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From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations.

Translational lung cancer research

Serrano MJ, Exposito-Hernández J, Guerrero R, Lopez-Hidalgo J, Aguilar M, Lorente JA, de Álava E, Garrido-Navas MC.
PMID: 32420057
Transl Lung Cancer Res. 2020 Apr;9(2):180-183. doi: 10.21037/tlcr.2020.03.07.

No abstract available.

Cite
Serrano MJ, Exposito-Hernández J, Guerrero R, et al. From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations. Transl Lung Cancer Res. 2020;9(2):180-183doi: 10.21037/tlcr.2020.03.07.
Serrano, M. J., Exposito-Hernández, J., Guerrero, R., Lopez-Hidalgo, J., Aguilar, M., Lorente, J. A., de Álava, E., & Garrido-Navas, M. C. (2020). From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations. Translational lung cancer research, 9(2), 180-183. https://doi.org/10.21037/tlcr.2020.03.07
Serrano, María José, et al. "From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations." Translational lung cancer research vol. 9,2 (2020): 180-183. doi: https://doi.org/10.21037/tlcr.2020.03.07
Serrano MJ, Exposito-Hernández J, Guerrero R, Lopez-Hidalgo J, Aguilar M, Lorente JA, de Álava E, Garrido-Navas MC. From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations. Transl Lung Cancer Res. 2020 Apr;9(2):180-183. doi: 10.21037/tlcr.2020.03.07. PMID: 32420057; PMCID: PMC7225138.
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Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation.

Cancers

Simon I, Perales S, Casado-Medina L, Rodríguez-Martínez A, Garrido-Navas MDC, Puche-Sanz I, Diaz-Mochon JJ, Alaminos C, Lupiañez P, Lorente JA, Serrano MJ, Real PJ.
PMID: 33807106
Cancers (Basel). 2021 Mar 23;13(6). doi: 10.3390/cancers13061483.

Androgen deprivation therapy (ADT) and novel hormonal agents (NHAs) (Abiraterone and Enzalutamide) are the goal standard for metastatic prostate cancer (PCa) treatment. Although ADT is initially effective, a subsequent castration resistance status (CRPC) is commonly developed. The expression of...

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Simon I, Perales S, Casado-Medina L, et al. Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation. Cancers (Basel). 2021;13(6)doi: 10.3390/cancers13061483.
Simon, I., Perales, S., Casado-Medina, L., Rodríguez-Martínez, A., Garrido-Navas, M. D. C., Puche-Sanz, I., Diaz-Mochon, J. J., Alaminos, C., Lupiañez, P., Lorente, J. A., Serrano, M. J., & Real, P. J. (2021). Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation. Cancers, 13(6), . https://doi.org/10.3390/cancers13061483
Simon, Iris, et al. "Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation." Cancers vol. 13,6 (2021). doi: https://doi.org/10.3390/cancers13061483
Simon I, Perales S, Casado-Medina L, Rodríguez-Martínez A, Garrido-Navas MDC, Puche-Sanz I, Diaz-Mochon JJ, Alaminos C, Lupiañez P, Lorente JA, Serrano MJ, Real PJ. Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation. Cancers (Basel). 2021 Mar 23;13(6). doi: 10.3390/cancers13061483. PMID: 33807106; PMCID: PMC8004828.
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Current Status of Genetic Counselling for Rare Diseases in Spain.

Diagnostics (Basel, Switzerland)

Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC.
PMID: 34943558
Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320.

Genetic Counselling is essential for providing personalised information and support to patients with Rare Diseases (RD). Unlike most other developed countries, Spain does not recognize geneticists or genetic counsellors as healthcare professionals Thus, patients with RD face not only...

