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Showing 1 to 12 of 20 entries
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A genome-wide association analysis identifies .

Oncotarget

Kimura M, Tamura Y, Guignabert C, Takei M, Kosaki K, Tanabe N, Tatsumi K, Saji T, Satoh T, Kataoka M, Kamitsuji S, Kamatani N, Thuillet R, Tu L, Humbert M, Fukuda K, Sano M.
PMID: 29088834
Oncotarget. 2017 Aug 24;8(43):74917-74926. doi: 10.18632/oncotarget.20459. eCollection 2017 Sep 26.

Pulmonary arterial hypertension (PAH) is a lethal disease that often affects the young. Although

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.

Arthritis research & therapy

Orvain C, Cauvet A, Prudent A, Guignabert C, Thuillet R, Ottaviani M, Tu L, Duhalde F, Nicco C, Batteux F, Avouac J, Wang N, Seaberg MA, Dillon SR, Allanore Y.
PMID: 34986869
Arthritis Res Ther. 2022 Jan 05;24(1):13. doi: 10.1186/s13075-021-02709-2.

BACKGROUND: Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and skin. Costimulatory molecules are key players during...

Phenotypic Diversity of Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension: Implications for Therapy.

Chest

Lechartier B, Berrebeh N, Huertas A, Humbert M, Guignabert C, Tu L.
PMID: 34391758
Chest. 2022 Jan;161(1):219-231. doi: 10.1016/j.chest.2021.08.040. Epub 2021 Aug 12.

Pulmonary arterial hypertension (PAH) is a progressive incurable condition that is characterized by extensive remodeling of the pulmonary circulation, leading to severe right-sided heart failure and death. Similar to other vascular contractile cells, pulmonary arterial smooth muscle cells play...

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension.

Journal of clinical medicine

Cai Z, Klein T, Geenen LW, Tu L, Tian S, van den Bosch AE, de Rijke YB, Reiss IKM, Boersma E, Duncker DJ, Boomars KA, Guignabert C, Merkus D.
PMID: 32344923
J Clin Med. 2020 Apr 25;9(5). doi: 10.3390/jcm9051248.

No abstract available.

[Tonnerre de Brest! 2020 Respiratory Research Days like no others…].

Revue des maladies respiratoires

Annesi-Maesano I, Bonniaud P, Bouchaud G, Boyer L, Frossard N, Gazzeri S, Gosset P, Gras D, Guibert C, Guignabert C, Mari B, Matecki S, Morelot C, Pilette C, Planes C, Plantier L, Polette M, Si-Tahar M, Taillé C, Vachier I.
PMID: 34024643
Rev Mal Respir. 2021 Jun;38(6):565-566. doi: 10.1016/j.rmr.2021.05.002. Epub 2021 May 21.

No abstract available.

Pulmonary hypertension associated with neurofibromatosis type 2.

Pulmonary circulation

Taniguchi H, Takashima T, Tu L, Thuillet R, Furukawa A, Furukawa Y, Kawamura A, Humbert M, Guignabert C, Tamura Y.
PMID: 34285798
Pulm Circ. 2021 Jul 05;11(3):20458940211029550. doi: 10.1177/20458940211029550. eCollection 2021.

Although precapillary pulmonary hypertension is a rare but severe complication of patients with neurofibromatosis type 1 (NF1), its association with NF2 remains unknown. Herein, we report a case of a 44-year-old woman who was initially diagnosed with idiopathic pulmonary...

The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy.

Nature reviews. Cardiology

Ricard N, Bailly S, Guignabert C, Simons M.
PMID: 33627876
Nat Rev Cardiol. 2021 Aug;18(8):565-580. doi: 10.1038/s41569-021-00517-4. Epub 2021 Feb 24.

Endothelial cells are at the interface between circulating blood and tissues. This position confers on them a crucial role in controlling oxygen and nutrient exchange and cellular trafficking between blood and the perfused organs. The endothelium adopts a structure...

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10.

Cardiovascular research

Bouvard C, Tu L, Rossi M, Desroches-Castan A, Berrebeh N, Helfer E, Roelants C, Liu H, Ouarne M, Chaumontel N, Mallet C, Battail C, Bikfalvi A, Humbert M, Savale L, Daubon T, Perret P, Tillet E, Guignabert C, Bailly S.
PMID: 34086873
Cardiovasc Res. 2021 Jun 04; doi: 10.1093/cvr/cvab187. Epub 2021 Jun 04.

AIMS: BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial hypertension (PAH), but their specific roles in the pathogenesis of the disease are still unclear. We aimed to study the roles of BMP9 and BMP10 in...

[Relevant issues in the pathology and pathobiology of pulmonary hypertension].

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW.
PMID: 25697030
Turk Kardiyol Dern Ars. 2014 Oct;42:5-16.

Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate. However, fundamental gaps remain in our understanding of the underlying pathological changes in pulmonary arteries and veins in the different forms of this syndrome. Although PH primarily affects...

[Targeting activin receptor IIA ligands for the treatment of pulmonary arterial hypertension].

Medecine sciences : M/S

Humbert M, Montani D, Savale L, Tu L, Guignabert C.
PMID: 34647870
Med Sci (Paris). 2021 Oct;37(10):839-843. doi: 10.1051/medsci/2021131. Epub 2021 Oct 14.

No abstract available.

Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction.

Frontiers in physiology

Karmouty-Quintana H, Guignabert C, Kwapiszewska G, Ormiston ML.
PMID: 30618793
Front Physiol. 2018 Dec 10;9:1777. doi: 10.3389/fphys.2018.01777. eCollection 2018.

No abstract available.

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure.

Pulmonary circulation

Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM.
PMID: 31798835
Pulm Circ. 2019 Nov 20;9(4):2045894019889775. doi: 10.1177/2045894019889775. eCollection 2019.

In order to intervene appropriately and develop disease-modifying therapeutics for pulmonary arterial hypertension, it is crucial to understand the mechanisms of disease pathogenesis and progression. We herein discuss four topics of disease mechanisms that are currently highly debated, yet...

Showing 1 to 12 of 20 entries