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Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population.

Frontiers in physiology

Kosanovic D, Platzek SM, Petrovic A, Sydykov A, Maripov A, Mamazhakypov A, Sartmyrzaeva M, Muratali Uulu K, Cholponbaeva M, Toktosunova A, Omurzakova N, Duishobaev M, Vroom C, Pak O, Weissmann N, Ghofrani HA, Sarybaev A, Schermuly RT.
PMID: 30804801
Front Physiol. 2019 Feb 05;10:54. doi: 10.3389/fphys.2019.00054. eCollection 2019.

No abstract available.

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Kosanovic D, Platzek SM, Petrovic A, et al. Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population. Front Physiol. 2019;10:54doi: 10.3389/fphys.2019.00054.
Kosanovic, D., Platzek, S. M., Petrovic, A., Sydykov, A., Maripov, A., Mamazhakypov, A., Sartmyrzaeva, M., Muratali Uulu, K., Cholponbaeva, M., Toktosunova, A., Omurzakova, N., Duishobaev, M., Vroom, C., Pak, O., Weissmann, N., Ghofrani, H. A., Sarybaev, A., & Schermuly, R. T. (2019). Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population. Frontiers in physiology, 1054. https://doi.org/10.3389/fphys.2019.00054
Kosanovic, Djuro, et al. "Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population." Frontiers in physiology vol. 10 (2019): 54. doi: https://doi.org/10.3389/fphys.2019.00054
Kosanovic D, Platzek SM, Petrovic A, Sydykov A, Maripov A, Mamazhakypov A, Sartmyrzaeva M, Muratali Uulu K, Cholponbaeva M, Toktosunova A, Omurzakova N, Duishobaev M, Vroom C, Pak O, Weissmann N, Ghofrani HA, Sarybaev A, Schermuly RT. Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population. Front Physiol. 2019 Feb 05;10:54. doi: 10.3389/fphys.2019.00054. eCollection 2019. PMID: 30804801; PMCID: PMC6370645.
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Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats.

Pulmonary circulation

Mamazhakypov A, Weiß A, Zukunft S, Sydykov A, Kojonazarov B, Wilhelm J, Vroom C, Petrovic A, Kosanovic D, Weissmann N, Seeger W, Fleming I, Iglarz M, Grimminger F, Ghofrani HA, Pullamsetti SS, Schermuly RT.
PMID: 33240483
Pulm Circ. 2020 Nov 11;10(4):2045894020947283. doi: 10.1177/2045894020947283. eCollection 2020.

Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investigated effects of tadalafil and macitentan alone or in combination...

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Mamazhakypov A, Weiß A, Zukunft S, et al. Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulm Circ. 2020;10(4):2045894020947283doi: 10.1177/2045894020947283.
Mamazhakypov, A., Weiß, A., Zukunft, S., Sydykov, A., Kojonazarov, B., Wilhelm, J., Vroom, C., Petrovic, A., Kosanovic, D., Weissmann, N., Seeger, W., Fleming, I., Iglarz, M., Grimminger, F., Ghofrani, H. A., Pullamsetti, S. S., & Schermuly, R. T. (2020). Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulmonary circulation, 10(4), 2045894020947283. https://doi.org/10.1177/2045894020947283
Mamazhakypov, Argen, et al. "Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats." Pulmonary circulation vol. 10,4 (2020): 2045894020947283. doi: https://doi.org/10.1177/2045894020947283
Mamazhakypov A, Weiß A, Zukunft S, Sydykov A, Kojonazarov B, Wilhelm J, Vroom C, Petrovic A, Kosanovic D, Weissmann N, Seeger W, Fleming I, Iglarz M, Grimminger F, Ghofrani HA, Pullamsetti SS, Schermuly RT. Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulm Circ. 2020 Nov 11;10(4):2045894020947283. doi: 10.1177/2045894020947283. eCollection 2020. PMID: 33240483; PMCID: PMC7672745.
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Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting.

Pharmacology & therapeutics

Mamazhakypov A, Hein L, Lother A.
PMID: 34480966
Pharmacol Ther. 2021 Sep 01;107987. doi: 10.1016/j.pharmthera.2021.107987. Epub 2021 Sep 01.

Pulmonary hypertension (PH) is a devastating condition characterized by pulmonary vascular remodelling, leading to progressive increase in pulmonary artery pressure and subsequent right ventricular failure. Aldosterone and the mineralocorticoid receptor (MR), a nuclear transcription factor, are key drivers of...

