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Model-based strategy for cell culture seed train layout verified at lab scale.

Cytotechnology

Kern S, Platas-Barradas O, Pörtner R, Frahm B.
PMID: 25795469
Cytotechnology. 2016 Aug;68(4):1019-32. doi: 10.1007/s10616-015-9858-9. Epub 2015 Mar 21.

Cell culture seed trains-the generation of a sufficient viable cell number for the inoculation of the production scale bioreactor, starting from incubator scale-are time- and cost-intensive. Accordingly, a seed train offers potential for optimization regarding its layout and the...

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Kern S, Platas-Barradas O, Pörtner R, et al. Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology. 2015;68(4):1019-32doi: 10.1007/s10616-015-9858-9.
Kern, S., Platas-Barradas, O., Pörtner, R., & Frahm, B. (2016). Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology, 68(4), 1019-32. https://doi.org/10.1007/s10616-015-9858-9
Kern, Simon, et al. "Model-based strategy for cell culture seed train layout verified at lab scale." Cytotechnology vol. 68,4 (2016): 1019-32. doi: https://doi.org/10.1007/s10616-015-9858-9
Kern S, Platas-Barradas O, Pörtner R, Frahm B. Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology. 2016 Aug;68(4):1019-32. doi: 10.1007/s10616-015-9858-9. Epub 2015 Mar 21. PMID: 25795469; PMCID: PMC4960151.
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Secondary phases and their influence on the composition of the kesterite phase in CZTS and CZTSe thin films.

Physical chemistry chemical physics : PCCP

Just J, Sutter-Fella CM, Lützenkirchen-Hecht D, Frahm R, Schorr S, Unold T.
PMID: 27240735
Phys Chem Chem Phys. 2016 Jun 21;18(23):15988-94. doi: 10.1039/c6cp00178e. Epub 2016 May 31.

Secondary phases zinc sulfide/selenide and copper sulfide in Cu2ZnSnS4 (CZTS) and Cu2ZnSnSe4 (CZTSe) thin film samples are investigated by X-ray absorption near edge structure (XANES) analysis at the chalcogen K-edges. Because of the formation of secondary phases the composition...

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Just J, Sutter-Fella CM, Lützenkirchen-Hecht D, et al. Secondary phases and their influence on the composition of the kesterite phase in CZTS and CZTSe thin films. Phys Chem Chem Phys. 2016;18(23):15988-94doi: 10.1039/c6cp00178e.
Just, J., Sutter-Fella, C. M., Lützenkirchen-Hecht, D., Frahm, R., Schorr, S., & Unold, T. (2016). Secondary phases and their influence on the composition of the kesterite phase in CZTS and CZTSe thin films. Physical chemistry chemical physics : PCCP, 18(23), 15988-94. https://doi.org/10.1039/c6cp00178e
Just, Justus, et al. "Secondary phases and their influence on the composition of the kesterite phase in CZTS and CZTSe thin films." Physical chemistry chemical physics : PCCP vol. 18,23 (2016): 15988-94. doi: https://doi.org/10.1039/c6cp00178e
Just J, Sutter-Fella CM, Lützenkirchen-Hecht D, Frahm R, Schorr S, Unold T. Secondary phases and their influence on the composition of the kesterite phase in CZTS and CZTSe thin films. Phys Chem Chem Phys. 2016 Jun 21;18(23):15988-94. doi: 10.1039/c6cp00178e. Epub 2016 May 31. PMID: 27240735.
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Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing.

Veterinary sciences

Tienken R, Kersten S, Hüther L, Frahm J, Meyer U, Dänicke S.
PMID: 29061952
Vet Sci. 2015 Dec 16;2(4):440-455. doi: 10.3390/vetsci2040440.

The present study aimed to examine the effective systemic bioavailability of niacin- with particular focus on its galenic form-and feed processing. Experiment 1 was conducted with 35 dairy cows to investigate the effects of various doses of oral supplemented...

