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Showing 1 to 12 of 75 entries
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Aging in the colonial chordate, .

Invertebrate reproduction & development

Munday R, Rodriguez D, Di Maio A, Kassmer S, Braden B, Taketa DA, Langenbacher A, De Tomaso A.
PMID: 26136620
Invertebr Reprod Dev. 2015 Jan 30;59:45-50. doi: 10.1080/07924259.2014.938197. Epub 2014 Dec 09.

What mechanisms underlie aging? One theory, the wear-and-tear model, attributes aging to progressive deterioration in the molecular and cellular machinery which eventually lead to death through the disruption of physiological homeostasis. The second suggests that life span is genetically...

Group health coaching: strengths, challenges, and next steps.

Global advances in health and medicine

Armstrong C, Wolever RQ, Manning L, Elam R, Moore M, Frates EP, Duskey H, Anderson C, Curtis RL, Masemer S, Lawson K.
PMID: 24416678
Glob Adv Health Med. 2013 May;2(3):95-102. doi: 10.7453/gahmj.2013.019.

There is great need for cost effective approaches to increase patient engagement and improve health and well-being. Health and wellness coaching has recently demonstrated great promise, but the majority of studies to date have focused on individual coaching (ie,...

Correction for Dreux et al., Ribonucleotide Reductase Repressor NrdR as a Novel Regulator for Motility and Chemotaxis during Adherent-Invasive Escherichia coli Infection.

Infection and immunity

Dreux N, Cendra Mdel M, Massier S, Darfeuille-Michaud A, Barnich N, Torrents E.
PMID: 26359369
Infect Immun. 2015 Oct;83(10):4174. doi: 10.1128/IAI.00728-15.

No abstract available.

Therapeutic manipulation of angiogenesis with miR-27b.

Vascular cell

Veliceasa D, Biyashev D, Qin G, Misener S, Mackie AR, Kishore R, Volpert OV.
PMID: 26161255
Vasc Cell. 2015 Jun 24;7:6. doi: 10.1186/s13221-015-0031-1. eCollection 2015.

BACKGROUND: Multiple studies demonstrated pro-angiogenic effects of microRNA (miR)-27b. Its targets include Notch ligand Dll4, Sprouty (Spry)-2, PPARγ and Semaphorin (SEMA) 6A. miR-27 effects in the heart are context-dependent: although it is necessary for ventricular maturation, targeted overexpression in...

Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer.

Oncotarget

Kluth M, Jung S, Habib O, Eshagzaiy M, Heinl A, Amschler N, Masser S, Mader M, Runte F, Barow P, Frogh S, Omari J, Möller-Koop C, Hube-Magg C, Weischenfeldt J, Korbel J, Steurer S, Krech T, Huland H, Graefen M, Minner S, Sauter G, Schlomm T, Simon R.
PMID: 29312579
Oncotarget. 2017 Nov 11;8(65):108923-108935. doi: 10.18632/oncotarget.22408. eCollection 2017 Dec 12.

Prostate cancer is characterized by recurrent deletions that can considerably vary in size. We hypothesized that large deletions develop from small deletions and that this "deletion lengthening" might have a "per se" carcinogenic role through a combinatorial effect of...

Excellent response to chemotherapy post immunotherapy.

Oncotarget

Dwary AD, Master S, Patel A, Cole C, Mansour R, Mills G, Koshy N, Peddi P, Burton G, Hammoud D, Beedupalli K.
PMID: 29207685
Oncotarget. 2017 Aug 08;8(53):91795-91802. doi: 10.18632/oncotarget.20030. eCollection 2017 Oct 31.

INTRODUCTION: Immunotherapy in the form of immune checkpoint inhibitors has changed the landscape of cancer treatment. Newer monoclonal antibodies are coming up and are being tested in various cancers during different stages of treatment. With the increasing use of...

iGluK-Deep: computational identification of lysine glutarylation sites using deep neural networks with general pseudo amino acid compositions.

