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Showing 1 to 12 of 99 entries
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Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?.

The journal of pathology. Clinical research

Noorani I, Petty G, Grundy PL, Sharpe G, Willaime-Morawek S, Harris S, Thomas GJ, Nicoll JA, Boche D.
PMID: 27499894
J Pathol Clin Res. 2015 Jan 14;1(2):67-75. doi: 10.1002/cjp2.7. eCollection 2015 Apr.

Brain tumour stem cells and microglia both promote the growth of astrocytomas, the commonest form of primary brain tumour, with recent emerging evidence that these cell types may interact in glioma models. It is unclear whether microglia and stem...

Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Molecular therapy. Nucleic acids

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS.
PMID: 25602582
Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the...

A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment.

PeerJ

Wilson GI, Holton MD, Walker J, Jones MW, Grundy E, Davies IM, Clarke D, Luckman A, Russill N, Wilson V, Plummer R, Wilson RP.
PMID: 26157643
PeerJ. 2015 Jun 18;3:e908. doi: 10.7717/peerj.908. eCollection 2015.

Understanding the way humans inform themselves about their environment is pivotal in helping explain our susceptibility to stimuli and how this modulates behaviour and movement patterns. We present a new device, the Human Interfaced Personal Observation Platform (HIPOP), which...

The impact of health system reform on remote health in Cambodia and the Philippines.

Rural and remote health

Grundy JJ.
PMID: 15869366
Rural Remote Health. 2001 Jan-Dec;1(1):84. Epub 2001 Mar 26.

UNLABELLED: Remoteness is commonly conceived of in the Western health context in terms of geographical or social isolation. These features of remoteness also apply to the developing nation context. However, the international context has additional dimensions of remoteness that...

Geographic variation and localised clustering of congenital anomalies in Great Britain.

Emerging themes in epidemiology

Armstrong BG, Dolk H, Pattenden S, Vrijheid M, Loane M, Rankin J, Dunn CE, Grundy C, Abramsky L, Boyd PA, Stone D, Wellesley D.
PMID: 17617898
Emerg Themes Epidemiol. 2007 Jul 06;4:14. doi: 10.1186/1742-7622-4-14.

BACKGROUND: Environmental pollution as a cause of congenital anomalies is sometimes suspected because of clustering of anomalies in areas of higher exposure. This highlights questions around spatial heterogeneity (clustering) in congenital anomaly rates. If spatial variation is endemic, then...

The value of magnetic resonance spectroscopy in tumour imaging.

Archives of disease in childhood

Peet AC, Arvanitis TN, Auer DP, Davies NP, Hargrave D, Howe FA, Jaspan T, Leach MO, Macarthur D, MacPherson L, Morgan PS, Natarajan K, Payne GS, Saunders D, Grundy RG.
PMID: 18463122
Arch Dis Child. 2008 Sep;93(9):725-7. doi: 10.1136/adc.2007.125237. Epub 2008 May 07.

No abstract available.

The buncefield oil depot fire of 2005: potential air-pollution health impacts under alternative meteorological scenarios.

PLoS currents

Mohan R, Walton HA, Thomson D, Webster H, Wilkinson P, Grundy C, Murray V, Leonardi G.
PMID: 22453896
PLoS Curr. 2012 Feb 02;4:RRN1300. doi: 10.1371/currents.RRN1300.

OBJECTIVE: To model the possible air pollution-related health impact of the 2005 oil depot fire at Buncefield, near London, UK, under alternative meteorological conditions to those experienced at the time.DESIGN: Atmospheric dispersion modelling of the smoke plume was conducted...

Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes.

Physical chemistry chemical physics : PCCP

Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.
PMID: 30916090
Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27.

The performance of binary electrolytes is governed by three transport properties: conductivity, salt diffusion coefficient, and transference number. Rigorous methods for measuring conductivity and the salt diffusion coefficient are well established and used routinely in the literature. The commonly...

Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice.

Tobacco induced diseases

Grundy EJ, Suddek T, Filippidis FT, Majeed A, Coronini-Cronberg S.
PMID: 32641924
Tob Induc Dis. 2020 Jul 03;18:58. doi: 10.18332/tid/124788. eCollection 2020.

INTRODUCTION: There has been significant speculation regarding the association between the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, coronavirus disease (COVID-19) and smoking. We provide an overview of the available literature regarding the association between smoking, risk of...

Report of the Expert Panel on Awareness and Behavior Change to the Board of Directors, American Heart Association.

Circulation

Carleton RA, Bazzarre T, Drake J, Dunn A, Fisher EB, Grundy SM, Hayman L, Hill MN, Maibach EW, Prochaska J, Schmid T, Smith SC, Susser MW, Worden JW.
PMID: 8653885
Circulation. 1996 May 01;93(9):1768-72. doi: 10.1161/01.cir.93.9.1768.

No abstract available.

Utility of metabolic syndrome as a risk enhancing factor in decision of statin use.

Journal of clinical lipidology

Vega GL, Wang J, Grundy SM.
PMID: 33663990
J Clin Lipidol. 2021 Mar-Apr;15(2):255-265. doi: 10.1016/j.jacl.2021.01.012. Epub 2021 Feb 16.

BACKGROUND: Statins effectively reduce risk for atherosclerotic cardiovascular disease (ASCVD) when 10-year risk is ≥ 7.5%. In many patients at intermediate risk (7.5-

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.

Journal of magnetic resonance imaging : JMRI

Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA.
PMID: 34842328
J Magn Reson Imaging. 2021 Nov 29; doi: 10.1002/jmri.28007. Epub 2021 Nov 29.

BACKGROUND: Medulloblastoma, ependymoma, and pilocytic astrocytoma are common pediatric posterior fossa tumors. These tumors show overlapping characteristics on conventional MRI scans, making diagnosis difficult.PURPOSE: To investigate whether apparent diffusion coefficient (ADC) values differ between tumor types and to identify...

Showing 1 to 12 of 99 entries