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Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.

ACS medicinal chemistry letters

Larson P, Kucaba TA, Xiong Z, Olin M, Griffith TS, Ferguson DM.
PMID: 29152046
ACS Med Chem Lett. 2017 Oct 16;8(11):1148-1152. doi: 10.1021/acsmedchemlett.7b00256. eCollection 2017 Nov 09.

A series of N1-modified imidazoquinolines were synthesized and screened for Toll-like receptors (TLR) 7 and 8 activities to identify recognition elements that confer high affinity binding and selectivity. These receptors are key targets in the development of immunomodulatory agents...

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Larson P, Kucaba TA, Xiong Z, et al. Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS Med Chem Lett. 2017;8(11):1148-1152doi: 10.1021/acsmedchemlett.7b00256.
Larson, P., Kucaba, T. A., Xiong, Z., Olin, M., Griffith, T. S., & Ferguson, D. M. (2017). Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS medicinal chemistry letters, 8(11), 1148-1152. https://doi.org/10.1021/acsmedchemlett.7b00256
Larson, Peter, et al. "Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8." ACS medicinal chemistry letters vol. 8,11 (2017): 1148-1152. doi: https://doi.org/10.1021/acsmedchemlett.7b00256
Larson P, Kucaba TA, Xiong Z, Olin M, Griffith TS, Ferguson DM. Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS Med Chem Lett. 2017 Oct 16;8(11):1148-1152. doi: 10.1021/acsmedchemlett.7b00256. eCollection 2017 Nov 09. PMID: 29152046; PMCID: PMC5683703.
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Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung.

Cardiovascular engineering and technology

Wu ZJ, Gellman B, Zhang T, Taskin ME, Dasse KA, Griffith BP.
PMID: 24839468
Cardiovasc Eng Technol. 2011 Dec 01;2(4):276-287. doi: 10.1007/s13239-011-0071-5.

The pediatric pump-lung (PediPL) is a miniaturized integrated pediatric pump-oxygenator specifically designed for cardiac or cardiopulmonary support for patients weighing 5-20 kg to allow mobility and extended use for 30 days. The PediPL incorporates a magnetically levitated impeller with...

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Wu ZJ, Gellman B, Zhang T, et al. Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung. Cardiovasc Eng Technol. 2011;2(4):276-287doi: 10.1007/s13239-011-0071-5.
Wu, Z. J., Gellman, B., Zhang, T., Taskin, M. E., Dasse, K. A., & Griffith, B. P. (2011). Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung. Cardiovascular engineering and technology, 2(4), 276-287. https://doi.org/10.1007/s13239-011-0071-5
Wu, Zhongjun J, et al. "Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung." Cardiovascular engineering and technology vol. 2,4 (2011): 276-287. doi: https://doi.org/10.1007/s13239-011-0071-5
Wu ZJ, Gellman B, Zhang T, Taskin ME, Dasse KA, Griffith BP. Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung. Cardiovasc Eng Technol. 2011 Dec 01;2(4):276-287. doi: 10.1007/s13239-011-0071-5. PMID: 24839468; PMCID: PMC4020008.
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Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method.

IMA journal of applied mathematics

Gao H, Carrick D, Berry C, Griffith BE, Luo X.
PMID: 27041786
IMA J Appl Math. 2014 Oct;79(5):978-1010. doi: 10.1093/imamat/hxu029. Epub 2014 Jul 01.

Detailed models of the biomechanics of the heart are important both for developing improved interventions for patients with heart disease and also for patient risk stratification and treatment planning. For instance, stress distributions in the heart affect cardiac remodelling,...

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Gao H, Carrick D, Berry C, et al. Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method. IMA J Appl Math. 2014;79(5):978-1010doi: 10.1093/imamat/hxu029.
Gao, H., Carrick, D., Berry, C., Griffith, B. E., & Luo, X. (2014). Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method. IMA journal of applied mathematics, 79(5), 978-1010. https://doi.org/10.1093/imamat/hxu029
Gao, Hao, et al. "Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method." IMA journal of applied mathematics vol. 79,5 (2014): 978-1010. doi: https://doi.org/10.1093/imamat/hxu029
Gao H, Carrick D, Berry C, Griffith BE, Luo X. Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method. IMA J Appl Math. 2014 Oct;79(5):978-1010. doi: 10.1093/imamat/hxu029. Epub 2014 Jul 01. PMID: 27041786; PMCID: PMC4816497.
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The Challenges of Data Quality Evaluation in a Joint Data Warehouse.

