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A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes.

Scientific reports

Mueller AJ, Tew SR, Vasieva O, Clegg PD, Canty-Laird EG.
PMID: 27670352
Sci Rep. 2016 Sep 27;6:33956. doi: 10.1038/srep33956.

Phenotypic plasticity of adult somatic cells has provided emerging avenues for the development of regenerative therapeutics. In musculoskeletal biology the mechanistic regulatory networks of genes governing the phenotypic plasticity of cartilage and tendon cells has not been considered systematically....

Identification of Equid herpesvirus 2 in tissue-engineered equine tendon.

Wellcome open research

Wardle R, Pullman JA, Haldenby S, Ressel L, Pope M, Clegg PD, Radford A, Stewart JP, Al-Saadi M, Dyer P, Peffers MJ.
PMID: 29152595
Wellcome Open Res. 2017 Oct 17;2:60. doi: 10.12688/wellcomeopenres.12176.2. eCollection 2017.

No abstract available.

Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice.

Inflammation and cell signaling

Morselli E, Criollo A, Rodriguez-Navas C, Clegg DJ.
PMID: 26046098
Inflamm Cell Signal. 2014;1(6):e561. doi: 10.14800/ics.561.

We show that chronic high fat diet (HFD) feeding affects the hypothalamus of male but not female mice. In our study we demonstrate that palmitic acid and sphingolipids accumulate in the central nervous system of HFD-fed males. Additionally, we...

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PLoS genetics

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ.
PMID: 27355579
PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun.

[This corrects the article DOI: 10.1371/journal.pgen.1005378.].

Glyph Visualization: A Fail-Safe Design Scheme Based on Quasi-Hamming Distances.

IEEE computer graphics and applications

Legg PA, Maguire E, Walton S, Chen M.
PMID: 27244727
IEEE Comput Graph Appl. 2017 Mar-Apr;37(2):31-41. doi: 10.1109/MCG.2016.66. Epub 2016 May 25.

In many spatial and temporal visualization applications, glyphs provide an effective means for encoding multivariate data. However, because glyphs are typically small, they are vulnerable to various perceptual errors. This article introduces the concept of a quasi-Hamming distance in...

Impact of gene flow from cultivated beet on genetic diversity of wild sea beet populations.

Molecular ecology

Bartsch D, Lehnen M, Clegg J, Pohl-Orf M, Schuphan I, Ellstrand NC.
PMID: 10583835
Mol Ecol. 1999 Oct;8(10):1733-41. doi: 10.1046/j.1365-294x.1999.00769.x.

Gene flow and introgression from cultivated plants may have important consequences for the conservation of wild plant populations. Cultivated beets (sugar beet, red beet and Swiss chard: Beta vulgaris ssp. vulgaris) are of particular concern because they are cross-compatible...

Creep behavior comparison of CMW1 and palacos R-40 clinical bone cements.

Journal of materials science. Materials in medicine

Liu C, Green SM, Watkins ND, Gregg PJ, McCaskie AW.
PMID: 15348171
J Mater Sci Mater Med. 2002 Nov;13(11):1021-8. doi: 10.1023/a:1020328218520.

The restrained dynamic creep behaviors of two clinical bone cements, Palacos R-40 and CMW1 have been investigated at room temperature and body temperature. It was found that the two cements demonstrated significantly different creep deformations, with Palacos R-40 bone...

On the origin of the lattice constant anomaly in nanocrystalline ceria.

Physical chemistry chemical physics : PCCP

Kossoy A, Feldman Y, Wachtel E, Gartsman K, Lubomirsky I, Fleig J, Maier J.
PMID: 16633592
Phys Chem Chem Phys. 2006 Mar 07;8(9):1111-5. doi: 10.1039/b513764k. Epub 2006 Jan 30.

The lattice parameter of nanocrystalline ceria films prepared by sputtering was monitored as a function of annealing temperature. Within the temperature range of 150-420 degrees C, an equilibrium with atmospheric oxygen is established within a few hours, whereas grain...

X-ray studies of the phases and phase transitions of liquid crystals.

Acta crystallographica. Section A, Foundations of crystallography

Clegg PS.
PMID: 15613757
Acta Crystallogr A. 2005 Jan;61:112-21. doi: 10.1107/S0108767304025991. Epub 2004 Dec 22.

A short review is given of recent X-ray diffraction studies of the phases and phase transitions of thermotropic liquid crystals. The areas covered are twist-grain-boundary phases, antiferroelectric phases studied with resonant X-ray diffraction and smectic phases within gel structures....

Fluid-bicontinuous gels stabilized by interfacial colloids: low and high molecular weight fluids.

Journal of physics. Condensed matter : an Institute of Physics journal

Clegg PS.
PMID: 21694193
J Phys Condens Matter. 2008 Mar 19;20(11):113101. doi: 10.1088/0953-8984/20/11/113101. Epub 2008 Feb 20.

Carefully tuned composite materials can have properties wholly unlike those of their separate constituents. We review the development of one example: colloid-stabilized emulsions with bicontinuous liquid domains. These non-equilibrium structures resemble the sponge mesophase of surfactants; however, in the...

Self-organization of particles with planar surface anchoring in a cholesteric liquid crystal.

Langmuir : the ACS journal of surfaces and colloids

Hijnen N, Wood TA, Wilson D, Clegg PS.
PMID: 20695597
Langmuir. 2010 Aug 17;26(16):13502-10. doi: 10.1021/la101420c.

We present birefringence and fluorescence confocal microscopy studies of melamine particles in a liquid-crystalline host solvent. The liquid crystal has a cholesteric phase at room temperature with a helical pitch that can be modified by changing the composition. The...

Cation diffusion in La(0.6)Sr(0.4)CoO(3-δ) below 800 °C and its relevance for Sr segregation.

Physical chemistry chemical physics : PCCP

Kubicek M, Rupp GM, Huber S, Penn A, Opitz AK, Bernardi J, Stöger-Pollach M, Hutter H, Fleig J.
PMID: 24390268
Phys Chem Chem Phys. 2014 Feb 14;16(6):2715-26. doi: 10.1039/c3cp51906f.

Cation diffusion was investigated in La0.6Sr0.4CoO3-δ (LSC) thin films on (100) yttria stabilized zirconia in the temperature range 625-800 °C. Isotopic ((86)Sr) and elemental tracers (Fe, Sm) were used to establish diffusion profiles of the cations in bi- and...

Showing 1 to 12 of 238 entries