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Controversy swirls around early goal-directed therapy in sepsis: pioneer defends ground-breaking approach to deadly disease

community settings

McKenna M.
GSID: xTwO64PsWbQJ
M McKenna - Annals of emergency medicine, 2008 - annemergmed.com

But the next step in the saga of early goal-directed therapy has been somewhat outside the norm. On August 14, the Wall Street Journal ran a front-page article that questioned both …

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McKenna, M. (2008). Controversy swirls around early goal-directed therapy in sepsis: pioneer defends ground-breaking approach to deadly disease. Annals of emergency medicine, 52(6), 651-654.
McKenna, Maryn. "Controversy swirls around early goal-directed therapy in sepsis: pioneer defends ground-breaking approach to deadly disease." Annals of emergency medicine 52.6 (2008): 651-654.
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Salter Harris Fractures of the Distal Femur: Learning Points From Two Cases Compared.

Journal of investigative medicine high impact case reports

McKenna SM, Hamilton SW, Barker SL.
PMID: 26425580
J Investig Med High Impact Case Rep. 2013 Jul 29;1(3):2324709613500238. doi: 10.1177/2324709613500238. eCollection 2013.

Salter Harris-type injuries of the distal femur should be treated as a dislocation of the knee and therefore as a medical emergency. Senior medical staff should be involved early, ankle-brachial index ratio should be measured in all patients and...

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McKenna SM, Hamilton SW, Barker SL. Salter Harris Fractures of the Distal Femur: Learning Points From Two Cases Compared. J Investig Med High Impact Case Rep. 2013;1(3):2324709613500238doi: 10.1177/2324709613500238.
McKenna, S. M., Hamilton, S. W., & Barker, S. L. (2013). Salter Harris Fractures of the Distal Femur: Learning Points From Two Cases Compared. Journal of investigative medicine high impact case reports, 1(3), 2324709613500238. https://doi.org/10.1177/2324709613500238
McKenna, Sean M, et al. "Salter Harris Fractures of the Distal Femur: Learning Points From Two Cases Compared." Journal of investigative medicine high impact case reports vol. 1,3 (2013): 2324709613500238. doi: https://doi.org/10.1177/2324709613500238
McKenna SM, Hamilton SW, Barker SL. Salter Harris Fractures of the Distal Femur: Learning Points From Two Cases Compared. J Investig Med High Impact Case Rep. 2013 Jul 29;1(3):2324709613500238. doi: 10.1177/2324709613500238. eCollection 2013. PMID: 26425580; PMCID: PMC4586811.
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Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

ACS medicinal chemistry letters

Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M.
PMID: 28947941
ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14.

We report the synthesis, biological evaluation, and structural study of a series of substituted heteroaryl-pyrazole carboxylic acid derivatives. These compounds have been developed as inhibitors of specific isoforms of carbonic anhydrase (CA), with potential as prototypes of a new...

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Cadoni R, Pala N, Lomelino C, et al. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017;8(9):941-946doi: 10.1021/acsmedchemlett.7b00229.
Cadoni, R., Pala, N., Lomelino, C., Mahon, B. P., McKenna, R., Dallocchio, R., Dessì, A., Carcelli, M., Rogolino, D., Sanna, V., Rassu, M., Iaccarino, C., Vullo, D., Supuran, C. T., & Sechi, M. (2017). Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS medicinal chemistry letters, 8(9), 941-946. https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni, Roberta, et al. "Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors." ACS medicinal chemistry letters vol. 8,9 (2017): 941-946. doi: https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14. PMID: 28947941; PMCID: PMC5601383.
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Extraction of Distinctive Antigens from Neoplastic Tissue.

Science (New York, N.Y.)

McKenna JM, Sanderson RP, Blakemore WS.
PMID: 17782631
Science. 1962 Feb 02;135(3501):370-1. doi: 10.1126/science.135.3501.370.

Antigens have been obtained from HeLa and J111 cells by treatment with fluorocarbon. Cross absorption studies revealed that the antigen from HeLa cells had no serologic relationship to normal human uterus. Antibody for HeLa extract coated red blood cells...

