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Showing 1 to 12 of 34 entries
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Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment.

The Science of the total environment

Wünscher G, Kersting H, Heberer H, Westmeier I, Wenzel V, Flechsig M, Matthaeus E.
PMID: 2057758
Sci Total Environ. 1991 Jan 01;101(1):101-9. doi: 10.1016/0048-9697(91)90108-q.

This paper describes the use of an interactive simulation system (SONCHES) as a model and databank system. The basic model is a physiologically based toxicokinetic model (partition coefficient concept). This model takes circulation times into consideration and includes a...

Palladium catalyzed synthesis and physical properties of indolo[2,3-b]quinoxalines.

Organic & biomolecular chemistry

Hung TQ, Hoang do H, Thang NN, Dang TT, Ayub K, Villinger A, Friedrich A, Lochbrunner S, Flechsig GU, Langer P.
PMID: 25001519
Org Biomol Chem. 2014 Aug 28;12(32):6151-66. doi: 10.1039/c4ob00841c. Epub 2014 Jul 08.

A series of indolo[2,3-b]quinoxaline derivatives were efficiently synthesized from 2,3-dibromoquinoxaline by two pathways. A one-pot approach using Pd-catalyzed two-fold C-N coupling and C-H activation reactions gave indolo[2,3-b]quinoxaline derivatives in good yields, but with limited substrate scope. In addition, a...

Numerical optimization of spherical variable-line-spacing grating X-ray spectrometers.

Journal of synchrotron radiation

Strocov VN, Schmitt T, Flechsig U, Patthey L, Chiuzbăian GS.
PMID: 21335898
J Synchrotron Radiat. 2011 Mar;18:134-42. doi: 10.1107/S0909049510054452. Epub 2011 Jan 29.

Operation of an X-ray spectrometer based on a spherical variable-line-spacing (VLS) grating is analyzed using dedicated ray-tracing software allowing fast optimization of the grating parameters and spectrometer geometry. The analysis is illustrated with optical design of a model spectrometer...

Superior therapeutic index of calmangafodipir in comparison to mangafodipir as a chemotherapy adjunct.

Translational oncology

Karlsson JO, Kurz T, Flechsig S, Näsström J, Andersson RG.
PMID: 23323161
Transl Oncol. 2012 Dec;5(6):492-502. doi: 10.1593/tlo.12238. Epub 2012 Dec 01.

Mangafodipir is a magnetic resonance imaging contrast agent with manganese superoxide dismutase (MnSOD) mimetic activity. The MnSOD mimetic activity protects healthy cells against oxidative stress-induced detrimental effects, e.g., myelosuppressive effects of chemotherapy drugs. The contrast property depends on in...

The Materials Science beamline upgrade at the Swiss Light Source.

Journal of synchrotron radiation

Willmott PR, Meister D, Leake SJ, Lange M, Bergamaschi A, Böge M, Calvi M, Cancellieri C, Casati N, Cervellino A, Chen Q, David C, Flechsig U, Gozzo F, Henrich B, Jäggi-Spielmann S, Jakob B, Kalichava I, Karvinen P, Krempasky J, Lüdeke A, Lüscher R, Maag S, Quitmann C, Reinle-Schmitt ML, Schmidt T, Schmitt B, Streun A, Vartiainen I, Vitins M, Wang X, Wullschleger R.
PMID: 23955029
J Synchrotron Radiat. 2013 Sep;20:667-82. doi: 10.1107/S0909049513018475. Epub 2013 Jul 16.

The Materials Science beamline at the Swiss Light Source has been operational since 2001. In late 2010, the original wiggler source was replaced with a novel insertion device, which allows unprecedented access to high photon energies from an undulator...

Remote Ischemic Preconditioning Neither Improves Survival nor Reduces Myocardial or Kidney Injury in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI).

Journal of clinical medicine

Flechsig M, Ruf TF, Troeger W, Wiedemann S, Quick S, Ibrahim K, Pfluecke C, Youssef A, Sveric KM, Winzer R, Heinzel FR, Linke A, Strasser RH, Zhang K, Heidrich FM.
PMID: 31936060
J Clin Med. 2020 Jan 07;9(1). doi: 10.3390/jcm9010160.

BACKGROUND: Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on myocardial injury, acute kidney injury (AKIN) and 6-month mortality in patients undergoing TAVI.METHODS: We performed a prospective...

Experimental station Bernina at SwissFEL: condensed matter physics on femtosecond time scales investigated by X-ray diffraction and spectroscopic methods.

