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Showing 1 to 12 of 307 entries
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Normalizing the Racial Divide in High School Computer Science

Science and underrepresentation

Holme JJ.
GSID: izOouoldH68J
J Margolis, R Estrella, J Goode, JJ Holme, K Nao - 2008 - ieeexplore.ieee.org

This chapter contains section titled: Westward Senior High School, No Opportunity to Learn Computer Science, Interest But No Place to Hang and Learn, Being Really, Really Smart to …

Optical method for automated measurement of glass micropipette tip geometry.

Precision engineering

Stockslager MA, Capocasale CM, Holst GL, Simon MD, Li Y, McGruder DJ, Rousseau EB, Stoy WA, Sulchek T, Forest CR.
PMID: 27672230
Precis Eng. 2016 Oct;46:88-95. doi: 10.1016/j.precisioneng.2016.04.003. Epub 2016 Apr 02.

Many experimental biological techniques utilize hollow glass needles called micropipettes to perform fluid extraction, cell manipulation, and electrophysiological recordings For electrophysiological recordings, micropipettes are typically fabricated immediately before use using a "pipette puller", which uses open-loop control to heat...

GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass.

Endocrinology, diabetes & metabolism case reports

Guimarães M, Rodrigues P, Pereira SS, Nora M, Gonçalves G, Albrechtsen NW, Hartmann B, Holst JJ, Monteiro MP.
PMID: 26266036
Endocrinol Diabetes Metab Case Rep. 2015;2015:150049. doi: 10.1530/EDM-15-0049. Epub 2015 Jul 15.

UNLABELLED: Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment...

On the role of gallbladder emptying and incretin hormones for nutrient-mediated TSH suppression in patients with type 2 diabetes.

Endocrine connections

Sonne DP, Lund A, Faber J, Holst JJ, Vilsbøll T, Knop FK.
PMID: 25277744
Endocr Connect. 2014 Dec;3(4):193-9. doi: 10.1530/EC-14-0088. Epub 2014 Oct 02.

Bile acids are possible candidate agents in newly identified pathways through which energy expenditure may be regulated. Preclinical studies suggest that bile acids activate the enzyme type 2 iodothyronine deiodinase, which deiodinates thyroxine (T4) to the biologically active triiodothyronine...

Stability of glucagon-like peptide 1 and glucagon in human plasma.

Endocrine connections

Wewer Albrechtsen NJ, Bak MJ, Hartmann B, Christensen LW, Kuhre RE, Deacon CF, Holst JJ.
PMID: 25596009
Endocr Connect. 2015 Mar;4(1):50-7. doi: 10.1530/EC-14-0126. Epub 2015 Jan 16.

To investigate the stability of glucagon-like peptide 1 (GLP-1) and glucagon in plasma under short- and long-term storage conditions. Pooled human plasma (n=20), to which a dipeptidyl peptidase 4 (DPP4) inhibitor and aprotinin were added, was spiked with synthetic...

Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males.

Endocrine connections

Skov J, Holst JJ, Gøtze JP, Frøkiær J, Christiansen JS.
PMID: 24327600
Endocr Connect. 2014 Jan 21;3(1):11-6. doi: 10.1530/EC-13-0087. Print 2014.

The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young...

L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.

American journal of cancer research

Wang Q, Holst J.
PMID: 26101697
Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015.

The L-type amino acid transporter (LAT) family are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2), are responsible for the majority of cellular leucine uptake. They...

Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome.

Endocrine connections

Glintborg D, Mumm H, Holst JJ, Andersen M.
PMID: 28432082
Endocr Connect. 2017 May;6(4):267-277. doi: 10.1530/EC-17-0034. Epub 2017 Apr 21.

CONTEXT: Insulin resistance in polycystic ovary syndrome (PCOS) may increase the risk of reactive hypoglycaemia (RH) and decrease glucagon-like peptide-1 (GLP-1) secretion. The possible effects of treatment with oral contraceptives (OCP) and/or metformin on GLP-1 secretion and risk of...

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

ACS medicinal chemistry letters

Balog A, Rampulla R, Martin GS, Krystek SR, Attar R, Dell-John J, DiMarco JD, Fairfax D, Gougoutas J, Holst CL, Nation A, Rizzo C, Rossiter LM, Schweizer L, Shan W, Spergel S, Spires T, Cornelius G, Gottardis M, Trainor G, Vite GD, Salvati ME.
PMID: 26288692
ACS Med Chem Lett. 2015 Jun 19;6(8):908-12. doi: 10.1021/acsmedchemlett.5b00173. eCollection 2015 Aug 13.

BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple human...

Giant Zn14 molecular building block in hydrogen-bonded network with permanent porosity for gas uptake.

Journal of the American Chemical Society

Mondal SS, Bhunia A, Kelling A, Schilde U, Janiak C, Holdt HJ.
PMID: 24313724
J Am Chem Soc. 2014 Jan 08;136(1):44-7. doi: 10.1021/ja410595q. Epub 2013 Dec 16.

In situ imidazolate-4,5-diamide-2-olate linker generation leads to the formation of a [Zn14(L2)12(O)(OH)2(H2O)4] molecular building block (MBB) with a Zn6 octahedron inscribed in a Zn8 cube. The MBBs connect by amide-amide hydrogen bonds to a 3D robust supramolecular network which...

Glucagon-like peptide-1: a basis for new approaches to the management of diabetes.

Drugs of today (Barcelona, Spain : 1998)

Deacon CF, Holst JJ, Carr RD.
PMID: 12973381
Drugs Today (Barc). 1999 Mar;35(3):159-70. doi: 10.1358/dot.1999.35.3.533845.

Type 2 diabetes mellitus is a metabolic disease resulting in raised blood sugar which, if not satisfactorily controlled, can cause severe and often debilitating complications. Unfortunately, for many patients, the existing therapies do not give adequate control. Glucagon-like peptide-1...

Conformational analysis of mixed oxathia crown ethers and their complexational ability towards Ag(I) and Pd(II)-an experimental solution NMR and theoretical molecular modelling study.

Organic & biomolecular chemistry

Holzberger A, Holdt HJ, Kleinpeter E.
PMID: 15188035
Org Biomol Chem. 2004 Jun 21;2(12):1691-7. doi: 10.1039/b402224f. Epub 2004 May 19.

Both the conformation and flexibility of four mixed oxathia crown ethers and their Ag(I) and Pd(II) complexes were studied by (1)H NMR (delta, J, NOE, T(1)), (13)C NMR, dynamic (1)H NMR spectroscopy and molecular modelling. The stoichiometry and stability...

Showing 1 to 12 of 307 entries