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Showing 1 to 12 of 15 entries
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Protection of Penaeus monodon from Infection of White spot syndrome virus by DNA Construct Expressing Long Hairpin-RNA Against ICP11 Gene.

Indian journal of virology : an official organ of Indian Virological Society

Das R, Karthireddy S, Gireesh-Babu P, Reddy AK, Krishna G, Chaudhari A.
PMID: 23637487
Indian J Virol. 2010 Oct;21(2):95-102. doi: 10.1007/s13337-011-0024-5. Epub 2011 Mar 16.

A plasmid construct (pICP11-LH) was designed to constitutively express long-hairpin RNA (lhRNA) against icp11 gene, which is reportedly the most highly expressed gene of White spot syndrome virus (WSSV) and likely to have an important role in viral pathogenesis....

An unusual presentation of pulmonary epitheloid hemangioendothelioma.

Respiratory medicine case reports

Sugunaraj JP, Pedroso C, Kethireddy S, Mogri M.
PMID: 26744650
Respir Med Case Rep. 2015 Jun 04;16:38-40. doi: 10.1016/j.rmcr.2015.05.016. eCollection 2015.

Pulmonary epitheloid hemangioendothelioma (PEHE) is a rare, often incidentally diagnosed, endothelial tumor of the lung. We present a case of a young adult who presented with acute hypoxemic respiratory failure and severe pulmonary hypertension with subsequent imaging and tissue...

Epicardial Adipose Tissue and Renal Disease.

Journal of clinical medicine

Aeddula NR, Cheungpasitporn W, Thongprayoon C, Pathireddy S.
PMID: 30832377
J Clin Med. 2019 Mar 02;8(3). doi: 10.3390/jcm8030299.

Epicardial adipose tissue (EAT) is derived from splanchnic mesoderm, localized anatomically between the myocardium and pericardial visceral layer, and surrounds the coronary arteries. Being a metabolically active organ, EAT secretes numerous cytokines, which moderate cardiovascular morphology and function. Through...

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents.

BMC chemistry

Bommera RK, Kethireddy S, Govindapur RR, Eppakayala L.
PMID: 33947440
BMC Chem. 2021 May 04;15(1):30. doi: 10.1186/s13065-021-00757-y.

BACKGROUND: 1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,βRESULTS: A set of 1,2,4-oxadiazole linked 5-fluoruracil derivatives (7a-j) were synthesized and their structures were confirmed...

Rare but not beyond care: a young female with altered mental status and seizures.

Oxford medical case reports

Pathireddy S, Bose S, Baradhi K, Aeddula NR.
PMID: 31398723
Oxf Med Case Reports. 2019 Aug 01;2019(8). doi: 10.1093/omcr/omz072.

A 40-year-old Caucasian lady with focal crescentic glomerulonephritis (p-ANCA) demonstrated by kidney biopsy, was treated with intravenous pulse steroids followed by weekly outpatient rituximab infusions (375 mg/m2). Five days after the fourth and final rituximab infusion, she developed headaches,...

Integrated Digital Health System Tools to Support Decision Making and Treatment Preparation in CKD: The PREPARE NOW Study.

Kidney medicine

Green JA, Ephraim PL, Hill-Briggs F, Browne T, Strigo TS, Hauer CL, Yule C, Stametz RA, Littlewood D, Pendergast JF, Peskoe S, Clair Russell JS, Norfolk E, Bucaloiu ID, Kethireddy S, Davis D, dePrisco J, Malloy D, Fulmer S, Martin J, Schatell D, Tangri N, Sees A, Siegrist C, Breed J, Billet J, Hackenberg M, Bhavsar NA, Boulware LE.
PMID: 34401724
Kidney Med. 2021 May 24;3(4):565-575.e1. doi: 10.1016/j.xkme.2021.03.009. eCollection 2021.

RATIONALE & OBJECTIVE: Digital health system tools to support shared decision making and preparation for kidney replacement treatments for patients with chronic kidney disease (CKD) are needed.STUDY DESIGN: Descriptive study of the implementation of digital infrastructure to support a...

Early Detection of Septic Shock Onset Using Interpretable Machine Learners.

Journal of clinical medicine

Misra D, Avula V, Wolk DM, Farag HA, Li J, Mehta YB, Sandhu R, Karunakaran B, Kethireddy S, Zand R, Abedi V.
PMID: 33467539
J Clin Med. 2021 Jan 15;10(2). doi: 10.3390/jcm10020301.

BACKGROUND: Developing a decision support system based on advances in machine learning is one area for strategic innovation in healthcare. Predicting a patient's progression to septic shock is an active field of translational research. The goal of this study...

A boosting inspired personalized threshold method for sepsis screening.

Journal of applied statistics

Feng C, Griffin P, Kethireddy S, Mei Y.
PMID: 34113056
J Appl Stat. 2021;48(1):154-175. doi: 10.1080/02664763.2020.1716695. Epub 2020 Jan 23.

Sepsis is one of the biggest risks to patient safety, with a natural mortality rate between 25% and 50%. It is difficult to diagnose, and no validated standard for diagnosis currently exists. A commonly used scoring criteria is the...

Synthesis of 2-cyclopropyl-3-(5-aryl-1H-pyrazol-3-yl)-1,8-naphthyridine.

Organic and medicinal chemistry letters

Bucha M, Eppakayala L, Maringanti TC, Tharikoppula G, Kethireddy S.
PMID: 26548992
Org Med Chem Lett. 2014 Dec;4(1):16. doi: 10.1186/s13588-014-0016-8. Epub 2014 Dec 21.

BACKGROUND: 1,8-Naphthyridine derivatives have attracted considerable attention because the 1,8-naphthyridine skeleton is present in many compounds that have been isolated from natural substances, with various biological activities.FINDINGS: N,N-dimethoxy-N-methyl-1,8-naphthyridine-3-carboxamide (1) on reaction with Grignard reagent forms 2-methoxy-1,8-naphthyridine-3-carbaldehyde (2). Compound 2...

Fungicidal versus fungistatic therapy of invasive .

Mycology

Kumar A, Zarychanski R, Pisipati A, Kumar A, Kethireddy S, Bow EJ.
PMID: 30123667
Mycology. 2018 Jan 09;9(2):116-128. doi: 10.1080/21501203.2017.1421592. eCollection 2018.

The purpose of this study was to determine whether fungicidal versus fungistatic pharmacotherapy of invasive candidiasis/candidemia yields superior outcomes. Data sources included MEDLINE (1966-June 2017), EMBASE (1980-June 2017), PubMed (1966-June 2017), Global Health-Ovid (inception to June 2017), LILACS Virtual...

Intensive Care Unit Discharge Delay and In-Hospital Mortality.

Journal of intensive care medicine

Ofoma UR, Kethireddy S.
PMID: 30514156
J Intensive Care Med. 2018 Dec 04;885066618816673. doi: 10.1177/0885066618816673. Epub 2018 Dec 04.

No abstract available.

Severe Respiratory Alkalosis in Acute Ischemic Stroke: A Rare Presentation.

Cureus

Muppidi V, Kolli S, Dandu V, Pathireddy S, Meegada S.
PMID: 32454525
Cureus. 2020 Apr 20;12(4):e7747. doi: 10.7759/cureus.7747.

Respiratory alkalosis is a rare but severe complication of acute ischemic stroke (AIS). In ischemic stroke, respiratory alkalosis results from hyperventilation due to the effect of stroke on the respiratory center. We report a case of a young male...

Showing 1 to 12 of 15 entries