Journal of synchrotron radiation

Ingold G, Abela R, Arrell C, Beaud P, Böhler P, Cammarata M, Deng Y, Erny C, Esposito V, Flechsig U, Follath R, Hauri C, Johnson S, Juranic P, Mancini GF, Mankowsky R, Mozzanica A, Oggenfuss RA, Patterson BD, Patthey L, Pedrini B, Rittmann J, Sala L, Savoini M, Svetina C, Zamofing T, Zerdane S, Lemke HT.
PMID: 31074452
J Synchrotron Radiat. 2019 May 01;26:874-886. doi: 10.1107/S160057751900331X. Epub 2019 Apr 15.

The Bernina instrument at the SwissFEL Aramis hard X-ray free-electron laser is designed for studying ultrafast phenomena in condensed matter and material science. Ultrashort pulses from an optical laser system covering a large wavelength range can be used to...

Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis.

Oncoimmunology

Dadrich M, Nicolay NH, Flechsig P, Bickelhaupt S, Hoeltgen L, Roeder F, Hauser K, Tietz A, Jenne J, Lopez R, Roehrich M, Wirkner U, Lahn M, Huber PE.
PMID: 27467922
Oncoimmunology. 2015 Dec 29;5(5):e1123366. doi: 10.1080/2162402X.2015.1123366. eCollection 2016 May.

Background : Radiotherapy (RT) is a mainstay for the treatment of lung cancer, but the effective dose is often limited by the development of radiation-induced pneumonitis and pulmonary fibrosis. Transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF)...

Experimental demonstration of a soft x-ray self-seeded free-electron laser.

Physical review letters

Ratner D, Abela R, Amann J, Behrens C, Bohler D, Bouchard G, Bostedt C, Boyes M, Chow K, Cocco D, Decker FJ, Ding Y, Eckman C, Emma P, Fairley D, Feng Y, Field C, Flechsig U, Gassner G, Hastings J, Heimann P, Huang Z, Kelez N, Krzywinski J, Loos H, Lutman A, Marinelli A, Marcus G, Maxwell T, Montanez P, Moeller S, Morton D, Nuhn HD, Rodes N, Schlotter W, Serkez S, Stevens T, Turner J, Walz D, Welch J, Wu J.
PMID: 25699448
Phys Rev Lett. 2015 Feb 06;114(5):054801. doi: 10.1103/PhysRevLett.114.054801. Epub 2015 Feb 06.

The Linac Coherent Light Source has added a self-seeding capability to the soft x-ray range using a grating monochromator system. We report the demonstration of soft x-ray self-seeding with a measured resolving power of 2000-5000, wavelength stability of 10(-4),...

Opportunities for Chemistry at the SwissFEL X-ray Free Electron Laser.

Chimia

Milne CJ, Beaud P, Deng Y, Erny C, Follath R, Flechsig U, Hauri CP, Ingold G, Juranic P, Knopp G, Lemke H, Pedrini B, Radi P, Patthey L.
PMID: 28576157
Chimia (Aarau). 2017 May 31;71(5):299-307. doi: 10.2533/chimia.2017.299.

X-ray techniques have long been applied to chemical research, ranging from powder diffraction tools to analyse material structure to X-ray fluorescence measurements for sample composition. The development of high-brightness, accelerator-based X-ray sources has allowed chemists to use similar techniques...

High-resolution soft X-ray beamline ADRESS at the Swiss Light Source for resonant inelastic X-ray scattering and angle-resolved photoelectron spectroscopies.

Journal of synchrotron radiation

Strocov VN, Schmitt T, Flechsig U, Schmidt T, Imhof A, Chen Q, Raabe J, Betemps R, Zimoch D, Krempasky J, Wang X, Grioni M, Piazzalunga A, Patthey L.
PMID: 20724785
J Synchrotron Radiat. 2010 Sep;17(5):631-43. doi: 10.1107/S0909049510019862. Epub 2010 Jul 10.

The concepts and technical realisation of the high-resolution soft X-ray beamline ADRESS operating in the energy range from 300 to 1600 eV and intended for resonant inelastic X-ray scattering (RIXS) and angle-resolved photoelectron spectroscopy (ARPES) are described. The photon...

A plane-grating monochromator beamline for the PTB undulators at BESSY II.

Journal of synchrotron radiation

Senf F, Flechsig U, Eggenstein F, Gudat W, Klein R, Rabus H, Ulm G.
PMID: 15263651
J Synchrotron Radiat. 1998 May 01;5:780-2. doi: 10.1107/S0909049597020323. Epub 1998 May 01.

At the BESSY II storage ring, the Physikalisch-Technische Bundesanstalt (PTB) will operate insertion devices dedicated to radiometric use. One branch of the appendant beamline system will be equipped with a grazing-incidence monochromator, described here. The monochromator concept is based...

Showing 1 to 12 of 34 entries