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Showing 1 to 12 of 37 entries
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Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography.

Alzheimer's research & therapy

Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD.
PMID: 25733984
Alzheimers Res Ther. 2015 Mar 02;7(1):8. doi: 10.1186/s13195-014-0093-y. eCollection 2015.

INTRODUCTION: Group comparisons demonstrate greater visuospatial and memory deficits and temporoparietal-predominant degeneration on neuroimaging in patients with corticobasal syndrome (CBS) found to have Alzheimer's disease (AD) pathology versus those with underlying frontotemporal lobar degeneration (FTLD). The value of these...

Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review.

Frontiers in neurology

Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R.
PMID: 30186225
Front Neurol. 2018 Aug 21;9:692. doi: 10.3389/fneur.2018.00692. eCollection 2018.

Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA) have been described, each...

Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia.

Neurocase

Tee BL, Deleon J, Chen Li Ying LK, Miller BL, Y Lo R, Europa E, Sudarsan S, Grasso S, Gorno-Tempini ML.
PMID: 34404317
Neurocase. 2021 Aug 17;1-10. doi: 10.1080/13554794.2021.1925302. Epub 2021 Aug 17.

Clinical understanding of primary progressive aphasia (PPA) has been established based on English-speaking population. The lack of linguistic diversity in research hinders the diagnosis of PPA in non-English speaking patients. This case report describes the tonal and orthographic deficits...

Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks.

Frontiers in human neuroscience

Hinkley LBN, De Witte E, Cahill-Thompson M, Mizuiri D, Garrett C, Honma S, Findlay A, Gorno-Tempini ML, Tarapore P, Kirsch HE, Mariën P, Houde JF, Berger M, Nagarajan SS.
PMID: 32499685
Front Hum Neurosci. 2020 May 15;14:105. doi: 10.3389/fnhum.2020.00105. eCollection 2020.

Magnetoencephalographic imaging (MEGI) offers a non-invasive alternative for defining preoperative language lateralization in neurosurgery patients. MEGI indeed can be used for accurate estimation of language lateralization with a complex language task - auditory verb generation. However, since language function...

Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.

Frontiers in neurology

Fan JM, Gorno-Tempini ML, Dronkers NF, Miller BL, Berger MS, Chang EF.
PMID: 33447252
Front Neurol. 2020 Dec 29;11:616764. doi: 10.3389/fneur.2020.616764. eCollection 2020.

Aphasia classifications and specialized language batteries differ across the fields of neurodegenerative disorders and lesional brain injuries, resulting in difficult comparisons of language deficits across etiologies. In this study, we present a simplified framework, in which a widely-used aphasia...

Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions.

Alzheimer disease and associated disorders

Rascovsky K, Hodges JR, Kipps CM, Johnson JK, Seeley WW, Mendez MF, Knopman D, Kertesz A, Mesulam M, Salmon DP, Galasko D, Chow TW, Decarli C, Hillis A, Josephs K, Kramer JH, Weintraub S, Grossman M, Gorno-Tempini ML, Miller BM.
PMID: 18090417
Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):S14-8. doi: 10.1097/WAD.0b013e31815c3445.

The most widely established diagnostic criteria for the behavioral variant of frontotemporal dementia have now been in use for almost a decade. Although consensus criteria have provided a much needed standard for frontotemporal dementia research, a growing body of...

Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.

Neuroscience and biobehavioral reviews

Geraudie A, Battista P, García AM, Allen IE, Miller ZA, Gorno-Tempini ML, Montembeault M.
PMID: 34673112
Neurosci Biobehav Rev. 2021 Dec;131:1076-1095. doi: 10.1016/j.neubiorev.2021.10.015. Epub 2021 Oct 19.

Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by behavioral and socio-emotional changes, impairments often extend to other cognitive functions. These include early speech and language deficits related to the disease's core neural disruptions. Yet, their scope and...

The resilience of the developing reading system: multi-modal evidence of incident and recovery after a pediatric stroke.

Neurocase

Borghesani V, Wang C, Miller C, Mandelli ML, Shapiro K, Miller Z, Fox C, Dronkers NF, Gorno-Tempini ML, Watson C.
PMID: 34503393
Neurocase. 2021 Sep 10;1-11. doi: 10.1080/13554794.2021.1957119. Epub 2021 Sep 10.

Decades of neuroscientific findings have elucidated the highly specialized brain areas involved in reading, especially along the ventral occipitotemporal stream where the critical step of recognizing words occurs. We report on a 14-year-old female with temporary dyslexia after a...

Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.

Alzheimer's & dementia (Amsterdam, Netherlands)

Staffaroni AM, Weintraub S, Rascovsky K, Rankin KP, Taylor J, Fields JA, Casaletto KB, Hillis AE, Lukic S, Gorno-Tempini ML, Heuer H, Teylan MA, Kukull WA, Miller BL, Boeve BF, Rosen HJ, Boxer AL, Kramer JH.
PMID: 33665340
Alzheimers Dement (Amst). 2021 Feb 20;13(1):e12148. doi: 10.1002/dad2.12148. eCollection 2021.

INTRODUCTION: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential...

Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia.

Neurocase

Tee BL, Deleon J, Chen Li Ying LK, Miller BL, Y Lo R, Europa E, Sudarsan S, Grasso S, Gorno-Tempini ML.
PMID: 34404317
Neurocase. 2021 Aug 17;1-10. doi: 10.1080/13554794.2021.1925302. Epub 2021 Aug 17.

Clinical understanding of primary progressive aphasia (PPA) has been established based on English-speaking population. The lack of linguistic diversity in research hinders the diagnosis of PPA in non-English speaking patients. This case report describes the tonal and orthographic deficits...

Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia.

Frontiers in human neuroscience

Dial HR, Gnanateja GN, Tessmer RS, Gorno-Tempini ML, Chandrasekaran B, Henry ML.
PMID: 33488371
Front Hum Neurosci. 2021 Jan 06;14:597694. doi: 10.3389/fnhum.2020.597694. eCollection 2020.

Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence also implicates impaired...

Connected speech markers of amyloid burden in primary progressive aphasia.

Cortex; a journal devoted to the study of the nervous system and behavior

Slegers A, Chafouleas G, Montembeault M, Bedetti C, Welch AE, Rabinovici GD, Langlais P, Gorno-Tempini ML, Brambati SM.
PMID: 34731686
Cortex. 2021 Dec;145:160-168. doi: 10.1016/j.cortex.2021.09.010. Epub 2021 Oct 07.

INTRODUCTION: Positron emission tomography (PET) amyloid imaging has become an important part of the diagnostic workup for patients with primary progressive aphasia (PPA) and uncertain underlying pathology. Here, we employ a semi-automated analysis of connected speech (CS) with a...

Showing 1 to 12 of 37 entries