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Showing 1 to 12 of 1403 entries
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Optimal Allocation of Gold Standard Testing under Constrained Availability: Application to Assessment of HIV Treatment Failure.

Journal of the American Statistical Association

Liu T, Hogan JW, Wang L, Zhang S, Kantor R.
PMID: 24672142
J Am Stat Assoc. 2013 Jan 01;108(504):1173-1188. doi: 10.1080/01621459.2013.810149.

The World Health Organization (WHO) guidelines for monitoring the effectiveness of HIV treatment in resource-limited settings (RLS) are mostly based on clinical and immunological markers (e.g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can...

The Biochemical Cascades of the Human Pancreatic .

Journal of bioanalysis & biomedicine

Kim JW, Luo JZ, Luo L.
PMID: 28503255
J Bioanal Biomed. 2015 Dec;7(6). doi: 10.4172/1948-593X.1000e133. Epub 2015 Dec 11.

Diabetes mellitus is a disease that poses a burden to the health care system due to its prevalence and chronic nature. Understanding β cell pathophysiology may lead to future therapeutic options for diabetes mellitus type 1 and 2. MicroRNAs...

Copper-Catalyzed Borylative Cross-Coupling of Allenes and Imines: Selective Three-Component Assembly of Branched Homoallyl Amines.

Angewandte Chemie (International ed. in English)

Rae J, Yeung K, McDouall JJ, Procter DJ.
PMID: 26632675
Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1102-7. doi: 10.1002/anie.201508959. Epub 2015 Dec 03.

A copper-catalyzed three-component coupling of allenes, bis(pinacolato)diboron, and imines allows regio-, chemo-, and diastereoselective assembly of branched α,β-substituted-γ-boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α-substituted-β-amino ketones....

Quantum spin dynamics and entanglement generation with hundreds of trapped ions.

Science (New York, N.Y.)

Bohnet JG, Sawyer BC, Britton JW, Wall ML, Rey AM, Foss-Feig M, Bollinger JJ.
PMID: 27284189
Science. 2016 Jun 10;352(6291):1297-301. doi: 10.1126/science.aad9958.

Quantum simulation of spin models can provide insight into problems that are difficult or impossible to study with classical computers. Trapped ions are an established platform for quantum simulation, but only systems with fewer than 20 ions have demonstrated...

Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits.

Frontiers in molecular neuroscience

Dixon CL, Zhang Y, Lynch JW.
PMID: 26778954
Front Mol Neurosci. 2015 Dec 23;8:80. doi: 10.3389/fnmol.2015.00080. eCollection 2015.

Fast inhibitory neurotransmission in the brain is mediated by wide range of GABAA receptor (GABAAR) and glycine receptor (GlyR) isoforms, each with different physiological and pharmacological properties. Because multiple isoforms are expressed simultaneously in most neurons, it is difficult...

The perceptual processing of fused multi-spectral imagery.

Cognitive research: principles and implications

Fox EL, Houpt JW.
PMID: 28180181
Cogn Res Princ Implic. 2016;1(1):31. doi: 10.1186/s41235-016-0030-7. Epub 2016 Dec 19.

Multi-spectral imagery can enhance decision-making by supplying multiple complementary sources of information. However, overloading an observer with information can deter decision-making. Hence, it is critical to assess multi-spectral image displays using human performance. Accuracy and response times (RTs) are...

Continuous Hydrologic and Water Quality Monitoring of Vernal Ponds.

Journal of visualized experiments : JoVE

Mina O, Gall HE, Chandler JW, Harper J, Taylor M.
PMID: 29155765
J Vis Exp. 2017 Nov 13;(129). doi: 10.3791/56466.

Vernal ponds, also referred to as vernal pools, provide critical ecosystem services and habitat for a variety of threatened and endangered species. However, they are vulnerable parts of the landscapes that are often poorly understood and understudied. Land use...

Luminescent Quadrupolar Borazine Oligomers: Synthesis, Photophysics, and Two-Photon Absorption Properties.

Chemistry (Weinheim an der Bergstrasse, Germany)

Chen P, Marshall AS, Chi SH, Yin X, Perry JW, Jäkle F.
PMID: 26514664
Chemistry. 2015 Dec 07;21(50):18237-47. doi: 10.1002/chem.201502268. Epub 2015 Oct 30.

A set of monodisperse bent donor-acceptor-donor-type conjugated borazine oligomers, BnNn+1 (n=1-4), incorporating electron-rich triarylamine donor and electron-deficient triarylborane acceptor units has been prepared through an iterative synthetic approach that takes advantage of highly selective silicon-boron and tin-boron exchange reactions....

Do Protective Behavioral Strategies Mediate the Effect of Preparty Motives on Event-Level Preparty Alcohol Use?.

Substance use & misuse

Montes KS, LaBrie JW, Froidevaux NM.
PMID: 27077727
Subst Use Misuse. 2016 Jul 02;51(8):1047-55. doi: 10.3109/10826084.2016.1152495. Epub 2016 Apr 14.

BACKGROUND: Research suggests that protective behavioral strategies (PBS) serve as one mechanism through which drinking motives can influence alcohol use. Whether these findings generalize to preparty drinking has yet to be examined.OBJECTIVES: The current study attempts to fill this...

Combined Electron-Diffraction and Spectroscopic Determination of the Structure of Spiropentane, C.

The journal of physical chemistry. A

Sandwisch JW, Erickson BA, Hedberg K, Nibler JW.
PMID: 28609622
J Phys Chem A. 2017 Jul 06;121(26):4923-4929. doi: 10.1021/acs.jpca.7b04450. Epub 2017 Jun 26.

Gas-phase electron-diffraction (GED) data have been combined with recent spectroscopic rotational constants to determine the r

A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases.

Frontiers in endocrinology

Wright JW, Kawas LH, Harding JW.
PMID: 24298267
Front Endocrinol (Lausanne). 2013 Oct 25;4:158. doi: 10.3389/fendo.2013.00158.

The brain renin-angiotensin system (RAS) has available the necessary functional components to produce the active ligands angiotensins II (AngII), angiotensin III, angiotensins (IV), angiotensin (1-7), and angiotensin (3-7). These ligands interact with several receptor proteins including AT1, AT2, AT4,...

Mechanistic insights into the Pd-catalyzed direct amination of allyl alcohols: evidence for an outer-sphere mechanism involving a palladium hydride intermediate.

Chemistry (Weinheim an der Bergstrasse, Germany)

Sawadjoon S, Sjöberg PJ, Orthaber A, Matsson O, Samec JS.
PMID: 24403056
Chemistry. 2014 Feb 03;20(6):1520-4. doi: 10.1002/chem.201303431. Epub 2014 Jan 08.

The mechanism of direct amination of allyl alcohol by a palladium triphenylphosphite complex has been explored. Labelling studies show that the reaction proceeds through a π-allylpalladium intermediate. A second-order dependence of reaction rate on allyl alcohol concentration was observed....

Showing 1 to 12 of 1403 entries