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Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus.

ISRN gastroenterology

Mizoshita T, Tanida S, Tsukamoto H, Ozeki K, Katano T, Ebi M, Mori Y, Kataoka H, Kamiya T, Joh T.
PMID: 23691335
ISRN Gastroenterol. 2013 Apr 09;2013:304894. doi: 10.1155/2013/304894. Print 2013.

Background. Tacrolimus (FK506) is effective for patients with ulcerative colitis (UC). However, there are few reports on tacrolimus therapy (TT) with respect to the relationship with endoscopic and clinicopathologic findings. Methods. Thirty patients with moderate/severe active UC refractory to...

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Mizoshita T, Tanida S, Tsukamoto H, et al. Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus. ISRN Gastroenterol. 2013;2013:304894doi: 10.1155/2013/304894.
Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Katano, T., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., & Joh, T. (2013). Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus. ISRN gastroenterology, 2013304894. https://doi.org/10.1155/2013/304894
Mizoshita, Tsutomu, et al. "Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus." ISRN gastroenterology vol. 2013 (2013): 304894. doi: https://doi.org/10.1155/2013/304894
Mizoshita T, Tanida S, Tsukamoto H, Ozeki K, Katano T, Ebi M, Mori Y, Kataoka H, Kamiya T, Joh T. Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus. ISRN Gastroenterol. 2013 Apr 09;2013:304894. doi: 10.1155/2013/304894. Print 2013. PMID: 23691335; PMCID: PMC3649514.
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Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement.

Frontiers in plant science

Katano M, Takahashi K, Hirano T, Kazama Y, Abe T, Tsukaya H, Ferjani A.
PMID: 26925070
Front Plant Sci. 2016 Feb 17;7:132. doi: 10.3389/fpls.2016.00132. eCollection 2016.

Efficient use of seed nutrient reserves is crucial for germination and establishment of plant seedlings. Mobilizing seed oil reserves in Arabidopsis involves β-oxidation, the glyoxylate cycle, and gluconeogenesis, which provide essential energy and the carbon skeletons needed to sustain...

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Katano M, Takahashi K, Hirano T, et al. Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement. Front Plant Sci. 2016;7:132doi: 10.3389/fpls.2016.00132.
Katano, M., Takahashi, K., Hirano, T., Kazama, Y., Abe, T., Tsukaya, H., & Ferjani, A. (2016). Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement. Frontiers in plant science, 7132. https://doi.org/10.3389/fpls.2016.00132
Katano, Mana, et al. "Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement." Frontiers in plant science vol. 7 (2016): 132. doi: https://doi.org/10.3389/fpls.2016.00132
Katano M, Takahashi K, Hirano T, Kazama Y, Abe T, Tsukaya H, Ferjani A. Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement. Front Plant Sci. 2016 Feb 17;7:132. doi: 10.3389/fpls.2016.00132. eCollection 2016. PMID: 26925070; PMCID: PMC4756126.
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The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke.

Frontiers in neurology

Ulm L, Hoffmann S, Nabavi D, Hermans M, Mackert BM, Hamilton F, Schmehl I, Jungehuelsing GJ, Montaner J, Bustamante A, Katan M, Hartmann A, Ebmeyer S, Dinter C, Wiemer JC, Hertel S, Meisel C, Anker SD, Meisel A.
PMID: 28484421
Front Neurol. 2017 Apr 24;8:153. doi: 10.3389/fneur.2017.00153. eCollection 2017.

BACKGROUND: Pneumonia is among the most common acute complications after stroke and is associated with poor long-term outcome. Biomarkers may help identifying stroke patients at high risk for developing stroke-associated pneumonia (SAP) and to guide early treatment.AIMS: This trial...

