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Showing 1 to 12 of 16 entries
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Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics.

Frontiers in oncology

Bogen JP, Grzeschik J, Jakobsen J, Bähre A, Hock B, Kolmar H.
PMID: 34123841
Front Oncol. 2021 May 27;11:672262. doi: 10.3389/fonc.2021.672262. eCollection 2021.

Bladder cancer is a frequent malignancy and has a clinical need for new therapeutic approaches. Antibody and protein technologies came a long way in recent years and new engineering approaches were applied to generate innovative therapeutic entities with novel...

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Bogen JP, Grzeschik J, Jakobsen J, et al. Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics. Front Oncol. 2021;11:672262doi: 10.3389/fonc.2021.672262.
Bogen, J. P., Grzeschik, J., Jakobsen, J., Bähre, A., Hock, B., & Kolmar, H. (2021). Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics. Frontiers in oncology, 11672262. https://doi.org/10.3389/fonc.2021.672262
Bogen, Jan P, et al. "Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics." Frontiers in oncology vol. 11 (2021): 672262. doi: https://doi.org/10.3389/fonc.2021.672262
Bogen JP, Grzeschik J, Jakobsen J, Bähre A, Hock B, Kolmar H. Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics. Front Oncol. 2021 May 27;11:672262. doi: 10.3389/fonc.2021.672262. eCollection 2021. PMID: 34123841; PMCID: PMC8191463.
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Collective-Mode Enhanced Matter-Wave Optics.

Physical review letters

Deppner C, Herr W, Cornelius M, Stromberger P, Sternke T, Grzeschik C, Grote A, Rudolph J, Herrmann S, Krutzik M, Wenzlawski A, Corgier R, Charron E, Guéry-Odelin D, Gaaloul N, Lämmerzahl C, Peters A, Windpassinger P, Rasel EM.
PMID: 34533345
Phys Rev Lett. 2021 Sep 03;127(10):100401. doi: 10.1103/PhysRevLett.127.100401.

In contrast to light, matter-wave optics of quantum gases deals with interactions even in free space and for ensembles comprising millions of atoms. We exploit these interactions in a quantum degenerate gas as an adjustable lens for coherent atom...

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Deppner C, Herr W, Cornelius M, et al. Collective-Mode Enhanced Matter-Wave Optics. Phys Rev Lett. 2021;127(10):100401doi: 10.1103/PhysRevLett.127.100401.
Deppner, C., Herr, W., Cornelius, M., Stromberger, P., Sternke, T., Grzeschik, C., Grote, A., Rudolph, J., Herrmann, S., Krutzik, M., Wenzlawski, A., Corgier, R., Charron, E., Guéry-Odelin, D., Gaaloul, N., Lämmerzahl, C., Peters, A., Windpassinger, P., & Rasel, E. M. (2021). Collective-Mode Enhanced Matter-Wave Optics. Physical review letters, 127(10), 100401. https://doi.org/10.1103/PhysRevLett.127.100401
Deppner, Christian, et al. "Collective-Mode Enhanced Matter-Wave Optics." Physical review letters vol. 127,10 (2021): 100401. doi: https://doi.org/10.1103/PhysRevLett.127.100401
Deppner C, Herr W, Cornelius M, Stromberger P, Sternke T, Grzeschik C, Grote A, Rudolph J, Herrmann S, Krutzik M, Wenzlawski A, Corgier R, Charron E, Guéry-Odelin D, Gaaloul N, Lämmerzahl C, Peters A, Windpassinger P, Rasel EM. Collective-Mode Enhanced Matter-Wave Optics. Phys Rev Lett. 2021 Sep 03;127(10):100401. doi: 10.1103/PhysRevLett.127.100401. PMID: 34533345.
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The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina

Dugel PU, Singh N, Francom S, Cantrell RA, Grzeschik SM, Fung AE.
PMID: 31047375
Ophthalmol Retina. 2018 Jul;2(7):667-675. doi: 10.1016/j.oret.2018.01.010. Epub 2018 Feb 27.

OBJECTIVE: Ranibizumab safety is well established for treatment of neovascular age-related macular degeneration (nAMD), but less is known about the risk of systemic serious adverse events (SAEs), specifically among patients with heightened baseline risk due to age (≥85 years)....

