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Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?.

The journal of pathology. Clinical research

Noorani I, Petty G, Grundy PL, Sharpe G, Willaime-Morawek S, Harris S, Thomas GJ, Nicoll JA, Boche D.
PMID: 27499894
J Pathol Clin Res. 2015 Jan 14;1(2):67-75. doi: 10.1002/cjp2.7. eCollection 2015 Apr.

Brain tumour stem cells and microglia both promote the growth of astrocytomas, the commonest form of primary brain tumour, with recent emerging evidence that these cell types may interact in glioma models. It is unclear whether microglia and stem...

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Noorani I, Petty G, Grundy PL, et al. Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?. J Pathol Clin Res. 2015;1(2):67-75doi: 10.1002/cjp2.7.
Noorani, I., Petty, G., Grundy, P. L., Sharpe, G., Willaime-Morawek, S., Harris, S., Thomas, G. J., Nicoll, J. A., & Boche, D. (2015). Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?. The journal of pathology. Clinical research, 1(2), 67-75. https://doi.org/10.1002/cjp2.7
Noorani, Imran, et al. "Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?." The journal of pathology. Clinical research vol. 1,2 (2015): 67-75. doi: https://doi.org/10.1002/cjp2.7
Noorani I, Petty G, Grundy PL, Sharpe G, Willaime-Morawek S, Harris S, Thomas GJ, Nicoll JA, Boche D. Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?. J Pathol Clin Res. 2015 Jan 14;1(2):67-75. doi: 10.1002/cjp2.7. eCollection 2015 Apr. PMID: 27499894; PMCID: PMC4858136.
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Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Molecular therapy. Nucleic acids

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS.
PMID: 25602582
Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the...

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Yu RZ, Grundy JS, Henry SP, et al. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015;4:e218doi: 10.1038/mtna.2014.69.
Yu, R. Z., Grundy, J. S., Henry, S. P., Kim, T. W., Norris, D. A., Burkey, J., Wang, Y., Vick, A., & Geary, R. S. (2015). Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Molecular therapy. Nucleic acids, 4e218. https://doi.org/10.1038/mtna.2014.69
Yu, Rosie Z, et al. "Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications." Molecular therapy. Nucleic acids vol. 4 (2015): e218. doi: https://doi.org/10.1038/mtna.2014.69
Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69. PMID: 25602582; PMCID: PMC4345302.
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A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment.

PeerJ

Wilson GI, Holton MD, Walker J, Jones MW, Grundy E, Davies IM, Clarke D, Luckman A, Russill N, Wilson V, Plummer R, Wilson RP.
PMID: 26157643
PeerJ. 2015 Jun 18;3:e908. doi: 10.7717/peerj.908. eCollection 2015.

Understanding the way humans inform themselves about their environment is pivotal in helping explain our susceptibility to stimuli and how this modulates behaviour and movement patterns. We present a new device, the Human Interfaced Personal Observation Platform (HIPOP), which...

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Wilson GI, Holton MD, Walker J, et al. A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment. PeerJ. 2015;3:e908doi: 10.7717/peerj.908.
Wilson, G. I., Holton, M. D., Walker, J., Jones, M. W., Grundy, E., Davies, I. M., Clarke, D., Luckman, A., Russill, N., Wilson, V., Plummer, R., & Wilson, R. P. (2015). A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment. PeerJ, 3e908. https://doi.org/10.7717/peerj.908
Wilson, Gwendoline Ixia, et al. "A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment." PeerJ vol. 3 (2015): e908. doi: https://doi.org/10.7717/peerj.908
Wilson GI, Holton MD, Walker J, Jones MW, Grundy E, Davies IM, Clarke D, Luckman A, Russill N, Wilson V, Plummer R, Wilson RP. A new perspective on how humans assess their surroundings; derivation of head orientation and its role in 'framing' the environment. PeerJ. 2015 Jun 18;3:e908. doi: 10.7717/peerj.908. eCollection 2015. PMID: 26157643; PMCID: PMC4476166.
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The impact of health system reform on remote health in Cambodia and the Philippines.

Rural and remote health

Grundy JJ.
PMID: 15869366
Rural Remote Health. 2001 Jan-Dec;1(1):84. Epub 2001 Mar 26.

UNLABELLED: Remoteness is commonly conceived of in the Western health context in terms of geographical or social isolation. These features of remoteness also apply to the developing nation context. However, the international context has additional dimensions of remoteness that...

