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Showing 1 to 12 of 110 entries
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Target Identification of .

Frontiers in pharmacology

Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP.
PMID: 29018348
Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017.

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and...

Stability of Metacarpal II dimensions in boys during adolescence.

American journal of human biology : the official journal of the Human Biology Council

Beunen GP, Blimkie CJR, Lefevre J, Dequeker J, Verbiest M, Geukens M.
PMID: 28548261
Am J Hum Biol. 1994;6(4):445-450. doi: 10.1002/ajhb.1310060405.

The stability of radiogrammetrically determined Metacarpal II (M II) bone dimensions was determined in 184 Belgian boys between 13 and 18 years of age. Stability was assessed by Fisher z transformations of Pearson correlations between discrete measurement intervals and...

Neurocognition after paediatric heart surgery: a systematic review and meta-analysis.

Open heart

Sterken C, Lemiere J, Vanhorebeek I, Van den Berghe G, Mesotten D.
PMID: 26568832
Open Heart. 2015 Oct 29;2(1):e000255. doi: 10.1136/openhrt-2015-000255. eCollection 2015.

UNLABELLED: Children with congenital heart disease (CHD) often experience difficulties in academic and daily functioning, which have been associated with intelligence and neurocognitive skills, including executive functions (EFs), attention and memory. We report the neurocognitive data of children with...

Bullying and harassment of trainees: an unspoken emergency?.

Emergency medicine Australasia : EMA

Jamieson J, Mitchell R, Le Fevre J, Perry A.
PMID: 26289402
Emerg Med Australas. 2015 Oct;27(5):464-7. doi: 10.1111/1742-6723.12465. Epub 2015 Aug 20.

No abstract available.

Variance Reduction Using Nonreversible Langevin Samplers.

Journal of statistical physics

Duncan AB, Lelièvre T, Pavliotis GA.
PMID: 27453589
J Stat Phys. 2016;163:457-491. doi: 10.1007/s10955-016-1491-2. Epub 2016 Mar 22.

A standard approach to computing expectations with respect to a given target measure is to introduce an overdamped Langevin equation which is reversible with respect to the target distribution, and to approximate the expectation by a time-averaging estimator. As...

ADAPTIVE MULTILEVEL SPLITTING IN MOLECULAR DYNAMICS SIMULATIONS.

ESAIM. Proceedings and surveys

Aristoff D, Lelièvre T, Mayne CG, Teo I.
PMID: 26005670
ESAIM Proc Surv. 2015 Jan;48:215-225. doi: 10.1051/proc/201448009.

Adaptive Multilevel Splitting (AMS) is a replica-based rare event sampling method that has been used successfully in high-dimensional stochastic simulations to identify trajectories across a high potential barrier separating one metastable state from another, and to estimate the probability...

The Extended Generalized Adaptive Biasing Force Algorithm for Multidimensional Free-Energy Calculations.

Journal of chemical theory and computation

Zhao T, Fu H, Lelièvre T, Shao X, Chipot C, Cai W.
PMID: 28253446
J Chem Theory Comput. 2017 Apr 11;13(4):1566-1576. doi: 10.1021/acs.jctc.7b00032. Epub 2017 Mar 15.

Free-energy calculations in multiple dimensions constitute a challenging problem, owing to the significant computational cost incurred to achieve ergodic sampling. The generalized adaptive biasing force (gABF) algorithm calculates n one-dimensional lists of biasing forces to approximate the n-dimensional matrix...

Immunological Evidence for the Existence of a Carrier Protein for Sucrose Transport in Tonoplast Vesicles from Red Beet (Beta vulgaris L.) Root Storage Tissue.

Plant physiology

Getz HP, Grosclaude J, Kurkdjian A, Lelievre F, Maretzki A, Guern J.
PMID: 12231863
Plant Physiol. 1993 Jul;102(3):751-760. doi: 10.1104/pp.102.3.751.

Monoclonal antibodies were raised in mice against a highly purified tonoplast fraction from isolated red beet (Beta vulgaris L. ssp. conditiva) root vacuoles. Positive hybridoma clones and sub-clones were identified by prescreening using an enzyme-linked immunosorbent assay (ELISA) and...

Daily physical activity and physical fitness from adolescence to adulthood: A longitudinal study.

American journal of human biology : the official journal of the Human Biology Council

Lefevre J, Philippaerts RM, Delvaux K, Thomis M, Vanreusel B, Eynde BV, Claessens AL, Lysens R, Renson R, Beunen G.
PMID: 11534040
Am J Hum Biol. 2000 Jul;12(4):487-497. doi: 10.1002/1520-6300(200007/08)12:4<487::AID-AJHB8>3.0.CO;2-W.

The stability of physical fitness and physical activity in Flemish males from 18 to 40 years of age was investigated. In addition, effects of a consistently low-activity or high-activity level during the same age period on physical fitness were...

5'CATGCAT-3' Elements Modulate the Expression of Glycinin Genes.

Plant physiology

Lelievre JM, Oliveira LO, Nielsen NC.
PMID: 16668640
Plant Physiol. 1992 Jan;98(1):387-91. doi: 10.1104/pp.98.1.387.

Promoters of most seed proteins in legumes contain one or more 5'-CATGCAT-3' elements. To test if these elements have a function in the expression of these genes, the 2.3 kilobase pairs Gy2 glycinin promoter was ligated to a beta-glucuronidase...

HIV-1 triggers mitochondrion death.

Mitochondrion

Arnoult D, Viollet L, Petit F, Lelièvre JD, Estaquier J.
PMID: 16120390
Mitochondrion. 2004 Jul;4(2):255-69. doi: 10.1016/j.mito.2004.06.010.

Apoptosis, a phenotype of programmed cell death involved in development and tissue homeostasis of multicellular organisms, brings into two major pathways and implies a central sensor: the mitochondria. Abnormalities in the cell death control can lead to a variety...

Intrinsic selectivity in capillary electrophoresis for chiral separations with dual cyclodextrin systems.

Analytical chemistry

Lelièvre F, Gareil P, Bahaddi Y, Galons H.
PMID: 21639191
Anal Chem. 1997 Feb 01;69(3):393-401. doi: 10.1021/ac960607r.

Defined as the ratio of the affinity factors of the analytes for a complexing agent, the intrinsic selectivity is representative of the very nature of the complexing agent. When more than one complexing agent are present in the background...

Showing 1 to 12 of 110 entries