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Creating Social Value via Undergraduate Design Thinking Course with K-12 STEM Education Outreach in Various Community Settings

K-12 STEM training

Hardy ET, Lam WA, Le JM.
GSID: xrcaP7YRA5wJ
ET Hardy, SI Fulmer, JM Le Doux, WA Lam - Biomedical Engineering …, 2022 - Springer

… STEM activities achieve the educational learning objectives?), we worked directly with hospital K-12 … following our state Department of Education K-12 educational assessment scale of 0…

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Hardy, E. T., Fulmer, S. I., Le Doux, J. M., & Lam, W. A. (2022). Creating Social Value via Undergraduate Design Thinking Course with K-12 STEM Education Outreach in Various Community Settings. Biomedical Engineering Education, 2(2), 253-263.
Hardy, Elaissa T., et al. "Creating Social Value via Undergraduate Design Thinking Course with K-12 STEM Education Outreach in Various Community Settings." Biomedical Engineering Education 2.2 (2022): 253-263.
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K-enriched WO3 nanobundles: high electrical conductivity and photocurrent with controlled polarity.

ACS applied materials & interfaces

Hu Z, Ji Z, Lim WW, Mukherjee B, Zhou C, Tok ES, Sow CH.
PMID: 23607498
ACS Appl Mater Interfaces. 2013 Jun 12;5(11):4731-8. doi: 10.1021/am303253p. Epub 2013 May 16.

Potassium ions are successfully intercalated into WO3 nanobundles with the integrity of the pseudo-orthorhombic structure remaining intact. The nanobundles display a 5-fold increase in the electrical conductivity. It changes from a value of 10(-4) Sm(-1) for pure WO3 to...

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Hu Z, Ji Z, Lim WW, et al. K-enriched WO3 nanobundles: high electrical conductivity and photocurrent with controlled polarity. ACS Appl Mater Interfaces. 2013;5(11):4731-8doi: 10.1021/am303253p.
Hu, Z., Ji, Z., Lim, W. W., Mukherjee, B., Zhou, C., Tok, E. S., & Sow, C. H. (2013). K-enriched WO3 nanobundles: high electrical conductivity and photocurrent with controlled polarity. ACS applied materials & interfaces, 5(11), 4731-8. https://doi.org/10.1021/am303253p
Hu, Zhibin, et al. "K-enriched WO3 nanobundles: high electrical conductivity and photocurrent with controlled polarity." ACS applied materials & interfaces vol. 5,11 (2013): 4731-8. doi: https://doi.org/10.1021/am303253p
Hu Z, Ji Z, Lim WW, Mukherjee B, Zhou C, Tok ES, Sow CH. K-enriched WO3 nanobundles: high electrical conductivity and photocurrent with controlled polarity. ACS Appl Mater Interfaces. 2013 Jun 12;5(11):4731-8. doi: 10.1021/am303253p. Epub 2013 May 16. PMID: 23607498.
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Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration.

Angewandte Chemie (International ed. in English)

Callingham M, Partridge BM, Lewis W, Lam HW.
PMID: 28980437
Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16352-16356. doi: 10.1002/anie.201709334. Epub 2017 Nov 24.

A chiral rhodium complex catalyzes the highly enantioselective coupling of arylboronic acids, 1,3-enynes, and imines to give homoallylic sulfamates. The key step is the generation of allylrhodium(I) species by alkenyl-to-allyl 1,4-rhodium(I) migration.

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Callingham M, Partridge BM, Lewis W, et al. Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angew Chem Int Ed Engl. 2017;56(51):16352-16356doi: 10.1002/anie.201709334.
Callingham, M., Partridge, B. M., Lewis, W., & Lam, H. W. (2017). Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angewandte Chemie (International ed. in English), 56(51), 16352-16356. https://doi.org/10.1002/anie.201709334
Callingham, Michael, et al. "Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration." Angewandte Chemie (International ed. in English) vol. 56,51 (2017): 16352-16356. doi: https://doi.org/10.1002/anie.201709334
Callingham M, Partridge BM, Lewis W, Lam HW. Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16352-16356. doi: 10.1002/anie.201709334. Epub 2017 Nov 24. PMID: 28980437; PMCID: PMC5765452.
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A telephone interview version of the middle childhood HOME Observation Measurement of the Environment.

Child: care, health and development

Lai WW, O'Mahony M, Mulligan A.
PMID: 26424127
Child Care Health Dev. 2015 Nov;41(6):1152-60. doi: 10.1111/cch.12281. Epub 2015 Sep 30.

BACKGROUND: The Home Observation Measurement of the Environment (HOME) is a 59-item observation and interview tool used to measure how suitable a child's home is for a child of his or her developmental age and has been used extensively...