Cite
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, et al. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021;11(12)doi: 10.3390/diagnostics11122320.
Álvaro-Sánchez, S., Abreu-Rodríguez, I., Abulí, A., Serra-Juhe, C., & Garrido-Navas, M. D. C. (2021). Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel, Switzerland), 11(12), . https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez, Sara, et al. "Current Status of Genetic Counselling for Rare Diseases in Spain." Diagnostics (Basel, Switzerland) vol. 11,12 (2021). doi: https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320. PMID: 34943558.
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Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream).

Cancers

Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC.
PMID: 34945008
Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386.

The isolation of circulating tumour cells (CTCs) in colorectal cancer (CRC) mostly relies on the expression of epithelial markers such as EpCAM, and phenotypic characterisation is usually performed under fluorescence microscopy with only one or two additional markers. This...

Cite
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, et al. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021;13(24)doi: 10.3390/cancers13246386.
Ruiz-Rodríguez, A. J., Molina-Vallejo, M. P., Aznar-Peralta, I., González Puga, C., Cañas García, I., González, E., Lorente, J. A., Serrano, M. J., & Garrido-Navas, M. C. (2021). Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers, 13(24), . https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez, Antonio J, et al. "Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream)." Cancers vol. 13,24 (2021). doi: https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386. PMID: 34945008; PMCID: PMC8699219.
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Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream).

Cancers

Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC.
PMID: 34945008
Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386.

The isolation of circulating tumour cells (CTCs) in colorectal cancer (CRC) mostly relies on the expression of epithelial markers such as EpCAM, and phenotypic characterisation is usually performed under fluorescence microscopy with only one or two additional markers. This...

Cite
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, et al. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021;13(24)doi: 10.3390/cancers13246386.
Ruiz-Rodríguez, A. J., Molina-Vallejo, M. P., Aznar-Peralta, I., González Puga, C., Cañas García, I., González, E., Lorente, J. A., Serrano, M. J., & Garrido-Navas, M. C. (2021). Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers, 13(24), . https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez, Antonio J, et al. "Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream)." Cancers vol. 13,24 (2021). doi: https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386. PMID: 34945008.
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Current Status of Genetic Counselling for Rare Diseases in Spain.

Diagnostics (Basel, Switzerland)

Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC.
PMID: 34943558
Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320.

Genetic Counselling is essential for providing personalised information and support to patients with Rare Diseases (RD). Unlike most other developed countries, Spain does not recognize geneticists or genetic counsellors as healthcare professionals Thus, patients with RD face not only...

Cite
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, et al. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021;11(12)doi: 10.3390/diagnostics11122320.
Álvaro-Sánchez, S., Abreu-Rodríguez, I., Abulí, A., Serra-Juhe, C., & Garrido-Navas, M. D. C. (2021). Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel, Switzerland), 11(12), . https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez, Sara, et al. "Current Status of Genetic Counselling for Rare Diseases in Spain." Diagnostics (Basel, Switzerland) vol. 11,12 (2021). doi: https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320. PMID: 34943558; PMCID: PMC8700506.
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Current Status of Genetic Counselling for Rare Diseases in Spain.

Diagnostics (Basel, Switzerland)

Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC.
PMID: 34943558
Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320.

Genetic Counselling is essential for providing personalised information and support to patients with Rare Diseases (RD). Unlike most other developed countries, Spain does not recognize geneticists or genetic counsellors as healthcare professionals Thus, patients with RD face not only...

Cite
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, et al. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021;11(12)doi: 10.3390/diagnostics11122320.
Álvaro-Sánchez, S., Abreu-Rodríguez, I., Abulí, A., Serra-Juhe, C., & Garrido-Navas, M. D. C. (2021). Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel, Switzerland), 11(12), . https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez, Sara, et al. "Current Status of Genetic Counselling for Rare Diseases in Spain." Diagnostics (Basel, Switzerland) vol. 11,12 (2021). doi: https://doi.org/10.3390/diagnostics11122320
Álvaro-Sánchez S, Abreu-Rodríguez I, Abulí A, Serra-Juhe C, Garrido-Navas MDC. Current Status of Genetic Counselling for Rare Diseases in Spain. Diagnostics (Basel). 2021 Dec 09;11(12). doi: 10.3390/diagnostics11122320. PMID: 34943558.
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The Polemic Diagnostic Role of .