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McKenna JM, Sanderson RP, Blakemore WS. Extraction of Distinctive Antigens from Neoplastic Tissue. Science. 1962;135(3501):370-1doi: 10.1126/science.135.3501.370.
McKenna, J. M., Sanderson, R. P., & Blakemore, W. S. (1962). Extraction of Distinctive Antigens from Neoplastic Tissue. Science (New York, N.Y.), 135(3501), 370-1. https://doi.org/10.1126/science.135.3501.370
McKenna, J M, et al. "Extraction of Distinctive Antigens from Neoplastic Tissue." Science (New York, N.Y.) vol. 135,3501 (1962): 370-1. doi: https://doi.org/10.1126/science.135.3501.370
McKenna JM, Sanderson RP, Blakemore WS. Extraction of Distinctive Antigens from Neoplastic Tissue. Science. 1962 Feb 02;135(3501):370-1. doi: 10.1126/science.135.3501.370. PMID: 17782631.
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CARCINOMA OF THE EYELID TREATED BY IRRADIATION-Analysis of 157 Primary and 22 Recurrent Cases.

California medicine

McKenna RJ, Macdonald I.
PMID: 18732494
Calif Med. 1962 Mar;96(3):184-9.

The eyelid is a frequent site for skin cancers of the face. Its location presents certain special problems in treatment from a cosmetic and functional standpoint. If untreated, a major deformity with possible loss of sight can result. This...

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McKenna RJ, Macdonald I. CARCINOMA OF THE EYELID TREATED BY IRRADIATION-Analysis of 157 Primary and 22 Recurrent Cases. Calif Med. 1962;96(3):184-9
McKenna, R. J., & Macdonald, I. (1962). CARCINOMA OF THE EYELID TREATED BY IRRADIATION-Analysis of 157 Primary and 22 Recurrent Cases. California medicine, 96(3), 184-9.
McKenna, R J, and Macdonald, I. "CARCINOMA OF THE EYELID TREATED BY IRRADIATION-Analysis of 157 Primary and 22 Recurrent Cases." California medicine vol. 96,3 (1962): 184-9.
McKenna RJ, Macdonald I. CARCINOMA OF THE EYELID TREATED BY IRRADIATION-Analysis of 157 Primary and 22 Recurrent Cases. Calif Med. 1962 Mar;96(3):184-9. PMID: 18732494; PMCID: PMC1575001.
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Henry MacCormac, M.D. 1879-1950.

A.M.A. archives of dermatology and syphilology

MACKENNA RM.
PMID: 14810247
AMA Arch Derm Syphilol. 1951 Apr;63(4):544. doi: 10.1001/archderm.1951.01570040138033.

No abstract available.

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MACKENNA RM. Henry MacCormac, M.D. 1879-1950. AMA Arch Derm Syphilol. 1951;63(4):544doi: 10.1001/archderm.1951.01570040138033.
MACKENNA, R. M. (1951). Henry MacCormac, M.D. 1879-1950. A.M.A. archives of dermatology and syphilology, 63(4), 544. https://doi.org/10.1001/archderm.1951.01570040138033
MACKENNA, R M B. "Henry MacCormac, M.D. 1879-1950." A.M.A. archives of dermatology and syphilology vol. 63,4 (1951): 544. doi: https://doi.org/10.1001/archderm.1951.01570040138033
MACKENNA RM. Henry MacCormac, M.D. 1879-1950. AMA Arch Derm Syphilol. 1951 Apr;63(4):544. doi: 10.1001/archderm.1951.01570040138033. PMID: 14810247.
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Immunophenotypic studies of monoclonal gammopathy of undetermined significance.

BMC clinical pathology

Olteanu H, Wang HY, Chen W, McKenna RW, Karandikar NJ.
PMID: 19040735
BMC Clin Pathol. 2008 Nov 28;8:13. doi: 10.1186/1472-6890-8-13.

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell dyscrasia, comprising the most indolent form of monoclonal gammopathy. However, approximately 25% of MGUS cases ultimately progress to plasma cell myeloma (PCM) or related diseases. It is...

