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Showing 1 to 12 of 42 entries
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Using graduate surveys to guide curricular reform.

Family medicine

Dill DR, Strenecky BJ, Davis JM, Holtzapple KE.
PMID: 3556888
Fam Med. 1986 Sep-Oct;18(5):314-5.

No abstract available.

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Dill DR, Strenecky BJ, Davis JM, et al. Using graduate surveys to guide curricular reform. Fam Med. 1986;18(5):314-5
Dill, D. R., Strenecky, B. J., Davis, J. M., & Holtzapple, K. E. (1986). Using graduate surveys to guide curricular reform. Family medicine, 18(5), 314-5.
Dill, D R, et al. "Using graduate surveys to guide curricular reform." Family medicine vol. 18,5 (1986): 314-5.
Dill DR, Strenecky BJ, Davis JM, Holtzapple KE. Using graduate surveys to guide curricular reform. Fam Med. 1986 Sep-Oct;18(5):314-5. PMID: 3556888.
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The HCH-1 model of enzymatic cellulose hydrolysis.

Biotechnology and bioengineering

Holtzapple MT, Caram HS, Humphrey AE.
PMID: 18553446
Biotechnol Bioeng. 1984 Jul;26(7):775-80. doi: 10.1002/bit.260260723.

Solka Floc BW200 was enzymatically hydrolyzed in a batch reactor using a commercial cellulase preparation. A total of 50 different hydrolysis conditions were run within a 10-fold range in enzyme concentration and a 30-fold range in cellulose concentration. The...

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Holtzapple MT, Caram HS, Humphrey AE. The HCH-1 model of enzymatic cellulose hydrolysis. Biotechnol Bioeng. 1984;26(7):775-80doi: 10.1002/bit.260260723.
Holtzapple, M. T., Caram, H. S., & Humphrey, A. E. (1984). The HCH-1 model of enzymatic cellulose hydrolysis. Biotechnology and bioengineering, 26(7), 775-80. https://doi.org/10.1002/bit.260260723
Holtzapple, M T, et al. "The HCH-1 model of enzymatic cellulose hydrolysis." Biotechnology and bioengineering vol. 26,7 (1984): 775-80. doi: https://doi.org/10.1002/bit.260260723
Holtzapple MT, Caram HS, Humphrey AE. The HCH-1 model of enzymatic cellulose hydrolysis. Biotechnol Bioeng. 1984 Jul;26(7):775-80. doi: 10.1002/bit.260260723. PMID: 18553446.
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Oxygen transfer in a pulse bioreactor.

Biotechnology and bioengineering

Monahan PB, Holtzapple MT.
PMID: 18613105
Biotechnol Bioeng. 1993 Sep 05;42(6):724-8. doi: 10.1002/bit.260420607.

Oxygen transfer in a novel pulse bioreactor has been evaluated. The agitator consists of a series of alternately fixed and movable parallel plates mounted so that the movable plates vibrate at 30 Hz causing a pulsating fluid motion. Pure...

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Monahan PB, Holtzapple MT. Oxygen transfer in a pulse bioreactor. Biotechnol Bioeng. 1993;42(6):724-8doi: 10.1002/bit.260420607.
Monahan, P. B., & Holtzapple, M. T. (1993). Oxygen transfer in a pulse bioreactor. Biotechnology and bioengineering, 42(6), 724-8. https://doi.org/10.1002/bit.260420607
Monahan, P B, and Holtzapple, M T. "Oxygen transfer in a pulse bioreactor." Biotechnology and bioengineering vol. 42,6 (1993): 724-8. doi: https://doi.org/10.1002/bit.260420607
Monahan PB, Holtzapple MT. Oxygen transfer in a pulse bioreactor. Biotechnol Bioeng. 1993 Sep 05;42(6):724-8. doi: 10.1002/bit.260420607. PMID: 18613105.
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A comparison of two empirical models for the enzymatic hydrolysis of pretreated poplar wood.