Journal of biomolecular structure & dynamics

Naseer S, Ali RF, Khan YD, Dominic PDD.
PMID: 34396935
J Biomol Struct Dyn. 2021 Aug 16;1-14. doi: 10.1080/07391102.2021.1962738. Epub 2021 Aug 16.

Lysine glutarylation is a post-translation modification which plays an important regulatory role in a variety of physiological and enzymatic processes including mitochondrial functions and metabolic processes both in eukaryotic and prokaryotic cells. This post-translational modification influences chromatin structure and...

Computational identification of 4-carboxyglutamate sites to supplement physiological studies using deep learning.

Scientific reports

Naseer S, Ali RF, Fati SM, Muneer A.
PMID: 34996975
Sci Rep. 2022 Jan 07;12(1):128. doi: 10.1038/s41598-021-03895-4.

In biological systems, Glutamic acid is a crucial amino acid which is used in protein biosynthesis. Carboxylation of glutamic acid is a significant post-translational modification which plays important role in blood coagulation by activating prothrombin to thrombin. Contrariwise, 4-carboxy-glutamate...

Identification and Affinity Determination of Protein-Antibody and Protein-Aptamer Epitopes by Biosensor-Mass Spectrometry Combination.

International journal of molecular sciences

Lupu LM, Wiegand P, Holdschick D, Mihoc D, Maeser S, Rawer S, Völklein F, Malek E, Barka F, Knauer S, Uth C, Hennermann J, Kleinekofort W, Hahn A, Barka G, Przybylski M.
PMID: 34884636
Int J Mol Sci. 2021 Nov 27;22(23). doi: 10.3390/ijms222312832.

Analytical methods for molecular characterization of diagnostic or therapeutic targets have recently gained high interest. This review summarizes the combination of mass spectrometry and surface plasmon resonance (SPR) biosensor analysis for identification and affinity determination of protein interactions with...

Endometriosis classification, staging and reporting systems: a review on the road to a universally accepted endometriosis classification.

Human reproduction open

, Vermeulen N, Abrao MS, Einarsson JI, Horne AW, Johnson NP, Lee TTM, Missmer S, Petrozza J, Tomassetti C, Zondervan KT, Grimbizis G, De Wilde RL.
PMID: 34693032
Hum Reprod Open. 2021 Oct 22;2021(4):hoab025. doi: 10.1093/hropen/hoab025. eCollection 2021.

STUDY QUESTION: Which endometriosis classification, staging and reporting systems have been published and validated for use in clinical practice?SUMMARY ANSWER: Of the 22 endometriosis classification, staging and reporting systems identified in this historical overview, only a few have been...

Incidence of symptomatic image-confirmed venous thromboembolism in outpatients managed in a hospital-led COVID-19 virtual ward.

EJHaem

Shapiro S, Fouad Alber K, Morton J, Wallis G, Britton M, Bunn A, Cheema H, Jalilzadeh Afshari S, Lin ECZ, Madge O, Naseer S, Ng E, Pora A, Sardar A, Brent A, Lasserson D.
PMID: 34909766
EJHaem. 2021 Nov;2(4):794-798. doi: 10.1002/jha2.305. Epub 2021 Oct 01.

No abstract available.

Genome Wide Identification and Comparative Analysis of the Serpin Gene Family in Brachypodium and Barley.

Plants (Basel, Switzerland)

Rehman S, Jørgensen B, Aziz E, Batool R, Naseer S, Rasmussen SK.
PMID: 33114466
Plants (Basel). 2020 Oct 26;9(11). doi: 10.3390/plants9111439.

Serpins (serine protease inhibitors) constitute one of the largest and most widely distributed superfamilies of protease inhibitors and have been identified in nearly all organisms. To gain significant insights, a comprehensive in silico analysis of the serpin gene family...

Showing 1 to 12 of 75 entries