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Ulm L, Hoffmann S, Nabavi D, et al. The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke. Front Neurol. 2017;8:153doi: 10.3389/fneur.2017.00153.
Ulm, L., Hoffmann, S., Nabavi, D., Hermans, M., Mackert, B. M., Hamilton, F., Schmehl, I., Jungehuelsing, G. J., Montaner, J., Bustamante, A., Katan, M., Hartmann, A., Ebmeyer, S., Dinter, C., Wiemer, J. C., Hertel, S., Meisel, C., Anker, S. D., & Meisel, A. (2017). The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke. Frontiers in neurology, 8153. https://doi.org/10.3389/fneur.2017.00153
Ulm, Lena, et al. "The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke." Frontiers in neurology vol. 8 (2017): 153. doi: https://doi.org/10.3389/fneur.2017.00153
Ulm L, Hoffmann S, Nabavi D, Hermans M, Mackert BM, Hamilton F, Schmehl I, Jungehuelsing GJ, Montaner J, Bustamante A, Katan M, Hartmann A, Ebmeyer S, Dinter C, Wiemer JC, Hertel S, Meisel C, Anker SD, Meisel A. The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke. Front Neurol. 2017 Apr 24;8:153. doi: 10.3389/fneur.2017.00153. eCollection 2017. PMID: 28484421; PMCID: PMC5402305.
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Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging.

Journal of medical ultrasonics (2001)

Wen YL, Kudo M, Minami Y, Chung H, Suetomi Y, Onda H, Kitano M, Kawasaki T, Maekawa K.
PMID: 27278304
J Med Ultrason (2001). 2003 Sep;30(3):141-51. doi: 10.1007/BF02481219.

OBJECTIVE: To compare the effectiveness of contrast-enhanced Dynamic Flow imaging and contrast-enhanced power Doppler imaging using Levovist(®) as a microbubble contrast agent in evaluating intratumoral vascularity in hepatocellular carcinoma (HCC).MATERIALS AND METHODS: Twenty-nine patients with 54 hepatocellular carcinoma nodules...

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Wen YL, Kudo M, Minami Y, et al. Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. J Med Ultrason (2001). 2003;30(3):141-51doi: 10.1007/BF02481219.
Wen, Y. L., Kudo, M., Minami, Y., Chung, H., Suetomi, Y., Onda, H., Kitano, M., Kawasaki, T., & Maekawa, K. (2003). Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. Journal of medical ultrasonics (2001), 30(3), 141-51. https://doi.org/10.1007/BF02481219
Wen, Yan Ling, et al. "Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging." Journal of medical ultrasonics (2001) vol. 30,3 (2003): 141-51. doi: https://doi.org/10.1007/BF02481219
Wen YL, Kudo M, Minami Y, Chung H, Suetomi Y, Onda H, Kitano M, Kawasaki T, Maekawa K. Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. J Med Ultrason (2001). 2003 Sep;30(3):141-51. doi: 10.1007/BF02481219. PMID: 27278304.
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Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report.

Oncology letters

Fasano M, Fabozzi A, Giordano G, Venturini F, Aurilio G, Cantile F, Fabozzi T, Ricci V, Santabarbara G, Morgillo F, Ciardiello F, De Vita F.
PMID: 28356988
Oncol Lett. 2017 Feb;13(2):979-983. doi: 10.3892/ol.2016.5523. Epub 2016 Dec 20.

The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient...

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Fasano M, Fabozzi A, Giordano G, et al. Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report. Oncol Lett. 2016;13(2):979-983doi: 10.3892/ol.2016.5523.
Fasano, M., Fabozzi, A., Giordano, G., Venturini, F., Aurilio, G., Cantile, F., Fabozzi, T., Ricci, V., Santabarbara, G., Morgillo, F., Ciardiello, F., & De Vita, F. (2017). Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report. Oncology letters, 13(2), 979-983. https://doi.org/10.3892/ol.2016.5523
Fasano, Morena, et al. "Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report." Oncology letters vol. 13,2 (2017): 979-983. doi: https://doi.org/10.3892/ol.2016.5523
Fasano M, Fabozzi A, Giordano G, Venturini F, Aurilio G, Cantile F, Fabozzi T, Ricci V, Santabarbara G, Morgillo F, Ciardiello F, De Vita F. Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report. Oncol Lett. 2017 Feb;13(2):979-983. doi: 10.3892/ol.2016.5523. Epub 2016 Dec 20. PMID: 28356988; PMCID: PMC5351201.
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Carcinoid tumor of the extrahepatic bile duct: report of a case.

Clinical journal of gastroenterology

Yasuda T, Imai G, Takemoto M, Yamasaki M, Ishikawa H, Kitano M, Nakai T, Takeyama Y.
PMID: 26181459
Clin J Gastroenterol. 2013 Apr;6(2):177-87. doi: 10.1007/s12328-013-0373-2. Epub 2013 Mar 23.

