UI Index

Life-threatening bradyarrhythmia with oral phenytoin overdose.

Journal of pharmacology & pharmacotherapeutics

Srinivasan G, Wyawahare M, Mathen PG, Subrahmanyam DK.
PMID: 26312007
J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):179-81. doi: 10.4103/0976-500X.162017.

We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer...

Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice.

Evidence-based complementary and alternative medicine : eCAM

Giridharan VV, Thandavarayan RA, Konishi T.
PMID: 26612995
Evid Based Complement Alternat Med. 2015;2015:584018. doi: 10.1155/2015/584018. Epub 2015 Nov 05.

The present study was designed to evaluate the preventive effect of antioxidative traditional oriental medicine formulae, Shengmai San (SMS) and LingGuiZhuGanTang (LGZGT), against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (i.p 30 mg·kg(-1) for 5 consecutive days) induced neurotoxicity. In in vitro antioxidant assays...

Serosurveillance of foot and mouth disease in Karnataka state, India: a 3 years study.

Virusdisease

Hegde R, Kowalli S, Nagaraja K, Dharanesha NK, Seema CM, Khan TA, Nagaraj GV, Srikala K, Sudharshana KJ, Nagaraju D, Rao S, Giridhara P, Byregowda SM.
PMID: 28466042
Virusdisease. 2016 Sep;27(3):294-302. doi: 10.1007/s13337-016-0340-x. Epub 2016 Aug 26.

A prospective serological investigation was conducted to determine the prevalence and distribution of foot-and-mouth disease (FMD), as well as to monitor the effectiveness of the FMD control programme (FMD-CP) through vaccination in Karnataka, India. Random serum samples were collected...

2,2,9-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4-(11H)-one.

Acta crystallographica. Section E, Structure reports online

Sridharan M, Prasad KJ, Zeller M.
PMID: 21581016
Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 22;64:o2156. doi: 10.1107/S1600536808033850.

The title compound, C(18)H(17)NO(2), was prepared from 1-hydr-oxy-7-methyl-carbazole and 3,3-dimethyl-acrylic acid with trifluoro-acetic acid as the cyclization catalyst. The mol-ecules contain an essentially planar 6-methyl-indole unit. The second aromatic ring is significantly bent away from the plane of this...

4,8-Dimethyl-pyrano[2,3-a]carbazol-2(11H)-one.

Acta crystallographica. Section E, Structure reports online

Sridharan M, Rajendra Prasad KJ, Thomas Gunaseelan A, Thiruvalluvar A, Butcher RJ.
PMID: 21582550
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65:o830. doi: 10.1107/S1600536809009854.

The mol-ecule of the title compound, C(17)H(13)NO(2), is nearly planar, the r.m.s. deviation for all non-H atoms excluding the two methyl C atoms being 0.089 Å. Inter-molecular N-H⋯O and C-H⋯O hydrogen bonds are found in the crystal structure. C-H⋯π...

Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats.

Journal of clinical biochemistry and nutrition

Arumugam S, Thandavarayan RA, Veeraveedu PT, Ma M, Giridharan VV, Arozal W, Sari FR, Sukumaran V, Lakshmanan A, Soetikno V, Suzuki K, Kodama M, Watanabe K.
PMID: 22448095
J Clin Biochem Nutr. 2012 Mar;50(2):139-44. doi: 10.3164/jcbn.11-44. Epub 2011 Nov 18.

Mulberry is commonly used as silkworm diet and an alternative medicine in Japan and China, has recently reported to contain many antioxidative flavanoid compounds and having the free radical scavenging effects. Antioxidants reduce cardiac oxidative stress and attenuate cardiac...

6-Chloro-3,4-di-hydro-9H-carbazol-1(2H)-one.

Acta crystallographica. Section E, Structure reports online

Sridharan M, Prasad KJ, Gunaseelan AT, Thiruvalluvar A, Butcher RJ.
PMID: 21203324
Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 31;64:o1635. doi: 10.1107/S1600536808023441.

The carbazole unit of the title mol-ecule, C(12)H(10)ClNO, is not planar. The dihedral angle between the benzene and pyrrole rings is 1.35 (10)°. The cyclo-hexene ring adopts an envelope conformation. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds form...

Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1.

Communicative & integrative biology

Giridharan SS, Cai B, Naslavsky N, Caplan S.
PMID: 23060965
Commun Integr Biol. 2012 Jul 01;5(4):384-7. doi: 10.4161/cib.20064.

Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how...

Emergent embolization of a ruptured splenic artery aneurysm complicating Menkes disease.

Radiology case reports

Olivieri JF, Jeyakumar A, Shivaram GM, Koo KSH, Monroe EJ.
PMID: 30275920
Radiol Case Rep. 2018 Sep 23;13(6):1267-1270. doi: 10.1016/j.radcr.2018.08.032. eCollection 2018 Dec.

We report a 7-year-old boy with Menkes disease complicated by rupture of a large splenic artery aneurysm. The aneurysm was successfully embolized with microcoils and n-butyl cyanoacrylate. Further angiographic evaluation revealed marked tortuosity of mesenteric and lower extremity vasculature,...

Sociodemographic and Medical Risk Factors Associated With Antepartum Depression.

Frontiers in public health

Babu GR, Murthy GVS, Singh N, Nath A, Rathnaiah M, Saldanha N, Deepa R, Kinra S.
PMID: 29770322
Front Public Health. 2018 May 02;6:127. doi: 10.3389/fpubh.2018.00127. eCollection 2018.

BACKGROUND: The increasing recognition of antenatal depression is an emerging area of concern in developing countries. We conducted a study to estimate the prevalence of antenatal mental distress and its relation with sociodemographic factors, obstetric factors, and physiological wellbeing...

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.

Nature medicine

Bolouri H, Farrar JE, Triche T, Ries RE, Lim EL, Alonzo TA, Ma Y, Moore R, Mungall AJ, Marra MA, Zhang J, Ma X, Liu Y, Liu Y, Auvil JMG, Davidsen TM, Gesuwan P, Hermida LC, Salhia B, Capone S, Ramsingh G, Zwaan CM, Noort S, Piccolo SR, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S.
PMID: 30705421
Nat Med. 2019 Mar;25(3):530. doi: 10.1038/s41591-019-0369-7.

In the version of this article originally published, the color key in Fig. 1a was wrong. In the Cytogenetics key, the box over t(8;21) originally was green. It should have been red, matching the color of the sections of...

Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer.

Frontiers in pharmacology

Selot R, Arumugam S, Mary B, Cheemadan S, Jayandharan GR.
PMID: 28769791
Front Pharmacol. 2017 Jul 17;8:441. doi: 10.3389/fphar.2017.00441. eCollection 2017.

Of the 12 common serotypes used for gene delivery applications, Adeno-associated virus (AAV)rh.10 serotype has shown sustained hepatic transduction and has the lowest seropositivity in humans. We have evaluated if further modifications to AAVrh.10 at its phosphodegron like regions...