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Showing 1 to 12 of 176 entries
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Co-operative T-T interactions in the human T suppressor cell circuit.

Immunology today

Ballieux RE, Heijnen CJ.
PMID: 25290240
Immunol Today. 1981 Oct;2(10):188-9. doi: 10.1016/0167-5699(81)90069-4.

No abstract available.

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Ballieux RE, Heijnen CJ. Co-operative T-T interactions in the human T suppressor cell circuit. Immunol Today. 1981;2(10):188-9doi: 10.1016/0167-5699(81)90069-4.
Ballieux, R. E., & Heijnen, C. J. (1981). Co-operative T-T interactions in the human T suppressor cell circuit. Immunology today, 2(10), 188-9. https://doi.org/10.1016/0167-5699(81)90069-4
Ballieux, R E, and Heijnen, C J. "Co-operative T-T interactions in the human T suppressor cell circuit." Immunology today vol. 2,10 (1981): 188-9. doi: https://doi.org/10.1016/0167-5699(81)90069-4
Ballieux RE, Heijnen CJ. Co-operative T-T interactions in the human T suppressor cell circuit. Immunol Today. 1981 Oct;2(10):188-9. doi: 10.1016/0167-5699(81)90069-4. PMID: 25290240.
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Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae.

Metabolites

Cueto-Rojas HF, Maleki Seifar R, Ten Pierick A, Heijnen SJ, Wahl A.
PMID: 27120628
Metabolites. 2016 Apr 23;6(2). doi: 10.3390/metabo6020012.

Ammonium (NH₄⁺) is the most common N-source for yeast fermentations, and N-limitation is frequently applied to reduce growth and increase product yields. While there is significant molecular knowledge on NH₄⁺ transport and assimilation, there have been few attempts to...

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Cueto-Rojas HF, Maleki Seifar R, Ten Pierick A, et al. Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae. Metabolites. 2016;6(2)doi: 10.3390/metabo6020012.
Cueto-Rojas, H. F., Maleki Seifar, R., Ten Pierick, A., Heijnen, S. J., & Wahl, A. (2016). Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae. Metabolites, 6(2), . https://doi.org/10.3390/metabo6020012
Cueto-Rojas, Hugo F, et al. "Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae." Metabolites vol. 6,2 (2016). doi: https://doi.org/10.3390/metabo6020012
Cueto-Rojas HF, Maleki Seifar R, Ten Pierick A, Heijnen SJ, Wahl A. Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae. Metabolites. 2016 Apr 23;6(2). doi: 10.3390/metabo6020012. PMID: 27120628; PMCID: PMC4931543.
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PP035. Genome-wide expression profile of first and second trimester human uterine natural killer cells.

Pregnancy hypertension

Post Uiterweer ED, Eijkelkamp N, Groot Koerkamp MJ, Peeters LL, Holstege FC, Heijnen CJ, Franx A.
PMID: 26105890
Pregnancy Hypertens. 2013 Apr;3(2):79. doi: 10.1016/j.preghy.2013.04.062. Epub 2013 Jun 06.

INTRODUCTION: Uterine Natural Killer (uNK) cells are key regulators of the placental bed during early placental development and account for 40% of decidual cells. uNK cells have been suggested to play a role in pregnancy complications including maternal placental...

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Post Uiterweer ED, Eijkelkamp N, Groot Koerkamp MJ, et al. PP035. Genome-wide expression profile of first and second trimester human uterine natural killer cells. Pregnancy Hypertens. 2013;3(2):79doi: 10.1016/j.preghy.2013.04.062.
Post Uiterweer, E. D., Eijkelkamp, N., Groot Koerkamp, M. J., Peeters, L. L., Holstege, F. C., Heijnen, C. J., & Franx, A. (2013). PP035. Genome-wide expression profile of first and second trimester human uterine natural killer cells. Pregnancy hypertension, 3(2), 79. https://doi.org/10.1016/j.preghy.2013.04.062
Post Uiterweer, Emiel D, et al. "PP035. Genome-wide expression profile of first and second trimester human uterine natural killer cells." Pregnancy hypertension vol. 3,2 (2013): 79. doi: https://doi.org/10.1016/j.preghy.2013.04.062
Post Uiterweer ED, Eijkelkamp N, Groot Koerkamp MJ, Peeters LL, Holstege FC, Heijnen CJ, Franx A. PP035. Genome-wide expression profile of first and second trimester human uterine natural killer cells. Pregnancy Hypertens. 2013 Apr;3(2):79. doi: 10.1016/j.preghy.2013.04.062. Epub 2013 Jun 06. PMID: 26105890.
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Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction.

