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Showing 1 to 12 of 74 entries
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Protective role of .

Toxicology reports

Purena R, Seth R, Bhatt R.
PMID: 29487802
Toxicol Rep. 2018 Feb 03;5:270-277. doi: 10.1016/j.toxrep.2018.01.008. eCollection 2018.

Nephrotoxicity is a major limiting factor in cisplatin treatment. In the present study hydro-ethanolic leaf extract of

Molecular Dynamics Simulations of Nucleic Acids. From Tetranucleotides to the Ribosome.

The journal of physical chemistry letters

Šponer J, Banáš P, Jurečka P, Zgarbová M, Kührová P, Havrila M, Krepl M, Stadlbauer P, Otyepka M.
PMID: 26270382
J Phys Chem Lett. 2014 May 15;5(10):1771-82. doi: 10.1021/jz500557y. Epub 2014 May 07.

We present a brief overview of explicit solvent molecular dynamics (MD) simulations of nucleic acids. We explain physical chemistry limitations of the simulations, namely, the molecular mechanics (MM) force field (FF) approximation and limited time scale. Further, we discuss...

Genetic characterization of cassava (Manihot esculenta) landraces in Brazil assessed with simple sequence repeats.

Genetics and molecular biology

Siqueira MV, Queiroz-Silva JR, Bressan EA, Borges A, Pereira KJ, Pinto JG, Veasey EA.
PMID: 21637653
Genet Mol Biol. 2009 Jan;32(1):104-10. doi: 10.1590/S1415-47572009005000010. Epub 2009 Jan 17.

Based on nine microsatellite loci, the aim of this study was to appraise the genetic diversity of 42 cassava (Manihot esculenta) landraces from selected regions in Brazil, and examine how this variety is distributed according to origin in several...

Refinement of the Cornell et al. Nucleic Acids Force Field Based on Reference Quantum Chemical Calculations of Glycosidic Torsion Profiles.

Journal of chemical theory and computation

Zgarbová M, Otyepka M, Sponer J, Mládek A, Banáš P, Cheatham TE, Jurečka P.
PMID: 21921995
J Chem Theory Comput. 2011 Sep 13;7(9):2886-2902. doi: 10.1021/ct200162x. Epub 2011 Aug 02.

We report a reparameterization of the glycosidic torsion χ of the Cornell et al. AMBER force field for RNA, χ(OL). The parameters remove destabilization of the anti region found in the ff99 force field and thus prevent formation of...

A- to B-DNA Transition in AMBER Force Fields and Its Coupling to Sugar Pucker.

Journal of chemical theory and computation

Zgarbová M, Jurečka P, Šponer J, Otyepka M.
PMID: 29207232
J Chem Theory Comput. 2018 Jan 09;14(1):319-328. doi: 10.1021/acs.jctc.7b00926. Epub 2017 Dec 21.

The A/B transition is a basic element of DNA conformational change. Because of its involvement in the sensing of the ionic conditions by DNA and in specific protein-DNA interactions, this transition is important for biological functions of DNA. Therefore,...

Correlation of pacing site in right ventricle with paced QRS complex duration.

Indian pacing and electrophysiology journal

Gupta A, Parakh N, Bansal R, Verma SK, Roy A, Sharma G, Yadav R, Naik N, Juenja R, Bahl VK.
PMID: 30125639
Indian Pacing Electrophysiol J. 2018 Nov - Dec;18(6):210-216. doi: 10.1016/j.ipej.2018.08.001. Epub 2018 Aug 17.

BACKGROUND: Pacing from RV mid septum and outflow tract septum has been proposed as a more physiological site of pacing and narrower paced QRS complex duration. The paced QRS morphology and duration in different RV pacing sites is under...

Androgen receptor and soy isoflavones in prostate cancer.

Molecular and clinical oncology

Sivoňová MK, Kaplán P, Tatarková Z, Lichardusová L, Dušenka R, Jurečeková J.
PMID: 30680195
Mol Clin Oncol. 2019 Feb;10(2):191-204. doi: 10.3892/mco.2018.1792. Epub 2018 Dec 11.

Androgens and androgen receptor (AR) play a critical role not only in normal prostate development, but also in prostate cancer. For that reason, androgen deprivation therapy (ADT) is the primary treatment for prostate cancer. However, the majority of patients...

Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis.

Pediatric rheumatology online journal

Heale LD, Houghton KM, Rezaei E, Baxter-Jones ADG, Tupper SM, Muhajarine N, Benseler SM, Boire G, Cabral DA, Campillo S, Chédeville G, Chetaille AL, Dancey P, Duffy C, Duffy KW, Ellsworth J, Guzman J, Huber AM, Jurencak R, Lang B, Laxer RM, Morishita K, Oen KG, Petty RE, Ramsey SE, Roth J, Schneider R, Scuccimarri R, Spiegel L, Stringer E, Tse SML, Tucker LB, Turvey SE, Yeung RSM, Rosenberg AM.
PMID: 34187498
Pediatr Rheumatol Online J. 2021 Jun 29;19(1):97. doi: 10.1186/s12969-021-00584-4.

BACKGROUND: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress...

The first comparative double-blind trial on efficacy and safety of ergotamine based five-component combination and sumatriptan in migraine without aura.

Hippokratia

Miljković S, Smajlović D, Tirić Campara M, Jurina R, Duranović Vinković L, Janković SM, Begović B, Ćeranić M.
PMID: 31213753
Hippokratia. 2018 Jan-Mar;22(1):17-22.

BACKGROUND: Dihydroergotamine or ergotamine are the most effective preparations for aborting acute attacks of migraine without aura.OBJECTIVE: The aim of our study was to compare the efficacy and safety of ergotamine based five-component drug combination and sumatriptan in the...

Sclerotherapy in the treatment of varicose veins : S2k guideline of the Deutsche Gesellschaft für Phlebologie (DGP) in cooperation with the following societies: DDG, DGA, DGG, BVP.

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

Rabe E, Breu FX, Flessenkämper I, Gerlach H, Guggenbichler S, Kahle B, Murena R, Reich-Schupke S, Schwarz T, Stücker M, Valesky E, Werth S, Pannier F.
PMID: 33252705
Hautarzt. 2020 Nov 30; doi: 10.1007/s00105-020-04705-0. Epub 2020 Nov 30.

No abstract available.

Sclerotherapy in the treatment of varicose veins : S2k guideline of the Deutsche Gesellschaft für Phlebologie (DGP) in cooperation with the following societies: DDG, DGA, DGG, BVP.

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

Rabe E, Breu FX, Flessenkämper I, Gerlach H, Guggenbichler S, Kahle B, Murena R, Reich-Schupke S, Schwarz T, Stücker M, Valesky E, Werth S, Pannier F.
PMID: 33252705
Hautarzt. 2021 Dec;72:23-36. doi: 10.1007/s00105-020-04705-0.

No abstract available.

Biomarkers for Drug Development in Propionic and Methylmalonic Acidemias.

Journal of inherited metabolic disease

Longo N, Sass JO, Jurecka A, Vockley J.
PMID: 35038174
J Inherit Metab Dis. 2022 Jan 17; doi: 10.1002/jimd.12478. Epub 2022 Jan 17.

There is an unmet need for the development and validation of biomarkers and surrogate endpoints for clinical trials in propionic acidemia (PA) and methylmalonic acidemia (MMA). This review examines the pathophysiology and clinical consequences of PA and MMA that...

Showing 1 to 12 of 74 entries