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Showing 1 to 12 of 21 entries
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Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates.

Frontiers in immunology

Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL, Loukas A.
PMID: 25999951
Front Immunol. 2015 May 05;6:213. doi: 10.3389/fimmu.2015.00213. eCollection 2015.

Schistosoma haematobium affects more than 100 million people throughout Africa and is the causative agent of urogenital schistosomiasis. The parasite is strongly associated with urothelial cancer in infected individuals and as such is designated a group I carcinogen by...

Efficacy of integrated school based de-worming and prompt malaria treatment on helminths -Plasmodium falciparum co-infections: A 33 months follow up study.

BMC international health and human rights

Midzi N, Mtapuri-Zinyowera S, Sangweme D, Paul NH, Makware G, Mapingure MP, Brouwer KC, Mudzori J, Hlerema G, Chadukura V, Mutapi F, Kumar N, Mduluza T.
PMID: 21696629
BMC Int Health Hum Rights. 2011 Jun 22;11:9. doi: 10.1186/1472-698X-11-9.

BACKGROUND: The geographical congruency in distribution of helminths and Plasmodium falciparum makes polyparasitism a common phenomenon in Sub Saharan Africa. The devastating effects of helminths-Plasmodium co-infections on primary school health have raised global interest for integrated control. However little...

Dynamics of paediatric urogenital schistosome infection, morbidity and treatment: a longitudinal study among preschool children in Zimbabwe.

BMJ global health

Osakunor DNM, Mduluza T, Midzi N, Chase-Topping M, Mutsaka-Makuvaza MJ, Chimponda T, Eyoh E, Mduluza T, Pfavayi LT, Wami WM, Amanfo SA, Murray J, Tshuma C, Woolhouse MEJ, Mutapi F.
PMID: 29616147
BMJ Glob Health. 2018 Mar 27;3(2):e000661. doi: 10.1136/bmjgh-2017-000661. eCollection 2018.

BACKGROUND: Recent research has shown that in schistosome-endemic areas preschool-aged children (PSAC), that is, ≤5 years, are at risk of infection. However, there exists a knowledge gap on the dynamics of infection and morbidity in this age group. In...

Systemic Sclerosis in Zimbabwe: Autoantibody Biomarkers, Clinical, and Laboratory Correlates.

Frontiers in immunology

Sibanda EN, Dube Y, Chakawa M, Mduluza T, Mutapi F.
PMID: 34858387
Front Immunol. 2021 Nov 09;12:679531. doi: 10.3389/fimmu.2021.679531. eCollection 2021.

INTRODUCTION: Systemic sclerosis (SScl) is an autoimmune disease whose prevalence is rarely reported in Africa. Autoantibodies are the biomarkers of the condition, precede overt disease and determine disease phenotypes. SSc specific autoantibodies also vary between racial groupings. Objective: To...

Fungal allergic sensitisation in young rural Zimbabwean children: Gut mycobiome and seroreactivity characteristics.

Current research in microbial sciences

Pfavayi LT, Sibanda EN, Baker S, Woolhouse M, Mduluza T, Mutapi F.
PMID: 35028627
Curr Res Microb Sci. 2021 Nov 16;2:100082. doi: 10.1016/j.crmicr.2021.100082. eCollection 2021 Dec.

BACKGROUND: The prevalence of allergic diseases has increased over the last few decades, with sensitisation to fungal allergens and gut microbiome dysbiosis implicated in this trend. The fungal community in the gut (mycobiome) has yet to be characterised and...

Interleukin-10 and tumour necrosis factor alpha promoter region polymorphisms and susceptibility to urogenital schistosomiasis in young Zimbabwean children living in .

Southern African journal of infectious diseases

Marume A, Vengesai A, Mann J, Mduluza T.
PMID: 34485462
S Afr J Infect Dis. 2020 Sep 03;35(1):11. doi: 10.4102/sajid.v35i1.11. eCollection 2020.

CONCLUSION: Interleukin-10 -1082 G/A, IL-10 -819 C/T and TNF-α -308 G/A SNPs were not significantly associated with susceptibility to

Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium.

Journal of parasitology research

Reilly L, Nausch N, Midzi N, Mduluza T, Mutapi F.
PMID: 22523639
J Parasitol Res. 2012;2012:128628. doi: 10.1155/2012/128628. Epub 2012 Feb 20.

Micronutrients play an important role in the development of effective immune responses. This study characterised a populations exposed to schistosome infections in terms of the relationship between micronutrients and immune responses. Levels of retinol binding protein (RBP; vitamin A...

Human parasitic protozoa in drinking water sources in rural Zimbabwe and their link to HIV infection.

Germs

Mtapuri-Zinyowera S, Ruhanya V, Midzi N, Berejena C, Chin'ombe N, Nziramasanga P, Nyandoro G, Mduluza T.
PMID: 25505741
Germs. 2014 Dec 01;4(4):86-91. doi: 10.11599/germs.2014.1061. eCollection 2014 Dec.

OBJECTIVE: We aimed to perform a risk assessment in a rural setting, where drinking water is obtained from both protected and unprotected deep or shallow wells, boreholes and springs. Water is consumed untreated and this poses a risk of...

Inflammation-modulating cytokine profile and lipid interaction in HIV-related risk factors for cardiovascular diseases.

Therapeutics and clinical risk management

Gori E, Mduluza T, Nyagura M, Stray-Pedersen B, Gomo ZA.
PMID: 27956833
Ther Clin Risk Manag. 2016 Nov 11;12:1659-1666. doi: 10.2147/TCRM.S117980. eCollection 2016.

HIV infection and antiretroviral therapy (ART) are associated with changes in plasma levels of lipoproteins, thus posing the risk of cardiovascular complications in infected individuals. The alteration in plasma lipoprotein levels results from dysregulation of inflammation-modulating cytokines that control...

Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.

Frontiers in immunology

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE, Mutapi F.
PMID: 25741337
Front Immunol. 2015 Feb 18;6:51. doi: 10.3389/fimmu.2015.00051. eCollection 2015.

The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions. Down regulation of CD3ζ leads to impairment of...

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe.

African journal of laboratory medicine

Marume A, Chimponda T, Vengesai A, Mushayi C, Mann J, Mduluza T.
PMID: 34007813
Afr J Lab Med. 2021 Apr 29;10(1):1138. doi: 10.4102/ajlm.v10i1.1138. eCollection 2021.

BACKGROUND: Knowledge gaps exist between host genetic factors and susceptibility to schistosomiasis.OBJECTIVE: This study determined cytokine levels and single nucleotide polymorphisms of tumour necrosis factor (TNF)-α (rs1800629) and interleukin (IL)-10 (rs1800871) and their possible impact on susceptibility to schistosomiasis...

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study.

The Lancet. Microbe

Pearson MS, Tedla BA, Mekonnen GG, Proietti C, Becker L, Nakajima R, Jasinskas A, Doolan DL, Amoah AS, Knopp S, Rollinson D, Ali SM, Kabole F, Hokke CH, Adegnika AA, Field MA, van Dam G, Corstjens PLAM, Mduluza T, Mutapi F, Oeuvray C, Greco B, Chaiyadet S, Laha T, Cai P, McManus DP, Bottazzi ME, Felgner PL, Sotillo J, Loukas A.
PMID: 34977830
Lancet Microbe. 2021 Nov;2(11):e617-e626. doi: 10.1016/S2666-5247(21)00150-6.

BACKGROUND: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the METHODS: We did a biomarker identification study, in which we...

Showing 1 to 12 of 21 entries