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Olteanu H, Wang HY, Chen W, et al. Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clin Pathol. 2008;8:13doi: 10.1186/1472-6890-8-13.
Olteanu, H., Wang, H. Y., Chen, W., McKenna, R. W., & Karandikar, N. J. (2008). Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC clinical pathology, 813. https://doi.org/10.1186/1472-6890-8-13
Olteanu, Horatiu, et al. "Immunophenotypic studies of monoclonal gammopathy of undetermined significance." BMC clinical pathology vol. 8 (2008): 13. doi: https://doi.org/10.1186/1472-6890-8-13
Olteanu H, Wang HY, Chen W, McKenna RW, Karandikar NJ. Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clin Pathol. 2008 Nov 28;8:13. doi: 10.1186/1472-6890-8-13. PMID: 19040735; PMCID: PMC2606678.
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Dermatology, the international outlook.

Journal of the American Medical Association

MACKENNA RM.
PMID: 20272530
J Am Med Assoc. 1947 Dec 27;135(17):1128-31. doi: 10.1001/jama.1947.02890170006002.

No abstract available.

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MACKENNA RM. Dermatology, the international outlook. J Am Med Assoc. 1947;135(17):1128-31doi: 10.1001/jama.1947.02890170006002.
MACKENNA, R. M. (1947). Dermatology, the international outlook. Journal of the American Medical Association, 135(17), 1128-31. https://doi.org/10.1001/jama.1947.02890170006002
MACKENNA, R M B. "Dermatology, the international outlook." Journal of the American Medical Association vol. 135,17 (1947): 1128-31. doi: https://doi.org/10.1001/jama.1947.02890170006002
MACKENNA RM. Dermatology, the international outlook. J Am Med Assoc. 1947 Dec 27;135(17):1128-31. doi: 10.1001/jama.1947.02890170006002. PMID: 20272530.
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The effects of cadmium and zinc interactions on the accumulation and tissue distribution of zinc and cadmium in lettuce and spinach.

Environmental pollution (Barking, Essex : 1987)

McKenna IM, Chaney RL, Williams FM.
PMID: 15091895
Environ Pollut. 1993;79(2):113-20. doi: 10.1016/0269-7491(93)90060-2.

The interactions between Zn and Cd on the concentration and tissue distribution of these metals in lettuce and spinach were studied at levels corresponding to background and Zn-Cd contaminated sites. Plants were grown in nutrient solutions containing 0.398-8.91 microM...

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McKenna IM, Chaney RL, Williams FM. The effects of cadmium and zinc interactions on the accumulation and tissue distribution of zinc and cadmium in lettuce and spinach. Environ Pollut. 1993;79(2):113-20doi: 10.1016/0269-7491(93)90060-2.
McKenna, I. M., Chaney, R. L., & Williams, F. M. (1993). The effects of cadmium and zinc interactions on the accumulation and tissue distribution of zinc and cadmium in lettuce and spinach. Environmental pollution (Barking, Essex : 1987), 79(2), 113-20. https://doi.org/10.1016/0269-7491(93)90060-2
McKenna, I M, et al. "The effects of cadmium and zinc interactions on the accumulation and tissue distribution of zinc and cadmium in lettuce and spinach." Environmental pollution (Barking, Essex : 1987) vol. 79,2 (1993): 113-20. doi: https://doi.org/10.1016/0269-7491(93)90060-2
McKenna IM, Chaney RL, Williams FM. The effects of cadmium and zinc interactions on the accumulation and tissue distribution of zinc and cadmium in lettuce and spinach. Environ Pollut. 1993;79(2):113-20. doi: 10.1016/0269-7491(93)90060-2. PMID: 15091895.
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Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.

ACS medicinal chemistry letters

Pala N, Micheletto L, Sechi M, Aggarwal M, Carta F, McKenna R, Supuran CT.
PMID: 25147616
ACS Med Chem Lett. 2014 Jun 07;5(8):927-30. doi: 10.1021/ml500196t. eCollection 2014 Aug 14.