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Grundy JJ. The impact of health system reform on remote health in Cambodia and the Philippines. Rural Remote Health. 2001;1(1):84
Grundy, J. J. (2001). The impact of health system reform on remote health in Cambodia and the Philippines. Rural and remote health, 1(1), 84.
Grundy, J J. "The impact of health system reform on remote health in Cambodia and the Philippines." Rural and remote health vol. 1,1 (2001): 84.
Grundy JJ. The impact of health system reform on remote health in Cambodia and the Philippines. Rural Remote Health. 2001 Jan-Dec;1(1):84. Epub 2001 Mar 26. PMID: 15869366.
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Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells.

Oncotarget

Grundy M, Balakrishnan S, Fox M, Seedhouse CH, Russell NH.
PMID: 30701031
Oncotarget. 2018 Dec 28;9(102):37777-37789. doi: 10.18632/oncotarget.26540. eCollection 2018 Dec 28.

Acute myeloid leukaemia (AML) cells often up-regulate pro-survival members of the BCL-2 protein family, such as BCL-2 and MCL-1, to avoid apoptosis. Venetoclax (ABT-199) targets BCL-2 and has shown promising efficacy in AML but over-expression of MCL-1 can cause...

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Grundy M, Balakrishnan S, Fox M, et al. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 2018;9(102):37777-37789doi: 10.18632/oncotarget.26540.
Grundy, M., Balakrishnan, S., Fox, M., Seedhouse, C. H., & Russell, N. H. (2018). Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget, 9(102), 37777-37789. https://doi.org/10.18632/oncotarget.26540
Grundy, Martin, et al. "Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells." Oncotarget vol. 9,102 (2018): 37777-37789. doi: https://doi.org/10.18632/oncotarget.26540
Grundy M, Balakrishnan S, Fox M, Seedhouse CH, Russell NH. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 2018 Dec 28;9(102):37777-37789. doi: 10.18632/oncotarget.26540. eCollection 2018 Dec 28. PMID: 30701031; PMCID: PMC6340871.
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Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes.

Physical chemistry chemical physics : PCCP

Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.
PMID: 30916090
Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27.

The performance of binary electrolytes is governed by three transport properties: conductivity, salt diffusion coefficient, and transference number. Rigorous methods for measuring conductivity and the salt diffusion coefficient are well established and used routinely in the literature. The commonly...

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Shah DB, Nguyen HQ, Grundy LS, et al. Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes. Phys Chem Chem Phys. 2019;21(15):7857-7866doi: 10.1039/c9cp00216b.
Shah, D. B., Nguyen, H. Q., Grundy, L. S., Olson, K. R., Mecham, S. J., DeSimone, J. M., & Balsara, N. P. (2019). Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes. Physical chemistry chemical physics : PCCP, 21(15), 7857-7866. https://doi.org/10.1039/c9cp00216b
Shah, Deep B, et al. "Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes." Physical chemistry chemical physics : PCCP vol. 21,15 (2019): 7857-7866. doi: https://doi.org/10.1039/c9cp00216b
Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP. Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes. Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27. PMID: 30916090.
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EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol.

Pilot and feasibility studies

Keats MR, Grandy SA, Giacomantonio N, MacDonald D, Rajda M, Younis T.
PMID: 27965861
Pilot Feasibility Stud. 2016 Aug 05;2:44. doi: 10.1186/s40814-016-0084-9. eCollection 2016.

BACKGROUND: Anthracyclines (AC), widely used and effective anticancer agents, are known to induce both acute and chronic declines in cardiovascular health, ranging in severity from asymptomatic, subclinical dysfunction to substantial cardiomyopathy leading to congestive heart failure and death. There...

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Keats MR, Grandy SA, Giacomantonio N, et al. EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol. Pilot Feasibility Stud. 2016;2:44doi: 10.1186/s40814-016-0084-9.
Keats, M. R., Grandy, S. A., Giacomantonio, N., MacDonald, D., Rajda, M., & Younis, T. (2016). EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol. Pilot and feasibility studies, 244. https://doi.org/10.1186/s40814-016-0084-9
Keats, Melanie R, et al. "EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol." Pilot and feasibility studies vol. 2 (2016): 44. doi: https://doi.org/10.1186/s40814-016-0084-9
Keats MR, Grandy SA, Giacomantonio N, MacDonald D, Rajda M, Younis T. EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol. Pilot Feasibility Stud. 2016 Aug 05;2:44. doi: 10.1186/s40814-016-0084-9. eCollection 2016. PMID: 27965861; PMCID: PMC5153674.
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Assessment of a neuro-developmental screening tool in children in Bhutan.