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Dugel PU, Singh N, Francom S, et al. The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration. Ophthalmol Retina. 2018;2(7):667-675doi: 10.1016/j.oret.2018.01.010.
Dugel, P. U., Singh, N., Francom, S., Cantrell, R. A., Grzeschik, S. M., & Fung, A. E. (2018). The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration. Ophthalmology. Retina, 2(7), 667-675. https://doi.org/10.1016/j.oret.2018.01.010
Dugel, Pravin U, et al. "The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration." Ophthalmology. Retina vol. 2,7 (2018): 667-675. doi: https://doi.org/10.1016/j.oret.2018.01.010
Dugel PU, Singh N, Francom S, Cantrell RA, Grzeschik SM, Fung AE. The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration. Ophthalmol Retina. 2018 Jul;2(7):667-675. doi: 10.1016/j.oret.2018.01.010. Epub 2018 Feb 27. PMID: 31047375.
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Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis.

Ophthalmology. Retina

Zarbin MA, Francom S, Grzeschik S, Tuomi L, Haskova Z, Macfadden W, Margaron P, Snow H, Cruess A, Staurenghi G, Dunger-Baldauf C.
PMID: 31047547
Ophthalmol Retina. 2018 Nov;2(11):1087-1096. doi: 10.1016/j.oret.2018.04.018. Epub 2018 Jun 11.

TOPIC: This study evaluated the cardiovascular/cerebrovascular safety profile of ranibizumab 0.5 mg versus sham ± verteporfin in patients with neovascular age-related macular degeneration (nAMD). In addition, comparisons of ranibizumab 0.3 mg with sham and ranibizumab 0.5 mg to 0.3...

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Zarbin MA, Francom S, Grzeschik S, et al. Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis. Ophthalmol Retina. 2018;2(11):1087-1096doi: 10.1016/j.oret.2018.04.018.
Zarbin, M. A., Francom, S., Grzeschik, S., Tuomi, L., Haskova, Z., Macfadden, W., Margaron, P., Snow, H., Cruess, A., Staurenghi, G., & Dunger-Baldauf, C. (2018). Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis. Ophthalmology. Retina, 2(11), 1087-1096. https://doi.org/10.1016/j.oret.2018.04.018
Zarbin, Marco A, et al. "Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis." Ophthalmology. Retina vol. 2,11 (2018): 1087-1096. doi: https://doi.org/10.1016/j.oret.2018.04.018
Zarbin MA, Francom S, Grzeschik S, Tuomi L, Haskova Z, Macfadden W, Margaron P, Snow H, Cruess A, Staurenghi G, Dunger-Baldauf C. Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis. Ophthalmol Retina. 2018 Nov;2(11):1087-1096. doi: 10.1016/j.oret.2018.04.018. Epub 2018 Jun 11. PMID: 31047547.
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Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media: A Kinetic Analysis of the Surface Reaction by Microfluidic SERS.

Angewandte Chemie (International ed. in English)

Xie W, Grzeschik R, Schlücker S.
PMID: 27690263
Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13729-13733. doi: 10.1002/anie.201605776. Epub 2016 Sep 30.

Hydrides are widely used in reduction reactions. In protic solvents, their hydrolysis generates molecular hydrogen as a second reducing agent. The competition between these two parallel reduction pathways has been overlooked so far since both typically yield the same...

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Xie W, Grzeschik R, Schlücker S. Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media: A Kinetic Analysis of the Surface Reaction by Microfluidic SERS. Angew Chem Int Ed Engl. 2016;55(44):13729-13733doi: 10.1002/anie.201605776.
Xie, W., Grzeschik, R., & Schlücker, S. (2016). Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media: A Kinetic Analysis of the Surface Reaction by Microfluidic SERS. Angewandte Chemie (International ed. in English), 55(44), 13729-13733. https://doi.org/10.1002/anie.201605776
Xie, Wei, et al. "Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media: A Kinetic Analysis of the Surface Reaction by Microfluidic SERS." Angewandte Chemie (International ed. in English) vol. 55,44 (2016): 13729-13733. doi: https://doi.org/10.1002/anie.201605776
Xie W, Grzeschik R, Schlücker S. Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media: A Kinetic Analysis of the Surface Reaction by Microfluidic SERS. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13729-13733. doi: 10.1002/anie.201605776. Epub 2016 Sep 30. PMID: 27690263.
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The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study.

