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Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.

ACS central science

Zimmerman MI, Hart KM, Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR.
PMID: 29296672
ACS Cent Sci. 2017 Dec 27;3(12):1311-1321. doi: 10.1021/acscentsci.7b00465. Epub 2017 Nov 21.

Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein's stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of relevant protein conformations and...

Cite
Zimmerman MI, Hart KM, Sibbald CA, et al. Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models. ACS Cent Sci. 2017;3(12):1311-1321doi: 10.1021/acscentsci.7b00465.
Zimmerman, M. I., Hart, K. M., Sibbald, C. A., Frederick, T. E., Jimah, J. R., Knoverek, C. R., Tolia, N. H., & Bowman, G. R. (2017). Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models. ACS central science, 3(12), 1311-1321. https://doi.org/10.1021/acscentsci.7b00465
Zimmerman, Maxwell I, et al. "Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models." ACS central science vol. 3,12 (2017): 1311-1321. doi: https://doi.org/10.1021/acscentsci.7b00465
Zimmerman MI, Hart KM, Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR. Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models. ACS Cent Sci. 2017 Dec 27;3(12):1311-1321. doi: 10.1021/acscentsci.7b00465. Epub 2017 Nov 21. PMID: 29296672; PMCID: PMC5746865.
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Opening of a cryptic pocket in β-lactamase increases penicillinase activity.

Proceedings of the National Academy of Sciences of the United States of America

Knoverek CR, Mallimadugula UL, Singh S, Rennella E, Frederick TE, Yuwen T, Raavicharla S, Kay LE, Bowman GR.
PMID: 34799442
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2106473118.

Understanding the functional role of protein-excited states has important implications in protein design and drug discovery. However, because these states are difficult to find and study, it is still unclear if excited states simply result from thermal fluctuations and...

Cite
Knoverek CR, Mallimadugula UL, Singh S, et al. Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proc Natl Acad Sci U S A. 2021;118(47)doi: 10.1073/pnas.2106473118.
Knoverek, C. R., Mallimadugula, U. L., Singh, S., Rennella, E., Frederick, T. E., Yuwen, T., Raavicharla, S., Kay, L. E., & Bowman, G. R. (2021). Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proceedings of the National Academy of Sciences of the United States of America, 118(47), . https://doi.org/10.1073/pnas.2106473118
Knoverek, Catherine R, et al. "Opening of a cryptic pocket in β-lactamase increases penicillinase activity." Proceedings of the National Academy of Sciences of the United States of America vol. 118,47 (2021). doi: https://doi.org/10.1073/pnas.2106473118
Knoverek CR, Mallimadugula UL, Singh S, Rennella E, Frederick TE, Yuwen T, Raavicharla S, Kay LE, Bowman GR. Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2106473118. PMID: 34799442; PMCID: PMC8617505.
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Showing 1 to 2 of 2 entries