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Natural History of Innate Host Defense Peptides.

Probiotics and antimicrobial proteins

Linde A, Wachter B, Höner OP, Dib L, Ross C, Tamayo AR, Blecha F, Melgarejo T.
PMID: 26783164
Probiotics Antimicrob Proteins. 2009 Dec;1(2):97-112. doi: 10.1007/s12602-009-9031-x.

Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features...

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Linde A, Wachter B, Höner OP, et al. Natural History of Innate Host Defense Peptides. Probiotics Antimicrob Proteins. 2009;1(2):97-112doi: 10.1007/s12602-009-9031-x.
Linde, A., Wachter, B., Höner, O. P., Dib, L., Ross, C., Tamayo, A. R., Blecha, F., & Melgarejo, T. (2009). Natural History of Innate Host Defense Peptides. Probiotics and antimicrobial proteins, 1(2), 97-112. https://doi.org/10.1007/s12602-009-9031-x
Linde, A, et al. "Natural History of Innate Host Defense Peptides." Probiotics and antimicrobial proteins vol. 1,2 (2009): 97-112. doi: https://doi.org/10.1007/s12602-009-9031-x
Linde A, Wachter B, Höner OP, Dib L, Ross C, Tamayo AR, Blecha F, Melgarejo T. Natural History of Innate Host Defense Peptides. Probiotics Antimicrob Proteins. 2009 Dec;1(2):97-112. doi: 10.1007/s12602-009-9031-x. PMID: 26783164.
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Value of FDG-PET in the Therapeutic Management of Recurrent Ovarian Cancer. Experience in 31 Patients.

Clinical positron imaging : official journal of the Institute for Clinical P.E.T

Maldonado A, Sancho F, Perez-Carrión R, Señor C, Moya F, Trampal C, Ossola G, Ortega F, Melgarejo M.
PMID: 14516618
Clin Positron Imaging. 1999 Nov;2(6):321. doi: 10.1016/s1095-0397(99)00081-3.

No abstract available.

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Maldonado A, Sancho F, Perez-Carrión R, et al. Value of FDG-PET in the Therapeutic Management of Recurrent Ovarian Cancer. Experience in 31 Patients. Clin Positron Imaging. 1999;2(6):321doi: 10.1016/s1095-0397(99)00081-3.
Maldonado, A., Sancho, F., Perez-Carrión, R., Señor, C., Moya, F., Trampal, C., Ossola, G., Ortega, F., & Melgarejo, M. (1999). Value of FDG-PET in the Therapeutic Management of Recurrent Ovarian Cancer. Experience in 31 Patients. Clinical positron imaging : official journal of the Institute for Clinical P.E.T, 2(6), 321. https://doi.org/10.1016/s1095-0397(99)00081-3
Maldonado, A, et al. "Value of FDG-PET in the Therapeutic Management of Recurrent Ovarian Cancer. Experience in 31 Patients." Clinical positron imaging : official journal of the Institute for Clinical P.E.T vol. 2,6 (1999): 321. doi: https://doi.org/10.1016/s1095-0397(99)00081-3
Maldonado A, Sancho F, Perez-Carrión R, Señor C, Moya F, Trampal C, Ossola G, Ortega F, Melgarejo M. Value of FDG-PET in the Therapeutic Management of Recurrent Ovarian Cancer. Experience in 31 Patients. Clin Positron Imaging. 1999 Nov;2(6):321. doi: 10.1016/s1095-0397(99)00081-3. PMID: 14516618.
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Capabilities of through-the-substrate microdiffraction: application of Patterson-function direct methods to synchrotron data from polished thin sections.

Journal of synchrotron radiation

Rius J, Labrador A, Crespi A, Frontera C, Vallcorba O, Melgarejo JC.
PMID: 21997914
J Synchrotron Radiat. 2011 Nov;18:891-8. doi: 10.1107/S0909049511038830. Epub 2011 Oct 06.

Some theoretical and practical aspects of the application of transmission microdiffraction (µXRD) to thin sections (≤30 µm thickness) of samples fixed or deposited on substrates are discussed. The principal characteristic of this technique is that the analysed micro-sized region...