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Lai WW, O'Mahony M, Mulligan A. A telephone interview version of the middle childhood HOME Observation Measurement of the Environment. Child Care Health Dev. 2015;41(6):1152-60doi: 10.1111/cch.12281.
Lai, W. W., O'Mahony, M., & Mulligan, A. (2015). A telephone interview version of the middle childhood HOME Observation Measurement of the Environment. Child: care, health and development, 41(6), 1152-60. https://doi.org/10.1111/cch.12281
Lai, W W, et al. "A telephone interview version of the middle childhood HOME Observation Measurement of the Environment." Child: care, health and development vol. 41,6 (2015): 1152-60. doi: https://doi.org/10.1111/cch.12281
Lai WW, O'Mahony M, Mulligan A. A telephone interview version of the middle childhood HOME Observation Measurement of the Environment. Child Care Health Dev. 2015 Nov;41(6):1152-60. doi: 10.1111/cch.12281. Epub 2015 Sep 30. PMID: 26424127.
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Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization.

Angewandte Chemie (International ed. in English)

Yap C, Lenagh-Snow GMJ, Karad SN, Lewis W, Diorazio LJ, Lam HW.
PMID: 28544752
Angew Chem Int Ed Engl. 2017 Jul 03;56(28):8216-8220. doi: 10.1002/anie.201703380. Epub 2017 Jun 12.

Enantioselective nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza- and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by...

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Yap C, Lenagh-Snow GMJ, Karad SN, et al. Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization. Angew Chem Int Ed Engl. 2017;56(28):8216-8220doi: 10.1002/anie.201703380.
Yap, C., Lenagh-Snow, G. M. J., Karad, S. N., Lewis, W., Diorazio, L. J., & Lam, H. W. (2017). Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization. Angewandte Chemie (International ed. in English), 56(28), 8216-8220. https://doi.org/10.1002/anie.201703380
Yap, Connor, et al. "Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization." Angewandte Chemie (International ed. in English) vol. 56,28 (2017): 8216-8220. doi: https://doi.org/10.1002/anie.201703380
Yap C, Lenagh-Snow GMJ, Karad SN, Lewis W, Diorazio LJ, Lam HW. Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization. Angew Chem Int Ed Engl. 2017 Jul 03;56(28):8216-8220. doi: 10.1002/anie.201703380. Epub 2017 Jun 12. PMID: 28544752; PMCID: PMC5499723.
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Functionalization of alkynes by a (salen)ruthenium(VI) nitrido complex.

Angewandte Chemie (International ed. in English)

Man WL, Xie J, Lo PK, Lam WW, Yiu SM, Lau KC, Lau TC.
PMID: 24962655
Angew Chem Int Ed Engl. 2014 Aug 04;53(32):8463-6. doi: 10.1002/anie.201404421. Epub 2014 Jun 24.

Exploring new reactivity of metal nitrides is of great interest because it can give insights to N2 fixation chemistry and provide new methods for nitrogenation of organic substrates. In this work, reaction of a (salen)ruthenium(VI) nitrido complex with various...

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Man WL, Xie J, Lo PK, et al. Functionalization of alkynes by a (salen)ruthenium(VI) nitrido complex. Angew Chem Int Ed Engl. 2014;53(32):8463-6doi: 10.1002/anie.201404421.
Man, W. L., Xie, J., Lo, P. K., Lam, W. W., Yiu, S. M., Lau, K. C., & Lau, T. C. (2014). Functionalization of alkynes by a (salen)ruthenium(VI) nitrido complex. Angewandte Chemie (International ed. in English), 53(32), 8463-6. https://doi.org/10.1002/anie.201404421
Man, Wai-Lun, et al. "Functionalization of alkynes by a (salen)ruthenium(VI) nitrido complex." Angewandte Chemie (International ed. in English) vol. 53,32 (2014): 8463-6. doi: https://doi.org/10.1002/anie.201404421
Man WL, Xie J, Lo PK, Lam WW, Yiu SM, Lau KC, Lau TC. Functionalization of alkynes by a (salen)ruthenium(VI) nitrido complex. Angew Chem Int Ed Engl. 2014 Aug 04;53(32):8463-6. doi: 10.1002/anie.201404421. Epub 2014 Jun 24. PMID: 24962655.
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Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration.

Angewandte Chemie (International ed. in English)

Partridge BM, Solana González J, Lam HW.
PMID: 24842318
Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6523-7. doi: 10.1002/anie.201403271. Epub 2014 May 19.

1,4-Metal migrations enable the remote functionalization of C-H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of...