Biotechnology and bioengineering

Holtzapple MT, Caram HS, Humphrey AE.
PMID: 18553480
Biotechnol Bioeng. 1984 Aug;26(8):936-41. doi: 10.1002/bit.260260818.

Two empirical models for the enzymatic hydrolysis of cellulose are used to analyze the same set of experimental data to determine if one model is superior to the other. Both models adequately describe the data. The parameters in both...

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Holtzapple MT, Caram HS, Humphrey AE. A comparison of two empirical models for the enzymatic hydrolysis of pretreated poplar wood. Biotechnol Bioeng. 1984;26(8):936-41doi: 10.1002/bit.260260818.
Holtzapple, M. T., Caram, H. S., & Humphrey, A. E. (1984). A comparison of two empirical models for the enzymatic hydrolysis of pretreated poplar wood. Biotechnology and bioengineering, 26(8), 936-41. https://doi.org/10.1002/bit.260260818
Holtzapple, M T, et al. "A comparison of two empirical models for the enzymatic hydrolysis of pretreated poplar wood." Biotechnology and bioengineering vol. 26,8 (1984): 936-41. doi: https://doi.org/10.1002/bit.260260818
Holtzapple MT, Caram HS, Humphrey AE. A comparison of two empirical models for the enzymatic hydrolysis of pretreated poplar wood. Biotechnol Bioeng. 1984 Aug;26(8):936-41. doi: 10.1002/bit.260260818. PMID: 18553480.
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ATP regeneration by thermostable ATP synthase.

Biotechnology and bioengineering

Nam KY, Struck DK, Holtzapple MT.
PMID: 18624363
Biotechnol Bioeng. 1996 Aug 05;51(3):305-16. doi: 10.1002/(SICI)1097-0290(19960805)51:3<305::AID-BIT6>3.0.CO;2-H.

We investigated the possibility of using thermostable ATP synthase (TF(0)F(1)) for a new ATP regeneration method. TF(0)F(1) was purified from a thermophilic bacterium, PS3, and reconstituted into liposomes. ATP synthesis experiments showed that TF(0)F(1) liposomes could synthesize ATP in...

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Nam KY, Struck DK, Holtzapple MT. ATP regeneration by thermostable ATP synthase. Biotechnol Bioeng. 1996;51(3):305-16doi: 10.1002/(SICI)1097-0290(19960805)51:3<305::AID-BIT6>3.0.CO;2-H.
Nam, K. Y., Struck, D. K., & Holtzapple, M. T. (1996). ATP regeneration by thermostable ATP synthase. Biotechnology and bioengineering, 51(3), 305-16. https://doi.org/10.1002/(SICI)1097-0290(19960805)51:3<305::AID-BIT6>3.0.CO;2-H
Nam, K Y, et al. "ATP regeneration by thermostable ATP synthase." Biotechnology and bioengineering vol. 51,3 (1996): 305-16. doi: https://doi.org/10.1002/(SICI)1097-0290(19960805)51:3<305::AID-BIT6>3.0.CO;2-H
Nam KY, Struck DK, Holtzapple MT. ATP regeneration by thermostable ATP synthase. Biotechnol Bioeng. 1996 Aug 05;51(3):305-16. doi: 10.1002/(SICI)1097-0290(19960805)51:3<305::AID-BIT6>3.0.CO;2-H. PMID: 18624363.
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Development of highly digestible animal feed from lignocellulosic biomass Part 1: Oxidative lime pretreatment (OLP) and ball milling of forage sorghum.

Translational animal science

Falls M, Meysing D, Lonkar S, Liang C, Karim MN, Carstens G, Tedeschi LO, Holtzapple MT.
PMID: 32704644
Transl Anim Sci. 2017 Apr 01;1(2):208-214. doi: 10.2527/tas2017.0024. eCollection 2017 Apr.

