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Alzheimer's disease drug development pipeline: 2019

pipeline programs

Cummings J, Sabbagh M.
GSID: 7wsf4B2228IJ
J Cummings, G Lee, A Ritter, M Sabbagh… - Alzheimer's & Dementia …, 2019 - Elsevier

… Alzheimer's disease (AD) has few available treatments, and there is a high rate of failure in AD drug development programs. Study of the AD drug development pipeline can provide insight into the evolution of drug development and how...

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Cummings, J., Lee, G., Ritter, A., Sabbagh, M., & Zhong, K. (2019). Alzheimer's disease drug development pipeline: 2019. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5, 272-293.
Cummings, Jeffrey, et al. "Alzheimer's disease drug development pipeline: 2019." Alzheimer's & Dementia: Translational Research & Clinical Interventions 5 (2019): 272-293.
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Target Identification of .

Frontiers in pharmacology

Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP.
PMID: 29018348
Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017.

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and...

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Mugumbate G, Mendes V, Blaszczyk M, et al. Target Identification of . Front Pharmacol. 2017;8:681doi: 10.3389/fphar.2017.00681.
Mugumbate, G., Mendes, V., Blaszczyk, M., Sabbah, M., Papadatos, G., Lelievre, J., Ballell, L., Barros, D., Abell, C., Blundell, T. L., & Overington, J. P. (2017). Target Identification of . Frontiers in pharmacology, 8681. https://doi.org/10.3389/fphar.2017.00681
Mugumbate, Grace, et al. "Target Identification of ." Frontiers in pharmacology vol. 8 (2017): 681. doi: https://doi.org/10.3389/fphar.2017.00681
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of . Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017. PMID: 29018348; PMCID: PMC5623190.
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Reply.

Ophthalmology

Traber GL, Weber KP, Sabah M, Keane PA, Plant GT.
PMID: 28528843
Ophthalmology. 2017 Jun;124(6):e56. doi: 10.1016/j.ophtha.2017.01.008.

No abstract available.

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Traber GL, Weber KP, Sabah M, et al. Reply. Ophthalmology. 2017;124(6):e56doi: 10.1016/j.ophtha.2017.01.008.
Traber, G. L., Weber, K. P., Sabah, M., Keane, P. A., & Plant, G. T. (2017). Reply. Ophthalmology, 124(6), e56. https://doi.org/10.1016/j.ophtha.2017.01.008
Traber, Ghislaine L, et al. "Reply." Ophthalmology vol. 124,6 (2017): e56. doi: https://doi.org/10.1016/j.ophtha.2017.01.008
Traber GL, Weber KP, Sabah M, Keane PA, Plant GT. Reply. Ophthalmology. 2017 Jun;124(6):e56. doi: 10.1016/j.ophtha.2017.01.008. PMID: 28528843.
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Resonance Effects in Photoemission Time Delays.

Physical review letters

Sabbar M, Heuser S, Boge R, Lucchini M, Carette T, Lindroth E, Gallmann L, Cirelli C, Keller U.
PMID: 26451550
Phys Rev Lett. 2015 Sep 25;115(13):133001. doi: 10.1103/PhysRevLett.115.133001. Epub 2015 Sep 23.

We present measurements of single-photon ionization time delays between the outermost valence electrons of argon and neon using a coincidence detection technique that allows for the simultaneous measurement of both species under identical conditions. The analysis of the measured...

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Sabbar M, Heuser S, Boge R, et al. Resonance Effects in Photoemission Time Delays. Phys Rev Lett. 2015;115(13):133001doi: 10.1103/PhysRevLett.115.133001.
Sabbar, M., Heuser, S., Boge, R., Lucchini, M., Carette, T., Lindroth, E., Gallmann, L., Cirelli, C., & Keller, U. (2015). Resonance Effects in Photoemission Time Delays. Physical review letters, 115(13), 133001. https://doi.org/10.1103/PhysRevLett.115.133001
Sabbar, M, et al. "Resonance Effects in Photoemission Time Delays." Physical review letters vol. 115,13 (2015): 133001. doi: https://doi.org/10.1103/PhysRevLett.115.133001
Sabbar M, Heuser S, Boge R, Lucchini M, Carette T, Lindroth E, Gallmann L, Cirelli C, Keller U. Resonance Effects in Photoemission Time Delays. Phys Rev Lett. 2015 Sep 25;115(13):133001. doi: 10.1103/PhysRevLett.115.133001. Epub 2015 Sep 23. PMID: 26451550.
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Foreign service special care opportunity in SCDA.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

Hicks J, Schaffer R, Frances D, Usher S, Barnes J, Sabbah A.
PMID: 26250531
Spec Care Dentist. 2015 Sep;35(5):206-213. doi: 10.1111/scd.12128. Epub 2015 Aug 07.

