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Showing 1 to 12 of 24 entries
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Self-efficacy instruments for patients with chronic diseases suffer from methodological limitations--a systematic review.

Health and quality of life outcomes

Frei A, Svarin A, Steurer-Stey C, Puhan MA.
PMID: 19781095
Health Qual Life Outcomes. 2009 Sep 26;7:86. doi: 10.1186/1477-7525-7-86.

BACKGROUND: Measurement of self-efficacy requires carefully developed and validated instruments. It is currently unclear whether available self-efficacy instruments for chronic diseases fulfill these requirements. Our aim was to systematically identify all existing self-efficacy scales for five major chronic diseases...

Obesity and brain illness: from cognitive and psychological evidences to obesity paradox.

Diabetes, metabolic syndrome and obesity : targets and therapy

Monda V, La Marra M, Perrella R, Caviglia G, Iavarone A, Chieffi S, Messina G, Carotenuto M, Monda M, Messina A.
PMID: 29200883
Diabetes Metab Syndr Obes. 2017 Nov 21;10:473-479. doi: 10.2147/DMSO.S148392. eCollection 2017.

Recent findings showed that obesity represents an additional risk factor to developing brain illness such as cognitive impairments and psychopathological disorders. However, some benefits of overweight in the elderly have been identified and an "obesity paradox" has been shown....

Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles.

Frontiers in aging neuroscience

Jacini F, Sorrentino P, Lardone A, Rucco R, Baselice F, Cavaliere C, Aiello M, Orsini M, Iavarone A, Manzo V, Carotenuto A, Granata C, Hillebrand A, Sorrentino G.
PMID: 30574086
Front Aging Neurosci. 2018 Dec 06;10:400. doi: 10.3389/fnagi.2018.00400. eCollection 2018.

There is general agreement that the neuropathological processes leading to Alzheimer's disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from...

The making of the glioblastoma classification.

British journal of cancer

Lasorella A, Iavarone A.
PMID: 33767415
Br J Cancer. 2021 Jul;125(1):4-6. doi: 10.1038/s41416-021-01360-7. Epub 2021 Mar 25.

Classification of cancer should lead to informative patients' stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic...

Anti-tumor effects of an ID antagonist with no observed acquired resistance.

NPJ breast cancer

Wojnarowicz PM, Escolano MG, Huang YH, Desai B, Chin Y, Shah R, Xu S, Yadav S, Yaklichkin S, Ouerfelli O, Soni RK, Philip J, Montrose DC, Healey JH, Rajasekhar VK, Garland WA, Ratiu J, Zhuang Y, Norton L, Rosen N, Hendrickson RC, Zhou XK, Iavarone A, Massague J, Dannenberg AJ, Lasorella A, Benezra R.
PMID: 34031428
NPJ Breast Cancer. 2021 May 24;7(1):58. doi: 10.1038/s41523-021-00266-0.

ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for degradation and impairs ocular neovascularization in mouse models. Here...

The Frontal Assessment Battery 20 years later: normative data for a shortened version (FAB15).

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Ilardi CR, Chieffi S, Scuotto C, Gamboz N, Galeone F, Sannino M, Garofalo E, La Marra M, Ronga B, Iavarone A.
PMID: 34410549
Neurol Sci. 2021 Aug 19; doi: 10.1007/s10072-021-05544-0. Epub 2021 Aug 19.

OBJECTIVE: The Frontal Assessment Battery (FAB) is a neuropsychological tool largely used to assess executive functions. Prior studies found a marked ceiling effect for the prehension behavior subtest (PBT) in healthy and clinical populations. Aims of the present study...

Memory for Spatial Locations in a Patient with Near Space Neglect and Optic Ataxia: Involvement of the Occipitotemporal Stream.

Frontiers in neurology

Chieffi S, Messina G, Messina A, Villano I, Monda V, Ambra FI, Garofalo E, Romano F, Mollica MP, Monda M, Iavarone A.
PMID: 28620345
Front Neurol. 2017 May 31;8:231. doi: 10.3389/fneur.2017.00231. eCollection 2017.

Previous studies suggested that the occipitoparietal stream orients attention toward the near/lower space and is involved in immediate reaching, whereas the occipitotemporal stream orients attention toward the far/upper space and is involved in delayed reaching. In the present study,...

Fatty acid profile and safety aspects of the edible oil prepared by artisans' at small-scale agricultural companies.

Food science & nutrition

Bartkiene E, Bartkevics V, Berzina Z, Klementaviciute J, Sidlauskiene S, Isariene A, Zeimiene V, Lele V, Mozuriene E.
PMID: 34646511
Food Sci Nutr. 2021 Aug 08;9(10):5402-5414. doi: 10.1002/fsn3.2495. eCollection 2021 Oct.

The aim of this study was to analyze the fatty acid (FA) profiles and mycotoxin and polycyclic aromatic hydrocarbon (PAH) concentrations in sea buckthorn (SB1, SB2), flaxseed (FL3, FL4, FL5), hempseed (HE6, HE7, HE8), camelina (CA9, CA10), and mustard...

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities.

Nature cancer

Garofano L, Migliozzi S, Oh YT, D'Angelo F, Najac RD, Ko A, Frangaj B, Caruso FP, Yu K, Yuan J, Zhao W, Di Stefano AL, Bielle F, Jiang T, Sims P, Suvà ML, Tang F, Su XD, Ceccarelli M, Sanson M, Lasorella A, Iavarone A.
PMID: 33681822
Nat Cancer. 2021 Feb;2(2):141-156. doi: 10.1038/s43018-020-00159-4. Epub 2021 Jan 11.

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and therapeutic vulnerabilities. A computational approach for unbiased identification of core biological traits of single cells and bulk tumors uncovered four tumor cell states and GBM subtypes distributed...

Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer's disease: systematic search and state-of-the-art review.

Aging clinical and experimental research

Ilardi CR, Chieffi S, Iachini T, Iavarone A.
PMID: 34232485
Aging Clin Exp Res. 2021 Jul 07; doi: 10.1007/s40520-021-01930-y. Epub 2021 Jul 07.

In the present review, we discuss the rationale and the clinical implications of assessing visuospatial working memory (VSWM), awareness of memory deficits, and visuomotor control in patients with mild cognitive impairment (MCI). These three domains are related to neural...

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.

Genome medicine

Chen AX, Gartrell RD, Zhao J, Upadhyayula PS, Zhao W, Yuan J, Minns HE, Dovas A, Bruce JN, Lasorella A, Iavarone A, Canoll P, Sims PA, Rabadan R.
PMID: 34011400
Genome Med. 2021 May 19;13(1):88. doi: 10.1186/s13073-021-00906-x.

BACKGROUND: Macrophages are the most common infiltrating immune cells in gliomas and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment remain poorly understood.METHODS: We combined...

From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments.

Brain sciences

Iachini T, Ruotolo F, Iavarone A, Mazzi MC, Ruggiero G.
PMID: 34827534
Brain Sci. 2021 Nov 19;11(11). doi: 10.3390/brainsci11111536.

A difficulty in encoding spatial information in an egocentric (i.e., body-to-object) and especially allocentric (i.e., object-to-object) manner, and impairments in executive function (EF) are typical in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Since executive functions are...

Showing 1 to 12 of 24 entries