To feed a growing population, alternative sources of animal feed (e.g., lignocellulose) are needed to replace grains (e.g., corn). Oxidative lime pretreatment (OLP) increases lignocellulose digestibility by removing lignin and hemicellulose acetyl content. Adding a mechanical pretreatment (e.g., ball...

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Falls M, Meysing D, Lonkar S, et al. Development of highly digestible animal feed from lignocellulosic biomass Part 1: Oxidative lime pretreatment (OLP) and ball milling of forage sorghum. Transl Anim Sci. 2017;1(2):208-214doi: 10.2527/tas2017.0024.
Falls, M., Meysing, D., Lonkar, S., Liang, C., Karim, M. N., Carstens, G., Tedeschi, L. O., & Holtzapple, M. T. (2017). Development of highly digestible animal feed from lignocellulosic biomass Part 1: Oxidative lime pretreatment (OLP) and ball milling of forage sorghum. Translational animal science, 1(2), 208-214. https://doi.org/10.2527/tas2017.0024
Falls, M, et al. "Development of highly digestible animal feed from lignocellulosic biomass Part 1: Oxidative lime pretreatment (OLP) and ball milling of forage sorghum." Translational animal science vol. 1,2 (2017): 208-214. doi: https://doi.org/10.2527/tas2017.0024
Falls M, Meysing D, Lonkar S, Liang C, Karim MN, Carstens G, Tedeschi LO, Holtzapple MT. Development of highly digestible animal feed from lignocellulosic biomass Part 1: Oxidative lime pretreatment (OLP) and ball milling of forage sorghum. Transl Anim Sci. 2017 Apr 01;1(2):208-214. doi: 10.2527/tas2017.0024. eCollection 2017 Apr. PMID: 32704644; PMCID: PMC7205335.
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Assessment of shock pretreatment and alkali pretreatment on corn stover using enzymatic hydrolysis.

Biotechnology progress

Olokede O, Hsu SC, Schiele S, Ju H, Holtzapple M.
PMID: 34591371
Biotechnol Prog. 2021 Sep 30;e3217. doi: 10.1002/btpr.3217. Epub 2021 Sep 30.

This study investigates digestibility enhancements of lignocellulose from shock pretreatment, alkaline pretreatment, and combination. Shock pretreatment subjects aqueous slurries of lignocellulose to shock waves, which disrupts its structure rendering it more susceptible to hydrolysis. Alkaline pretreatment submerges the biomass...

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Olokede O, Hsu SC, Schiele S, et al. Assessment of shock pretreatment and alkali pretreatment on corn stover using enzymatic hydrolysis. Biotechnol Prog. 2021;e3217doi: 10.1002/btpr.3217.
Olokede, O., Hsu, S. C., Schiele, S., Ju, H., & Holtzapple, M. (2021). Assessment of shock pretreatment and alkali pretreatment on corn stover using enzymatic hydrolysis. Biotechnology progress, e3217. https://doi.org/10.1002/btpr.3217
Olokede, Opeyemi, et al. "Assessment of shock pretreatment and alkali pretreatment on corn stover using enzymatic hydrolysis." Biotechnology progress vol. (2021): e3217. doi: https://doi.org/10.1002/btpr.3217
Olokede O, Hsu SC, Schiele S, Ju H, Holtzapple M. Assessment of shock pretreatment and alkali pretreatment on corn stover using enzymatic hydrolysis. Biotechnol Prog. 2021 Sep 30;e3217. doi: 10.1002/btpr.3217. Epub 2021 Sep 30. PMID: 34591371.
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FLUTE: Fast and reliable knowledge retrieval from biomedical literature.

Database : the journal of biological databases and curation

Holtzapple E, Telmer CA, Miskov-Zivanov N.
PMID: 32761077
Database (Oxford). 2020 Jan 01;2020. doi: 10.1093/database/baaa056.

State-of-the-art machine reading methods extract, in hours, hundreds of thousands of events from the biomedical literature. However, many of the extracted biomolecular interactions are incorrect or not relevant for computational modeling of a system of interest. Therefore, rapid, automated...