EGEMS (Washington, DC)

Bae CJ, Griffith S, Fan Y, Dunphy C, Thompson N, Urchek J, Parchman A, Katzan IL.
PMID: 26290882
EGEMS (Wash DC). 2015 May 22;3(1):1125. doi: 10.13063/2327-9214.1125. eCollection 2015.

INTRODUCTION: The use of clinically derived data from electronic health records (EHRs) and other electronic clinical systems can greatly facilitate clinical research as well as operational and quality initiatives. One approach for making these data available is to incorporate...

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Bae CJ, Griffith S, Fan Y, et al. The Challenges of Data Quality Evaluation in a Joint Data Warehouse. EGEMS (Wash DC). 2015;3(1):1125doi: 10.13063/2327-9214.1125.
Bae, C. J., Griffith, S., Fan, Y., Dunphy, C., Thompson, N., Urchek, J., Parchman, A., & Katzan, I. L. (2015). The Challenges of Data Quality Evaluation in a Joint Data Warehouse. EGEMS (Washington, DC), 3(1), 1125. https://doi.org/10.13063/2327-9214.1125
Bae, Charles J, et al. "The Challenges of Data Quality Evaluation in a Joint Data Warehouse." EGEMS (Washington, DC) vol. 3,1 (2015): 1125. doi: https://doi.org/10.13063/2327-9214.1125
Bae CJ, Griffith S, Fan Y, Dunphy C, Thompson N, Urchek J, Parchman A, Katzan IL. The Challenges of Data Quality Evaluation in a Joint Data Warehouse. EGEMS (Wash DC). 2015 May 22;3(1):1125. doi: 10.13063/2327-9214.1125. eCollection 2015. PMID: 26290882; PMCID: PMC4537084.
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Invited Commentary.

The Annals of thoracic surgery

Griffith BP.
PMID: 28935301
Ann Thorac Surg. 2017 Oct;104(4):1264-1266. doi: 10.1016/j.athoracsur.2017.05.056.

No abstract available.

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Griffith BP. Invited Commentary. Ann Thorac Surg. 2017;104(4):1264-1266doi: 10.1016/j.athoracsur.2017.05.056.
Griffith, B. P. (2017). Invited Commentary. The Annals of thoracic surgery, 104(4), 1264-1266. https://doi.org/10.1016/j.athoracsur.2017.05.056
Griffith, Bartley P. "Invited Commentary." The Annals of thoracic surgery vol. 104,4 (2017): 1264-1266. doi: https://doi.org/10.1016/j.athoracsur.2017.05.056
Griffith BP. Invited Commentary. Ann Thorac Surg. 2017 Oct;104(4):1264-1266. doi: 10.1016/j.athoracsur.2017.05.056. PMID: 28935301.
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Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects.

Optics express

Griffith AG, Yu M, Okawachi Y, Cardenas J, Mohanty A, Gaeta AL, Lipson M.
PMID: 27410323
Opt Express. 2016 Jun 13;24(12):13044-50. doi: 10.1364/OE.24.013044.

We demonstrate the first low-noise mid-IR frequency comb source using a silicon microresonator. Our observation of strong Raman scattering lines in the generated comb suggests that interplay between Raman and four-wave mixing plays a role in the generated low-noise...

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Griffith AG, Yu M, Okawachi Y, et al. Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects. Opt Express. 2016;24(12):13044-50doi: 10.1364/OE.24.013044.
Griffith, A. G., Yu, M., Okawachi, Y., Cardenas, J., Mohanty, A., Gaeta, A. L., & Lipson, M. (2016). Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects. Optics express, 24(12), 13044-50. https://doi.org/10.1364/OE.24.013044
Griffith, Austin G, et al. "Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects." Optics express vol. 24,12 (2016): 13044-50. doi: https://doi.org/10.1364/OE.24.013044
Griffith AG, Yu M, Okawachi Y, Cardenas J, Mohanty A, Gaeta AL, Lipson M. Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects. Opt Express. 2016 Jun 13;24(12):13044-50. doi: 10.1364/OE.24.013044. PMID: 27410323.
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Constraints on coastal dune invasion for a notorious plant invader.