Cancers

Garrido-Navas MC, García-Díaz A, Molina-Vallejo MP, González-Martínez C, Alcaide Lucena M, Cañas-García I, Bayarri C, Delgado JR, González E, Lorente JA, Serrano MJ.
PMID: 33198130
Cancers (Basel). 2020 Nov 12;12(11). doi: 10.3390/cancers12113343.

Being minimally invasive and thus allowing repeated measures over time, liquid biopsies are taking over traditional solid biopsies in certain circumstances such as those for unreachable tumors, very early stages or treatment monitoring. However, regarding

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Garrido-Navas MC, García-Díaz A, Molina-Vallejo MP, et al. The Polemic Diagnostic Role of . Cancers (Basel). 2020;12(11)doi: 10.3390/cancers12113343.
Garrido-Navas, M. C., García-Díaz, A., Molina-Vallejo, M. P., González-Martínez, C., Alcaide Lucena, M., Cañas-García, I., Bayarri, C., Delgado, J. R., González, E., Lorente, J. A., & Serrano, M. J. (2020). The Polemic Diagnostic Role of . Cancers, 12(11), . https://doi.org/10.3390/cancers12113343
Garrido-Navas, M Carmen, et al. "The Polemic Diagnostic Role of ." Cancers vol. 12,11 (2020). doi: https://doi.org/10.3390/cancers12113343
Garrido-Navas MC, García-Díaz A, Molina-Vallejo MP, González-Martínez C, Alcaide Lucena M, Cañas-García I, Bayarri C, Delgado JR, González E, Lorente JA, Serrano MJ. The Polemic Diagnostic Role of . Cancers (Basel). 2020 Nov 12;12(11). doi: 10.3390/cancers12113343. PMID: 33198130; PMCID: PMC7696715.
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Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in .

Life (Basel, Switzerland)

Garrido-Navas MC, Tippins F, Barwell J, Hoffman J, Codd V, Royle NJ.
PMID: 33142697
Life (Basel). 2020 Oct 31;10(11). doi: 10.3390/life10110265.

Lynch syndrome (LS) is an inherited predisposition to early onset of various cancers, caused by mutation in a DNA mismatch repair (MMR) gene. In heterozygous MMR

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Garrido-Navas MC, Tippins F, Barwell J, et al. Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in . Life (Basel). 2020;10(11)doi: 10.3390/life10110265.
Garrido-Navas, M. C., Tippins, F., Barwell, J., Hoffman, J., Codd, V., & Royle, N. J. (2020). Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in . Life (Basel, Switzerland), 10(11), . https://doi.org/10.3390/life10110265
Garrido-Navas, M Carmen, et al. "Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in ." Life (Basel, Switzerland) vol. 10,11 (2020). doi: https://doi.org/10.3390/life10110265
Garrido-Navas MC, Tippins F, Barwell J, Hoffman J, Codd V, Royle NJ. Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in . Life (Basel). 2020 Oct 31;10(11). doi: 10.3390/life10110265. PMID: 33142697; PMCID: PMC7692680.
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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy.

Cancer discovery

Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, Cristofanilli M, Gil-Bazo I, Pauwels P, Malapelle U, Russo A, Lorente JA, Ruiz-Rodriguez AJ, Paz-Ares LG, Vilar E, Raez LE, Cardona AF, Rolfo C.
PMID: 33037026
Cancer Discov. 2020 Nov;10(11):1635-1644. doi: 10.1158/2159-8290.CD-20-0466. Epub 2020 Oct 09.

Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the...

