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Genetic risk variants for social anxiety.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J.
PMID: 28512750
Am J Med Genet B Neuropsychiatr Genet. 2017 Jun;174(4):470-482. doi: 10.1002/ajmg.b.32541. Epub 2017 Apr 27.

No abstract available.

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Stein MB, Chen CY, Jain S, et al. Genetic risk variants for social anxiety. Am J Med Genet B Neuropsychiatr Genet. 2017;174(4):470-482doi: 10.1002/ajmg.b.32541.
Stein, M. B., Chen, C. Y., Jain, S., Jensen, K. P., He, F., Heeringa, S. G., Kessler, R. C., Maihofer, A., Nock, M. K., Ripke, S., Sun, X., Thomas, M. L., Ursano, R. J., Smoller, J. W., Gelernter, J. (2017). Genetic risk variants for social anxiety. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 174(4), 470-482. https://doi.org/10.1002/ajmg.b.32541
Stein, Murray B, et al. "Genetic risk variants for social anxiety." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics vol. 174,4 (2017): 470-482. doi: https://doi.org/10.1002/ajmg.b.32541
Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J. Genetic risk variants for social anxiety. Am J Med Genet B Neuropsychiatr Genet. 2017 Jun;174(4):470-482. doi: 10.1002/ajmg.b.32541. Epub 2017 Apr 27. PMID: 28512750.
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A Preliminary Examination of the Relationship Between the .

Psychological trauma : theory, research, practice and policy

Banducci AN, Gomes M, MacPherson L, Lejuez CW, Potenza MN, Gelernter J, Amstadter AB.
PMID: 24932352
Psychol Trauma. 2014 Jan 01;6(1):1-7. doi: 10.1037/a0031121.

Childhood emotional abuse (CEA) is a pervasive problem associated with negative sequelae such as elevated depressive symptoms. Key stress-related genes, such as the

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Banducci AN, Gomes M, MacPherson L, et al. A Preliminary Examination of the Relationship Between the . Psychol Trauma. 2014;6(1):1-7doi: 10.1037/a0031121.
Banducci, A. N., Gomes, M., MacPherson, L., Lejuez, C. W., Potenza, M. N., Gelernter, J., & Amstadter, A. B. (2014). A Preliminary Examination of the Relationship Between the . Psychological trauma : theory, research, practice and policy, 6(1), 1-7. https://doi.org/10.1037/a0031121
Banducci, Anne N, et al. "A Preliminary Examination of the Relationship Between the ." Psychological trauma : theory, research, practice and policy vol. 6,1 (2014): 1-7. doi: https://doi.org/10.1037/a0031121
Banducci AN, Gomes M, MacPherson L, Lejuez CW, Potenza MN, Gelernter J, Amstadter AB. A Preliminary Examination of the Relationship Between the . Psychol Trauma. 2014 Jan 01;6(1):1-7. doi: 10.1037/a0031121. PMID: 24932352; PMCID: PMC4057058.
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Empirical Explorations of SYNCHEM.

Science (New York, N.Y.)

Gelernter HL, Sanders AF, Larsen DL, Agarwal KK, Boivie RH, Spritzer GA, Searleman JE.
PMID: 17836062
Science. 1977 Sep 09;197(4308):1041-9. doi: 10.1126/science.197.4308.1041.

During the past several years, a substantial body of experience has accumulated in the use of SYNCHEM, a large-scale program which is able to discover synthesis routes for relatively complex organic structures without on-line guidance on the part of...

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Gelernter HL, Sanders AF, Larsen DL, et al. Empirical Explorations of SYNCHEM. Science. 1977;197(4308):1041-9doi: 10.1126/science.197.4308.1041.
Gelernter, H. L., Sanders, A. F., Larsen, D. L., Agarwal, K. K., Boivie, R. H., Spritzer, G. A., & Searleman, J. E. (1977). Empirical Explorations of SYNCHEM. Science (New York, N.Y.), 197(4308), 1041-9. https://doi.org/10.1126/science.197.4308.1041
Gelernter, H L, et al. "Empirical Explorations of SYNCHEM." Science (New York, N.Y.) vol. 197,4308 (1977): 1041-9. doi: https://doi.org/10.1126/science.197.4308.1041
Gelernter HL, Sanders AF, Larsen DL, Agarwal KK, Boivie RH, Spritzer GA, Searleman JE. Empirical Explorations of SYNCHEM. Science. 1977 Sep 09;197(4308):1041-9. doi: 10.1126/science.197.4308.1041. PMID: 17836062.
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The role and challenges of exome sequencing in studies of human diseases.

