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(2)H- and(13)C-labeled amino acids generated by obligate methylotrophs Biosynthesis and MS monitoring.

Amino acids

Karnaukhova EN, Reshetova OS, Semenov SY, Skladnev DA, Tsygankov YD.
PMID: 24190786
Amino Acids. 1994 Jun;6(2):165-76. doi: 10.1007/BF00805844.

Biosynthetic preparation of(2)H- and(13)C- labeled amino acids was studied using a leucine-producing mutant of the obligate methylotroph,Methylobacillus flagellatum. The strain was cultivated in various media containing(13)C- or(2)H-analogs of methanol. The total protein from each experiment was subjected to acid...

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Karnaukhova EN, Reshetova OS, Semenov SY, et al. (2)H- and(13)C-labeled amino acids generated by obligate methylotrophs Biosynthesis and MS monitoring. Amino Acids. 1994;6(2):165-76doi: 10.1007/BF00805844.
Karnaukhova, E. N., Reshetova, O. S., Semenov, S. Y., Skladnev, D. A., & Tsygankov, Y. D. (1994). (2)H- and(13)C-labeled amino acids generated by obligate methylotrophs Biosynthesis and MS monitoring. Amino acids, 6(2), 165-76. https://doi.org/10.1007/BF00805844
Karnaukhova, E N, et al. "(2)H- and(13)C-labeled amino acids generated by obligate methylotrophs Biosynthesis and MS monitoring." Amino acids vol. 6,2 (1994): 165-76. doi: https://doi.org/10.1007/BF00805844
Karnaukhova EN, Reshetova OS, Semenov SY, Skladnev DA, Tsygankov YD. (2)H- and(13)C-labeled amino acids generated by obligate methylotrophs Biosynthesis and MS monitoring. Amino Acids. 1994 Jun;6(2):165-76. doi: 10.1007/BF00805844. PMID: 24190786.
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Characterization of heme binding to recombinant α1-microglobulin.

Frontiers in physiology

Karnaukhova E, Rutardottir S, Rajabi M, Wester Rosenlöf L, Alayash AI, Åkerström B.
PMID: 25538624
Front Physiol. 2014 Dec 04;5:465. doi: 10.3389/fphys.2014.00465. eCollection 2014.

BACKGROUND: Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work...

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Karnaukhova E, Rutardottir S, Rajabi M, et al. Characterization of heme binding to recombinant α1-microglobulin. Front Physiol. 2014;5:465doi: 10.3389/fphys.2014.00465.
Karnaukhova, E., Rutardottir, S., Rajabi, M., Wester Rosenlöf, L., Alayash, A. I., & Åkerström, B. (2014). Characterization of heme binding to recombinant α1-microglobulin. Frontiers in physiology, 5465. https://doi.org/10.3389/fphys.2014.00465
Karnaukhova, Elena, et al. "Characterization of heme binding to recombinant α1-microglobulin." Frontiers in physiology vol. 5 (2014): 465. doi: https://doi.org/10.3389/fphys.2014.00465
Karnaukhova E, Rutardottir S, Rajabi M, Wester Rosenlöf L, Alayash AI, Åkerström B. Characterization of heme binding to recombinant α1-microglobulin. Front Physiol. 2014 Dec 04;5:465. doi: 10.3389/fphys.2014.00465. eCollection 2014. PMID: 25538624; PMCID: PMC4255499.
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Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Dyachenko NV, Khoroshutin AV, Sotnikova YA, Karnoukhova VA, Tokarev SD, Anisimov AV, Fedorov YV, Fedorova OA.
PMID: 31657424
Photochem Photobiol Sci. 2019 Dec 01;18(12):2901-2911. doi: 10.1039/c9pp00289h. Epub 2019 Oct 28.

Photochemical oxidative cyclization of 2- and 3-thienylstilbenes (heterostilbenes) containing mono-, di- and trimethoxy groups in the benzene ring or heterocyclic fragment results in the formation of isomeric thieno-annelated polycyclic aromatic compounds demonstrating optical properties that differ from those of...

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Dyachenko NV, Khoroshutin AV, Sotnikova YA, et al. Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes. Photochem Photobiol Sci. 2019;18(12):2901-2911doi: 10.1039/c9pp00289h.
Dyachenko, N. V., Khoroshutin, A. V., Sotnikova, Y. A., Karnoukhova, V. A., Tokarev, S. D., Anisimov, A. V., Fedorov, Y. V., & Fedorova, O. A. (2019). Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 18(12), 2901-2911. https://doi.org/10.1039/c9pp00289h
Dyachenko, Natalia V, et al. "Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology vol. 18,12 (2019): 2901-2911. doi: https://doi.org/10.1039/c9pp00289h
Dyachenko NV, Khoroshutin AV, Sotnikova YA, Karnoukhova VA, Tokarev SD, Anisimov AV, Fedorov YV, Fedorova OA. Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes. Photochem Photobiol Sci. 2019 Dec 01;18(12):2901-2911. doi: 10.1039/c9pp00289h. Epub 2019 Oct 28. PMID: 31657424.
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A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes .

Organic & biomolecular chemistry

Kutasevich AV, Niktarov AS, Uvarova ES, Karnoukhova VA, Mityanov VS.
PMID: 34596641
Org Biomol Chem. 2021 Oct 27;19(41):8988-8998. doi: 10.1039/d1ob01441b.

A new synthetic approach for obtaining previously unknown bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes has been developed. It is based on 1,3-dipolar cycloaddition between 2-unsubstituted imidazole

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Kutasevich AV, Niktarov AS, Uvarova ES, et al. A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes . Org Biomol Chem. 2021;19(41):8988-8998doi: 10.1039/d1ob01441b.
Kutasevich, A. V., Niktarov, A. S., Uvarova, E. S., Karnoukhova, V. A., & Mityanov, V. S. (2021). A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes . Organic & biomolecular chemistry, 19(41), 8988-8998. https://doi.org/10.1039/d1ob01441b
Kutasevich, Anton V, et al. "A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes ." Organic & biomolecular chemistry vol. 19,41 (2021): 8988-8998. doi: https://doi.org/10.1039/d1ob01441b
Kutasevich AV, Niktarov AS, Uvarova ES, Karnoukhova VA, Mityanov VS. A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes . Org Biomol Chem. 2021 Oct 27;19(41):8988-8998. doi: 10.1039/d1ob01441b. PMID: 34596641.
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C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development.

Current medicinal chemistry

Karnaukhova E.
PMID: 34348603
Curr Med Chem. 2022;29(3):467-488. doi: 10.2174/0929867328666210804085636.

Human C1-Inhibitor (C1INH), also known as C1-esterase inhibitor, is an important multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of complement, contact, coagulation, and fibrinolytic systems. C1INH belongs to a superfamily of serine proteinase inhibitors (serpins)...

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Karnaukhova E. C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Curr Med Chem. 2022;29(3):467-488doi: 10.2174/0929867328666210804085636.
Karnaukhova, E. (2022). C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Current medicinal chemistry, 29(3), 467-488. https://doi.org/10.2174/0929867328666210804085636
Karnaukhova, Elena. "C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development." Current medicinal chemistry vol. 29,3 (2022): 467-488. doi: https://doi.org/10.2174/0929867328666210804085636
Karnaukhova E. C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Curr Med Chem. 2022;29(3):467-488. doi: 10.2174/0929867328666210804085636. PMID: 34348603.
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Diastereodivergent synthesis of dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties.

Organic & biomolecular chemistry

Izmest'ev AN, Gazieva GA, Karnoukhova VA, Kravchenko AN.
PMID: 32856678
Org Biomol Chem. 2020 Sep 21;18(35):6905-6911. doi: 10.1039/d0ob01628d. Epub 2020 Aug 28.

Highly diastereoselective methods for the synthesis of two different diastereomers of polynuclear dispiroheterocyclic compounds with five chiral centers comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties (dispiro[imidazo[4,5-e]thiazolo[2,3-c]-1,2,4-triazine-7,3'-pyrrolidine-2',3''-indoles]) have been developed on the basis of a dipolar cycloaddition of azomethine ylides to benzylidene...

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Izmest'ev AN, Gazieva GA, Karnoukhova VA, et al. Diastereodivergent synthesis of dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties. Org Biomol Chem. 2020;18(35):6905-6911doi: 10.1039/d0ob01628d.
Izmest'ev, A. N., Gazieva, G. A., Karnoukhova, V. A., & Kravchenko, A. N. (2020). Diastereodivergent synthesis of dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties. Organic & biomolecular chemistry, 18(35), 6905-6911. https://doi.org/10.1039/d0ob01628d
Izmest'ev, Alexei N, et al. "Diastereodivergent synthesis of dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties." Organic & biomolecular chemistry vol. 18,35 (2020): 6905-6911. doi: https://doi.org/10.1039/d0ob01628d
Izmest'ev AN, Gazieva GA, Karnoukhova VA, Kravchenko AN. Diastereodivergent synthesis of dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties. Org Biomol Chem. 2020 Sep 21;18(35):6905-6911. doi: 10.1039/d0ob01628d. Epub 2020 Aug 28. PMID: 32856678.
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An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy.

