstract available.

Integration of evidence across human and model organism studies: A meeting report.

Genes, brain, and behavior

Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW.
PMID: 33893716
Genes Brain Behav. 2021 Apr 23;e12738. doi: 10.1111/gbb.12738. Epub 2021 Apr 23.

The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR...

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.

Psychological medicine

Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A.
PMID: 34231451
Psychol Med. 2021 Jul 07;1-9. doi: 10.1017/S003329172100266X. Epub 2021 Jul 07.

BACKGROUND: Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders.METHODS: We used the largest published GWAS for AUD (total cases = 77 822) and SCZ...

Showing 1 to 12 of 39 entries