We report a rare case of carcinoid tumor of the extrahepatic bile duct. A 69-year-old woman with a history of hyperthyroidism was diagnosed to have a tumor of the extrahepatic bile duct. Laparotomy, for presumed cholangiocarcinoma, revealed a 2.5-cm-long,...

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Yasuda T, Imai G, Takemoto M, et al. Carcinoid tumor of the extrahepatic bile duct: report of a case. Clin J Gastroenterol. 2013;6(2):177-87doi: 10.1007/s12328-013-0373-2.
Yasuda, T., Imai, G., Takemoto, M., Yamasaki, M., Ishikawa, H., Kitano, M., Nakai, T., & Takeyama, Y. (2013). Carcinoid tumor of the extrahepatic bile duct: report of a case. Clinical journal of gastroenterology, 6(2), 177-87. https://doi.org/10.1007/s12328-013-0373-2
Yasuda, Takeo, et al. "Carcinoid tumor of the extrahepatic bile duct: report of a case." Clinical journal of gastroenterology vol. 6,2 (2013): 177-87. doi: https://doi.org/10.1007/s12328-013-0373-2
Yasuda T, Imai G, Takemoto M, Yamasaki M, Ishikawa H, Kitano M, Nakai T, Takeyama Y. Carcinoid tumor of the extrahepatic bile duct: report of a case. Clin J Gastroenterol. 2013 Apr;6(2):177-87. doi: 10.1007/s12328-013-0373-2. Epub 2013 Mar 23. PMID: 26181459.
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Nonequilibrium molecular dynamics simulations of nanoconfined fluids at solid-liquid interfaces.

The Journal of chemical physics

Morciano M, Fasano M, Nold A, Braga C, Yatsyshin P, Sibley DN, Goddard BD, Chiavazzo E, Asinari P, Kalliadasis S.
PMID: 28668055
J Chem Phys. 2017 Jun 28;146(24):244507. doi: 10.1063/1.4986904.

We investigate the hydrodynamic properties of a Lennard-Jones fluid confined to a nanochannel using molecular dynamics simulations. For channels of different widths and hydrophilic-hydrophobic surface wetting properties, profiles of the fluid density, stress, and viscosity across the channel are...

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Morciano M, Fasano M, Nold A, et al. Nonequilibrium molecular dynamics simulations of nanoconfined fluids at solid-liquid interfaces. J Chem Phys. 2017;146(24):244507doi: 10.1063/1.4986904.
Morciano, M., Fasano, M., Nold, A., Braga, C., Yatsyshin, P., Sibley, D. N., Goddard, B. D., Chiavazzo, E., Asinari, P., & Kalliadasis, S. (2017). Nonequilibrium molecular dynamics simulations of nanoconfined fluids at solid-liquid interfaces. The Journal of chemical physics, 146(24), 244507. https://doi.org/10.1063/1.4986904
Morciano, M, et al. "Nonequilibrium molecular dynamics simulations of nanoconfined fluids at solid-liquid interfaces." The Journal of chemical physics vol. 146,24 (2017): 244507. doi: https://doi.org/10.1063/1.4986904
Morciano M, Fasano M, Nold A, Braga C, Yatsyshin P, Sibley DN, Goddard BD, Chiavazzo E, Asinari P, Kalliadasis S. Nonequilibrium molecular dynamics simulations of nanoconfined fluids at solid-liquid interfaces. J Chem Phys. 2017 Jun 28;146(24):244507. doi: 10.1063/1.4986904. PMID: 28668055.
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Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).

Scientific reports

Margineanu A, Chan JJ, Kelly DJ, Warren SC, Flatters D, Kumar S, Katan M, Dunsby CW, French PM.
PMID: 27654516
Sci Rep. 2016 Sep 22;6:33621. doi: 10.1038/srep33621.

No abstract available.