Beilstein journal of organic chemistry

Izmest'ev AN, Gazieva GA, Sigay NV, Serkov SA, Karnoukhova VA, Kachala VV, Shashkov AS, Zanin IE, Kravchenko AN, Makhova NN.
PMID: 28144290
Beilstein J Org Chem. 2016 Oct 24;12:2240-2249. doi: 10.3762/bjoc.12.216. eCollection 2016.

An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-

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Izmest'ev AN, Gazieva GA, Sigay NV, et al. An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy. Beilstein J Org Chem. 2016;12:2240-2249doi: 10.3762/bjoc.12.216.
Izmest'ev, A. N., Gazieva, G. A., Sigay, N. V., Serkov, S. A., Karnoukhova, V. A., Kachala, V. V., Shashkov, A. S., Zanin, I. E., Kravchenko, A. N., & Makhova, N. N. (2016). An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy. Beilstein journal of organic chemistry, 122240-2249. https://doi.org/10.3762/bjoc.12.216
Izmest'ev, Alexei N, et al. "An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy." Beilstein journal of organic chemistry vol. 12 (2016): 2240-2249. doi: https://doi.org/10.3762/bjoc.12.216
Izmest'ev AN, Gazieva GA, Sigay NV, Serkov SA, Karnoukhova VA, Kachala VV, Shashkov AS, Zanin IE, Kravchenko AN, Makhova NN. An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy. Beilstein J Org Chem. 2016 Oct 24;12:2240-2249. doi: 10.3762/bjoc.12.216. eCollection 2016. PMID: 28144290; PMCID: PMC5238633.
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[Application of theoretical group methods in the modeling of complex systems].

Biofizika

Karnaukhov AV, Karnaukhova EV.
PMID: 18954015
Biofizika. 2008 Sep-Oct;53(5):849-55.

It has been shown that theoretical group methods can be applied in studies of complex physical and biological systems in which the phenomenon of self-organization takes place. The problem of calculating the parameters of climatic sensitivity with allowance for...

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Karnaukhov AV, Karnaukhova EV. [Application of theoretical group methods in the modeling of complex systems]. Biofizika. 2008;53(5):849-55
Karnaukhov, A. V., & Karnaukhova, E. V. (2008). [Application of theoretical group methods in the modeling of complex systems]. Biofizika, 53(5), 849-55.
Karnaukhov, A V, and Karnaukhova, E V. "[Application of theoretical group methods in the modeling of complex systems]." Biofizika vol. 53,5 (2008): 849-55.
Karnaukhov AV, Karnaukhova EV. [Application of theoretical group methods in the modeling of complex systems]. Biofizika. 2008 Sep-Oct;53(5):849-55. Russian. PMID: 18954015.
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Multifragmentation induced by relativistic alpha projectiles.

Physical review letters

Avdeyev SP, Barth R, Bochkarev OV, Chulkov LV, Karcz W, Karnaukhov VA, Kuzmin EA, Kuznetsov WD, Lips V, Neubert W, Norbeck E, Oeschler H, Petrov LA.
PMID: 10055654
Phys Rev Lett. 1994 Mar 14;72(11):1604-1607. doi: 10.1103/PhysRevLett.72.1604.

No abstract available.

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Avdeyev SP, Barth R, Bochkarev OV, et al. Multifragmentation induced by relativistic alpha projectiles. Phys Rev Lett. 1994;72(11):1604-1607doi: 10.1103/PhysRevLett.72.1604.
Avdeyev, S. P., Barth, R., Bochkarev, O. V., Chulkov, L. V., Karcz, W., Karnaukhov, V. A., Kuzmin, E. A., Kuznetsov, W. D., Lips, V., Neubert, W., Norbeck, E., Oeschler, H., & Petrov, L. A. (1994). Multifragmentation induced by relativistic alpha projectiles. Physical review letters, 72(11), 1604-1607. https://doi.org/10.1103/PhysRevLett.72.1604
Avdeyev, et al. "Multifragmentation induced by relativistic alpha projectiles." Physical review letters vol. 72,11 (1994): 1604-1607. doi: https://doi.org/10.1103/PhysRevLett.72.1604
Avdeyev SP, Barth R, Bochkarev OV, Chulkov LV, Karcz W, Karnaukhov VA, Kuzmin EA, Kuznetsov WD, Lips V, Neubert W, Norbeck E, Oeschler H, Petrov LA. Multifragmentation induced by relativistic alpha projectiles. Phys Rev Lett. 1994 Mar 14;72(11):1604-1607. doi: 10.1103/PhysRevLett.72.1604. PMID: 10055654.
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C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development.

