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Showing 1 to 12 of 21 entries
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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.

ACS medicinal chemistry letters

McElroy WT, Tan Z, Ho G, Paliwal S, Li G, Seganish WM, Tulshian D, Tata J, Fischmann TO, Sondey C, Bian H, Bober L, Jackson J, Garlisi CG, Devito K, Fossetta J, Lundell D, Niu X.
PMID: 26101573
ACS Med Chem Lett. 2015 May 12;6(6):677-82. doi: 10.1021/acsmedchemlett.5b00106. eCollection 2015 Jun 11.

IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified a pyrazole class of IRAK4 inhibitors that were determined...

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

ACS medicinal chemistry letters

Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Boga SB, Alhassan AB, Yu Y, Vaccaro H, Liu S, Yang C, Wu H, Cooper A, de Man J, Kaptein A, Maloney K, Hornak V, Gao YD, Fischmann TO, Raaijmakers H, Vu-Pham D, Presland J, Mansueto M, Xu Z, Leccese E, Zhang-Hoover J, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Kim R, Kozlowski JA.
PMID: 26985298
ACS Med Chem Lett. 2015 Dec 19;7(2):198-203. doi: 10.1021/acsmedchemlett.5b00463. eCollection 2016 Feb 11.

Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell...

Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Carlisi CO, Norman L, Murphy CM, Christakou A, Chantiluke K, Giampietro V, Simmons A, Brammer M, Murphy DG, Mataix-Cols D, Rubia K.
PMID: 29167833
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):644-654. doi: 10.1016/j.bpsc.2016.12.005.

BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to...

A CD3/CD28 microbead-based HIV-1 viral outgrowth assay.

Journal of virus eradication

Kuzmichev YV, Veenhuis RT, Pohlmeyer CW, Garliss CC, Walker-Sperling VE, Blankson JN.
PMID: 28435692
J Virus Erad. 2017 Apr 01;3(2):85-89.

AIMS: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated feeder cells, or...

CD8 Effector T Cells Function Synergistically With Broadly Neutralizing Antibodies to Enhance Suppression of HIV Infection.

Frontiers in immunology

Veenhuis RT, Garliss CC, Bailey JR, Blankson JN.
PMID: 34394110
Front Immunol. 2021 Jul 29;12:708355. doi: 10.3389/fimmu.2021.708355. eCollection 2021.

HIV-specific CD8 T cells and broadly neutralizing antibodies (bNAbs) both contribute to the control of viremia, but in most cases, neither can completely suppress viral replication. To date, therapeutic vaccines have not been successful in eliciting HIV-specific CD8 T...

Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.

ACS medicinal chemistry letters

Huang X, Brubaker J, Zhou W, Biju PJ, Xiao L, Shao N, Huang Y, Dong L, Liu Z, Bitar R, Buevich A, Jung J, Peterson SL, Butcher JW, Close J, Martinez M, MacCoss RN, Zhang H, Crawford S, McCormick KD, Aslanian R, Nargund R, Correll C, Gervais F, Qiu H, Yang X, Garlisi C, Rindgen D, Maloney KM, Siliphaivanh P, Palani A.
PMID: 30034600
ACS Med Chem Lett. 2018 Jun 23;9(7):679-684. doi: 10.1021/acsmedchemlett.8b00145. eCollection 2018 Jul 12.

A novel series of tricyclic tetrahydroquinolines were identified as potent and selective CRTh2 receptor antagonists. The agonism and antagonism switch was achieved through structure-based drug design (SBDD) using a CRTh2 receptor homologue model. The challenge of very low exposures...

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

ACS infectious diseases

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.
PMID: 26878058
ACS Infect Dis. 2015 Jan 09;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.

Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, has generated interest in the...

The influence of nitrogen doping on the electronic structure of the valence and conduction band in TiO.

Journal of synchrotron radiation

Wojtaszek K, Wach A, Czapla-Masztafiak J, Tyrala K, Sá J, Yıldız Özer L, Garlisi C, Palmisano G, Szlachetko J.
PMID: 30655479
J Synchrotron Radiat. 2019 Jan 01;26:145-151. doi: 10.1107/S1600577518016685. Epub 2019 Jan 01.

X-ray emission spectroscopy (XES) and X-ray absorption spectroscopy (XAS) provide a unique opportunity to probe both the highest occupied and the lowest unoccupied states in matter with bulk sensitivity. In this work, a combination of valence-to-core XES and pre-edge...

Whole Cow's Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow's Milk Sensitivity in Adults.

Nutrients

Carroccio A, Soresi M, Mantia B, Fayer F, La Blasca F, Seidita A, D'Alcamo A, Florena AM, Tinè C, Garlisi C, Mansueto P.
PMID: 34836089
Nutrients. 2021 Oct 27;13(11). doi: 10.3390/nu13113833.

BACKGROUND: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in...

The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Woldemeskel BA, Karaba AH, Garliss CC, Beck EJ, Wang KH, Laeyendecker O, Cox AL, Blankson JN.
PMID: 34293114
Clin Infect Dis. 2021 Jul 22; doi: 10.1093/cid/ciab648. Epub 2021 Jul 22.

Previous studies have shown that certain vaccines induce suboptimal responses in people living with HIV (PLWH). However, responses to SARS-CoV-2 vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune...

Using genetic algorithms to uncover individual differences in how humans represent facial emotion.

Royal Society open science

Carlisi CO, Reed K, Helmink FGL, Lachlan R, Cosker DP, Viding E, Mareschal I.
PMID: 34659775
R Soc Open Sci. 2021 Oct 13;8(10):202251. doi: 10.1098/rsos.202251. eCollection 2021 Oct.

Emotional facial expressions critically impact social interactions and cognition. However, emotion research to date has generally relied on the assumption that people represent categorical emotions in the same way, using standardized stimulus sets and overlooking important individual differences. To...

Integrated Nano- and Macroscale Investigation of Photoinduced Hydrophilicity in TiO.

Langmuir : the ACS journal of surfaces and colloids

Garlisi C, Scandura G, Palmisano G, Chiesa M, Lai CY.
PMID: 27788003
Langmuir. 2016 Nov 15;32(45):11813-11818. doi: 10.1021/acs.langmuir.6b03756. Epub 2016 Nov 07.

The hydrophilicity of titanium dioxide has been investigated for films, deposited on glass by e-beam evaporation, being exposed to UV radiation and subjected to thermal annealing. The wettability alteration has been showed to depend upon both treatments, and insights...

Showing 1 to 12 of 21 entries