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Rius J, Labrador A, Crespi A, et al. Capabilities of through-the-substrate microdiffraction: application of Patterson-function direct methods to synchrotron data from polished thin sections. J Synchrotron Radiat. 2011;18:891-8doi: 10.1107/S0909049511038830.
Rius, J., Labrador, A., Crespi, A., Frontera, C., Vallcorba, O., & Melgarejo, J. C. (2011). Capabilities of through-the-substrate microdiffraction: application of Patterson-function direct methods to synchrotron data from polished thin sections. Journal of synchrotron radiation, 18891-8. https://doi.org/10.1107/S0909049511038830
Rius, Jordi, et al. "Capabilities of through-the-substrate microdiffraction: application of Patterson-function direct methods to synchrotron data from polished thin sections." Journal of synchrotron radiation vol. 18 (2011): 891-8. doi: https://doi.org/10.1107/S0909049511038830
Rius J, Labrador A, Crespi A, Frontera C, Vallcorba O, Melgarejo JC. Capabilities of through-the-substrate microdiffraction: application of Patterson-function direct methods to synchrotron data from polished thin sections. J Synchrotron Radiat. 2011 Nov;18:891-8. doi: 10.1107/S0909049511038830. Epub 2011 Oct 06. PMID: 21997914.
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First Report of Brown Rot Caused by Monilinia fructicola in Peach Orchards in Ebro Valley, Spain.

Plant disease

De Cal A, Gell I, Usall J, Viñas I, Melgarejo P.
PMID: 30764386
Plant Dis. 2009 Jul;93(7):763. doi: 10.1094/PDIS-93-7-0763A.

Monilinia fructicola causes brown rot of stone fruit in India, Japan, the Republic of Korea, Oceania, and North and South America and is in the A2 list of quarantine organisms for Europe. M. fructicola was found in peach orchards...

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De Cal A, Gell I, Usall J, et al. First Report of Brown Rot Caused by Monilinia fructicola in Peach Orchards in Ebro Valley, Spain. Plant Dis. 2009;93(7):763doi: 10.1094/PDIS-93-7-0763A.
De Cal, A., Gell, I., Usall, J., Viñas, I., & Melgarejo, P. (2009). First Report of Brown Rot Caused by Monilinia fructicola in Peach Orchards in Ebro Valley, Spain. Plant disease, 93(7), 763. https://doi.org/10.1094/PDIS-93-7-0763A
De Cal, A, et al. "First Report of Brown Rot Caused by Monilinia fructicola in Peach Orchards in Ebro Valley, Spain." Plant disease vol. 93,7 (2009): 763. doi: https://doi.org/10.1094/PDIS-93-7-0763A
De Cal A, Gell I, Usall J, Viñas I, Melgarejo P. First Report of Brown Rot Caused by Monilinia fructicola in Peach Orchards in Ebro Valley, Spain. Plant Dis. 2009 Jul;93(7):763. doi: 10.1094/PDIS-93-7-0763A. PMID: 30764386.
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Detection of Latent Monilinia Infections in Nectarine Flowers and Fruit by qPCR.

Plant disease

Garcia-Benitez C, Melgarejo P, De Cal A.
PMID: 30682929
Plant Dis. 2017 Jun;101(6):1002-1008. doi: 10.1094/PDIS-11-16-1682-RE. Epub 2017 Mar 20.

Most stone fruit with a latent brown rot infection caused by Monilinia do not develop visible signs of disease until the arrival of fruit at the markets or the consumer's homes. The overnight freezing-incubation technique (ONFIT) is a well-established...