Cite
Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, et al. Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer Discov. 2020;10(11):1635-1644doi: 10.1158/2159-8290.CD-20-0466.
Serrano, M. J., Garrido-Navas, M. C., Diaz Mochon, J. J., Cristofanilli, M., Gil-Bazo, I., Pauwels, P., Malapelle, U., Russo, A., Lorente, J. A., Ruiz-Rodriguez, A. J., Paz-Ares, L. G., Vilar, E., Raez, L. E., Cardona, A. F., Rolfo, C. (2020). Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer discovery, 10(11), 1635-1644. https://doi.org/10.1158/2159-8290.CD-20-0466
Serrano, Maria Jose, et al. "Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy." Cancer discovery vol. 10,11 (2020): 1635-1644. doi: https://doi.org/10.1158/2159-8290.CD-20-0466
Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, Cristofanilli M, Gil-Bazo I, Pauwels P, Malapelle U, Russo A, Lorente JA, Ruiz-Rodriguez AJ, Paz-Ares LG, Vilar E, Raez LE, Cardona AF, Rolfo C. Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer Discov. 2020 Nov;10(11):1635-1644. doi: 10.1158/2159-8290.CD-20-0466. Epub 2020 Oct 09. PMID: 33037026.
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Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream).

Cancers

Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC.
PMID: 34945008
Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386.

The isolation of circulating tumour cells (CTCs) in colorectal cancer (CRC) mostly relies on the expression of epithelial markers such as EpCAM, and phenotypic characterisation is usually performed under fluorescence microscopy with only one or two additional markers. This...

Cite
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, et al. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021;13(24)doi: 10.3390/cancers13246386.
Ruiz-Rodríguez, A. J., Molina-Vallejo, M. P., Aznar-Peralta, I., González Puga, C., Cañas García, I., González, E., Lorente, J. A., Serrano, M. J., & Garrido-Navas, M. C. (2021). Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers, 13(24), . https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez, Antonio J, et al. "Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream)." Cancers vol. 13,24 (2021). doi: https://doi.org/10.3390/cancers13246386
Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC. Deep Phenotypic Characterisation of CTCs by Combination of Microfluidic Isolation (IsoFlux) and Imaging Flow Cytometry (ImageStream). Cancers (Basel). 2021 Dec 20;13(24). doi: 10.3390/cancers13246386. PMID: 34945008.
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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy.

Cancer discovery

Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, Cristofanilli M, Gil-Bazo I, Pauwels P, Malapelle U, Russo A, Lorente JA, Ruiz-Rodriguez AJ, Paz-Ares LG, Vilar E, Raez LE, Cardona AF, Rolfo C.
PMID: 33037026
Cancer Discov. 2020 Nov;10(11):1635-1644. doi: 10.1158/2159-8290.CD-20-0466. Epub 2020 Oct 09.

Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the...

Cite
Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, et al. Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer Discov. 2020;10(11):1635-1644doi: 10.1158/2159-8290.CD-20-0466.
Serrano, M. J., Garrido-Navas, M. C., Diaz Mochon, J. J., Cristofanilli, M., Gil-Bazo, I., Pauwels, P., Malapelle, U., Russo, A., Lorente, J. A., Ruiz-Rodriguez, A. J., Paz-Ares, L. G., Vilar, E., Raez, L. E., Cardona, A. F., Rolfo, C. (2020). Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer discovery, 10(11), 1635-1644. https://doi.org/10.1158/2159-8290.CD-20-0466
Serrano, Maria Jose, et al. "Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy." Cancer discovery vol. 10,11 (2020): 1635-1644. doi: https://doi.org/10.1158/2159-8290.CD-20-0466
Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, Cristofanilli M, Gil-Bazo I, Pauwels P, Malapelle U, Russo A, Lorente JA, Ruiz-Rodriguez AJ, Paz-Ares LG, Vilar E, Raez LE, Cardona AF, Rolfo C. Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy. Cancer Discov. 2020 Nov;10(11):1635-1644. doi: 10.1158/2159-8290.CD-20-0466. Epub 2020 Oct 09. PMID: 33037026.
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Showing 1 to 12 of 12 entries