Frontiers in genetics

Wang Z, Liu X, Yang BZ, Gelernter J.
PMID: 24032039
Front Genet. 2013 Aug 26;4:160. doi: 10.3389/fgene.2013.00160.

Recent advances in next-generation sequencing technologies have transformed the genetics study of human diseases; this is an era of unprecedented productivity. Exome sequencing, the targeted sequencing of the protein-coding portion of the human genome, has been shown to be...

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Wang Z, Liu X, Yang BZ, et al. The role and challenges of exome sequencing in studies of human diseases. Front Genet. 2013;4:160doi: 10.3389/fgene.2013.00160.
Wang, Z., Liu, X., Yang, B. Z., & Gelernter, J. (2013). The role and challenges of exome sequencing in studies of human diseases. Frontiers in genetics, 4160. https://doi.org/10.3389/fgene.2013.00160
Wang, Zuoheng, et al. "The role and challenges of exome sequencing in studies of human diseases." Frontiers in genetics vol. 4 (2013): 160. doi: https://doi.org/10.3389/fgene.2013.00160
Wang Z, Liu X, Yang BZ, Gelernter J. The role and challenges of exome sequencing in studies of human diseases. Front Genet. 2013 Aug 26;4:160. doi: 10.3389/fgene.2013.00160. PMID: 24032039; PMCID: PMC3752524.
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Components of cross-frequency modulation in health and disease.

Frontiers in systems neuroscience

Allen EA, Liu J, Kiehl KA, Gelernter J, Pearlson GD, Perrone-Bizzozero NI, Calhoun VD.
PMID: 21808609
Front Syst Neurosci. 2011 Jul 14;5:59. doi: 10.3389/fnsys.2011.00059. eCollection 2011.

The cognitive deficits associated with schizophrenia are commonly believed to arise from the abnormal temporal integration of information, however a quantitative approach to assess network coordination is lacking. Here, we propose to use cross-frequency modulation (cfM), the dependence of...

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Allen EA, Liu J, Kiehl KA, et al. Components of cross-frequency modulation in health and disease. Front Syst Neurosci. 2011;5:59doi: 10.3389/fnsys.2011.00059.
Allen, E. A., Liu, J., Kiehl, K. A., Gelernter, J., Pearlson, G. D., Perrone-Bizzozero, N. I., & Calhoun, V. D. (2011). Components of cross-frequency modulation in health and disease. Frontiers in systems neuroscience, 559. https://doi.org/10.3389/fnsys.2011.00059
Allen, Elena A, et al. "Components of cross-frequency modulation in health and disease." Frontiers in systems neuroscience vol. 5 (2011): 59. doi: https://doi.org/10.3389/fnsys.2011.00059
Allen EA, Liu J, Kiehl KA, Gelernter J, Pearlson GD, Perrone-Bizzozero NI, Calhoun VD. Components of cross-frequency modulation in health and disease. Front Syst Neurosci. 2011 Jul 14;5:59. doi: 10.3389/fnsys.2011.00059. eCollection 2011. PMID: 21808609; PMCID: PMC3139214.
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Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

Nature communications

Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J.
PMID: 31481659
Nat Commun. 2019 Sep 03;10(1):4050. doi: 10.1038/s41467-019-11916-0.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Kranzler HR, Zhou H, Kember RL, et al. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat Commun. 2019;10(1):4050doi: 10.1038/s41467-019-11916-0.
Kranzler, H. R., Zhou, H., Kember, R. L., Smith, R. V., Justice, A. C., Damrauer, S., Tsao, P. S., Klarin, D., Baras, A., Reid, J., Overton, J., Rader, D. J., Cheng, Z., Tate, J. P., Becker, W. C., Concato, J., Xu, K., Polimanti, R., Zhao, H., & Gelernter, J. (2019). Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature communications, 10(1), 4050. https://doi.org/10.1038/s41467-019-11916-0
Kranzler, Henry R, et al. "Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations." Nature communications vol. 10,1 (2019): 4050. doi: https://doi.org/10.1038/s41467-019-11916-0
Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat Commun. 2019 Sep 03;10(1):4050. doi: 10.1038/s41467-019-11916-0. PMID: 31481659; PMCID: PMC6722074.
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Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder.