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Garcia-Benitez C, Melgarejo P, De Cal A. Detection of Latent Monilinia Infections in Nectarine Flowers and Fruit by qPCR. Plant Dis. 2017;101(6):1002-1008doi: 10.1094/PDIS-11-16-1682-RE.
Garcia-Benitez, C., Melgarejo, P., & De Cal, A. (2017). Detection of Latent Monilinia Infections in Nectarine Flowers and Fruit by qPCR. Plant disease, 101(6), 1002-1008. https://doi.org/10.1094/PDIS-11-16-1682-RE
Garcia-Benitez, C, et al. "Detection of Latent Monilinia Infections in Nectarine Flowers and Fruit by qPCR." Plant disease vol. 101,6 (2017): 1002-1008. doi: https://doi.org/10.1094/PDIS-11-16-1682-RE
Garcia-Benitez C, Melgarejo P, De Cal A. Detection of Latent Monilinia Infections in Nectarine Flowers and Fruit by qPCR. Plant Dis. 2017 Jun;101(6):1002-1008. doi: 10.1094/PDIS-11-16-1682-RE. Epub 2017 Mar 20. PMID: 30682929.
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Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation.

Journal of clinical medicine

Pérez-Valero J, Caballero Pintado MV, Melgarejo F, García-Sánchez AJ, Garcia-Haro J, García Córdoba F, García Córdoba JA, Pinar E, García Alberola A, Matilla-García M, Curtin P, Arora M, Ruiz Marín M.
PMID: 31684004
J Clin Med. 2019 Nov 02;8(11). doi: 10.3390/jcm8111840.

Atrial fibrillation (AF) is a sustained cardiac arrhythmia associated with stroke, heart failure, and related health conditions. Though easily diagnosed upon presentation in a clinical setting, the transient and/or intermittent emergence of AF episodes present diagnostic and clinical monitoring...

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Pérez-Valero J, Caballero Pintado MV, Melgarejo F, et al. Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation. J Clin Med. 2019;8(11)doi: 10.3390/jcm8111840.
Pérez-Valero, J., Caballero Pintado, M. V., Melgarejo, F., García-Sánchez, A. J., Garcia-Haro, J., García Córdoba, F., García Córdoba, J. A., Pinar, E., García Alberola, A., Matilla-García, M., Curtin, P., Arora, M., & Ruiz Marín, M. (2019). Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation. Journal of clinical medicine, 8(11), . https://doi.org/10.3390/jcm8111840
Pérez-Valero, Jesús, et al. "Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation." Journal of clinical medicine vol. 8,11 (2019). doi: https://doi.org/10.3390/jcm8111840
Pérez-Valero J, Caballero Pintado MV, Melgarejo F, García-Sánchez AJ, Garcia-Haro J, García Córdoba F, García Córdoba JA, Pinar E, García Alberola A, Matilla-García M, Curtin P, Arora M, Ruiz Marín M. Symbolic Recurrence Analysis of RR Interval to Detect Atrial Fibrillation. J Clin Med. 2019 Nov 02;8(11). doi: 10.3390/jcm8111840. PMID: 31684004; PMCID: PMC6912662.
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Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis.

Pathogens (Basel, Switzerland)

Krumbeck JA, Reiter AM, Pohl JC, Tang S, Kim YJ, Linde A, Prem A, Melgarejo T.
PMID: 34358054
Pathogens. 2021 Jul 17;10(7). doi: 10.3390/pathogens10070904.

Previous studies have suggested the involvement of viral and bacterial components in the initiation and progression of feline chronic gingivostomatitis (FCGS), but the role of fungi remains entirely unknown. This pilot study aimed to investigate the bacteriome and mycobiome...

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Krumbeck JA, Reiter AM, Pohl JC, et al. Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis. Pathogens. 2021;10(7)doi: 10.3390/pathogens10070904.
Krumbeck, J. A., Reiter, A. M., Pohl, J. C., Tang, S., Kim, Y. J., Linde, A., Prem, A., & Melgarejo, T. (2021). Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis. Pathogens (Basel, Switzerland), 10(7), . https://doi.org/10.3390/pathogens10070904
Krumbeck, Janina A, et al. "Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis." Pathogens (Basel, Switzerland) vol. 10,7 (2021). doi: https://doi.org/10.3390/pathogens10070904
Krumbeck JA, Reiter AM, Pohl JC, Tang S, Kim YJ, Linde A, Prem A, Melgarejo T. Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis. Pathogens. 2021 Jul 17;10(7). doi: 10.3390/pathogens10070904. PMID: 34358054; PMCID: PMC8308807.
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Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies.