AoB PLANTS

Griffith AB, Ahmed T, Hildner AL, Kuckreja S, Long S.
PMID: 26558705
AoB Plants. 2015 Nov 10;7. doi: 10.1093/aobpla/plv126.

Although most biological invasions are not successful, relatively few studies have examined otherwise notorious invaders in systems where they are not highly problematic. The annual grass Bromus tectorum is a dominant invader in western North America, but is usually...

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Griffith AB, Ahmed T, Hildner AL, et al. Constraints on coastal dune invasion for a notorious plant invader. AoB Plants. 2015;7doi: 10.1093/aobpla/plv126.
Griffith, A. B., Ahmed, T., Hildner, A. L., Kuckreja, S., & Long, S. (2015). Constraints on coastal dune invasion for a notorious plant invader. AoB PLANTS, 7. https://doi.org/10.1093/aobpla/plv126
Griffith, Alden B, et al. "Constraints on coastal dune invasion for a notorious plant invader." AoB PLANTS vol. 7 (2015). doi: https://doi.org/10.1093/aobpla/plv126
Griffith AB, Ahmed T, Hildner AL, Kuckreja S, Long S. Constraints on coastal dune invasion for a notorious plant invader. AoB Plants. 2015 Nov 10;7. doi: 10.1093/aobpla/plv126. PMID: 26558705; PMCID: PMC4676798.
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Strategies for Unambiguous Detection of Allelic Heterozygosity via Direct DNA Sequencing of PCR Products: Application to the HLA DRB1 Locus.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology

Wu J, Griffith BB, Bassinger S, Moehlenkamp C, Brodie SG, Wu Y, Gribble GG, Troup GM, Williams TM.
PMID: 10330204
Mol Diagn. 1996 Jun;1(2):89-98. doi: 10.1054/MODI00100089.

Background: Many genetic loci exhibit substantial heterogeneity: the human leukocyte antigen (HLA) DRB loci include 139 alleles and the cystic fibrosis transmembrane regulator gene more than 500 known mutations. Identification of alleles at these loci is cumbersome with typical...

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Wu J, Griffith BB, Bassinger S, et al. Strategies for Unambiguous Detection of Allelic Heterozygosity via Direct DNA Sequencing of PCR Products: Application to the HLA DRB1 Locus. Mol Diagn. 1996;1(2):89-98doi: 10.1054/MODI00100089.
Wu, J., Griffith, B. B., Bassinger, S., Moehlenkamp, C., Brodie, S. G., Wu, Y., Gribble, G. G., Troup, G. M., & Williams, T. M. (1996). Strategies for Unambiguous Detection of Allelic Heterozygosity via Direct DNA Sequencing of PCR Products: Application to the HLA DRB1 Locus. Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology, 1(2), 89-98. https://doi.org/10.1054/MODI00100089
Wu, et al. "Strategies for Unambiguous Detection of Allelic Heterozygosity via Direct DNA Sequencing of PCR Products: Application to the HLA DRB1 Locus." Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology vol. 1,2 (1996): 89-98. doi: https://doi.org/10.1054/MODI00100089
Wu J, Griffith BB, Bassinger S, Moehlenkamp C, Brodie SG, Wu Y, Gribble GG, Troup GM, Williams TM. Strategies for Unambiguous Detection of Allelic Heterozygosity via Direct DNA Sequencing of PCR Products: Application to the HLA DRB1 Locus. Mol Diagn. 1996 Jun;1(2):89-98. doi: 10.1054/MODI00100089. PMID: 10330204.
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Heart-lung transplantation.

Texas Heart Institute journal

Griffith BP.
PMID: 15227291
Tex Heart Inst J. 1987 Dec;14(4):364-8.

