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Viswanathan G, Mamazhakypov A, Schermuly RT, et al. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018;5:179doi: 10.3389/fcvm.2018.00179.
Viswanathan, G., Mamazhakypov, A., Schermuly, R. T., & Rajagopal, S. (2018). The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Frontiers in cardiovascular medicine, 5179. https://doi.org/10.3389/fcvm.2018.00179
Viswanathan, Gayathri, et al. "The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension." Frontiers in cardiovascular medicine vol. 5 (2018): 179. doi: https://doi.org/10.3389/fcvm.2018.00179
Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S. The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension. Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018. PMID: 30619886; PMCID: PMC6305072.
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Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018.

The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.

Frontiers in cardiovascular medicine

Gayathri Viswanathan, Argen Mamazhakypov, Ralph T Schermuly, Sudarshan Rajagopal

Affiliations

  1. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.
  2. Department of Internal Medicine, Member of the German Center for Lung Research (DZL), Justus Liebig University of Giessen, Giessen, Germany.

PMID: 30619886 PMCID: PMC6305072 DOI: 10.3389/fcvm.2018.00179

Abstract

Pressure overload of the right ventricle (RV) in pulmonary arterial hypertension (PAH) leads to RV remodeling and failure, an important determinant of outcome in patients with PAH. Several G protein-coupled receptors (GPCRs) are differentially regulated in the RV myocardium, contributing to the pathogenesis of RV adverse remodeling and dysfunction. Many pharmacological agents that target GPCRs have been demonstrated to result in beneficial effects on left ventricular (LV) failure, such as beta-adrenergic receptor and angiotensin receptor antagonists. However, the role of such drugs on RV remodeling and performance is not known at this time. Moreover, many of these same receptors are also expressed in the pulmonary vasculature, which could result in complex effects in PAH. This manuscript reviews the role of GPCRs in the RV remodeling and dysfunction and discusses activating and blocking GPCR signaling to potentially attenuate remodeling while promoting improvements of RV function in PAH.

Keywords: G protein-coupled receptor; dysfunction; pulmonary hypertension; remodeling; right ventricle

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