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Showing 1 to 12 of 486 entries
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Integration of climate change into the senior secondary school Agricultural Science curriculum in Nigeria

science curriculum

Ikehi ME, Florence O, Cajethan UI.
GSID: HNsqmNNLGvsJ
ME Ikehi, O Florence, UI Cajethan - 2014 - dspace.unn.edu.ng

… the senior secondary school agricultural science curriculum in countries such as Nigeria. … 23 items were required for integration in the curriculum while 11 materials were identified to help … the agricultural science curriculum for teaching in secondary...

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

ACS medicinal chemistry letters

Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J.
PMID: 27326329
ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022. eCollection 2016 Jun 09.

We demonstrate a designed scaffold-hop approach to the discovery of 2,8-disubstituted-1,6-naphthyridine- and 4,6-disubstituted-isoquinoline-based dual CDK8/19 ligands. Optimized compounds in both series exhibited rapid aldehyde oxidase-mediated metabolism, which could be abrogated by introduction of an amino substituent at C5 of...

Fetal Outcomes After Diabetic Ketoacidosis During Pregnancy.

Diabetes care

Morrison FJR, Movassaghian M, Seely EW, Curran A, Shubina M, Morton-Eggleston E, Zera CA, Ecker JL, Brown FM, Turchin A.
PMID: 28606900
Diabetes Care. 2017 Jul;40(7):e77-e79. doi: 10.2337/dc17-0186.

No abstract available.

Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis.

Frontiers in cellular neuroscience

Bowerman M, Vincent T, Scamps F, Perrin FE, Camu W, Raoul C.
PMID: 24312006
Front Cell Neurosci. 2013 Nov 19;7:214. doi: 10.3389/fncel.2013.00214.

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder characterized by the progressive and selective loss of both upper and lower motoneurons. The neurodegenerative process is accompanied by a sustained inflammation in the brain and spinal cord. The neuron-immune...

The effects of industry sponsorship on comparator selection in trial registrations for neuropsychiatric conditions in children.

PloS one

Dunn AG, Mandl KD, Coiera E, Bourgeois FT.
PMID: 24376857
PLoS One. 2013 Dec 23;8(12):e84951. doi: 10.1371/journal.pone.0084951. eCollection 2013.

Pediatric populations continue to be understudied in clinical drug trials despite the increasing use of pharmacotherapy in children, particularly with psychotropic drugs. Most pertinent to the clinical selection of drug interventions are trials directly comparing drugs against other drugs....

HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.

Frontiers in integrative neuroscience

Varodayan FP, Harrison NL.
PMID: 24376402
Front Integr Neurosci. 2013 Dec 11;7:89. doi: 10.3389/fnint.2013.00089. eCollection 2013.

Many central synapses are highly sensitive to alcohol, and it is now accepted that short-term alterations in synaptic function may lead to longer-term changes in circuit function. The regulation of postsynaptic receptors by alcohol has been well studied, but...

Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis.

Frontiers in cellular neuroscience

Gerber YN, Privat A, Perrin FE.
PMID: 24409117
Front Cell Neurosci. 2013 Dec 27;7:280. doi: 10.3389/fncel.2013.00280. eCollection 2013.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typified by a massive loss of motor neurons with few therapeutic options. The exact cause of neuronal degeneration is unknown but it is now admitted that ALS is a multifactorial...

Effectiveness of coral relocation as a mitigation strategy in Kāne'ohe Bay, Hawai'i.

PeerJ

Rodgers KS, Lorance K, Richards Donà A, Stender Y, Lager C, Jokiel PL.
PMID: 28560102
PeerJ. 2017 May 23;5:e3346. doi: 10.7717/peerj.3346. eCollection 2017.

Coral reef restoration and management techniques are in ever-increasing demand due to the global decline of coral reefs in the last several decades. Coral relocation has been established as an appropriate restoration technique in select cases, particularly where corals...

Oral Health Status of the Elderly at Tonga, West Region, Cameroon.

International journal of dentistry

Michele Lolita Y, Ashu Michael A, Hubert N, Florence D, Jacques B.
PMID: 26633972
Int J Dent. 2015;2015:820416. doi: 10.1155/2015/820416. Epub 2015 Nov 08.

Objectives. The aim of this study was to determine the oral health status of elderly persons in Tonga, West Region of Cameroon. Methodology. This is a cross-sectional study of persons of at least 65 years, living in Tonga village,...

Atypical acid-fast (chromogenic) organisms complicating pulmonary disease.

Diseases of the chest

FLORENCE H.
PMID: 13356728
Dis Chest. 1956 Sep;30(3):250-76. doi: 10.1378/chest.30.3.250.

No abstract available.

Molecular similarity analysis and virtual screening by mapping of consensus positions in binary-transformed chemical descriptor spaces with variable dimensionality.

Journal of chemical information and computer sciences

Godden JW, Furr JR, Xue L, Stahura FL, Bajorath J.
PMID: 14741007
J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):21-9. doi: 10.1021/ci0302963.

A novel compound classification algorithm is described that operates in binary molecular descriptor spaces and groups active compounds together in a computationally highly efficient manner. The method involves the transformation of continuous descriptor value ranges into a binary format,...

Health care models guiding mental health policy in Kenya 1965 - 1997.

International journal of mental health systems

Muga FA, Jenkins R.
PMID: 20426855
Int J Ment Health Syst. 2010 Apr 28;4(1):9. doi: 10.1186/1752-4458-4-9.

BACKGROUND: Mental health policy is needed to set the strategy and direction for the provision of mental health services in a country. Policy formulation does not occur in a vacuum, however, but is influenced by local and international factors...

Showing 1 to 12 of 486 entries