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Holtzapple E, Telmer CA, Miskov-Zivanov N. FLUTE: Fast and reliable knowledge retrieval from biomedical literature. Database (Oxford). 2020;2020doi: 10.1093/database/baaa056.
Holtzapple, E., Telmer, C. A., & Miskov-Zivanov, N. (2020). FLUTE: Fast and reliable knowledge retrieval from biomedical literature. Database : the journal of biological databases and curation, 2020. https://doi.org/10.1093/database/baaa056
Holtzapple, Emilee, et al. "FLUTE: Fast and reliable knowledge retrieval from biomedical literature." Database : the journal of biological databases and curation vol. 2020 (2020). doi: https://doi.org/10.1093/database/baaa056
Holtzapple E, Telmer CA, Miskov-Zivanov N. FLUTE: Fast and reliable knowledge retrieval from biomedical literature. Database (Oxford). 2020 Jan 01;2020. doi: 10.1093/database/baaa056. PMID: 32761077; PMCID: PMC7408180.
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Preschool Participation and BMI at Kindergarten Entry: The Case for Early Behavioral Intervention.

Journal of obesity

McGrady ME, Mitchell MJ, Theodore SN, Sersion B, Holtzapple E.
PMID: 20721345
J Obes. 2010;2010. doi: 10.1155/2010/360407. Epub 2010 Apr 18.

Preschool years (ages 3-5) are a critical period in growth and development. Emerging studies suggest that preschool attendance may be linked to future weight, and perhaps obesity. This study examined relationships between public preschool attendance, demographic variables, and weight...

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McGrady ME, Mitchell MJ, Theodore SN, et al. Preschool Participation and BMI at Kindergarten Entry: The Case for Early Behavioral Intervention. J Obes. 2010;2010doi: 10.1155/2010/360407.
McGrady, M. E., Mitchell, M. J., Theodore, S. N., Sersion, B., & Holtzapple, E. (2010). Preschool Participation and BMI at Kindergarten Entry: The Case for Early Behavioral Intervention. Journal of obesity, 2010. https://doi.org/10.1155/2010/360407
McGrady, Meghan E, et al. "Preschool Participation and BMI at Kindergarten Entry: The Case for Early Behavioral Intervention." Journal of obesity vol. 2010 (2010). doi: https://doi.org/10.1155/2010/360407
McGrady ME, Mitchell MJ, Theodore SN, Sersion B, Holtzapple E. Preschool Participation and BMI at Kindergarten Entry: The Case for Early Behavioral Intervention. J Obes. 2010;2010. doi: 10.1155/2010/360407. Epub 2010 Apr 18. PMID: 20721345; PMCID: PMC2915775.
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Biomass conversion to mixed alcohol fuels using the MixAlco process.

Applied biochemistry and biotechnology

Holtzapple MT, Davison RR, Ross MK, Albrett-Lee S, Nagwani M, Lee CM, Lee C, Adelson S, Kaar W, Gaskin D, Shirage H, Chang NS, Chang VS, Loescher ME.
PMID: 15304682
Appl Biochem Biotechnol. 1999;77:609-31. doi: 10.1385/abab:79:1-3:609.

The MixAlco process is a patented technology that converts any biodegradable material (e.g., sorted municipal solid waste, sewage sludge, industrial biosludge, manure, agricultural residues, energy crops) into mixed alcohol fuels containing predominantly 2-propanol, but also higher alcohols up to...

