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Showing 1 to 12 of 132 entries
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Involvement of Cannabinoid Signaling in Vincristine-Induced Gastrointestinal Dysmotility in the Rat.

Frontiers in pharmacology

Vera G, López-Pérez AE, Uranga JA, Girón R, Martín-Fontelles MI, Abalo R.
PMID: 28220074
Front Pharmacol. 2017 Feb 06;8:37. doi: 10.3389/fphar.2017.00037. eCollection 2017.

No abstract available.

Synchronization unveils the organization of ecological networks with positive and negative interactions.

Chaos (Woodbury, N.Y.)

Girón A, Saiz H, Bacelar FS, Andrade RF, Gómez-Gardeñes J.
PMID: 27368792
Chaos. 2016 Jun;26(6):065302. doi: 10.1063/1.4952960.

Network science has helped to understand the organization principles of the interactions among the constituents of large complex systems. However, recently, the high resolution of the data sets collected has allowed to capture the different types of interactions coexisting...

Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

ACS medicinal chemistry letters

Pérez-Fernández R, Fresno N, Macías-González M, Elguero J, Decara J, Girón R, Rodríguez-Álvarez A, Martín MI, Rodríguez de Fonseca F, Goya P.
PMID: 24936232
ACS Med Chem Lett. 2011 Sep 16;2(11):793-7. doi: 10.1021/ml200091q. eCollection 2011 Nov 10.

This letter describes the synthesis and in vitro and in vivo evaluation of dual ligands targeting the cannabinoid and peroxisome proliferator-activated receptors (PPAR). These compounds were obtained from fusing the pharmacophores of fibrates and the diarylpyrazole rimonabant, a cannabinoid...

Hypertrophic cardiomyopathy: a review.

Clinical Medicine Insights. Cardiology

Houston BA, Stevens GR.
PMID: 25657602
Clin Med Insights Cardiol. 2015 Jan 26;8:53-65. doi: 10.4137/CMC.S15717. eCollection 2014.

Hypertrophic cardiomyopathy (HCM) is a global disease with cases reported in all continents, affecting people of both genders and of various racial and ethnic origins. Widely accepted as a monogenic disease caused by a mutation in 1 of 13...

Annual direct medical costs of bronchiectasis treatment: Impact of severity, exacerbations, chronic bronchial colonization and chronic obstructive pulmonary disease coexistence.

Chronic respiratory disease

de la Rosa D, Martínez-Garcia MA, Olveira C, Girón R, Máiz L, Prados C.
PMID: 27072020
Chron Respir Dis. 2016 Nov;13(4):361-371. doi: 10.1177/1479972316643698. Epub 2016 Jul 07.

Patients with bronchiectasis (BE) present exacerbations that increase with severity of the disease. We aimed to determine the annual cost of BE treatment according to its severity, determined by FACED score, as well as the parameters associated with higher...

Estimating a graphical intra-class correlation coefficient (GICC) using multivariate probit-linear mixed models.

Computational statistics & data analysis

Yue C, Chen S, Sair HI, Airan R, Caffo BS.
PMID: 26190878
Comput Stat Data Anal. 2015 Sep;89:126-133. doi: 10.1016/j.csda.2015.02.012.

Data reproducibility is a critical issue in all scientific experiments. In this manuscript, the problem of quantifying the reproducibility of graphical measurements is considered. The image intra-class correlation coefficient (I2C2) is generalized and the graphical intra-class correlation coefficient (GICC)...

Cyto-colpo-histological Study in Sexual Workers.

Journal of lower genital tract disease

Núñez JT, Delgado M, Pino G, Girón H, Bolet B.
PMID: 17050977
J Low Genit Tract Dis. 2001 Oct;5(4):208-11.

OBJECTIVE: To determine the false-negative, false-positive, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) rates of Pap smears and colposcopy in sexual workers.MATERIALS AND METHODS: Four hundred thirty-eight prostitutes were given a gynecological examination, Pap smear,...

Study of the acidic deposition phenomenon over Alexandria city.

The Journal of the Egyptian Public Health Association

Noweir KH, El-Marakby FA, Zaki GR, Ibrahim AK.
PMID: 18992208
J Egypt Public Health Assoc. 2008;83(1):147-64.

Acid deposition commonly occurs due to conversion of primary acidic pollutants (SO2 & NO2) into secondary pollutants (H2SO4 & HNO3 and their salts). The main natural sources of acid deposition in Alexandria include lightening and microbial processes. Anthropogenic sources...

The inoperable valvular heart disease patient:the pluses and minuses of percutaneous valvular replacement.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Fuster V, Goldbarg SH, Hansalia RJ, Stevens GR, Tiyyagura SR.
PMID: 19755254
EuroIntervention. 2006 Aug;2(2):154-60.

The spectrum of potentially successful treatment options for inoperable valvular disease is limited. Aortic valvuloplasty may offer temporary improvement in symptoms and some survival benefit in select non-surgical patients with aortic stenosis, but it does not improve long-term outcome....

Mechanism of the schultz-dale reaction in the denervated diaphragmatic muscle of the Guinea pig.

The Journal of general physiology

Alonso-Deflorida F, Del Castillo J, García X, Gijón E.
PMID: 19873612
J Gen Physiol. 1968 May 01;51(5):677-93. doi: 10.1085/jgp.51.5.677.

The mechanism of the contractions elicited by specific antigens in immunologically sensitized muscle tissue (Schultz-Dale responses) has been investigated on single fibers of denervated guinea pig hemidiaphragms. This preparation can be either actively or passively allergized, showing Schultz-Dale responses...

On the regioselectivity of the Diels-Alder cycloaddition to C.

Physical chemistry chemical physics : PCCP

El Bakouri O, Garcia-Borràs M, Girón RM, Filippone S, Martín N, Solà M.
PMID: 29417103
Phys Chem Chem Phys. 2018 May 03;20(17):11577-11585. doi: 10.1039/c7cp07965f.

Controlling the regioselectivity in the exohedral functionalization of fullerenes and endohedral metallofullerenes is essential to produce specific desired fullerene derivatives. In this work, using density functional theory (DFT) calculations, we show that the regioselectivity of the Diels-Alder (DA) cycloaddition...

Reversible Stereodivergent Cycloaddition of Racemic Helicenes to [60]Fullerene: A Chiral Resolution Strategy.

Organic letters

Girón RM, Ouyang J, Favereau L, Vanthuyne N, Crassous J, Filippone S, Martín N.
PMID: 29522351
Org Lett. 2018 Apr 06;20(7):1764-1767. doi: 10.1021/acs.orglett.8b00256. Epub 2018 Mar 09.

[60]Fullerene and its rarely explored reversible covalent chemistry have been harnessed as an efficient alternative for the chiral resolution of racemates. By using only catalytic amounts of chiral agents, stereodivergent 1,3-dipolar cycloadditions of racemic helicenes onto [60]fullerene were carried...

Showing 1 to 12 of 132 entries