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Partridge BM, Solana González J, Lam HW. Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration. Angew Chem Int Ed Engl. 2014;53(25):6523-7doi: 10.1002/anie.201403271.
Partridge, B. M., Solana González, J., & Lam, H. W. (2014). Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration. Angewandte Chemie (International ed. in English), 53(25), 6523-7. https://doi.org/10.1002/anie.201403271
Partridge, Benjamin M, et al. "Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration." Angewandte Chemie (International ed. in English) vol. 53,25 (2014): 6523-7. doi: https://doi.org/10.1002/anie.201403271
Partridge BM, Solana González J, Lam HW. Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration. Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6523-7. doi: 10.1002/anie.201403271. Epub 2014 May 19. PMID: 24842318; PMCID: PMC4464530.
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Synthesis of spiroindanes by palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes involving C-H functionalization.

Chemical communications (Cambridge, England)

Khan I, Chidipudi SR, Lam HW.
PMID: 25571940
Chem Commun (Camb). 2015 Feb 14;51(13):2613-6. doi: 10.1039/c4cc09496d.

The synthesis of spiroindanes by the palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes with 2-aryl cyclic 1,3-dicarbonyl compounds is described. Examples of the dearomatizing oxidative annulation of 1,3-dienes with 1-aryl-2-naphthols are also presented.

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Khan I, Chidipudi SR, Lam HW. Synthesis of spiroindanes by palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes involving C-H functionalization. Chem Commun (Camb). 2015;51(13):2613-6doi: 10.1039/c4cc09496d.
Khan, I., Chidipudi, S. R., & Lam, H. W. (2015). Synthesis of spiroindanes by palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes involving C-H functionalization. Chemical communications (Cambridge, England), 51(13), 2613-6. https://doi.org/10.1039/c4cc09496d
Khan, Imtiaz, et al. "Synthesis of spiroindanes by palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes involving C-H functionalization." Chemical communications (Cambridge, England) vol. 51,13 (2015): 2613-6. doi: https://doi.org/10.1039/c4cc09496d
Khan I, Chidipudi SR, Lam HW. Synthesis of spiroindanes by palladium-catalyzed oxidative annulation of non- or weakly activated 1,3-dienes involving C-H functionalization. Chem Commun (Camb). 2015 Feb 14;51(13):2613-6. doi: 10.1039/c4cc09496d. PMID: 25571940.
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Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway.

Cell & bioscience

Lau SK, Lam CW, Curreem SO, Lee KC, Chow WN, Lau CC, Sridhar S, Wong SC, Martelli P, Hui SW, Yuen KY, Woo PC.
PMID: 26097677
Cell Biosci. 2015 Jun 02;5:26. doi: 10.1186/s13578-015-0018-x. eCollection 2015.

BACKGROUND: Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse. However, diagnosis of melioidosis can be difficult, especially in culture-negative cases. While metabolomics represents an uprising...

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Lau SK, Lam CW, Curreem SO, et al. Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway. Cell Biosci. 2015;5:26doi: 10.1186/s13578-015-0018-x.
Lau, S. K., Lam, C. W., Curreem, S. O., Lee, K. C., Chow, W. N., Lau, C. C., Sridhar, S., Wong, S. C., Martelli, P., Hui, S. W., Yuen, K. Y., & Woo, P. C. (2015). Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway. Cell & bioscience, 526. https://doi.org/10.1186/s13578-015-0018-x
Lau, Susanna K P, et al. "Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway." Cell & bioscience vol. 5 (2015): 26. doi: https://doi.org/10.1186/s13578-015-0018-x
Lau SK, Lam CW, Curreem SO, Lee KC, Chow WN, Lau CC, Sridhar S, Wong SC, Martelli P, Hui SW, Yuen KY, Woo PC. Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway. Cell Biosci. 2015 Jun 02;5:26. doi: 10.1186/s13578-015-0018-x. eCollection 2015. PMID: 26097677; PMCID: PMC4475313.
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Catalytic 1,4-rhodium(III) migration enables 1,3-enynes to function as one-carbon oxidative annulation partners in C-H functionalizations.

Angewandte Chemie (International ed. in English)

Burns DJ, Lam HW.
PMID: 25048465
Angew Chem Int Ed Engl. 2014 Sep 08;53(37):9931-5. doi: 10.1002/anie.201406072. Epub 2014 Jul 22.

1,3-Enynes containing allylic hydrogens cis to the alkyne are shown to act as one-carbon partners, rather than two-carbon partners, in various rhodium-catalyzed oxidative annulations. The mechanism of these unexpected transformations is proposed to occur through double C-H activation, involving...