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Holtzapple MT, Davison RR, Ross MK, et al. Biomass conversion to mixed alcohol fuels using the MixAlco process. Appl Biochem Biotechnol. 1999;77:609-31doi: 10.1385/abab:79:1-3:609.
Holtzapple, M. T., Davison, R. R., Ross, M. K., Albrett-Lee, S., Nagwani, M., Lee, C. M., Lee, C., Adelson, S., Kaar, W., Gaskin, D., Shirage, H., Chang, N. S., Chang, V. S., & Loescher, M. E. (1999). Biomass conversion to mixed alcohol fuels using the MixAlco process. Applied biochemistry and biotechnology, 77609-31. https://doi.org/10.1385/abab:79:1-3:609
Holtzapple, M T, et al. "Biomass conversion to mixed alcohol fuels using the MixAlco process." Applied biochemistry and biotechnology vol. 77 (1999): 609-31. doi: https://doi.org/10.1385/abab:79:1-3:609
Holtzapple MT, Davison RR, Ross MK, Albrett-Lee S, Nagwani M, Lee CM, Lee C, Adelson S, Kaar W, Gaskin D, Shirage H, Chang NS, Chang VS, Loescher ME. Biomass conversion to mixed alcohol fuels using the MixAlco process. Appl Biochem Biotechnol. 1999;77:609-31. doi: 10.1385/abab:79:1-3:609. PMID: 15304682.
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Human cystinosis: intracellular deposition of cystine.

Science (New York, N.Y.)

Hummeler K, Zajac BA, Genel M, Holtzapple PG, Segal S.
PMID: 17768922
Science. 1970 May 15;168(3933):859-60. doi: 10.1126/science.168.3933.859.

Membrane-limited inclusions were found in the cytoplasm of cells of the rectal mucosa, leukocytes, and cultured fibroblasts from two humans with cystinosis. Most of the inclusions contained amorphous material, presumably cystine. In cells of the rectal mucosa the material...

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Hummeler K, Zajac BA, Genel M, et al. Human cystinosis: intracellular deposition of cystine. Science. 1970;168(3933):859-60doi: 10.1126/science.168.3933.859.
Hummeler, K., Zajac, B. A., Genel, M., Holtzapple, P. G., & Segal, S. (1970). Human cystinosis: intracellular deposition of cystine. Science (New York, N.Y.), 168(3933), 859-60. https://doi.org/10.1126/science.168.3933.859
Hummeler, K, et al. "Human cystinosis: intracellular deposition of cystine." Science (New York, N.Y.) vol. 168,3933 (1970): 859-60. doi: https://doi.org/10.1126/science.168.3933.859
Hummeler K, Zajac BA, Genel M, Holtzapple PG, Segal S. Human cystinosis: intracellular deposition of cystine. Science. 1970 May 15;168(3933):859-60. doi: 10.1126/science.168.3933.859. PMID: 17768922.
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Parametric analysis of the errors associated with the Michaelis-Menten equation.

Biotechnology and bioengineering

Brown RF, Holtzapple MT.
PMID: 18595055
Biotechnol Bioeng. 1990 Dec 20;36(11):1141-50. doi: 10.1002/bit.260361109.

Based on the well-known mechanism describing Michaelis-Menten kinetics, three rate expressions may be developed: the exact solution (Model 1), a rate equation resulting from the pseudo-steady-state assumption (Model 2), and Model 2 with the additional assumption that the amount...

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Brown RF, Holtzapple MT. Parametric analysis of the errors associated with the Michaelis-Menten equation. Biotechnol Bioeng. 1990;36(11):1141-50doi: 10.1002/bit.260361109.
Brown, R. F., & Holtzapple, M. T. (1990). Parametric analysis of the errors associated with the Michaelis-Menten equation. Biotechnology and bioengineering, 36(11), 1141-50. https://doi.org/10.1002/bit.260361109
Brown, R F, and Holtzapple, M T. "Parametric analysis of the errors associated with the Michaelis-Menten equation." Biotechnology and bioengineering vol. 36,11 (1990): 1141-50. doi: https://doi.org/10.1002/bit.260361109
Brown RF, Holtzapple MT. Parametric analysis of the errors associated with the Michaelis-Menten equation. Biotechnol Bioeng. 1990 Dec 20;36(11):1141-50. doi: 10.1002/bit.260361109. PMID: 18595055.
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Showing 1 to 12 of 42 entries