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Showing 1 to 12 of 44 entries
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Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Nature

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.
PMID: 27706144
Nature. 2016 Dec 01;540(7631):150. doi: 10.1038/nature19851. Epub 2016 Oct 05.

No abstract available.

Patient-Funded Trials: Opportunity or Liability?.

Cell stem cell

Wenner DM, Kimmelman J, London AJ.
PMID: 26253199
Cell Stem Cell. 2015 Aug 06;17(2):135-7. doi: 10.1016/j.stem.2015.07.016.

Patient-funded trials (PFTs) are gaining traction as a means of accelerating clinical translation. However, such trials sidestep mechanisms that promote rigor, relevance, efficiency, and fairness. We recommend that funding bodies or research institutions establish mechanisms for merit review of...

Research in dental caries control.

The Journal of the Albert Einstein Medical Center, Philadelphia

KIMMELMAN BB, GROSSMAN B.
PMID: 13756004
J Albert Einstein Med Cent (Phila). 1961 Apr;9:102-5.

No abstract available.

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.

Cancer & metabolism

Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA.
PMID: 26462257
Cancer Metab. 2015 Oct 12;3:12. doi: 10.1186/s40170-015-0137-1. eCollection 2015.

BACKGROUND: Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferation. Enzymes involved in this pathway (GLS1 (mitochondrial glutaminase 1), GOT1 (cytoplasmic glutamate oxaloacetate transaminase 1),...

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

Stem cell reports

Lovell-Badge R, Anthony E, Barker RA, Bubela T, Brivanlou AH, Carpenter M, Charo RA, Clark A, Clayton E, Cong Y, Daley GQ, Fu J, Fujita M, Greenfield A, Goldman SA, Hill L, Hyun I, Isasi R, Kahn J, Kato K, Kim JS, Kimmelman J, Knoblich JA, Mathews D, Montserrat N, Mosher J, Munsie M, Nakauchi H, Naldini L, Naughton G, Niakan K, Ogbogu U, Pedersen R, Rivron N, Rooke H, Rossant J, Round J, Saitou M, Sipp D, Steffann J, Sugarman J, Surani A, Takahashi J, Tang F, Turner L, Zettler PJ, Zhai X.
PMID: 34048692
Stem Cell Reports. 2021 Jun 08;16(6):1398-1408. doi: 10.1016/j.stemcr.2021.05.012. Epub 2021 May 27.

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy...

Reply to 'Correcting the ASCO position on phase I clinical trials in cancer'.

Nature reviews. Clinical oncology

Kimmelman J.
PMID: 31857690
Nat Rev Clin Oncol. 2020 Feb;17(2):125-126. doi: 10.1038/s41571-019-0312-3.

No abstract available.

Response-Evaluating human trials: FDA's role.

Science (New York, N.Y.)

Shah SK, Kimmelman J, Lyerly AD, Lynch HF, Miller FG, Palacios R, Pardo CA, Zorrilla C.
PMID: 29930129
Science. 2018 Jun 22;360(6395):1308-1309. doi: 10.1126/science.aau0865. Epub 2018 Jun 21.

No abstract available.

The Role of Autophagy in Cancer.

Annual review of cancer biology

Santana-Codina N, Mancias JD, Kimmelman AC.
PMID: 31119201
Annu Rev Cancer Biol. 2017 Mar;1:19-39. doi: 10.1146/annurev-cancerbio-041816-122338.

Autophagy is a highly conserved and regulated process that targets proteins and damaged organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and cell survival. The role of autophagy in cancer is dynamic and depends, in part, on...

The Effect of Overdose Education and Naloxone Distribution: An Umbrella Review of Systematic Reviews.

American journal of public health

Razaghizad A, Windle SB, Filion KB, Gore G, Kudrina I, Paraskevopoulos E, Kimmelman J, Martel MO, Eisenberg MJ.
PMID: 34464184
Am J Public Health. 2021 Aug;111(8):1516-1517. doi: 10.2105/AJPH.2021.306306a.

No abstract available.

Author Correction: Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models.

Nature communications

Herter-Sprie GS, Korideck H, Christensen CL, Herter JM, Rhee K, Berbeco RI, Bennett DG, Akbay EA, Kozono D, Mak RH, Makrigiorgos GM, Kimmelman AC, Wong KK.
PMID: 32273495
Nat Commun. 2020 Apr 09;11(1):1835. doi: 10.1038/s41467-020-15348-z.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Clinical trials (London, England)

Kimmelman J.
PMID: 34738471
Clin Trials. 2021 Dec;18(6):645-646. doi: 10.1177/17407745211057186. Epub 2021 Nov 05.

No abstract available.

Metabolic Codependencies in the Tumor Microenvironment.

Cancer discovery

Dey P, Kimmelman AC, DePinho RA.
PMID: 33504580
Cancer Discov. 2021 May;11(5):1067-1081. doi: 10.1158/2159-8290.CD-20-1211. Epub 2021 Jan 27.

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This reprogramming is driven by the combined actions of oncogenic alterations in cancer cells and host cell factors acting on cancer cells in the tumor microenvironment. Cancer cell-intrinsic mechanisms activate...

Showing 1 to 12 of 44 entries