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Tienken R, Kersten S, Hüther L, et al. Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing. Vet Sci. 2015;2(4):440-455doi: 10.3390/vetsci2040440.
Tienken, R., Kersten, S., Hüther, L., Frahm, J., Meyer, U., & Dänicke, S. (2015). Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing. Veterinary sciences, 2(4), 440-455. https://doi.org/10.3390/vetsci2040440
Tienken, Reka, et al. "Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing." Veterinary sciences vol. 2,4 (2015): 440-455. doi: https://doi.org/10.3390/vetsci2040440
Tienken R, Kersten S, Hüther L, Frahm J, Meyer U, Dänicke S. Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing. Vet Sci. 2015 Dec 16;2(4):440-455. doi: 10.3390/vetsci2040440. PMID: 29061952; PMCID: PMC5644646.
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Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity.

Animals : an open access journal from MDPI

Tienken R, Kersten S, Frahm J, Hüther L, Meyer U, Huber K, Rehage J, Dänicke S.
PMID: 26479393
Animals (Basel). 2015 Sep 08;5(3):910-33. doi: 10.3390/ani5030391.

The periparturient period is critical according to health, productivity and profitability. As this period is fundamental for the success of the lactation period, the interest in improving periparturient health by dietary supplements increased in recent years. The present study...

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Tienken R, Kersten S, Frahm J, et al. Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity. Animals (Basel). 2015;5(3):910-33doi: 10.3390/ani5030391.
Tienken, R., Kersten, S., Frahm, J., Hüther, L., Meyer, U., Huber, K., Rehage, J., & Dänicke, S. (2015). Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity. Animals : an open access journal from MDPI, 5(3), 910-33. https://doi.org/10.3390/ani5030391
Tienken, Reka, et al. "Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity." Animals : an open access journal from MDPI vol. 5,3 (2015): 910-33. doi: https://doi.org/10.3390/ani5030391
Tienken R, Kersten S, Frahm J, Hüther L, Meyer U, Huber K, Rehage J, Dänicke S. Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity. Animals (Basel). 2015 Sep 08;5(3):910-33. doi: 10.3390/ani5030391. PMID: 26479393; PMCID: PMC4598713.
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Correlation between QRS Duration, Pulmonary Insufficiency and Right Ventricle Performance in Totally Corrected Tetralogy of Fallot.

Iranian journal of pediatrics

Tanasan A, Kocharian A, Zanjani KS, Payravian FK, Torabian S.
PMID: 24800023
Iran J Pediatr. 2013 Oct;23(5):593-6.

OBJECTIVE: Despite progresses in surgical correction of Tetralogy of Fallot, pulmonary insufficiency and progressive dysfunction of the right ventricle impress its long-term prognosis. In this study we examined the correlations between QRS duration, pulmonary insufficiency and right ventricular performance...

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Tanasan A, Kocharian A, Zanjani KS, et al. Correlation between QRS Duration, Pulmonary Insufficiency and Right Ventricle Performance in Totally Corrected Tetralogy of Fallot. Iran J Pediatr. 2013;23(5):593-6
Tanasan, A., Kocharian, A., Zanjani, K. S., Payravian, F. K., & Torabian, S. (2013). Correlation between QRS Duration, Pulmonary Insufficiency and Right Ventricle Performance in Totally Corrected Tetralogy of Fallot. Iranian journal of pediatrics, 23(5), 593-6.
Tanasan, Asadolah, et al. "Correlation between QRS Duration, Pulmonary Insufficiency and Right Ventricle Performance in Totally Corrected Tetralogy of Fallot." Iranian journal of pediatrics vol. 23,5 (2013): 593-6.
Tanasan A, Kocharian A, Zanjani KS, Payravian FK, Torabian S. Correlation between QRS Duration, Pulmonary Insufficiency and Right Ventricle Performance in Totally Corrected Tetralogy of Fallot. Iran J Pediatr. 2013 Oct;23(5):593-6. PMID: 24800023; PMCID: PMC4006512.
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Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals.

Journal of AIDS & clinical research

Fuchs JD, Bart PA, Frahm N, Morgan C, Gilbert PB, Kochar N, DeRosa SC, Tomaras GD, Wagner TM, Baden LR, Koblin BA, Rouphael NG, Kalams SA, Keefer MC, Goepfert PA, Sobieszczyk ME, Mayer KH, Swann E, Liao HX, Haynes BF, Graham BS, McElrath MJ.
PMID: 26587311
J AIDS Clin Res. 2015 May;6(5). doi: 10.4172/2155-6113.1000461. Epub 2015 May 23.

