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Showing 1 to 12 of 418 entries
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Coexistence of adenomyosis uteri and endometrial cancer is associated with an improved prognosis compared with endometrial cancer only.

Oncology letters

Hertlein L, Rath J, Zeder-Göss C, Fürst S, Bayer D, Trillsch F, Mahner S, Burges A, Jeschke U.
PMID: 28927080
Oncol Lett. 2017 Sep;14(3):3302-3308. doi: 10.3892/ol.2017.6592. Epub 2017 Jul 18.

The present study aimed to identify differences in protein expression in cases of endometrioid endometrial cancer (EEC) with and without coexisting adenomyosis uteri (AM), and to evaluate the histopathological and prognostic distinctions. The total cohort included 22 patients in...

Changes in the Microenvironment of Nitroxide Radicals around the Glass Transition Temperature.

The journal of physical chemistry. B

Bordignon E, Nalepa AI, Savitsky A, Braun L, Jeschke G.
PMID: 26266707
J Phys Chem B. 2015 Oct 29;119(43):13797-806. doi: 10.1021/acs.jpcb.5b04104. Epub 2015 Aug 20.

For structural characterization by pulsed EPR methods, spin-labeled macromolecules are routinely studied at cryogenic temperatures. The equilibration of the conformational ensemble during shock-freezing occurs to a good approximation at the glass transition temperature (Tg). In this work, we used...

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Journal of clinical and translational research

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.
PMID: 26722668
J Clin Transl Res. 2015;1(2):100-106. doi: 10.18053/jctres.201502.004. Epub 2015 Sep 30.

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology...

Copper ESEEM and HYSCORE through ultra-wideband chirp EPR spectroscopy.

The Journal of chemical physics

Segawa TF, Doll A, Pribitzer S, Jeschke G.
PMID: 26233121
J Chem Phys. 2015 Jul 28;143(4):044201. doi: 10.1063/1.4927088.

The main limitation of pulse electron paramagnetic resonance (EPR) spectroscopy is its narrow excitation bandwidth. Ultra-wideband (UWB) excitation with frequency-swept chirp pulses over several hundreds of megahertz overcomes this drawback. This allows to excite electron spin echo envelope modulation...

The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis.

Obesity science & practice

Kalani A, Bami H, Tiboni M, Jaeschke R, Adachi JD, Lau AN.
PMID: 29071108
Obes Sci Pract. 2017 Jun 27;3(3):319-332. doi: 10.1002/osp4.113. eCollection 2017 Sep.

BACKGROUND: Concerns have emerged about post-operative decreases in calcium and vitamin D following bariatric surgery. This review explores changes in metabolic bone health in persons with obesity undergoing gastric bypass surgery compared to non-surgical controls, providing an updated and...

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.

Journal of clinical and translational research

Ramachandran A, Jaeschke H.
PMID: 28670625
J Clin Transl Res. 2017 Feb;3:157-169. doi: 10.18053/jctres.03.2017S1.002. Epub 2017 Feb 12.

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation. Studies in the mouse model, which closely...

Characterization of Protein Conformational Changes with Sparse Spin-Label Distance Constraints.

Journal of chemical theory and computation

Jeschke G.
PMID: 26593026
J Chem Theory Comput. 2012 Oct 09;8(10):3854-63. doi: 10.1021/ct300113z. Epub 2012 May 03.

The combination of site-directed spin labeling with pulse EPR distance measurements can provide a moderate number of distance constraints on the nanometer length scale for proteins in different states. By adapting an existing algorithm (Zheng, W.; Brooks, B. R....

Detection of Circulating Tumour Cells from Blood of Breast Cancer Patients via RT-qPCR.

Cancers

Andergassen U, Kölbl AC, Hutter S, Friese K, Jeschke U.
PMID: 24202442
Cancers (Basel). 2013 Sep 25;5(4):1212-20. doi: 10.3390/cancers5041212.

Breast cancer is still the most frequent cause of cancer-related death in women worldwide. Often death is not caused only by the primary tumour itself, but also by metastatic lesions. Today it is largely accepted, that these remote metastases...

Artefact suppression in 5-pulse double electron electron resonance for distance distribution measurements.

Physical chemistry chemical physics : PCCP

Breitgoff FD, Soetbeer J, Doll A, Jeschke G, Polyhach YO.
PMID: 28590496
Phys Chem Chem Phys. 2017 Jun 21;19(24):15766-15779. doi: 10.1039/c7cp01488k.

A 5-pulse version of the Double Electron Electron Resonance (DEER) experiment with Carr-Purcell delays and an additional pump pulse has been shown to significantly extend the experimentally accessible distance range in cases where nuclear spin diffusion dominates electron spin...

History of metabolic treatments in burn care.

Wounds : a compendium of clinical research and practice

Al-Mousawi AM, Jeschke MG, Herndon DN.
PMID: 25942607
Wounds. 2008 Jul;20(7):185-91.

This article discusses the recent history of advances in burn care and increased understanding that have led to achievements in modulating the metabolic response following burn injury and significant improvements in patient outcomes. The authors describe the development of...

Large-Scale Point-Cloud Visualization through Localized Textured Surface Reconstruction.

IEEE transactions on visualization and computer graphics

Arikan M, Preiner R, Scheiblauer C, Jeschke S, Wimmer M.
PMID: 26357377
IEEE Trans Vis Comput Graph. 2014 Sep;20(9):1280-92. doi: 10.1109/TVCG.2014.2312011.

In this paper, we introduce a novel scene representation for the visualization of large-scale point clouds accompanied by a set of high-resolution photographs. Many real-world applications deal with very densely sampled point-cloud data, which are augmented with photographs that...

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.

Archives of toxicology

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Pereira IVA, Willebrords J, Yanguas SC, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M.
PMID: 28243680
Arch Toxicol. 2017 May;91(5):2263-2264. doi: 10.1007/s00204-016-1929-y.

No abstract available.

Showing 1 to 12 of 418 entries