Current medicinal chemistry

Karnaukhova E.
PMID: 34348603
Curr Med Chem. 2021 Aug 03; doi: 10.2174/0929867328666210804085636. Epub 2021 Aug 03.

Human C1-Inhibitor (C1INH), also known as C1-esterase inhibitor, is an important multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of complement, contact, coagulation, and fibrinolytic systems. C1INH belongs to a superfamily of serine proteinase inhibitor (serpins)...

Cite
Karnaukhova E. C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Curr Med Chem. 2021;doi: 10.2174/0929867328666210804085636.
Karnaukhova, E. (2021). C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Current medicinal chemistry, . https://doi.org/10.2174/0929867328666210804085636
Karnaukhova, Elena. "C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development." Current medicinal chemistry vol. (2021). doi: https://doi.org/10.2174/0929867328666210804085636
Karnaukhova E. C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development. Curr Med Chem. 2021 Aug 03; doi: 10.2174/0929867328666210804085636. Epub 2021 Aug 03. PMID: 34348603.
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Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization.

Molecules (Basel, Switzerland)

Suponitsky KY, Fedyanin IV, Karnoukhova VA, Zalomlenkov VA, Gidaspov AA, Bakharev VV, Sheremetev AB.
PMID: 34946534
Molecules. 2021 Dec 09;26(24). doi: 10.3390/molecules26247452.

Co-crystallization is an elegant technique to tune the physical properties of crystalline solids. In the field of energetic materials, co-crystallization is currently playing an important role in the engineering of crystals with improved performance. Here, based on an analysis...

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Suponitsky KY, Fedyanin IV, Karnoukhova VA, et al. Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization. Molecules. 2021;26(24)doi: 10.3390/molecules26247452.
Suponitsky, K. Y., Fedyanin, I. V., Karnoukhova, V. A., Zalomlenkov, V. A., Gidaspov, A. A., Bakharev, V. V., & Sheremetev, A. B. (2021). Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization. Molecules (Basel, Switzerland), 26(24), . https://doi.org/10.3390/molecules26247452
Suponitsky, Kyrill Yu, et al. "Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization." Molecules (Basel, Switzerland) vol. 26,24 (2021). doi: https://doi.org/10.3390/molecules26247452
Suponitsky KY, Fedyanin IV, Karnoukhova VA, Zalomlenkov VA, Gidaspov AA, Bakharev VV, Sheremetev AB. Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization. Molecules. 2021 Dec 09;26(24). doi: 10.3390/molecules26247452. PMID: 34946534.
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Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).

Oncogenesis

Makhov P, Bychkov I, Faezov B, Deneka A, Kudinov A, Nicolas E, Brebion R, Avril E, Cai KQ, Kharin LV, Voloshin M, Frantsiyants E, Karnaukhov N, Kit OI, Topchu I, Fazliyeva R, Nikonova AS, Serebriiskii IG, Borghaei H, Edelman M, Dulaimi E, Golemis EA, Boumber Y.
PMID: 33723247
Oncogenesis. 2021 Mar 15;10(3):29. doi: 10.1038/s41389-021-00317-y.

Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression, and drives NSCLC metastasis. We evaluated the mechanism...

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Makhov P, Bychkov I, Faezov B, et al. Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Oncogenesis. 2021;10(3):29doi: 10.1038/s41389-021-00317-y.
Makhov, P., Bychkov, I., Faezov, B., Deneka, A., Kudinov, A., Nicolas, E., Brebion, R., Avril, E., Cai, K. Q., Kharin, L. V., Voloshin, M., Frantsiyants, E., Karnaukhov, N., Kit, O. I., Topchu, I., Fazliyeva, R., Nikonova, A. S., Serebriiskii, I. G., Borghaei, H., Edelman, M., Dulaimi, E., Golemis, E. A., & Boumber, Y. (2021). Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Oncogenesis, 10(3), 29. https://doi.org/10.1038/s41389-021-00317-y
Makhov, Petr, et al. "Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)." Oncogenesis vol. 10,3 (2021): 29. doi: https://doi.org/10.1038/s41389-021-00317-y
Makhov P, Bychkov I, Faezov B, Deneka A, Kudinov A, Nicolas E, Brebion R, Avril E, Cai KQ, Kharin LV, Voloshin M, Frantsiyants E, Karnaukhov N, Kit OI, Topchu I, Fazliyeva R, Nikonova AS, Serebriiskii IG, Borghaei H, Edelman M, Dulaimi E, Golemis EA, Boumber Y. Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Oncogenesis. 2021 Mar 15;10(3):29. doi: 10.1038/s41389-021-00317-y. PMID: 33723247; PMCID: PMC7961039.
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