Frontiers in aging neuroscience

Hartmeyer S, Grzeschik R, Wolbers T, Wiener JM.
PMID: 28775689
Front Aging Neurosci. 2017 Jul 20;9:235. doi: 10.3389/fnagi.2017.00235. eCollection 2017.

Route learning is a common navigation task affected by cognitive aging. Here we present a novel experimental paradigm to investigate whether age-related declines in executive control of attention contributes to route learning deficits. A young and an older participant...

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Hartmeyer S, Grzeschik R, Wolbers T, et al. The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study. Front Aging Neurosci. 2017;9:235doi: 10.3389/fnagi.2017.00235.
Hartmeyer, S., Grzeschik, R., Wolbers, T., & Wiener, J. M. (2017). The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study. Frontiers in aging neuroscience, 9235. https://doi.org/10.3389/fnagi.2017.00235
Hartmeyer, Steffen, et al. "The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study." Frontiers in aging neuroscience vol. 9 (2017): 235. doi: https://doi.org/10.3389/fnagi.2017.00235
Hartmeyer S, Grzeschik R, Wolbers T, Wiener JM. The Effects of Attentional Engagement on Route Learning Performance in a Virtual Environment: An Aging Study. Front Aging Neurosci. 2017 Jul 20;9:235. doi: 10.3389/fnagi.2017.00235. eCollection 2017. PMID: 28775689; PMCID: PMC5517407.
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Acromelia-oligodontia syndrome.

Clinical case reports

Talasila J, Pachigolla R, Yarlagadda KVSN, Vuppala R, Grzeschik KH, Kiran K V S S, Rose CM, Gottesman GS, Urban Z.
PMID: 28588849
Clin Case Rep. 2017 May 05;5(6):968-974. doi: 10.1002/ccr3.956. eCollection 2017 Jun.

This case report describes a patient with ankyloglossia, oligodontia, unilateral hypoplasia of the zygoma and mandible, along with bilateral distal reduction anomalies of his limbs without long bone abnormalities. This may represent a mild variant of oromandibular limb hypogenesis...

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Talasila J, Pachigolla R, Yarlagadda KVSN, et al. Acromelia-oligodontia syndrome. Clin Case Rep. 2017;5(6):968-974doi: 10.1002/ccr3.956.
Talasila, J., Pachigolla, R., Yarlagadda, K. V. S. N., Vuppala, R., Grzeschik, K. H., Kiran K V S, S., Rose, C. M., Gottesman, G. S., & Urban, Z. (2017). Acromelia-oligodontia syndrome. Clinical case reports, 5(6), 968-974. https://doi.org/10.1002/ccr3.956
Talasila, Jyothirmai, et al. "Acromelia-oligodontia syndrome." Clinical case reports vol. 5,6 (2017): 968-974. doi: https://doi.org/10.1002/ccr3.956
Talasila J, Pachigolla R, Yarlagadda KVSN, Vuppala R, Grzeschik KH, Kiran K V S S, Rose CM, Gottesman GS, Urban Z. Acromelia-oligodontia syndrome. Clin Case Rep. 2017 May 05;5(6):968-974. doi: 10.1002/ccr3.956. eCollection 2017 Jun. PMID: 28588849; PMCID: PMC5458011.
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The spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly.

Journal of children's orthopaedics

Debeer P, Devriendt K, De Smet L, Deravel T, Gonzalez-Meneses A, Grzeschik KH, Fryns JP.
PMID: 19308487
J Child Orthop. 2007 Jul;1(2):143-50. doi: 10.1007/s11832-007-0022-8. Epub 2007 May 10.

PURPOSE: Greig cephalopolysyndactyly (GCPS) (OMIM 175700), a rare autosomal dominant disorder, is characterized by a distinct combination of craniofacial, hand and foot malformations. The hand and foot malformations often require orthopedic assessment and treatment. The disorder is caused by...