BACKGROUND: Recombinant adenovirus serotype 5 (rAd5)-vectored HIV-1 vaccines have not prevented HIV-1 infection or disease and pre-existing Ad5 neutralizing antibodies may limit the clinical utility of Ad5 vectors globally. Using a rare Ad serotype vector, such as Ad35, may...

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Fuchs JD, Bart PA, Frahm N, et al. Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals. J AIDS Clin Res. 2015;6(5)doi: 10.4172/2155-6113.1000461.
Fuchs, J. D., Bart, P. A., Frahm, N., Morgan, C., Gilbert, P. B., Kochar, N., DeRosa, S. C., Tomaras, G. D., Wagner, T. M., Baden, L. R., Koblin, B. A., Rouphael, N. G., Kalams, S. A., Keefer, M. C., Goepfert, P. A., Sobieszczyk, M. E., Mayer, K. H., Swann, E., Liao, H. X., Haynes, B. F., Graham, B. S., McElrath, M. J. (2015). Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals. Journal of AIDS & clinical research, 6(5), . https://doi.org/10.4172/2155-6113.1000461
Fuchs, Jonathan D, et al. "Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals." Journal of AIDS & clinical research vol. 6,5 (2015). doi: https://doi.org/10.4172/2155-6113.1000461
Fuchs JD, Bart PA, Frahm N, Morgan C, Gilbert PB, Kochar N, DeRosa SC, Tomaras GD, Wagner TM, Baden LR, Koblin BA, Rouphael NG, Kalams SA, Keefer MC, Goepfert PA, Sobieszczyk ME, Mayer KH, Swann E, Liao HX, Haynes BF, Graham BS, McElrath MJ. Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals. J AIDS Clin Res. 2015 May;6(5). doi: 10.4172/2155-6113.1000461. Epub 2015 May 23. PMID: 26587311; PMCID: PMC4648371.
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Time-Resolved X-ray Diffraction Study of Solid Combustion Reactions.

Science (New York, N.Y.)

Wong J, Larson EM, Holt JB, Waide PA, Rupp B, Frahm R.
PMID: 17812168
Science. 1990 Sep 21;249(4975):1406-9. doi: 10.1126/science.249.4975.1406.

Real-time synchrotron diffraction has been used to monitor the phase transformations of highly exothermic, fast self-propagating solid combustion reactions on a subsecond time scale down to 100 milliseconds and in some instances to 10 milliseconds. Three systems were investigated:...

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Wong J, Larson EM, Holt JB, et al. Time-Resolved X-ray Diffraction Study of Solid Combustion Reactions. Science. 1990;249(4975):1406-9doi: 10.1126/science.249.4975.1406.
Wong, J., Larson, E. M., Holt, J. B., Waide, P. A., Rupp, B., & Frahm, R. (1990). Time-Resolved X-ray Diffraction Study of Solid Combustion Reactions. Science (New York, N.Y.), 249(4975), 1406-9. https://doi.org/10.1126/science.249.4975.1406
Wong, J, et al. "Time-Resolved X-ray Diffraction Study of Solid Combustion Reactions." Science (New York, N.Y.) vol. 249,4975 (1990): 1406-9. doi: https://doi.org/10.1126/science.249.4975.1406
Wong J, Larson EM, Holt JB, Waide PA, Rupp B, Frahm R. Time-Resolved X-ray Diffraction Study of Solid Combustion Reactions. Science. 1990 Sep 21;249(4975):1406-9. doi: 10.1126/science.249.4975.1406. PMID: 17812168.
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Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot".

Journal of translational medicine

Bihl FK, Loggi E, Chisholm JV, Hewitt HS, Henry LM, Linde C, Suscovich TJ, Wong JT, Frahm N, Andreone P, Brander C.
PMID: 15888204
J Transl Med. 2005 May 11;3(1):20. doi: 10.1186/1479-5876-3-20.

The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses against multiple viral infections. Thus, the development of assay systems, which optimize cell...