A foreign service clinic in Guatemala caring for patients with special needs was initiated by joining SCDA efforts with the Open Wide Foundation. The trip included five SCDA members: two AEGD residents and three support staff. Open Wide participants...

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Hicks J, Schaffer R, Frances D, et al. Foreign service special care opportunity in SCDA. Spec Care Dentist. 2015;35(5):206-213doi: 10.1111/scd.12128.
Hicks, J., Schaffer, R., Frances, D., Usher, S., Barnes, J., & Sabbah, A. (2015). Foreign service special care opportunity in SCDA. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 35(5), 206-213. https://doi.org/10.1111/scd.12128
Hicks, Jeff, et al. "Foreign service special care opportunity in SCDA." Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry vol. 35,5 (2015): 206-213. doi: https://doi.org/10.1111/scd.12128
Hicks J, Schaffer R, Frances D, Usher S, Barnes J, Sabbah A. Foreign service special care opportunity in SCDA. Spec Care Dentist. 2015 Sep;35(5):206-213. doi: 10.1111/scd.12128. Epub 2015 Aug 07. PMID: 26250531.
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Light polarization under water near sunrise.

Journal of the Optical Society of America. A, Optics, image science, and vision

Sabbah S, Shashar N.
PMID: 17728829
J Opt Soc Am A Opt Image Sci Vis. 2007 Jul;24(7):2049-56. doi: 10.1364/josaa.24.002049.

Dramatic and rapid changes in the intensity and spectrum of light under water at dusk and dawn are well known, but reports regarding the light's polarization at these periods are sparse. Using a rapid spectropolarimeter, we examined the spatial...

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Sabbah S, Shashar N. Light polarization under water near sunrise. J Opt Soc Am A Opt Image Sci Vis. 2007;24(7):2049-56doi: 10.1364/josaa.24.002049.
Sabbah, S., & Shashar, N. (2007). Light polarization under water near sunrise. Journal of the Optical Society of America. A, Optics, image science, and vision, 24(7), 2049-56. https://doi.org/10.1364/josaa.24.002049
Sabbah, Shai, and Shashar, Nadav. "Light polarization under water near sunrise." Journal of the Optical Society of America. A, Optics, image science, and vision vol. 24,7 (2007): 2049-56. doi: https://doi.org/10.1364/josaa.24.002049
Sabbah S, Shashar N. Light polarization under water near sunrise. J Opt Soc Am A Opt Image Sci Vis. 2007 Jul;24(7):2049-56. doi: 10.1364/josaa.24.002049. PMID: 17728829.
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A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ.
PMID: 18631960
Alzheimers Dement. 2008 May;4(3):156-63. doi: 10.1016/j.jalz.2008.03.005.

No abstract available.

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Khachaturian ZS, Petersen RC, Gauthier S, et al. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008;4(3):156-63doi: 10.1016/j.jalz.2008.03.005.
Khachaturian, Z. S., Petersen, R. C., Gauthier, S., Buckholtz, N., Corey-Bloom, J. P., Evans, B., Fillit, H., Foster, N., Greenberg, B., Grundman, M., Sano, M., Simpkins, J., Schneider, L. S., Weiner, M. W., Galasko, D., Hyman, B., Kuller, L., Schenk, D., Snyder, S., Thomas, R. G., Tuszynski, M. H., Vellas, B., Wurtman, R. J., Snyder, P. J., Frank, R. A., Albert, M., Doody, R., Ferris, S., Kaye, J., Koo, E., Morrison-Bogorad, M., Reisberg, B., Salmon, D. P., Gilman, S., Mohs, R., Aisen, P. S., Breitner, J. C., Cummings, J. L., Kawas, C., Phelps, C., Poirier, J., Sabbagh, M., Touchon, J., Khachaturian, A. S., & Bain, L. J. (2008). A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimer's & dementia : the journal of the Alzheimer's Association, 4(3), 156-63. https://doi.org/10.1016/j.jalz.2008.03.005
Khachaturian, Zaven S, et al. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 4,3 (2008): 156-63. doi: https://doi.org/10.1016/j.jalz.2008.03.005
Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008 May;4(3):156-63. doi: 10.1016/j.jalz.2008.03.005. PMID: 18631960; PMCID: PMC2544623.
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The effects of coffee consumption on sleep and melatonin secretion.