Molecular psychiatry

Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP.
PMID: 28831200
Mol Psychiatry. 2017 Sep;22(9):1225. doi: 10.1038/mp.2017.169.

No abstract available.

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Lippard ETC, Jensen KP, Wang F, et al. Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder. Mol Psychiatry. 2017;22(9):1225doi: 10.1038/mp.2017.169.
Lippard, E. T. C., Jensen, K. P., Wang, F., Johnston, J. A. Y., Spencer, L., Pittman, B., Gelernter, J., & Blumberg, H. P. (2017). Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder. Molecular psychiatry, 22(9), 1225. https://doi.org/10.1038/mp.2017.169
Lippard, E T C, et al. "Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder." Molecular psychiatry vol. 22,9 (2017): 1225. doi: https://doi.org/10.1038/mp.2017.169
Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder. Mol Psychiatry. 2017 Sep;22(9):1225. doi: 10.1038/mp.2017.169. PMID: 28831200.
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Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of .

Journal of clinical medicine

Polimanti R, Nuñez YZ, Gelernter J.
PMID: 30813263
J Clin Med. 2019 Feb 22;8(2). doi: 10.3390/jcm8020269.

No abstract available.

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Polimanti R, Nuñez YZ, Gelernter J. Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of . J Clin Med. 2019;8(2)doi: 10.3390/jcm8020269.
Polimanti, R., Nuñez, Y. Z., & Gelernter, J. (2019). Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of . Journal of clinical medicine, 8(2), . https://doi.org/10.3390/jcm8020269
Polimanti, Renato, et al. "Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of ." Journal of clinical medicine vol. 8,2 (2019). doi: https://doi.org/10.3390/jcm8020269
Polimanti R, Nuñez YZ, Gelernter J. Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of . J Clin Med. 2019 Feb 22;8(2). doi: 10.3390/jcm8020269. PMID: 30813263; PMCID: PMC6406512.
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Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.

Journal of clinical medicine

Wendt FR, Muniz Carvalho C, Pathak GA, Gelernter J, Polimanti R.
PMID: 31766499
J Clin Med. 2019 Nov 21;8(12). doi: 10.3390/jcm8122040.

Computerized device use (CDU) is societally ubiquitous but its effects on mental health are unknown. We performed genetic correlation, Mendelian randomization, and latent causal variable analyses to identify shared genetic mechanisms between psychiatric disorders (Psychiatric Genomics Consortium; 14,477 <...

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Wendt FR, Muniz Carvalho C, Pathak GA, et al. Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. J Clin Med. 2019;8(12)doi: 10.3390/jcm8122040.
Wendt, F. R., Muniz Carvalho, C., Pathak, G. A., Gelernter, J., & Polimanti, R. (2019). Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. Journal of clinical medicine, 8(12), . https://doi.org/10.3390/jcm8122040
Wendt, Frank R, et al. "Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders." Journal of clinical medicine vol. 8,12 (2019). doi: https://doi.org/10.3390/jcm8122040
Wendt FR, Muniz Carvalho C, Pathak GA, Gelernter J, Polimanti R. Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. J Clin Med. 2019 Nov 21;8(12). doi: 10.3390/jcm8122040. PMID: 31766499; PMCID: PMC6947231.
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Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study.

Brain imaging and behavior

Meda SA, Gelernter J, Gruen JR, Calhoun VD, Meng H, Cope NA, Pearlson GD.
PMID: 19096528
Brain Imaging Behav. 2008 Mar;2(1):21-26. doi: 10.1007/s11682-007-9012-1.

OBJECTIVE: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of...