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Margineanu A, Chan JJ, Kelly DJ, et al. Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM). Sci Rep. 2016;6:33621doi: 10.1038/srep33621.
Margineanu, A., Chan, J. J., Kelly, D. J., Warren, S. C., Flatters, D., Kumar, S., Katan, M., Dunsby, C. W., & French, P. M. (2016). Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM). Scientific reports, 633621. https://doi.org/10.1038/srep33621
Margineanu, Anca, et al. "Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM)." Scientific reports vol. 6 (2016): 33621. doi: https://doi.org/10.1038/srep33621
Margineanu A, Chan JJ, Kelly DJ, Warren SC, Flatters D, Kumar S, Katan M, Dunsby CW, French PM. Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM). Sci Rep. 2016 Sep 22;6:33621. doi: 10.1038/srep33621. PMID: 27654516; PMCID: PMC5032009.
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Impact of a new medical network system on the efficiency of treatment for eating disorders in Japan: a retrospective observational study.

BioPsychoSocial medicine

Moriya J, Kayano M, Yoshiuchi K.
PMID: 29026437
Biopsychosoc Med. 2017 Oct 01;11:27. doi: 10.1186/s13030-017-0113-9. eCollection 2017.

BACKGROUND: In Japan, patients generally have free access to any hospital or clinic. This could lead to reduced efficiency in the treatment for eating disorders (EDs) because there are only a limited number of doctors who can treat ED...

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Moriya J, Kayano M, Yoshiuchi K. Impact of a new medical network system on the efficiency of treatment for eating disorders in Japan: a retrospective observational study. Biopsychosoc Med. 2017;11:27doi: 10.1186/s13030-017-0113-9.
Moriya, J., Kayano, M., & Yoshiuchi, K. (2017). Impact of a new medical network system on the efficiency of treatment for eating disorders in Japan: a retrospective observational study. BioPsychoSocial medicine, 1127. https://doi.org/10.1186/s13030-017-0113-9
Moriya, Junko, et al. "Impact of a new medical network system on the efficiency of treatment for eating disorders in Japan: a retrospective observational study." BioPsychoSocial medicine vol. 11 (2017): 27. doi: https://doi.org/10.1186/s13030-017-0113-9
Moriya J, Kayano M, Yoshiuchi K. Impact of a new medical network system on the efficiency of treatment for eating disorders in Japan: a retrospective observational study. Biopsychosoc Med. 2017 Oct 01;11:27. doi: 10.1186/s13030-017-0113-9. eCollection 2017. PMID: 29026437; PMCID: PMC5623064.
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Thermal transport across nanoparticle-fluid interfaces: the interplay of interfacial curvature and nanoparticle-fluid interactions.

Physical chemistry chemical physics : PCCP

Tascini AS, Armstrong J, Chiavazzo E, Fasano M, Asinari P, Bresme F.
PMID: 28083587
Phys Chem Chem Phys. 2017 Jan 25;19(4):3244-3253. doi: 10.1039/c6cp06403e.

We investigate the general dependence of the thermal transport across nanoparticle-fluid interfaces using molecular dynamics computations. We show that the thermal conductance depends strongly both on the wetting characteristics of the nanoparticle-fluid interface and on the nanoparticle size. Strong...

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Tascini AS, Armstrong J, Chiavazzo E, et al. Thermal transport across nanoparticle-fluid interfaces: the interplay of interfacial curvature and nanoparticle-fluid interactions. Phys Chem Chem Phys. 2017;19(4):3244-3253doi: 10.1039/c6cp06403e.
Tascini, A. S., Armstrong, J., Chiavazzo, E., Fasano, M., Asinari, P., & Bresme, F. (2017). Thermal transport across nanoparticle-fluid interfaces: the interplay of interfacial curvature and nanoparticle-fluid interactions. Physical chemistry chemical physics : PCCP, 19(4), 3244-3253. https://doi.org/10.1039/c6cp06403e
Tascini, Anna Sofia, et al. "Thermal transport across nanoparticle-fluid interfaces: the interplay of interfacial curvature and nanoparticle-fluid interactions." Physical chemistry chemical physics : PCCP vol. 19,4 (2017): 3244-3253. doi: https://doi.org/10.1039/c6cp06403e
Tascini AS, Armstrong J, Chiavazzo E, Fasano M, Asinari P, Bresme F. Thermal transport across nanoparticle-fluid interfaces: the interplay of interfacial curvature and nanoparticle-fluid interactions. Phys Chem Chem Phys. 2017 Jan 25;19(4):3244-3253. doi: 10.1039/c6cp06403e. PMID: 28083587.
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Intermediate-Spin Iron(III) Complexes Having a Redox-Noninnocent Macrocyclic Tetraamido Ligand.