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Bihl FK, Loggi E, Chisholm JV, et al. Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot". J Transl Med. 2005;3(1):20doi: 10.1186/1479-5876-3-20.
Bihl, F. K., Loggi, E., Chisholm, J. V., Hewitt, H. S., Henry, L. M., Linde, C., Suscovich, T. J., Wong, J. T., Frahm, N., Andreone, P., & Brander, C. (2005). Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot". Journal of translational medicine, 3(1), 20. https://doi.org/10.1186/1479-5876-3-20
Bihl, Florian K, et al. "Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot"." Journal of translational medicine vol. 3,1 (2005): 20. doi: https://doi.org/10.1186/1479-5876-3-20
Bihl FK, Loggi E, Chisholm JV, Hewitt HS, Henry LM, Linde C, Suscovich TJ, Wong JT, Frahm N, Andreone P, Brander C. Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot". J Transl Med. 2005 May 11;3(1):20. doi: 10.1186/1479-5876-3-20. PMID: 15888204; PMCID: PMC1164435.
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Suppression of MRI truncation artifacts using total variation constrained data extrapolation.

International journal of biomedical imaging

Block KT, Uecker M, Frahm J.
PMID: 18784847
Int J Biomed Imaging. 2008;2008:184123. doi: 10.1155/2008/184123.

The finite sampling of k-space in MRI causes spurious image artifacts, known as Gibbs ringing, which result from signal truncation at the border of k-space. The effect is especially visible for acquisitions at low resolution and commonly reduced by...

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Block KT, Uecker M, Frahm J. Suppression of MRI truncation artifacts using total variation constrained data extrapolation. Int J Biomed Imaging. 2008;2008:184123doi: 10.1155/2008/184123.
Block, K. T., Uecker, M., & Frahm, J. (2008). Suppression of MRI truncation artifacts using total variation constrained data extrapolation. International journal of biomedical imaging, 2008184123. https://doi.org/10.1155/2008/184123
Block, Kai Tobias, et al. "Suppression of MRI truncation artifacts using total variation constrained data extrapolation." International journal of biomedical imaging vol. 2008 (2008): 184123. doi: https://doi.org/10.1155/2008/184123
Block KT, Uecker M, Frahm J. Suppression of MRI truncation artifacts using total variation constrained data extrapolation. Int J Biomed Imaging. 2008;2008:184123. doi: 10.1155/2008/184123. PMID: 18784847; PMCID: PMC2531202.
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X-ray near-edge absorption study of temperature-induced low-spin-to-high-spin change in metallo-supramolecular assemblies.

Chemphyschem : a European journal of chemical physics and physical chemistry

Arezki B, Schwarz G, Bodenthin Y, Luetzenkirchen-Hecht D, Markert C, Wagner R, Frahm R, Kurth DG, Pietsch U.
PMID: 21275032
Chemphyschem. 2011 Feb 07;12(2):405-10. doi: 10.1002/cphc.201000428. Epub 2010 Dec 22.

X-ray absorption near the iron K edge (XANES) was used to investigate the characteristics of temperature-induced low-spin-to-high-spin change (SC) in metallo-supramolecular polyelectrolyte amphiphile complexes (PAC) containing FeN(6) octahedra attached to two or six amphiphilic molecules. Compared to the typical...

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Arezki B, Schwarz G, Bodenthin Y, et al. X-ray near-edge absorption study of temperature-induced low-spin-to-high-spin change in metallo-supramolecular assemblies. Chemphyschem. 2010;12(2):405-10doi: 10.1002/cphc.201000428.
Arezki, B., Schwarz, G., Bodenthin, Y., Luetzenkirchen-Hecht, D., Markert, C., Wagner, R., Frahm, R., Kurth, D. G., & Pietsch, U. (2011). X-ray near-edge absorption study of temperature-induced low-spin-to-high-spin change in metallo-supramolecular assemblies. Chemphyschem : a European journal of chemical physics and physical chemistry, 12(2), 405-10. https://doi.org/10.1002/cphc.201000428
Arezki, Bahia, et al. "X-ray near-edge absorption study of temperature-induced low-spin-to-high-spin change in metallo-supramolecular assemblies." Chemphyschem : a European journal of chemical physics and physical chemistry vol. 12,2 (2011): 405-10. doi: https://doi.org/10.1002/cphc.201000428
Arezki B, Schwarz G, Bodenthin Y, Luetzenkirchen-Hecht D, Markert C, Wagner R, Frahm R, Kurth DG, Pietsch U. X-ray near-edge absorption study of temperature-induced low-spin-to-high-spin change in metallo-supramolecular assemblies. Chemphyschem. 2011 Feb 07;12(2):405-10. doi: 10.1002/cphc.201000428. Epub 2010 Dec 22. PMID: 21275032.
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T-REX: new software for advanced QEXAFS data analysis.