Gates open research

Wong B, Grundy S, Tshering L, Tshering K, Mateen FJ.
PMID: 31460495
Gates Open Res. 2019 Sep 11;3:1496. doi: 10.12688/gatesopenres.13037.2. eCollection 2019.

No abstract available.

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Wong B, Grundy S, Tshering L, et al. Assessment of a neuro-developmental screening tool in children in Bhutan. Gates Open Res. 2019;3:1496doi: 10.12688/gatesopenres.13037.2.
Wong, B., Grundy, S., Tshering, L., Tshering, K., & Mateen, F. J. (2019). Assessment of a neuro-developmental screening tool in children in Bhutan. Gates open research, 31496. https://doi.org/10.12688/gatesopenres.13037.2
Wong, Brian, et al. "Assessment of a neuro-developmental screening tool in children in Bhutan." Gates open research vol. 3 (2019): 1496. doi: https://doi.org/10.12688/gatesopenres.13037.2
Wong B, Grundy S, Tshering L, Tshering K, Mateen FJ. Assessment of a neuro-developmental screening tool in children in Bhutan. Gates Open Res. 2019 Sep 11;3:1496. doi: 10.12688/gatesopenres.13037.2. eCollection 2019. PMID: 31460495; PMCID: PMC6694285.
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Influence of oat components on lipid digestion using an .

Food hydrocolloids

Grundy MML, McClements DJ, Ballance S, Wilde PJ.
PMID: 30283194
Food Hydrocoll. 2018 Oct;83:253-264. doi: 10.1016/j.foodhyd.2018.05.018.

Depletion flocculation is a well-known instability mechanism that can occur in oil-in-water emulsions when the concentration of non-adsorbed polysaccharide exceeds a certain level. This critical flocculation concentration depends on the molecular characteristics of the polysaccharide molecules, such as their...

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Grundy MML, McClements DJ, Ballance S, et al. Influence of oat components on lipid digestion using an . Food Hydrocoll. 2018;83:253-264doi: 10.1016/j.foodhyd.2018.05.018.
Grundy, M. M. L., McClements, D. J., Ballance, S., & Wilde, P. J. (2018). Influence of oat components on lipid digestion using an . Food hydrocolloids, 83253-264. https://doi.org/10.1016/j.foodhyd.2018.05.018
Grundy, Myriam M L, et al. "Influence of oat components on lipid digestion using an ." Food hydrocolloids vol. 83 (2018): 253-264. doi: https://doi.org/10.1016/j.foodhyd.2018.05.018
Grundy MML, McClements DJ, Ballance S, Wilde PJ. Influence of oat components on lipid digestion using an . Food Hydrocoll. 2018 Oct;83:253-264. doi: 10.1016/j.foodhyd.2018.05.018. PMID: 30283194; PMCID: PMC6020131.
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Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice.

Tobacco induced diseases

Grundy EJ, Suddek T, Filippidis FT, Majeed A, Coronini-Cronberg S.
PMID: 32641924
Tob Induc Dis. 2020 Jul 03;18:58. doi: 10.18332/tid/124788. eCollection 2020.

INTRODUCTION: There has been significant speculation regarding the association between the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, coronavirus disease (COVID-19) and smoking. We provide an overview of the available literature regarding the association between smoking, risk of...

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Grundy EJ, Suddek T, Filippidis FT, et al. Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice. Tob Induc Dis. 2020;18:58doi: 10.18332/tid/124788.
Grundy, E. J., Suddek, T., Filippidis, F. T., Majeed, A., & Coronini-Cronberg, S. (2020). Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice. Tobacco induced diseases, 1858. https://doi.org/10.18332/tid/124788
Grundy, Emily J, et al. "Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice." Tobacco induced diseases vol. 18 (2020): 58. doi: https://doi.org/10.18332/tid/124788
Grundy EJ, Suddek T, Filippidis FT, Majeed A, Coronini-Cronberg S. Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice. Tob Induc Dis. 2020 Jul 03;18:58. doi: 10.18332/tid/124788. eCollection 2020. PMID: 32641924; PMCID: PMC7336902.
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Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth.

Science (New York, N.Y.)