Enzyme and microbial technology

Diender MB, Straathof AJ, van der Does T, Zomerdijk M, Heijnen JJ.
PMID: 11024520
Enzyme Microb Technol. 2000 Nov 01;27(8):576-582. doi: 10.1016/s0141-0229(00)00245-3.

Amoxicillin can be produced in an enzymatic suspension-to-suspension reaction in which the substrate(s) and product(s) are mainly present as solid particles, while the reaction takes place in the liquid phase. During these suspension-to-suspension reactions different subprocesses take place, such...

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Diender MB, Straathof AJ, van der Does T, et al. Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction. Enzyme Microb Technol. 2000;27(8):576-582doi: 10.1016/s0141-0229(00)00245-3.
Diender, M. B., Straathof, A. J., van der Does T, Zomerdijk, M., & Heijnen, J. J. (2000). Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction. Enzyme and microbial technology, 27(8), 576-582. https://doi.org/10.1016/s0141-0229(00)00245-3
Diender, et al. "Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction." Enzyme and microbial technology vol. 27,8 (2000): 576-582. doi: https://doi.org/10.1016/s0141-0229(00)00245-3
Diender MB, Straathof AJ, van der Does T, Zomerdijk M, Heijnen JJ. Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction. Enzyme Microb Technol. 2000 Nov 01;27(8):576-582. doi: 10.1016/s0141-0229(00)00245-3. PMID: 11024520.
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Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase.

Enzyme and microbial technology

Willeman WF, Hanefeld U, Straathof AJ, Heijnen JJ.
PMID: 10938422
Enzyme Microb Technol. 2000 Sep 01;27(6):423-433. doi: 10.1016/s0141-0229(00)00226-x.

Consistent sets of kinetic parameters were estimated for the synthesis of (R)-mandelonitrile, catalyzed by Prunus amygdalus hydroxynitrile lyase, at 5 and 25 degrees C and pH 5.5 by progress curve analysis. The rate constants and equilibrium constants of the...

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Willeman WF, Hanefeld U, Straathof AJ, et al. Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase. Enzyme Microb Technol. 2000;27(6):423-433doi: 10.1016/s0141-0229(00)00226-x.
Willeman, W. F., Hanefeld, U., Straathof, A. J., & Heijnen, J. J. (2000). Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase. Enzyme and microbial technology, 27(6), 423-433. https://doi.org/10.1016/s0141-0229(00)00226-x
Willeman, et al. "Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase." Enzyme and microbial technology vol. 27,6 (2000): 423-433. doi: https://doi.org/10.1016/s0141-0229(00)00226-x
Willeman WF, Hanefeld U, Straathof AJ, Heijnen JJ. Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase. Enzyme Microb Technol. 2000 Sep 01;27(6):423-433. doi: 10.1016/s0141-0229(00)00226-x. PMID: 10938422.
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Determination of growth and coupled nitrification/denitrification by immobilized Thiosphaera pantotropha using measurement and modeling of oxygen profiles.

Biotechnology and bioengineering

Hooijmans CM, Geraats SG, van Neil EW, Robertson LA, Heijnen JJ, Luyben KC.
PMID: 18597293
Biotechnol Bioeng. 1990 Nov;36(9):931-9. doi: 10.1002/bit.260360908.

