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Showing 1 to 12 of 68 entries
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Intracerebral haemorrhage in Down syndrome: protected or predisposed?.

F1000Research

Buss L, Fisher E, Hardy J, Nizetic D, Groet J, Pulford L, Strydom A.
PMID: 27239286
F1000Res. 2016 May 12;5. doi: 10.12688/f1000research.7819.1. eCollection 2016.

Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel walls...

The importance of understanding individual differences in Down syndrome.

F1000Research

Karmiloff-Smith A, Al-Janabi T, D'Souza H, Groet J, Massand E, Mok K, Startin C, Fisher E, Hardy J, Nizetic D, Tybulewicz V, Strydom A.
PMID: 27019699
F1000Res. 2016 Mar 23;5. doi: 10.12688/f1000research.7506.1. eCollection 2016.

In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide...

Regulation of BLM Nucleolar Localization.

Genes

Tangeman L, McIlhatton MA, Grierson P, Groden J, Acharya S.
PMID: 27657136
Genes (Basel). 2016 Sep 21;7(9). doi: 10.3390/genes7090069.

Defects in coordinated ribosomal RNA (rRNA) transcription in the nucleolus cause cellular and organismal growth deficiencies. Bloom's syndrome, an autosomal recessive human disorder caused by mutated recQ-like helicase BLM, presents with growth defects suggestive of underlying defects in rRNA...

Alternative Macrophage Activation Is Increased in Asthma.

American journal of respiratory cell and molecular biology

Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M.
PMID: 27248771
Am J Respir Cell Mol Biol. 2016 Oct;55(4):467-475. doi: 10.1165/rcmb.2015-0295OC.

The immune responses of type 2 T helper cells (Th2) play an important role in asthma and promote the differentiation of alternatively activated (M2) macrophages. M2 macrophages have been increasingly understood to contribute to Th2 immunity. We hypothesized that...

[The double system of child protection: a French original].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Martins D, Girodet D.
PMID: 10941496
Arch Pediatr. 2000 Jul;7(7):773-8. doi: 10.1016/s0929-693x(00)80161-x.

France has a double system of child welfare as decreed by the law of July 1989. Social welfare is under the responsibility of the Regional Council (social services, early childhood health services, and child protection services). These type of...

Investigation of the interaction between hydrogen and screw dislocation in silicon by first-principles calculations.

Journal of physics. Condensed matter : an Institute of Physics journal

Matsubara M, Godet J, Pizzagalli L.
PMID: 21386298
J Phys Condens Matter. 2010 Jan 27;22(3):035803. doi: 10.1088/0953-8984/22/3/035803. Epub 2009 Dec 21.

The stability of atomic and molecular hydrogen in the vicinity of a screw dislocation in silicon has been investigated using first-principles calculations. The lowest energy configurations are obtained for H atoms located in the dislocation core, suggesting that the...

Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome.

Oncotarget

Masliantsev K, Pinel B, Balbous A, Guichet PO, Tachon G, Milin S, Godet J, Duchesne M, Berger A, Petropoulos C, Wager M, Karayan-Tapon L.
PMID: 29423098
Oncotarget. 2017 Dec 16;9(3):3968-3979. doi: 10.18632/oncotarget.23374. eCollection 2018 Jan 09.

Glioblastoma (GBM) represents the most common and lethal primary malignant brain tumor. The standard treatment for glioblastoma patients involves surgical resection with concomitant radio and chemotherapy. Despite today's clinical protocol, the prognosis for patients remains very poor with a...

Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC.

Current colorectal cancer reports

Perchiniak EM, Groden J.
PMID: 23308069
Curr Colorectal Cancer Rep. 2011 Jun 01;7(2):145-151. doi: 10.1007/s11888-011-0088-z.

Colorectal cancer (CRC) results from the progressive accumulation of both genetic and epigenetic alterations that lead to the transformation of normal colorectal epithelium to benign (adenoma) and invasive (carcinoma) disease. Since its discovery in mutated form as the causative...

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Molecular psychiatry

Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D, Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D.
PMID: 32647257
Mol Psychiatry. 2020 Jul 10; doi: 10.1038/s41380-020-0806-5. Epub 2020 Jul 10.

A population of more than six million people worldwide at high risk of Alzheimer's disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy...

Prospective evaluation of the connected biofeedback EMY Kegel trainer in the management of stress urinary incontinence.

Journal of gynecology obstetrics and human reproduction

Jochum F, Garbin O, Godet J, Ragueneau M, Meyer C, Billecocq S, Lecointre L, Akladios C, Host A.
PMID: 34861424
J Gynecol Obstet Hum Reprod. 2021 Dec 01;51(2):102280. doi: 10.1016/j.jogoh.2021.102280. Epub 2021 Dec 01.

INTRODUCTION: The aim of this study was to evaluate changes in the quality of life with the connected biofeedback EMY Kegel trainer in patients suffering from stress urinary incontinence. Materiel and methods: This was a prospective, single-center, non-comparative study,...

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Molecular psychiatry

Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D, Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D.
PMID: 34272490
Mol Psychiatry. 2021 Jul 16; doi: 10.1038/s41380-021-01206-x. Epub 2021 Jul 16.

No abstract available.

Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Piotin A, Godet J, Trubiano JA, Grandbastien M, Guénard-Bilbault L, de Blay F, Metz-Favre C.
PMID: 34271183
Ann Allergy Asthma Immunol. 2022 Jan;128(1):27-32. doi: 10.1016/j.anai.2021.07.005. Epub 2021 Jul 13.

BACKGROUND: The challenge of delabeling amoxicillin allergy is an important issue for patients and clinicians, especially when anaphylaxis is reported. A recent study has proposed a clinical decision rule, PEN-FAST, to identify low-risk penicillin allergies.OBJECTIVE: To validate the PEN-FAST...

Showing 1 to 12 of 68 entries