Sleep medicine

Shilo L, Sabbah H, Hadari R, Kovatz S, Weinberg U, Dolev S, Dagan Y, Shenkman L.
PMID: 14592218
Sleep Med. 2002 May;3(3):271-3. doi: 10.1016/s1389-9457(02)00015-1.

BACKGROUND: In this study we examined the effects of caffeine on sleep quality and melatonin secretion. Melatonin is the principal hormone responsible for synchronization of sleep. Melatonin secretion is controlled by neurotransmitters that can be affected by caffeine.METHODS: In...

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Shilo L, Sabbah H, Hadari R, et al. The effects of coffee consumption on sleep and melatonin secretion. Sleep Med. 2002;3(3):271-3doi: 10.1016/s1389-9457(02)00015-1.
Shilo, L., Sabbah, H., Hadari, R., Kovatz, S., Weinberg, U., Dolev, S., Dagan, Y., & Shenkman, L. (2002). The effects of coffee consumption on sleep and melatonin secretion. Sleep medicine, 3(3), 271-3. https://doi.org/10.1016/s1389-9457(02)00015-1
Shilo, Lotan, et al. "The effects of coffee consumption on sleep and melatonin secretion." Sleep medicine vol. 3,3 (2002): 271-3. doi: https://doi.org/10.1016/s1389-9457(02)00015-1
Shilo L, Sabbah H, Hadari R, Kovatz S, Weinberg U, Dolev S, Dagan Y, Shenkman L. The effects of coffee consumption on sleep and melatonin secretion. Sleep Med. 2002 May;3(3):271-3. doi: 10.1016/s1389-9457(02)00015-1. PMID: 14592218.
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Synchronization and beam forming in an array of repulsively coupled oscillators.

Physical review. E, Statistical, nonlinear, and soft matter physics

Rulkov NF, Tsimring L, Larsen ML, Gabbay M.
PMID: 17279982
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Nov;74(5):056205. doi: 10.1103/PhysRevE.74.056205. Epub 2006 Nov 15.

We study the dynamics of an array of Stuart-Landau oscillators with repulsive coupling. Autonomous network with global repulsive coupling settles on one from a continuum of synchronized regimes characterized by zero mean field. Driving this array by an external...

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Rulkov NF, Tsimring L, Larsen ML, et al. Synchronization and beam forming in an array of repulsively coupled oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2006;74(5):056205doi: 10.1103/PhysRevE.74.056205.
Rulkov, N. F., Tsimring, L., Larsen, M. L., & Gabbay, M. (2006). Synchronization and beam forming in an array of repulsively coupled oscillators. Physical review. E, Statistical, nonlinear, and soft matter physics, 74(5), 056205. https://doi.org/10.1103/PhysRevE.74.056205
Rulkov, N F, et al. "Synchronization and beam forming in an array of repulsively coupled oscillators." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 74,5 (2006): 056205. doi: https://doi.org/10.1103/PhysRevE.74.056205
Rulkov NF, Tsimring L, Larsen ML, Gabbay M. Synchronization and beam forming in an array of repulsively coupled oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Nov;74(5):056205. doi: 10.1103/PhysRevE.74.056205. Epub 2006 Nov 15. PMID: 17279982.
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Underwater light polarization and radiance fluctuations induced by surface waves.

Applied optics

Sabbah S, Shashar N.
PMID: 16799688
Appl Opt. 2006 Jul 01;45(19):4726-39. doi: 10.1364/ao.45.004726.