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Burns DJ, Lam HW. Catalytic 1,4-rhodium(III) migration enables 1,3-enynes to function as one-carbon oxidative annulation partners in C-H functionalizations. Angew Chem Int Ed Engl. 2014;53(37):9931-5doi: 10.1002/anie.201406072.
Burns, D. J., & Lam, H. W. (2014). Catalytic 1,4-rhodium(III) migration enables 1,3-enynes to function as one-carbon oxidative annulation partners in C-H functionalizations. Angewandte Chemie (International ed. in English), 53(37), 9931-5. https://doi.org/10.1002/anie.201406072
Burns, David J, and Lam, Hon Wai. "Catalytic 1,4-rhodium(III) migration enables 1,3-enynes to function as one-carbon oxidative annulation partners in C-H functionalizations." Angewandte Chemie (International ed. in English) vol. 53,37 (2014): 9931-5. doi: https://doi.org/10.1002/anie.201406072
Burns DJ, Lam HW. Catalytic 1,4-rhodium(III) migration enables 1,3-enynes to function as one-carbon oxidative annulation partners in C-H functionalizations. Angew Chem Int Ed Engl. 2014 Sep 08;53(37):9931-5. doi: 10.1002/anie.201406072. Epub 2014 Jul 22. PMID: 25048465; PMCID: PMC4464529.
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Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong.

Clinical and translational medicine

Siu WK, Lam CW, Mak CM, Lau ET, Tang MH, Tang WF, Poon-Mak RS, Lee CC, Hung SF, Leung PW, Kwong KL, Yau EK, Ng GS, Fong NC, Chan KY.
PMID: 27271878
Clin Transl Med. 2016 Dec;5(1):18. doi: 10.1186/s40169-016-0098-1. Epub 2016 May 16.

BACKGROUND: Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum disorder (ASD). In this regard, diagnostic yield of array...

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Siu WK, Lam CW, Mak CM, et al. Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong. Clin Transl Med. 2016;5(1):18doi: 10.1186/s40169-016-0098-1.
Siu, W. K., Lam, C. W., Mak, C. M., Lau, E. T., Tang, M. H., Tang, W. F., Poon-Mak, R. S., Lee, C. C., Hung, S. F., Leung, P. W., Kwong, K. L., Yau, E. K., Ng, G. S., Fong, N. C., & Chan, K. Y. (2016). Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong. Clinical and translational medicine, 5(1), 18. https://doi.org/10.1186/s40169-016-0098-1
Siu, Wai-Kwan, et al. "Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong." Clinical and translational medicine vol. 5,1 (2016): 18. doi: https://doi.org/10.1186/s40169-016-0098-1
Siu WK, Lam CW, Mak CM, Lau ET, Tang MH, Tang WF, Poon-Mak RS, Lee CC, Hung SF, Leung PW, Kwong KL, Yau EK, Ng GS, Fong NC, Chan KY. Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong. Clin Transl Med. 2016 Dec;5(1):18. doi: 10.1186/s40169-016-0098-1. Epub 2016 May 16. PMID: 27271878; PMCID: PMC4896892.
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BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer.

Oncogenesis

Gong C, Yao S, Gomes AR, Man EP, Lee HJ, Gong G, Chang S, Kim SB, Fujino K, Kim SW, Park SK, Lee JW, Lee MH, Khoo US, Lam EW.
PMID: 27043660
Oncogenesis. 2016 Apr 04;5:e214. doi: 10.1038/oncsis.2016.23.

BRCA1 mutation or depletion correlates with basal-like phenotype and poor prognosis in breast cancer but the underlying reason remains elusive. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1 deficiency is associated with...

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Gong C, Yao S, Gomes AR, et al. BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer. Oncogenesis. 2016;5:e214doi: 10.1038/oncsis.2016.23.
Gong, C., Yao, S., Gomes, A. R., Man, E. P., Lee, H. J., Gong, G., Chang, S., Kim, S. B., Fujino, K., Kim, S. W., Park, S. K., Lee, J. W., Lee, M. H., Khoo, U. S., & Lam, E. W. (2016). BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer. Oncogenesis, 5e214. https://doi.org/10.1038/oncsis.2016.23
Gong, C, et al. "BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer." Oncogenesis vol. 5 (2016): e214. doi: https://doi.org/10.1038/oncsis.2016.23
Gong C, Yao S, Gomes AR, Man EP, Lee HJ, Gong G, Chang S, Kim SB, Fujino K, Kim SW, Park SK, Lee JW, Lee MH, Khoo US, Lam EW. BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer. Oncogenesis. 2016 Apr 04;5:e214. doi: 10.1038/oncsis.2016.23. PMID: 27043660; PMCID: PMC4848836.
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Showing 1 to 12 of 803 entries