Grundy WM, Bird MK, Britt DT, Cook JC, Cruikshank DP, Howett CJA, Krijt S, Linscott IR, Olkin CB, Parker AH, Protopapa S, Ruaud M, Umurhan OM, Young LA, Dalle Ore CM, Kavelaars JJ, Keane JT, Pendleton YJ, Porter SB, Scipioni F, Spencer JR, Stern SA, Verbiscer AJ, Weaver HA, Binzel RP, Buie MW, Buratti BJ, Cheng A, Earle AM, Elliott HA, Gabasova L, Gladstone GR, Hill ME, Horanyi M, Jennings DE, Lunsford AW, McComas DJ, McKinnon WB, McNutt RL, Moore JM, Parker JW, Quirico E, Reuter DC, Schenk PM, Schmitt B, Showalter MR, Singer KN, Weigle GE, Zangari AM.
PMID: 32054693
Science. 2020 Feb 28;367(6481). doi: 10.1126/science.aay3705. Epub 2020 Feb 13.

The outer Solar System object (486958) Arrokoth (provisional designation 2014 MU

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Grundy WM, Bird MK, Britt DT, et al. Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth. Science. 2020;367(6481)doi: 10.1126/science.aay3705.
Grundy, W. M., Bird, M. K., Britt, D. T., Cook, J. C., Cruikshank, D. P., Howett, C. J. A., Krijt, S., Linscott, I. R., Olkin, C. B., Parker, A. H., Protopapa, S., Ruaud, M., Umurhan, O. M., Young, L. A., Dalle Ore, C. M., Kavelaars, J. J., Keane, J. T., Pendleton, Y. J., Porter, S. B., Scipioni, F., Spencer, J. R., Stern, S. A., Verbiscer, A. J., Weaver, H. A., Binzel, R. P., Buie, M. W., Buratti, B. J., Cheng, A., Earle, A. M., Elliott, H. A., Gabasova, L., Gladstone, G. R., Hill, M. E., Horanyi, M., Jennings, D. E., Lunsford, A. W., McComas, D. J., McKinnon, W. B., McNutt, R. L., Moore, J. M., Parker, J. W., Quirico, E., Reuter, D. C., Schenk, P. M., Schmitt, B., Showalter, M. R., Singer, K. N., Weigle, G. E., & Zangari, A. M. (2020). Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth. Science (New York, N.Y.), 367(6481), . https://doi.org/10.1126/science.aay3705
Grundy, W M, et al. "Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth." Science (New York, N.Y.) vol. 367,6481 (2020). doi: https://doi.org/10.1126/science.aay3705
Grundy WM, Bird MK, Britt DT, Cook JC, Cruikshank DP, Howett CJA, Krijt S, Linscott IR, Olkin CB, Parker AH, Protopapa S, Ruaud M, Umurhan OM, Young LA, Dalle Ore CM, Kavelaars JJ, Keane JT, Pendleton YJ, Porter SB, Scipioni F, Spencer JR, Stern SA, Verbiscer AJ, Weaver HA, Binzel RP, Buie MW, Buratti BJ, Cheng A, Earle AM, Elliott HA, Gabasova L, Gladstone GR, Hill ME, Horanyi M, Jennings DE, Lunsford AW, McComas DJ, McKinnon WB, McNutt RL, Moore JM, Parker JW, Quirico E, Reuter DC, Schenk PM, Schmitt B, Showalter MR, Singer KN, Weigle GE, Zangari AM. Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth. Science. 2020 Feb 28;367(6481). doi: 10.1126/science.aay3705. Epub 2020 Feb 13. PMID: 32054693.
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Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex.

The journals of gerontology. Series A, Biological sciences and medical sciences

Bisset ES, Heinze-Milne S, Grandy SA, Howlett SE.
PMID: 34610102
J Gerontol A Biol Sci Med Sci. 2022 Jan 07;77(1):41-46. doi: 10.1093/gerona/glab297.

Aerobic exercise is a promising intervention to attenuate frailty, but preclinical studies have used only male animals. We investigated the impact of voluntary aerobic exercise on frailty, biological age (FRailty Inferred Geriatric Health Timeline [FRIGHT] clock), predicted life expectancy...

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Bisset ES, Heinze-Milne S, Grandy SA, et al. Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex. J Gerontol A Biol Sci Med Sci. 2022;77(1):41-46doi: 10.1093/gerona/glab297.
Bisset, E. S., Heinze-Milne, S., Grandy, S. A., & Howlett, S. E. (2022). Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(1), 41-46. https://doi.org/10.1093/gerona/glab297
Bisset, Elise S, et al. "Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 77,1 (2022): 41-46. doi: https://doi.org/10.1093/gerona/glab297
Bisset ES, Heinze-Milne S, Grandy SA, Howlett SE. Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex. J Gerontol A Biol Sci Med Sci. 2022 Jan 07;77(1):41-46. doi: 10.1093/gerona/glab297. PMID: 34610102; PMCID: PMC8751786.
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