Journal of synchrotron radiation

Stötzel J, Lützenkirchen-Hecht D, Grunwaldt JD, Frahm R.
PMID: 23093750
J Synchrotron Radiat. 2012 Nov;19:920-9. doi: 10.1107/S0909049512038599. Epub 2012 Oct 18.

New approaches to analyze the data generated by modern time-resolved X-ray absorption spectroscopy instrumentation are presented as part of a new analysis software to handle files containing typically a few thousand EXAFS spectra. Various filter techniques to remove high-frequency...

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Stötzel J, Lützenkirchen-Hecht D, Grunwaldt JD, et al. T-REX: new software for advanced QEXAFS data analysis. J Synchrotron Radiat. 2012;19:920-9doi: 10.1107/S0909049512038599.
Stötzel, J., Lützenkirchen-Hecht, D., Grunwaldt, J. D., & Frahm, R. (2012). T-REX: new software for advanced QEXAFS data analysis. Journal of synchrotron radiation, 19920-9. https://doi.org/10.1107/S0909049512038599
Stötzel, Jan, et al. "T-REX: new software for advanced QEXAFS data analysis." Journal of synchrotron radiation vol. 19 (2012): 920-9. doi: https://doi.org/10.1107/S0909049512038599
Stötzel J, Lützenkirchen-Hecht D, Grunwaldt JD, Frahm R. T-REX: new software for advanced QEXAFS data analysis. J Synchrotron Radiat. 2012 Nov;19:920-9. doi: 10.1107/S0909049512038599. Epub 2012 Oct 18. PMID: 23093750.
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Properties and Planned Use of the Intense THz Radiation from ELBE at Dresden-Rossendorf.

Journal of biological physics

Fahmy K, Furlinski G, Gippner P, Grosse E, Piest H, Seidel W, Sczepan M, Wohlfarth D, Wolf A, Wuensch R.
PMID: 23345848
J Biol Phys. 2003 Jun;29(2):303-7. doi: 10.1023/A:1024473616212.

The radiation source ELBE atDresden-Rossendorf is centered around asuperconducting ELectron accelerator ofhigh Brilliance and low Emittance (ELBE) which produces electronbeams up to 40 MeV. This new facility delivers secondary radiation of differentkinds. Special emphasis will be given tothe production...

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Fahmy K, Furlinski G, Gippner P, et al. Properties and Planned Use of the Intense THz Radiation from ELBE at Dresden-Rossendorf. J Biol Phys. 2003;29(2):303-7doi: 10.1023/A:1024473616212.
Fahmy, K., Furlinski, G., Gippner, P., Grosse, E., Piest, H., Seidel, W., Sczepan, M., Wohlfarth, D., Wolf, A., & Wuensch, R. (2003). Properties and Planned Use of the Intense THz Radiation from ELBE at Dresden-Rossendorf. Journal of biological physics, 29(2), 303-7. https://doi.org/10.1023/A:1024473616212
Fahmy, K, et al. "Properties and Planned Use of the Intense THz Radiation from ELBE at Dresden-Rossendorf." Journal of biological physics vol. 29,2 (2003): 303-7. doi: https://doi.org/10.1023/A:1024473616212
Fahmy K, Furlinski G, Gippner P, Grosse E, Piest H, Seidel W, Sczepan M, Wohlfarth D, Wolf A, Wuensch R. Properties and Planned Use of the Intense THz Radiation from ELBE at Dresden-Rossendorf. J Biol Phys. 2003 Jun;29(2):303-7. doi: 10.1023/A:1024473616212. PMID: 23345848; PMCID: PMC3456406.
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