Inorganic chemistry

Kojima T, Ogishima F, Nishibu T, Kotani H, Ishizuka T, Okajima T, Nozawa S, Shiota Y, Yoshizawa K, Ohtsu H, Kawano M, Shiga T, Oshio H.
PMID: 29547281
Inorg Chem. 2018 Aug 20;57(16):9683-9695. doi: 10.1021/acs.inorgchem.8b00037. Epub 2018 Mar 16.

An iron(III) complex having a dibenzotetraethyltetraamido macrocyclic ligand (DTTM

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Kojima T, Ogishima F, Nishibu T, et al. Intermediate-Spin Iron(III) Complexes Having a Redox-Noninnocent Macrocyclic Tetraamido Ligand. Inorg Chem. 2018;57(16):9683-9695doi: 10.1021/acs.inorgchem.8b00037.
Kojima, T., Ogishima, F., Nishibu, T., Kotani, H., Ishizuka, T., Okajima, T., Nozawa, S., Shiota, Y., Yoshizawa, K., Ohtsu, H., Kawano, M., Shiga, T., & Oshio, H. (2018). Intermediate-Spin Iron(III) Complexes Having a Redox-Noninnocent Macrocyclic Tetraamido Ligand. Inorganic chemistry, 57(16), 9683-9695. https://doi.org/10.1021/acs.inorgchem.8b00037
Kojima, Takahiko, et al. "Intermediate-Spin Iron(III) Complexes Having a Redox-Noninnocent Macrocyclic Tetraamido Ligand." Inorganic chemistry vol. 57,16 (2018): 9683-9695. doi: https://doi.org/10.1021/acs.inorgchem.8b00037
Kojima T, Ogishima F, Nishibu T, Kotani H, Ishizuka T, Okajima T, Nozawa S, Shiota Y, Yoshizawa K, Ohtsu H, Kawano M, Shiga T, Oshio H. Intermediate-Spin Iron(III) Complexes Having a Redox-Noninnocent Macrocyclic Tetraamido Ligand. Inorg Chem. 2018 Aug 20;57(16):9683-9695. doi: 10.1021/acs.inorgchem.8b00037. Epub 2018 Mar 16. PMID: 29547281.
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MicroRNA 150-5p Improves Risk Classification for Mortality within 90 Days after Acute Ischemic Stroke.

Journal of stroke

Scherrer N, Fays F, Mueller B, Luft A, Fluri F, Christ-Crain M, Devaux Y, Katan M.
PMID: 29037006
J Stroke. 2017 Sep;19(3):323-332. doi: 10.5853/jos.2017.00423. Epub 2017 Sep 29.

BACKGROUND AND PURPOSE: Micro ribonucleic acid-150-5p (miR-150-5p) regulates proinflammatory cytokines as well as vessel integrity. We evaluated the incremental prognostic value of logarithm (log) of miR-150-5p plasma levels after ischemic stroke.METHODS: In a prospective cohort study, levels of miR-150-5p...

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Scherrer N, Fays F, Mueller B, et al. MicroRNA 150-5p Improves Risk Classification for Mortality within 90 Days after Acute Ischemic Stroke. J Stroke. 2017;19(3):323-332doi: 10.5853/jos.2017.00423.
Scherrer, N., Fays, F., Mueller, B., Luft, A., Fluri, F., Christ-Crain, M., Devaux, Y., & Katan, M. (2017). MicroRNA 150-5p Improves Risk Classification for Mortality within 90 Days after Acute Ischemic Stroke. Journal of stroke, 19(3), 323-332. https://doi.org/10.5853/jos.2017.00423
Scherrer, Natalie, et al. "MicroRNA 150-5p Improves Risk Classification for Mortality within 90 Days after Acute Ischemic Stroke." Journal of stroke vol. 19,3 (2017): 323-332. doi: https://doi.org/10.5853/jos.2017.00423
Scherrer N, Fays F, Mueller B, Luft A, Fluri F, Christ-Crain M, Devaux Y, Katan M. MicroRNA 150-5p Improves Risk Classification for Mortality within 90 Days after Acute Ischemic Stroke. J Stroke. 2017 Sep;19(3):323-332. doi: 10.5853/jos.2017.00423. Epub 2017 Sep 29. PMID: 29037006; PMCID: PMC5647633.
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