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Showing 1 to 8 of 8 entries
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Clinical, Pathological, and Molecular Studies of Two Families with Iodide Organification Defect.

Endocrine pathology

Rego KG, Billerbeck AE, Targovnik HM, Santos CL, Alkmin MG, Barbosa S, Camargo R, Medeiros-Neto G.
PMID: 12114670
Endocr Pathol. 1997;8(1):37-47. doi: 10.1007/BF02739706.

Two unrelated families (CA and NA) in which an iodide organification defect (lOD) was present in two siblings of each family were studied. These patients had congenital goiters with hypothyroidism and a positive perchlorate discharge test. Examination of the...

Pathological Findings in Dyshormonogenetic Goiter with Defective Iodide Transport.

Endocrine pathology

Camargo RY, Gross JL, Silveiro SP, Knobel M, Medeiros-Neto G.
PMID: 12114713
Endocr Pathol. 1998;9(3):225-233. doi: 10.1007/BF02739962.

An adult male patient (38 yr old) with a large congenital goiter with hypothyroidism was suspected of having a defective iodide (L) transport mechanism based on low thyroid uptake and a very low salivary/plasma ratio. Moreover the high serum...

Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.

International journal of endocrinology

Camargo RY, Kanamura CT, Friguglietti CU, Nogueira CR, Iorcansky S, Tincani AJ, Bezerra AK, Brust E, Koyama FC, Camargo AA, Rego FOR, Galante PAF, Medeiros-Neto G, Rubio IGS.
PMID: 29593791
Int J Endocrinol. 2018 Feb 08;2018:4682876. doi: 10.1155/2018/4682876. eCollection 2018.

Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic...

Intrachromosomal karyotype asymmetry in Orchidaceae.

Genetics and molecular biology

Medeiros-Neto E, Nollet F, Moraes AP, Felix LP.
PMID: 28644507
Genet Mol Biol. 2017 Jul-Sep;40(3):610-619. doi: 10.1590/1678-4685-GMB-2016-0264. Epub 2017 Jun 22.

The asymmetry indexes have helped cytotaxonomists to interpret and classify plant karyotypes for species delimitation efforts. However, there is no consensus about the best method to calculate the intrachromosomal asymmetry. The present study aimed to compare different intrachromosomal asymmetry...

Familial Congenital Hypothyroidism Caused by Abnormal and Bioinactive TSH due to Mutations in the beta-Subunit Gene.

Trends in endocrinology and metabolism: TEM

Medeiros-Neto G, de Lacerda L, Wondisford FE.
PMID: 18406781
Trends Endocrinol Metab. 1997 Jan-Feb;8(1):15-20. doi: 10.1016/s1043-2760(96)00203-2.

Hereditary TSH deficiency is a rare autosomal recessive disease described in inbred Japanese families and in Greek and Brazilian kindreds. The TSH-beta-subunit gene has been shown to be the site of mutations that will give rise to truncated proteins...

Dyshormonogenetic goiter: A morphological and immunohistochemical study.

Endocrine pathology

Matos PS, Bisi H, Medeiros-Neto G.
PMID: 32370435
Endocr Pathol. 1994 Mar;5(1):49-58. doi: 10.1007/BF02921370.

A retrospective morphological and immunohistochemical study of 21 cases of dyshormonogenetic goiter was carried out correlating patterns of hyperplasia and the atypias of the glandular tissues with specific defects in hormonal synthesis, including (1) thyroglobulin synthesis defect (Group I,...

Studies on functional and morphological aspects in human multinodular simple goiter tissues.

Endocrine pathology

Knobel M, Bisi H, de Araujo Peres C, Medeiros-Neto G.
PMID: 32370455
Endocr Pathol. 1993 Dec;4(4):205-214. doi: 10.1007/BF02915463.

Samples from 2 different locations within the same euthyroid multinodular goiters (SMG) and normal (N) human thyroids were assayed for their content of DNA, thyroglobulin (Tg), and stable iodine (

Amino Acid Composition of Proteins Extracted from Endemic Goiter Glands.

Endocrine pathology

Baggio MC, Medeiros-Neto G, Osawa Y, Nguyen NY, Santisteban P, Knobel M, Groliman EE.
PMID: 12114641
Endocr Pathol. 1996;7(2):137-143. doi: 10.1007/BF02739973.

Proteins were isolated and characterized in thyroid tissue of six patients from Brazil with endemic goiter. Biochemical studies of these thyroidal proteins included gel filtration, electrophoresis, and amino acid analysis. In addition to thyroglobulin, two of the most abundant...

Showing 1 to 8 of 8 entries