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Debeer P, Devriendt K, De Smet L, et al. The spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly. J Child Orthop. 2007;1(2):143-50doi: 10.1007/s11832-007-0022-8.
Debeer, P., Devriendt, K., De Smet, L., Deravel, T., Gonzalez-Meneses, A., Grzeschik, K. H., & Fryns, J. P. (2007). The spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly. Journal of children's orthopaedics, 1(2), 143-50. https://doi.org/10.1007/s11832-007-0022-8
Debeer, Philippe, et al. "The spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly." Journal of children's orthopaedics vol. 1,2 (2007): 143-50. doi: https://doi.org/10.1007/s11832-007-0022-8
Debeer P, Devriendt K, De Smet L, Deravel T, Gonzalez-Meneses A, Grzeschik KH, Fryns JP. The spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly. J Child Orthop. 2007 Jul;1(2):143-50. doi: 10.1007/s11832-007-0022-8. Epub 2007 May 10. PMID: 19308487; PMCID: PMC2656707.
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Evolution and functional diversification of the GLI family of transcription factors in vertebrates.

Evolutionary bioinformatics online

Abbasi AA, Goode DK, Amir S, Grzeschik KH.
PMID: 19812723
Evol Bioinform Online. 2009 May 18;5:5-13. doi: 10.4137/ebo.s2322.

BACKGROUND: In vertebrates the "SONIC HEDGEHOG" signalling pathway has been implicated in cell-fate determination, proliferation and the patterning of many different cell types and organs. As the GLI family members (GLI1, GLI2 and GLI3) are key mediators of hedgehog...

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Abbasi AA, Goode DK, Amir S, et al. Evolution and functional diversification of the GLI family of transcription factors in vertebrates. Evol Bioinform Online. 2009;5:5-13doi: 10.4137/ebo.s2322.
Abbasi, A. A., Goode, D. K., Amir, S., & Grzeschik, K. H. (2009). Evolution and functional diversification of the GLI family of transcription factors in vertebrates. Evolutionary bioinformatics online, 55-13. https://doi.org/10.4137/ebo.s2322
Abbasi, Amir Ali, et al. "Evolution and functional diversification of the GLI family of transcription factors in vertebrates." Evolutionary bioinformatics online vol. 5 (2009): 5-13. doi: https://doi.org/10.4137/ebo.s2322
Abbasi AA, Goode DK, Amir S, Grzeschik KH. Evolution and functional diversification of the GLI family of transcription factors in vertebrates. Evol Bioinform Online. 2009 May 18;5:5-13. doi: 10.4137/ebo.s2322. PMID: 19812723; PMCID: PMC2747127.
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Interferometry with Bose-Einstein condensates in microgravity.

Physical review letters

Müntinga H, Ahlers H, Krutzik M, Wenzlawski A, Arnold S, Becker D, Bongs K, Dittus H, Duncker H, Gaaloul N, Gherasim C, Giese E, Grzeschik C, Hänsch TW, Hellmig O, Herr W, Herrmann S, Kajari E, Kleinert S, Lämmerzahl C, Lewoczko-Adamczyk W, Malcolm J, Meyer N, Nolte R, Peters A, Popp M, Reichel J, Roura A, Rudolph J, Schiemangk M, Schneider M, Seidel ST, Sengstock K, Tamma V, Valenzuela T, Vogel A, Walser R, Wendrich T, Windpassinger P, Zeller W, van Zoest T, Ertmer W, Schleich WP, Rasel EM.
PMID: 23496709
Phys Rev Lett. 2013 Mar 01;110(9):093602. doi: 10.1103/PhysRevLett.110.093602. Epub 2013 Feb 25.

Atom interferometers covering macroscopic domains of space-time are a spectacular manifestation of the wave nature of matter. Because of their unique coherence properties, Bose-Einstein condensates are ideal sources for an atom interferometer in extended free fall. In this Letter...