An oxygen microsensor in combination with mathematical modeling was used to determine the behavior of immobilized Thiosphaera pantotropha. This organism can convert ammonia completely to nitrogen gas under aerobic conditions (coupled nitrification/denitrification) and denitrifies nitrate at highest rates under...

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Hooijmans CM, Geraats SG, van Neil EW, et al. Determination of growth and coupled nitrification/denitrification by immobilized Thiosphaera pantotropha using measurement and modeling of oxygen profiles. Biotechnol Bioeng. 1990;36(9):931-9doi: 10.1002/bit.260360908.
Hooijmans, C. M., Geraats, S. G., van Neil, E. W., Robertson, L. A., Heijnen, J. J., & Luyben, K. C. (1990). Determination of growth and coupled nitrification/denitrification by immobilized Thiosphaera pantotropha using measurement and modeling of oxygen profiles. Biotechnology and bioengineering, 36(9), 931-9. https://doi.org/10.1002/bit.260360908
Hooijmans, C M, et al. "Determination of growth and coupled nitrification/denitrification by immobilized Thiosphaera pantotropha using measurement and modeling of oxygen profiles." Biotechnology and bioengineering vol. 36,9 (1990): 931-9. doi: https://doi.org/10.1002/bit.260360908
Hooijmans CM, Geraats SG, van Neil EW, Robertson LA, Heijnen JJ, Luyben KC. Determination of growth and coupled nitrification/denitrification by immobilized Thiosphaera pantotropha using measurement and modeling of oxygen profiles. Biotechnol Bioeng. 1990 Nov;36(9):931-9. doi: 10.1002/bit.260360908. PMID: 18597293.
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New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants.

Biotechnology and bioengineering

Straathof AJ, Heijnen JJ.
PMID: 18629914
Biotechnol Bioeng. 1996 Nov 05;52(3):433-7. doi: 10.1002/(SICI)1097-0290(19961105)52:3<433::AID-BIT10>3.0.CO;2-K.

For an enzymatic reaction the rate constants in the assumed mechanism (k(1), k(-1), etc.) sometimes can be calculated from the steady-state parameter values (V(max), K(m), etc.) and sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring...

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Straathof AJ, Heijnen JJ. New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants. Biotechnol Bioeng. 1996;52(3):433-7doi: 10.1002/(SICI)1097-0290(19961105)52:3<433::AID-BIT10>3.0.CO;2-K.
Straathof, A. J., & Heijnen, J. J. (1996). New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants. Biotechnology and bioengineering, 52(3), 433-7. https://doi.org/10.1002/(SICI)1097-0290(19961105)52:3<433::AID-BIT10>3.0.CO;2-K
Straathof, A J, and Heijnen, J J. "New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants." Biotechnology and bioengineering vol. 52,3 (1996): 433-7. doi: https://doi.org/10.1002/(SICI)1097-0290(19961105)52:3<433::AID-BIT10>3.0.CO;2-K
Straathof AJ, Heijnen JJ. New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants. Biotechnol Bioeng. 1996 Nov 05;52(3):433-7. doi: 10.1002/(SICI)1097-0290(19961105)52:3<433::AID-BIT10>3.0.CO;2-K. PMID: 18629914.
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A metabolic model for biological phosphorus removal by denitrifying organisms.

Biotechnology and bioengineering

Kuba T, Murnleitner E, van Loosdrecht MC, Heijnen JJ.
PMID: 18629947
Biotechnol Bioeng. 1996 Dec 20;52(6):685-95. doi: 10.1002/(SICI)1097-0290(19961220)52:6<685::AID-BIT6>3.0.CO;2-K.

A metabolic model for biological phosphorus removal under denitrifying conditions has been established. The model is based on previous work with aerobic phosphorus removal. The form of the kinetic equations used is the same as for the aerobic model....

