Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 43 entries
Sorted by: Best Match Show Resources per page
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Cell host & microbe

Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešič M, Huttenhower C, Knip M, Xavier RJ.
PMID: 25662751
Cell Host Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 05.

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort...

Publisher Correction: Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Nature microbiology

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.
PMID: 30723264
Nat Microbiol. 2019 Mar;4(3):545. doi: 10.1038/s41564-019-0393-x.

In the version of this Article originally published, in the first sentence of the second paragraph of the Discussion section, the word "operingrationally" should have read "operationally". This has now been amended in all versions of the Article.

Neurological and Cognitive Performance After Childhood Encephalitis.

Frontiers in pediatrics

Pöyhönen H, Setänen S, Isaksson N, Nyman M, Nyman A, Peltola V, Lähdesmäki T.
PMID: 33889554
Front Pediatr. 2021 Apr 06;9:646684. doi: 10.3389/fped.2021.646684. eCollection 2021.

No abstract available.

LuxRep: a technical replicate-aware method for bisulfite sequencing data analysis.

BMC bioinformatics

Malonzo MH, Halla-Aho V, Konki M, Lund RJ, Lähdesmäki H.
PMID: 35030989
BMC Bioinformatics. 2022 Jan 14;23(1):41. doi: 10.1186/s12859-021-04546-1.

BACKGROUND: DNA methylation is commonly measured using bisulfite sequencing (BS-seq). The quality of a BS-seq library is measured by its bisulfite conversion efficiency. Libraries with low conversion rates are typically excluded from analysis resulting in reduced coverage and increased...

Using multi-step proposal distribution for improved MCMC convergence in Bayesian network structure learning.

EURASIP journal on bioinformatics & systems biology

Larjo A, Lähdesmäki H.
PMID: 28316611
EURASIP J Bioinform Syst Biol. 2015 Jun 20;2015:6. doi: 10.1186/s13637-015-0024-7. eCollection 2015 Dec.

Bayesian networks have become popular for modeling probabilistic relationships between entities. As their structure can also be given a causal interpretation about the studied system, they can be used to learn, for example, regulatory relationships of genes or proteins...

Influence of overjet and overbite on soft tissue profile in mature adults: A cross-sectional population study.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

Kanavakis G, Krooks L, Lähdesmäki R, Pirttiniemi P.
PMID: 30591167
Am J Orthod Dentofacial Orthop. 2019 Jan;155(1):57-63.e3. doi: 10.1016/j.ajodo.2018.02.015.

INTRODUCTION: The aim of this study was to explore the association of soft tissue profile and severity of overbite and overjet in a large adult population.METHODS: The study population consisted of 1630 adults (age, 46 years; 712 men, 919...

Corrigendum: Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature.

Frontiers in immunology

Kelkka T, Savola P, Bhattacharya D, Huuhtanen J, Lönnberg T, Kankainen M, Paalanen K, Tyster M, Lepistö M, Ellonen P, Smolander J, Eldfors S, Yadav B, Khan S, Koivuniemi R, Sjöwall C, Elo LL, Lähdesmäki H, Maeda Y, Nishikawa H, Leirisalo-Repo M, Sokka-Isler T, Mustjoki S.
PMID: 34135915
Front Immunol. 2021 May 31;12:710831. doi: 10.3389/fimmu.2021.710831. eCollection 2021.

[This corrects the article DOI: 10.3389/fimmu.2020.578848.].

Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis.

Genome medicine

Plichta DR, Somani J, Pichaud M, Wallace ZS, Fernandes AD, Perugino CA, Lähdesmäki H, Stone JH, Vlamakis H, Chung DC, Khanna D, Pillai S, Xavier RJ.
PMID: 33648559
Genome Med. 2021 Feb 28;13(1):35. doi: 10.1186/s13073-021-00853-7.

BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established...

Comparing Laparoscopic Elective Sigmoid Resection With Conservative Treatment in Improving Quality of Life of Patients With Diverticulitis: The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) Randomized Clinical Trial.

JAMA surgery

Santos A, Mentula P, Pinta T, Ismail S, Rautio T, Juusela R, Lähdesmäki A, Scheinin T, Sallinen V.
PMID: 33206182
JAMA Surg. 2021 Feb 01;156(2):129-136. doi: 10.1001/jamasurg.2020.5151.

IMPORTANCE: Diverticulitis has a tendency to recur and affect quality of life.OBJECTIVE: To assess whether sigmoid resection is superior to conservative treatment in improving quality of life of patients with recurrent, complicated, or persistent painful diverticulitis.DESIGN, SETTING, AND PARTICIPANTS:...

Infant and Child MRI: A Review of Scanning Procedures.

Frontiers in neuroscience

Copeland A, Silver E, Korja R, Lehtola SJ, Merisaari H, Saukko E, Sinisalo S, Saunavaara J, Lähdesmäki T, Parkkola R, Nolvi S, Karlsson L, Karlsson H, Tuulari JJ.
PMID: 34321992
Front Neurosci. 2021 Jul 12;15:666020. doi: 10.3389/fnins.2021.666020. eCollection 2021.

Magnetic resonance imaging (MRI) is a safe method to examine human brain. However, a typical MR scan is very sensitive to motion, and it requires the subject to lie still during the acquisition, which is a major challenge for...

Incisor Occlusion Affects Profile Shape Variation in Middle-Aged Adults.

Journal of clinical medicine

Kanavakis G, Silvola AS, Halazonetis D, Lähdesmäki R, Pirttiniemi P.
PMID: 33671163
J Clin Med. 2021 Feb 17;10(4). doi: 10.3390/jcm10040800.

BACKGROUND: The aim of this study was to assess the effect of overjet and overbite on profile shape in middle-aged individuals.METHODS: The study population comprised 1754 46-year-old individuals, members of the 1966 Northern Finland Birth Cohort. Their profile images...

Effect of taurine, GABA and glutamate on the distribution of Na(+) and K(+) ions between the isolated synaptosomes and incubation medium.

Neuroscience letters

Lähdesmäki P, Pajunen A.
PMID: 19604938
Neurosci Lett. 1977 Mar;4(3):167-70. doi: 10.1016/0304-3940(77)90132-x.

Isolated synaptosomes of calf brain cortex lost 90% of their original Na(+) content and 70% of their K(+) content during 30 min incubation in Na(+)- and K(+)-free iso-osmotic medium. Electrical stimulation, and 5 mmol/l of taurine or GABA significantly...

Showing 1 to 12 of 43 entries