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Meda SA, Gelernter J, Gruen JR, et al. Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study. Brain Imaging Behav. 2008;2(1):21-26doi: 10.1007/s11682-007-9012-1.
Meda, S. A., Gelernter, J., Gruen, J. R., Calhoun, V. D., Meng, H., Cope, N. A., & Pearlson, G. D. (2008). Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study. Brain imaging and behavior, 2(1), 21-26. https://doi.org/10.1007/s11682-007-9012-1
Meda, Shashwath A, et al. "Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study." Brain imaging and behavior vol. 2,1 (2008): 21-26. doi: https://doi.org/10.1007/s11682-007-9012-1
Meda SA, Gelernter J, Gruen JR, Calhoun VD, Meng H, Cope NA, Pearlson GD. Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study. Brain Imaging Behav. 2008 Mar;2(1):21-26. doi: 10.1007/s11682-007-9012-1. PMID: 19096528; PMCID: PMC2605089.
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Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.

Neurobiology of stress

Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R.
PMID: 33665242
Neurobiol Stress. 2021 Feb 18;14:100309. doi: 10.1016/j.ynstr.2021.100309. eCollection 2021 May.

Epidemiologic studies recognize that trauma and posttraumatic stress are associated with heightened suicidal behavior severity, yet examination of these associations from a genetic perspective is limited. We performed a multivariate gene-by-environment genome-wide interaction study (GEWIS) of suicidality in 123,633...

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Wendt FR, Pathak GA, Levey DF, et al. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiol Stress. 2021;14:100309doi: 10.1016/j.ynstr.2021.100309.
Wendt, F. R., Pathak, G. A., Levey, D. F., Nuñez, Y. Z., Overstreet, C., Tyrrell, C., Adhikari, K., De Angelis, F., Tylee, D. S., Goswami, A., Krystal, J. H., Abdallah, C. G., Stein, M. B., Kranzler, H. R., Gelernter, J., & Polimanti, R. (2021). Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology of stress, 14100309. https://doi.org/10.1016/j.ynstr.2021.100309
Wendt, Frank R, et al. "Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality." Neurobiology of stress vol. 14 (2021): 100309. doi: https://doi.org/10.1016/j.ynstr.2021.100309
Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiol Stress. 2021 Feb 18;14:100309. doi: 10.1016/j.ynstr.2021.100309. eCollection 2021 May. PMID: 33665242; PMCID: PMC7905234.
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Genome-Wide Association Study of Opioid Cessation.

Journal of clinical medicine

Cox JW, Sherva RM, Lunetta KL, Johnson EC, Martin NG, Degenhardt L, Agrawal A, Nelson EC, Kranzler HR, Gelernter J, Farrer LA.
PMID: 31936517
J Clin Med. 2020 Jan 09;9(1). doi: 10.3390/jcm9010180.

The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-related deaths. However, the genetic basis for the ability to discontinue opioid use has not been investigated. We performed a genome-wide association study (GWAS) of opioid...

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Cox JW, Sherva RM, Lunetta KL, et al. Genome-Wide Association Study of Opioid Cessation. J Clin Med. 2020;9(1)doi: 10.3390/jcm9010180.
Cox, J. W., Sherva, R. M., Lunetta, K. L., Johnson, E. C., Martin, N. G., Degenhardt, L., Agrawal, A., Nelson, E. C., Kranzler, H. R., Gelernter, J., & Farrer, L. A. (2020). Genome-Wide Association Study of Opioid Cessation. Journal of clinical medicine, 9(1), . https://doi.org/10.3390/jcm9010180
Cox, Jiayi W, et al. "Genome-Wide Association Study of Opioid Cessation." Journal of clinical medicine vol. 9,1 (2020). doi: https://doi.org/10.3390/jcm9010180
Cox JW, Sherva RM, Lunetta KL, Johnson EC, Martin NG, Degenhardt L, Agrawal A, Nelson EC, Kranzler HR, Gelernter J, Farrer LA. Genome-Wide Association Study of Opioid Cessation. J Clin Med. 2020 Jan 09;9(1). doi: 10.3390/jcm9010180. PMID: 31936517; PMCID: PMC7019731.
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