The underwater light field is an ever-changing environment. Surface waves induce variability in the radiance and the light's polarization. We examined the dependence of the polarization fluctuations associated with diffuse light (not including contribution from direct skylight) on the...

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Sabbah S, Shashar N. Underwater light polarization and radiance fluctuations induced by surface waves. Appl Opt. 2006;45(19):4726-39doi: 10.1364/ao.45.004726.
Sabbah, S., & Shashar, N. (2006). Underwater light polarization and radiance fluctuations induced by surface waves. Applied optics, 45(19), 4726-39. https://doi.org/10.1364/ao.45.004726
Sabbah, Shai, and Shashar, Nadav. "Underwater light polarization and radiance fluctuations induced by surface waves." Applied optics vol. 45,19 (2006): 4726-39. doi: https://doi.org/10.1364/ao.45.004726
Sabbah S, Shashar N. Underwater light polarization and radiance fluctuations induced by surface waves. Appl Opt. 2006 Jul 01;45(19):4726-39. doi: 10.1364/ao.45.004726. PMID: 16799688.
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Antitumour-promoting and cytotoxic constituents of etlingera elatior.

The Malaysian journal of medical sciences : MJMS

Habsah M, Ali A, Lajis N, Sukari M, Yap Y, Kikuzaki H, Nakatani N.
PMID: 22605941
Malays J Med Sci. 2005 Jan;12(1):6-12.

Phytochemical studies on rhizome of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13-trien-16,15-olide (4), stigmast-4-en-3-one (5), stigmast-4-ene-3,6-dione (6), stigmast-4-en-6b-ol-3-one (7), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (8). 1 and 4 were new compounds. Compounds 5 and 7...

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Habsah M, Ali A, Lajis N, et al. Antitumour-promoting and cytotoxic constituents of etlingera elatior. Malays J Med Sci. 2005;12(1):6-12
Habsah, M., Ali, A., Lajis, N., Sukari, M., Yap, Y., Kikuzaki, H., & Nakatani, N. (2005). Antitumour-promoting and cytotoxic constituents of etlingera elatior. The Malaysian journal of medical sciences : MJMS, 12(1), 6-12.
Habsah, M, et al. "Antitumour-promoting and cytotoxic constituents of etlingera elatior." The Malaysian journal of medical sciences : MJMS vol. 12,1 (2005): 6-12.
Habsah M, Ali A, Lajis N, Sukari M, Yap Y, Kikuzaki H, Nakatani N. Antitumour-promoting and cytotoxic constituents of etlingera elatior. Malays J Med Sci. 2005 Jan;12(1):6-12. PMID: 22605941; PMCID: PMC3349407.
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Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between.

The journal of physical chemistry. A

West B, Useli-Bacchitta F, Sabbah H, Blanchet V, Bodi A, Mayer PM, Joblin C.
PMID: 25133586
J Phys Chem A. 2014 Sep 11;118(36):7824-31. doi: 10.1021/jp506420u. Epub 2014 Aug 27.

The unimolecular dissociation of the pyrene radical cation, C16H10(+•), has been explored using a combination of computational techniques and experimental approaches, such as multiple photon absorption in the cold ion trap Piège à Ions pour la Recherche et l'Etude...

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West B, Useli-Bacchitta F, Sabbah H, et al. Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between. J Phys Chem A. 2014;118(36):7824-31doi: 10.1021/jp506420u.
West, B., Useli-Bacchitta, F., Sabbah, H., Blanchet, V., Bodi, A., Mayer, P. M., & Joblin, C. (2014). Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between. The journal of physical chemistry. A, 118(36), 7824-31. https://doi.org/10.1021/jp506420u
West, Brandi, et al. "Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between." The journal of physical chemistry. A vol. 118,36 (2014): 7824-31. doi: https://doi.org/10.1021/jp506420u
West B, Useli-Bacchitta F, Sabbah H, Blanchet V, Bodi A, Mayer PM, Joblin C. Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between. J Phys Chem A. 2014 Sep 11;118(36):7824-31. doi: 10.1021/jp506420u. Epub 2014 Aug 27. PMID: 25133586.
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Showing 1 to 12 of 295 entries