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Müntinga H, Ahlers H, Krutzik M, et al. Interferometry with Bose-Einstein condensates in microgravity. Phys Rev Lett. 2013;110(9):093602doi: 10.1103/PhysRevLett.110.093602.
Müntinga, H., Ahlers, H., Krutzik, M., Wenzlawski, A., Arnold, S., Becker, D., Bongs, K., Dittus, H., Duncker, H., Gaaloul, N., Gherasim, C., Giese, E., Grzeschik, C., Hänsch, T. W., Hellmig, O., Herr, W., Herrmann, S., Kajari, E., Kleinert, S., Lämmerzahl, C., Lewoczko-Adamczyk, W., Malcolm, J., Meyer, N., Nolte, R., Peters, A., Popp, M., Reichel, J., Roura, A., Rudolph, J., Schiemangk, M., Schneider, M., Seidel, S. T., Sengstock, K., Tamma, V., Valenzuela, T., Vogel, A., Walser, R., Wendrich, T., Windpassinger, P., Zeller, W., van Zoest, T., Ertmer, W., Schleich, W. P., & Rasel, E. M. (2013). Interferometry with Bose-Einstein condensates in microgravity. Physical review letters, 110(9), 093602. https://doi.org/10.1103/PhysRevLett.110.093602
Müntinga, H, et al. "Interferometry with Bose-Einstein condensates in microgravity." Physical review letters vol. 110,9 (2013): 093602. doi: https://doi.org/10.1103/PhysRevLett.110.093602
Müntinga H, Ahlers H, Krutzik M, Wenzlawski A, Arnold S, Becker D, Bongs K, Dittus H, Duncker H, Gaaloul N, Gherasim C, Giese E, Grzeschik C, Hänsch TW, Hellmig O, Herr W, Herrmann S, Kajari E, Kleinert S, Lämmerzahl C, Lewoczko-Adamczyk W, Malcolm J, Meyer N, Nolte R, Peters A, Popp M, Reichel J, Roura A, Rudolph J, Schiemangk M, Schneider M, Seidel ST, Sengstock K, Tamma V, Valenzuela T, Vogel A, Walser R, Wendrich T, Windpassinger P, Zeller W, van Zoest T, Ertmer W, Schleich WP, Rasel EM. Interferometry with Bose-Einstein condensates in microgravity. Phys Rev Lett. 2013 Mar 01;110(9):093602. doi: 10.1103/PhysRevLett.110.093602. Epub 2013 Feb 25. PMID: 23496709.
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Comodulation masking release in an off-frequency masking paradigm.

The Journal of the Acoustical Society of America

Grzeschik R, Lübken B, Verhey JL.
PMID: 26328732
J Acoust Soc Am. 2015 Aug;138(2):1194-205. doi: 10.1121/1.4928134.

Detection threshold of a sinusoidal signal masked by a broadband masker is lower when on- and off-frequency masker components have a correlated envelope, compared to a condition in which these masker components have different envelopes. This effect is commonly...

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Grzeschik R, Lübken B, Verhey JL. Comodulation masking release in an off-frequency masking paradigm. J Acoust Soc Am. 2015;138(2):1194-205doi: 10.1121/1.4928134.
Grzeschik, R., Lübken, B., & Verhey, J. L. (2015). Comodulation masking release in an off-frequency masking paradigm. The Journal of the Acoustical Society of America, 138(2), 1194-205. https://doi.org/10.1121/1.4928134
Grzeschik, Ramona, et al. "Comodulation masking release in an off-frequency masking paradigm." The Journal of the Acoustical Society of America vol. 138,2 (2015): 1194-205. doi: https://doi.org/10.1121/1.4928134
Grzeschik R, Lübken B, Verhey JL. Comodulation masking release in an off-frequency masking paradigm. J Acoust Soc Am. 2015 Aug;138(2):1194-205. doi: 10.1121/1.4928134. PMID: 26328732.
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lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK.

Cancers

Parsons LM, Grzeschik NA, Richardson HE.
PMID: 24743776
Cancers (Basel). 2014 Apr 16;6(2):879-96. doi: 10.3390/cancers6020879.

In both Drosophila and mammalian systems, the Hippo (Hpo) signalling pathway controls tissue growth by inhibiting cell proliferation and promoting apoptosis. The core pathway consists of a protein kinase Hpo (MST1/2 in mammals) that is regulated by a number...

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Parsons LM, Grzeschik NA, Richardson HE. lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK. Cancers (Basel). 2014;6(2):879-96doi: 10.3390/cancers6020879.
Parsons, L. M., Grzeschik, N. A., & Richardson, H. E. (2014). lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK. Cancers, 6(2), 879-96. https://doi.org/10.3390/cancers6020879
Parsons, Linda M, et al. "lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK." Cancers vol. 6,2 (2014): 879-96. doi: https://doi.org/10.3390/cancers6020879
Parsons LM, Grzeschik NA, Richardson HE. lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK. Cancers (Basel). 2014 Apr 16;6(2):879-96. doi: 10.3390/cancers6020879. PMID: 24743776; PMCID: PMC4074808.
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