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Showing 1 to 12 of 94 entries
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Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?.

The journal of pathology. Clinical research

Noorani I, Petty G, Grundy PL, Sharpe G, Willaime-Morawek S, Harris S, Thomas GJ, Nicoll JA, Boche D.
PMID: 27499894
J Pathol Clin Res. 2015 Jan 14;1(2):67-75. doi: 10.1002/cjp2.7. eCollection 2015 Apr.

Brain tumour stem cells and microglia both promote the growth of astrocytomas, the commonest form of primary brain tumour, with recent emerging evidence that these cell types may interact in glioma models. It is unclear whether microglia and stem...

Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Molecular therapy. Nucleic acids

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS.
PMID: 25602582
Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the...

A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment.

PeerJ

Wilson GI, Holton MD, Walker J, Jones MW, Grundy E, Davies IM, Clarke D, Luckman A, Russill N, Wilson V, Plummer R, Wilson RP.
PMID: 26157643
PeerJ. 2015 Jun 18;3:e908. doi: 10.7717/peerj.908. eCollection 2015.

Understanding the way humans inform themselves about their environment is pivotal in helping explain our susceptibility to stimuli and how this modulates behaviour and movement patterns. We present a new device, the Human Interfaced Personal Observation Platform (HIPOP), which...

The impact of health system reform on remote health in Cambodia and the Philippines.

Rural and remote health

Grundy JJ.
PMID: 15869366
Rural Remote Health. 2001 Jan-Dec;1(1):84. Epub 2001 Mar 26.

UNLABELLED: Remoteness is commonly conceived of in the Western health context in terms of geographical or social isolation. These features of remoteness also apply to the developing nation context. However, the international context has additional dimensions of remoteness that...

The value of magnetic resonance spectroscopy in tumour imaging.

Archives of disease in childhood

Peet AC, Arvanitis TN, Auer DP, Davies NP, Hargrave D, Howe FA, Jaspan T, Leach MO, Macarthur D, MacPherson L, Morgan PS, Natarajan K, Payne GS, Saunders D, Grundy RG.
PMID: 18463122
Arch Dis Child. 2008 Sep;93(9):725-7. doi: 10.1136/adc.2007.125237. Epub 2008 May 07.

No abstract available.

Corrigendum to "Comparative effectiveness of pediatric integrative medicine as an adjunct to usual care for pediatric inpatients of a North American tertiary care centre: A study protocol for a pragmatic cluster controlled trial" [Contemp. Clin. Trials Commun. (2017) 12-18].

Contemporary clinical trials communications

Vohra S, Schlegelmilch M, Jou H, Hartfield D, Mayan M, Ohinmaa A, Wilson B, Spavor M, Grundy P.
PMID: 29741163
Contemp Clin Trials Commun. 2017 Apr 21;6:147. doi: 10.1016/j.conctc.2017.04.004. eCollection 2017 Jun.

[This corrects the article DOI: 10.1016/j.conctc.2016.11.002.].

Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes.

Physical chemistry chemical physics : PCCP

Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.
PMID: 30916090
Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27.

The performance of binary electrolytes is governed by three transport properties: conductivity, salt diffusion coefficient, and transference number. Rigorous methods for measuring conductivity and the salt diffusion coefficient are well established and used routinely in the literature. The commonly...

Contacts between elderly parents and their children in four European countries: current patterns and future prospects.

European journal of ageing

Tomassini C, Kalogirou S, Grundy E, Fokkema T, Martikainen P, Broese van Groenou M, Karisto A.
PMID: 28794702
Eur J Ageing. 2004 Dec;1(1):54-63. doi: 10.1007/s10433-004-0003-4. Epub 2004 Nov 09.

Frequency of contacts with the family is an indicator of the strength of intergenerational exchange and potential support for older people. Although the availability of children clearly represents a constraint on potential family support, the extent of interaction with...

Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice.

Tobacco induced diseases

Grundy EJ, Suddek T, Filippidis FT, Majeed A, Coronini-Cronberg S.
PMID: 32641924
Tob Induc Dis. 2020 Jul 03;18:58. doi: 10.18332/tid/124788. eCollection 2020.

INTRODUCTION: There has been significant speculation regarding the association between the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, coronavirus disease (COVID-19) and smoking. We provide an overview of the available literature regarding the association between smoking, risk of...

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.

Journal of magnetic resonance imaging : JMRI

Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA.
PMID: 34842328
J Magn Reson Imaging. 2021 Nov 29; doi: 10.1002/jmri.28007. Epub 2021 Nov 29.

BACKGROUND: Medulloblastoma, ependymoma, and pilocytic astrocytoma are common pediatric posterior fossa tumors. These tumors show overlapping characteristics on conventional MRI scans, making diagnosis difficult.PURPOSE: To investigate whether apparent diffusion coefficient (ADC) values differ between tumor types and to identify...

CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Neuro-oncology advances

Fountain DM, Piper RJ, Poon MTC, Solomou G, Brennan PM, Chowdhury YA, Colombo F, Elmoslemany T, Ewbank FG, Grundy PL, Hasan MT, Hilling M, Hutchinson PJ, Karabatsou K, Kolias AG, McSorley NJ, Millward CP, Phang I, Plaha P, Price SJ, Rominiyi O, Sage W, Shumon S, Silva IL, Smith SJ, Surash S, Thomson S, Lau JY, Watts C, Jenkinson MD.
PMID: 34056602
Neurooncol Adv. 2021 Jan 28;3(1):vdab014. doi: 10.1093/noajnl/vdab014. eCollection 2021.

BACKGROUND: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors.METHODS: We performed a...

Impact of the First Generation of Children's Oncology Group Clinical Trials on Clinical Practice for Wilms Tumor.

Journal of the National Comprehensive Cancer Network : JNCCN

Dome JS, Mullen EA, Dix DB, Gratias EJ, Ehrlich PF, Daw NC, Geller JI, Chintagumpala M, Khanna G, Kalapurakal JA, Renfro LA, Perlman EJ, Grundy PE, Fernandez CV.
PMID: 34416705
J Natl Compr Canc Netw. 2021 Aug 01;19(8):978-985. doi: 10.6004/jnccn.2021.7070.

Refinements in surgery, radiation therapy, and chemotherapy since the mid-20th century have resulted in a survival rate exceeding 90% for patients with Wilms tumor (WT). Although this figure is remarkable, a significant proportion of patients continue to have event-free...

Showing 1 to 12 of 94 entries