A series of novel benzene- and 2,3,5,6-tetrafluorobenzenesulfonamide was synthesized by using a click chemistry approach starting from azido-substituted sulfonamides and alkynes, incorporating aryl, alkyl, cycloalkyl, and amino-/hydroxy-/halogenoalkyl moieties. The new compounds were medium potency inhibitors of the cytosolic carbonic...

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Pala N, Micheletto L, Sechi M, et al. Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. ACS Med Chem Lett. 2014;5(8):927-30doi: 10.1021/ml500196t.
Pala, N., Micheletto, L., Sechi, M., Aggarwal, M., Carta, F., McKenna, R., & Supuran, C. T. (2014). Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. ACS medicinal chemistry letters, 5(8), 927-30. https://doi.org/10.1021/ml500196t
Pala, Nicolino, et al. "Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry." ACS medicinal chemistry letters vol. 5,8 (2014): 927-30. doi: https://doi.org/10.1021/ml500196t
Pala N, Micheletto L, Sechi M, Aggarwal M, Carta F, McKenna R, Supuran CT. Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. ACS Med Chem Lett. 2014 Jun 07;5(8):927-30. doi: 10.1021/ml500196t. eCollection 2014 Aug 14. PMID: 25147616; PMCID: PMC4137363.
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Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors.

International journal of medicinal chemistry

Mboge MY, Kota A, McKenna R, Frost SC.
PMID: 30112206
Int J Med Chem. 2018 Jul 16;2018:2906519. doi: 10.1155/2018/2906519. eCollection 2018.

Carbonic anhydrases (CAs) are thought to be important for regulating pH in the tumor microenvironment. A few of the CA isoforms are upregulated in cancer cells, with only limited expression in normal cells. For these reasons, there is interest...

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Mboge MY, Kota A, McKenna R, et al. Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors. Int J Med Chem. 2018;2018:2906519doi: 10.1155/2018/2906519.
Mboge, M. Y., Kota, A., McKenna, R., & Frost, S. C. (2018). Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors. International journal of medicinal chemistry, 20182906519. https://doi.org/10.1155/2018/2906519
Mboge, Mam Y, et al. "Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors." International journal of medicinal chemistry vol. 2018 (2018): 2906519. doi: https://doi.org/10.1155/2018/2906519
Mboge MY, Kota A, McKenna R, Frost SC. Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors. Int J Med Chem. 2018 Jul 16;2018:2906519. doi: 10.1155/2018/2906519. eCollection 2018. PMID: 30112206; PMCID: PMC6077552.
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Food Addiction, Binge Eating Disorder, and Obesity: Is There a Relationship?.

Behavioral sciences (Basel, Switzerland)

Burrows T, Skinner J, McKenna R, Rollo M.
PMID: 28805749
Behav Sci (Basel). 2017 Aug 14;7(3). doi: 10.3390/bs7030054.

Existing research suggests that there is an overlap between binge eating disorder (BED) and the construct of 'food addiction' (FA). The objective of this study was to determine the overlapping features of BED and FA through a comparison of...

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Burrows T, Skinner J, McKenna R, et al. Food Addiction, Binge Eating Disorder, and Obesity: Is There a Relationship?. Behav Sci (Basel). 2017;7(3)doi: 10.3390/bs7030054.
Burrows, T., Skinner, J., McKenna, R., & Rollo, M. (2017). Food Addiction, Binge Eating Disorder, and Obesity: Is There a Relationship?. Behavioral sciences (Basel, Switzerland), 7(3), . https://doi.org/10.3390/bs7030054
Burrows, Tracy, et al. "Food Addiction, Binge Eating Disorder, and Obesity: Is There a Relationship?." Behavioral sciences (Basel, Switzerland) vol. 7,3 (2017). doi: https://doi.org/10.3390/bs7030054
Burrows T, Skinner J, McKenna R, Rollo M. Food Addiction, Binge Eating Disorder, and Obesity: Is There a Relationship?. Behav Sci (Basel). 2017 Aug 14;7(3). doi: 10.3390/bs7030054. PMID: 28805749; PMCID: PMC5618062.
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Showing 1 to 12 of 201 entries