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Mugumbate G, Mendes V, Blaszczyk M, et al. Target Identification of . Front Pharmacol. 2017;8:681doi: 10.3389/fphar.2017.00681.
Mugumbate, G., Mendes, V., Blaszczyk, M., Sabbah, M., Papadatos, G., Lelievre, J., Ballell, L., Barros, D., Abell, C., Blundell, T. L., & Overington, J. P. (2017). Target Identification of . Frontiers in pharmacology, 8681. https://doi.org/10.3389/fphar.2017.00681
Mugumbate, Grace, et al. "Target Identification of ." Frontiers in pharmacology vol. 8 (2017): 681. doi: https://doi.org/10.3389/fphar.2017.00681
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of . Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017. PMID: 29018348; PMCID: PMC5623190.
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Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017.

Target Identification of .

Frontiers in pharmacology

Grace Mugumbate, Vitor Mendes, Michal Blaszczyk, Mohamad Sabbah, George Papadatos, Joel Lelievre, Lluis Ballell, David Barros, Chris Abell, Tom L Blundell, John P Overington

Affiliations

  1. European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom.
  2. Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
  3. Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
  4. Diseases of the Developing World, GlaxoSmithKline, Madrid, Spain.
  5. Medicines Discovery Catapult, Alderley Edge, United Kingdom.

PMID: 29018348 PMCID: PMC5623190 DOI: 10.3389/fphar.2017.00681

Abstract

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approaches followed by biophysical and biochemical validation have been used to identify targets for

Keywords: EthR; InhA; Mycobacterium tuberculosis; drug resistance; phenotypic hits; target identification

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