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Mamazhakypov A, Hein L, Lother A. Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting. Pharmacol Ther. 2021;107987doi: 10.1016/j.pharmthera.2021.107987.
Mamazhakypov, A., Hein, L., & Lother, A. (2021). Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting. Pharmacology & therapeutics, 107987. https://doi.org/10.1016/j.pharmthera.2021.107987
Mamazhakypov, Argen, et al. "Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting." Pharmacology & therapeutics vol. (2021): 107987. doi: https://doi.org/10.1016/j.pharmthera.2021.107987
Mamazhakypov A, Hein L, Lother A. Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting. Pharmacol Ther. 2021 Sep 01;107987. doi: 10.1016/j.pharmthera.2021.107987. Epub 2021 Sep 01. PMID: 34480966.
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The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.

Frontiers in cardiovascular medicine

Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S.
PMID: 30619886
Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018.

Pressure overload of the right ventricle (RV) in pulmonary arterial hypertension (PAH) leads to RV remodeling and failure, an important determinant of outcome in patients with PAH. Several G protein-coupled receptors (GPCRs) are differentially regulated in the RV myocardium,...

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Viswanathan G, Mamazhakypov A, Schermuly RT, et al. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018;5:179doi: 10.3389/fcvm.2018.00179.
Viswanathan, G., Mamazhakypov, A., Schermuly, R. T., & Rajagopal, S. (2018). The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Frontiers in cardiovascular medicine, 5179. https://doi.org/10.3389/fcvm.2018.00179
Viswanathan, Gayathri, et al. "The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension." Frontiers in cardiovascular medicine vol. 5 (2018): 179. doi: https://doi.org/10.3389/fcvm.2018.00179
Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018. PMID: 30619886; PMCID: PMC6305072.
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Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers.

Frontiers in physiology

Sydykov A, Mamazhakypov A, Petrovic A, Kosanovic D, Sarybaev AS, Weissmann N, Ghofrani HA, Schermuly RT.
PMID: 29875701
Front Physiol. 2018 May 23;9:609. doi: 10.3389/fphys.2018.00609. eCollection 2018.

Adverse right ventricular (RV) remodeling leads to ventricular dysfunction and failure that represents an important determinant of outcome in patients with pulmonary hypertension (PH). Recent evidence indicates that inflammatory activation contributes to the pathogenesis of adverse RV remodeling and...

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Sydykov A, Mamazhakypov A, Petrovic A, et al. Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers. Front Physiol. 2018;9:609doi: 10.3389/fphys.2018.00609.
Sydykov, A., Mamazhakypov, A., Petrovic, A., Kosanovic, D., Sarybaev, A. S., Weissmann, N., Ghofrani, H. A., & Schermuly, R. T. (2018). Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers. Frontiers in physiology, 9609. https://doi.org/10.3389/fphys.2018.00609
Sydykov, Akylbek, et al. "Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers." Frontiers in physiology vol. 9 (2018): 609. doi: https://doi.org/10.3389/fphys.2018.00609
Sydykov A, Mamazhakypov A, Petrovic A, Kosanovic D, Sarybaev AS, Weissmann N, Ghofrani HA, Schermuly RT. Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers. Front Physiol. 2018 May 23;9:609. doi: 10.3389/fphys.2018.00609. eCollection 2018. PMID: 29875701; PMCID: PMC5974151.
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Cancer and pulmonary hypertension: Learning lessons and real-life interplay.

Global cardiology science & practice

Pullamsetti SS, Nayakanti S, Chelladurai P, Mamazhakypov A, Mansouri S, Savai R, Seeger W.
PMID: 33150154
Glob Cardiol Sci Pract. 2020 Apr 30;2020(1):e202010. doi: 10.21542/gcsp.2020.10.

This article reviews the scientific reasons that support the intriguing vision of pulmonary hypertension (PH) as a disease with a cancer-like nature and to understand whether this point of view may have fruitful consequences for the overall management of...

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Pullamsetti SS, Nayakanti S, Chelladurai P, et al. Cancer and pulmonary hypertension: Learning lessons and real-life interplay. Glob Cardiol Sci Pract. 2020;2020(1):e202010doi: 10.21542/gcsp.2020.10.
Pullamsetti, S. S., Nayakanti, S., Chelladurai, P., Mamazhakypov, A., Mansouri, S., Savai, R., & Seeger, W. (2020). Cancer and pulmonary hypertension: Learning lessons and real-life interplay. Global cardiology science & practice, 2020(1), e202010. https://doi.org/10.21542/gcsp.2020.10
Pullamsetti, Soni Savai, et al. "Cancer and pulmonary hypertension: Learning lessons and real-life interplay." Global cardiology science & practice vol. 2020,1 (2020): e202010. doi: https://doi.org/10.21542/gcsp.2020.10
Pullamsetti SS, Nayakanti S, Chelladurai P, Mamazhakypov A, Mansouri S, Savai R, Seeger W. Cancer and pulmonary hypertension: Learning lessons and real-life interplay. Glob Cardiol Sci Pract. 2020 Apr 30;2020(1):e202010. doi: 10.21542/gcsp.2020.10. PMID: 33150154; PMCID: PMC7590929.
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Showing 1 to 6 of 6 entries