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Kuba T, Murnleitner E, van Loosdrecht MC, et al. A metabolic model for biological phosphorus removal by denitrifying organisms. Biotechnol Bioeng. 1996;52(6):685-95doi: 10.1002/(SICI)1097-0290(19961220)52:6<685::AID-BIT6>3.0.CO;2-K.
Kuba, T., Murnleitner, E., van Loosdrecht, M. C., & Heijnen, J. J. (1996). A metabolic model for biological phosphorus removal by denitrifying organisms. Biotechnology and bioengineering, 52(6), 685-95. https://doi.org/10.1002/(SICI)1097-0290(19961220)52:6<685::AID-BIT6>3.0.CO;2-K
Kuba, T, et al. "A metabolic model for biological phosphorus removal by denitrifying organisms." Biotechnology and bioengineering vol. 52,6 (1996): 685-95. doi: https://doi.org/10.1002/(SICI)1097-0290(19961220)52:6<685::AID-BIT6>3.0.CO;2-K
Kuba T, Murnleitner E, van Loosdrecht MC, Heijnen JJ. A metabolic model for biological phosphorus removal by denitrifying organisms. Biotechnol Bioeng. 1996 Dec 20;52(6):685-95. doi: 10.1002/(SICI)1097-0290(19961220)52:6<685::AID-BIT6>3.0.CO;2-K. PMID: 18629947.
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Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations.

Biotechnology and bioengineering

Gjaltema A, Vinke JL, van Loosdrecht MC, Heijnen JJ.
PMID: 18629963
Biotechnol Bioeng. 1997 Jan 05;53(1):88-99. doi: 10.1002/(SICI)1097-0290(19970105)53:1<88::AID-BIT12>3.0.CO;2-5.

The detachment of biomass from suspended biofilm pellets in three-phase internal loop airlift reactors was investigated under nongrowth conditions and in the presence of bare carrier particles. In different sets of experiments, the concentrations of biofilm pellets and bare...

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Gjaltema A, Vinke JL, van Loosdrecht MC, et al. Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations. Biotechnol Bioeng. 1997;53(1):88-99doi: 10.1002/(SICI)1097-0290(19970105)53:1<88::AID-BIT12>3.0.CO;2-5.
Gjaltema, A., Vinke, J. L., van Loosdrecht, M. C., & Heijnen, J. J. (1997). Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations. Biotechnology and bioengineering, 53(1), 88-99. https://doi.org/10.1002/(SICI)1097-0290(19970105)53:1<88::AID-BIT12>3.0.CO;2-5
Gjaltema, A, et al. "Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations." Biotechnology and bioengineering vol. 53,1 (1997): 88-99. doi: https://doi.org/10.1002/(SICI)1097-0290(19970105)53:1<88::AID-BIT12>3.0.CO;2-5
Gjaltema A, Vinke JL, van Loosdrecht MC, Heijnen JJ. Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations. Biotechnol Bioeng. 1997 Jan 05;53(1):88-99. doi: 10.1002/(SICI)1097-0290(19970105)53:1<88::AID-BIT12>3.0.CO;2-5. PMID: 18629963.
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Influence of oxygen adsorption on the dynamic K(L)a measurement in three-phase slurry reactors.

Biotechnology and bioengineering

Boon M, Meeder TA, Heijnen JJ, Luyben KC.
PMID: 18601219
Biotechnol Bioeng. 1992 Nov;40(9):1097-106. doi: 10.1002/bit.260400914.

To check for possible mass transfer limitations of oxygen and/or carbon dioxide in kinetic experiments on microbial desulphurization of coal, it is important to properly measure the volumetric mass transfer coefficient (k(L)a) especially at high slurry densities. Volumetric mass...