The survival rate (average, 50%) of patients undergoing cardiopulmonary transplantation falls well below that expected for cardiac transplantation alone. We give a broad overview of the various grounds upon which this difference is likely based and discuss recent advances...

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Griffith BP. Heart-lung transplantation. Tex Heart Inst J. 1987;14(4):364-8
Griffith, B. P. (1987). Heart-lung transplantation. Texas Heart Institute journal, 14(4), 364-8.
Griffith, B P. "Heart-lung transplantation." Texas Heart Institute journal vol. 14,4 (1987): 364-8.
Griffith BP. Heart-lung transplantation. Tex Heart Inst J. 1987 Dec;14(4):364-8. PMID: 15227291; PMCID: PMC324759.
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C-reactive protein monitoring in the management of intracranial abscess.

Annals of Saudi medicine

Jamjoom A, Brown E, Griffith H.
PMID: 17590824
Ann Saudi Med. 1991 Nov;11(6):681-7. doi: 10.5144/0256-4947.1991.681.

C-reactive protein (CRP) content was measured serially in 12 patients with intracranial abscess. All patients had undergone surgery and were treated with antimicrobial therapy. The CRP content ultimately returned to normal in 11 patients and this correlated with good...

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Jamjoom A, Brown E, Griffith H. C-reactive protein monitoring in the management of intracranial abscess. Ann Saudi Med. 1991;11(6):681-7doi: 10.5144/0256-4947.1991.681.
Jamjoom, A., Brown, E., & Griffith, H. (1991). C-reactive protein monitoring in the management of intracranial abscess. Annals of Saudi medicine, 11(6), 681-7. https://doi.org/10.5144/0256-4947.1991.681
Jamjoom, A, et al. "C-reactive protein monitoring in the management of intracranial abscess." Annals of Saudi medicine vol. 11,6 (1991): 681-7. doi: https://doi.org/10.5144/0256-4947.1991.681
Jamjoom A, Brown E, Griffith H. C-reactive protein monitoring in the management of intracranial abscess. Ann Saudi Med. 1991 Nov;11(6):681-7. doi: 10.5144/0256-4947.1991.681. PMID: 17590824.
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MUSCLE RELAXATION IN SURGERY.

Canadian Medical Association journal

Griffith HR.
PMID: 20324072
Can Med Assoc J. 1947 Mar;56(3):281-3.

No abstract available.

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Griffith HR. MUSCLE RELAXATION IN SURGERY. Can Med Assoc J. 1947;56(3):281-3
Griffith, H. R. (1947). MUSCLE RELAXATION IN SURGERY. Canadian Medical Association journal, 56(3), 281-3.
Griffith, H R. "MUSCLE RELAXATION IN SURGERY." Canadian Medical Association journal vol. 56,3 (1947): 281-3.
Griffith HR. MUSCLE RELAXATION IN SURGERY. Can Med Assoc J. 1947 Mar;56(3):281-3. PMID: 20324072.
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THE GENETICS OF RETINOBLASTOMA.

The British journal of ophthalmology

Griffith AD, Sorsby A.
PMID: 18170018
Br J Ophthalmol. 1944 Jun;28(6):279-93. doi: 10.1136/bjo.28.6.279.

No abstract available.

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Griffith AD, Sorsby A. THE GENETICS OF RETINOBLASTOMA. Br J Ophthalmol. 1944;28(6):279-93doi: 10.1136/bjo.28.6.279.
Griffith, A. D., & Sorsby, A. (1944). THE GENETICS OF RETINOBLASTOMA. The British journal of ophthalmology, 28(6), 279-93. https://doi.org/10.1136/bjo.28.6.279
Griffith, A D, and Sorsby, A. "THE GENETICS OF RETINOBLASTOMA." The British journal of ophthalmology vol. 28,6 (1944): 279-93. doi: https://doi.org/10.1136/bjo.28.6.279
Griffith AD, Sorsby A. THE GENETICS OF RETINOBLASTOMA. Br J Ophthalmol. 1944 Jun;28(6):279-93. doi: 10.1136/bjo.28.6.279. PMID: 18170018; PMCID: PMC510367.
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Showing 1 to 12 of 303 entries