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Boon M, Meeder TA, Heijnen JJ, et al. Influence of oxygen adsorption on the dynamic K(L)a measurement in three-phase slurry reactors. Biotechnol Bioeng. 1992;40(9):1097-106doi: 10.1002/bit.260400914.
Boon, M., Meeder, T. A., Heijnen, J. J., & Luyben, K. C. (1992). Influence of oxygen adsorption on the dynamic K(L)a measurement in three-phase slurry reactors. Biotechnology and bioengineering, 40(9), 1097-106. https://doi.org/10.1002/bit.260400914
Boon, M, et al. "Influence of oxygen adsorption on the dynamic K(L)a measurement in three-phase slurry reactors." Biotechnology and bioengineering vol. 40,9 (1992): 1097-106. doi: https://doi.org/10.1002/bit.260400914
Boon M, Meeder TA, Heijnen JJ, Luyben KC. Influence of oxygen adsorption on the dynamic K(L)a measurement in three-phase slurry reactors. Biotechnol Bioeng. 1992 Nov;40(9):1097-106. doi: 10.1002/bit.260400914. PMID: 18601219.
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Kinetics and stoichiometry of growth of plant cell cultures of Catharanthus roseus and Nicotiana tabacum in batch and continuous fermentors.

Biotechnology and bioengineering

van Gulik WM, Ten Hoopen HJ, Heijnen JJ.
PMID: 18601193
Biotechnol Bioeng. 1992 Oct 20;40(8):863-74. doi: 10.1002/bit.260400802.

Plant cell suspension cultures of Catharanthus roseus and Nicotiana tabacum were grown in stirred tank bioreactors operated in batch and continuous mode. The stoichiometry of growth of both species in steady-state glucose limited chemostats was studied at a range...

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van Gulik WM, Ten Hoopen HJ, Heijnen JJ. Kinetics and stoichiometry of growth of plant cell cultures of Catharanthus roseus and Nicotiana tabacum in batch and continuous fermentors. Biotechnol Bioeng. 1992;40(8):863-74doi: 10.1002/bit.260400802.
van Gulik, W. M., Ten Hoopen, H. J., & Heijnen, J. J. (1992). Kinetics and stoichiometry of growth of plant cell cultures of Catharanthus roseus and Nicotiana tabacum in batch and continuous fermentors. Biotechnology and bioengineering, 40(8), 863-74. https://doi.org/10.1002/bit.260400802
van Gulik, W M, et al. "Kinetics and stoichiometry of growth of plant cell cultures of Catharanthus roseus and Nicotiana tabacum in batch and continuous fermentors." Biotechnology and bioengineering vol. 40,8 (1992): 863-74. doi: https://doi.org/10.1002/bit.260400802
van Gulik WM, Ten Hoopen HJ, Heijnen JJ. Kinetics and stoichiometry of growth of plant cell cultures of Catharanthus roseus and Nicotiana tabacum in batch and continuous fermentors. Biotechnol Bioeng. 1992 Oct 20;40(8):863-74. doi: 10.1002/bit.260400802. PMID: 18601193.
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Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors.

Biotechnology and bioengineering

Tijhuis L, van Loosdrecht MC, Heijnen JJ.
PMID: 18618795
Biotechnol Bioeng. 1994 Aug 20;44(5):595-608. doi: 10.1002/bit.260440506.

In this article, the conditions for aerobic biofilm formation on suspended particles, the dynamics of biofilm formation, and the biomass production during the start-up of a Biofilm Airlift Suspension reactor (BAS reactor) have been studied. The dynamics of biofilm...

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Tijhuis L, van Loosdrecht MC, Heijnen JJ. Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors. Biotechnol Bioeng. 1994;44(5):595-608doi: 10.1002/bit.260440506.
Tijhuis, L., van Loosdrecht, M. C., & Heijnen, J. J. (1994). Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors. Biotechnology and bioengineering, 44(5), 595-608. https://doi.org/10.1002/bit.260440506
Tijhuis, L, et al. "Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors." Biotechnology and bioengineering vol. 44,5 (1994): 595-608. doi: https://doi.org/10.1002/bit.260440506
Tijhuis L, van Loosdrecht MC, Heijnen JJ. Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors. Biotechnol Bioeng. 1994 Aug 20;44(5):595-608. doi: 10.1002/bit.260440506. PMID: 18618795.
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