Mayo Clinic proceedings

Petrovic D, Pruijm M, Ponte B, Dhayat NA, Ackermann D, Ehret G, Ansermot N, Vogt B, Martin PY, Stringhini S, Estoppey-Younès S, Thijs L, Zhang Z, Melgarejo JD, Eap CB, Staessen JA, Bochud M, Guessous I.
PMID: 34579945
Mayo Clin Proc. 2021 Dec;96(12):3071-3085. doi: 10.1016/j.mayocp.2021.05.030. Epub 2021 Sep 25.

OBJECTIVE: To investigate the relations between caffeine-derived metabolites (methylxanthines) and plasma lipids by use of population-based data from 2 European countries.METHODS: Families were randomly selected from the general population of northern Belgium (FLEMENGHO), from August 12, 1985, until November...

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Petrovic D, Pruijm M, Ponte B, et al. Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clin Proc. 2021;96(12):3071-3085doi: 10.1016/j.mayocp.2021.05.030.
Petrovic, D., Pruijm, M., Ponte, B., Dhayat, N. A., Ackermann, D., Ehret, G., Ansermot, N., Vogt, B., Martin, P. Y., Stringhini, S., Estoppey-Younès, S., Thijs, L., Zhang, Z., Melgarejo, J. D., Eap, C. B., Staessen, J. A., Bochud, M., & Guessous, I. (2021). Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clinic proceedings, 96(12), 3071-3085. https://doi.org/10.1016/j.mayocp.2021.05.030
Petrovic, Dusan, et al. "Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies." Mayo Clinic proceedings vol. 96,12 (2021): 3071-3085. doi: https://doi.org/10.1016/j.mayocp.2021.05.030
Petrovic D, Pruijm M, Ponte B, Dhayat NA, Ackermann D, Ehret G, Ansermot N, Vogt B, Martin PY, Stringhini S, Estoppey-Younès S, Thijs L, Zhang Z, Melgarejo JD, Eap CB, Staessen JA, Bochud M, Guessous I. Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clin Proc. 2021 Dec;96(12):3071-3085. doi: 10.1016/j.mayocp.2021.05.030. Epub 2021 Sep 25. PMID: 34579945.
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Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia.

Neuropharmacology

de la Rocha-Muñoz A, Melgarejo E, Aragón C, López-Corcuera B.
PMID: 33794243
Neuropharmacology. 2021 May 15;189:108543. doi: 10.1016/j.neuropharm.2021.108543. Epub 2021 Mar 29.

Hyperekplexia is a rare sensorimotor syndrome characterized by pathological startle reflex in response to unexpected trivial stimuli for which there is no specific treatment. Neonates suffer from hypertonia and are at high risk of sudden death due to apnea...

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de la Rocha-Muñoz A, Melgarejo E, Aragón C, et al. Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia. Neuropharmacology. 2021;189:108543doi: 10.1016/j.neuropharm.2021.108543.
de la Rocha-Muñoz, A., Melgarejo, E., Aragón, C., & López-Corcuera, B. (2021). Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia. Neuropharmacology, 189108543. https://doi.org/10.1016/j.neuropharm.2021.108543
de la Rocha-Muñoz, Andrés, et al. "Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia." Neuropharmacology vol. 189 (2021): 108543. doi: https://doi.org/10.1016/j.neuropharm.2021.108543
de la Rocha-Muñoz A, Melgarejo E, Aragón C, López-Corcuera B. Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia. Neuropharmacology. 2021 May 15;189:108543. doi: 10.1016/j.neuropharm.2021.108543. Epub 2021 Mar 29. PMID: 33794243.
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Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements.

Hypertension (Dallas, Tex. : 1979)

McEvoy JW, Yang WY, Thijs L, Zhang ZY, Melgarejo JD, Boggia J, Hansen TW, Asayama K, Ohkubo T, Dolan E, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Lind L, Filipovský J, Maestre GE, Li Y, Wang JG, Imai Y, Kawecka-Jaszcz K, Sandoya E, Narkiewicz K, O'Brien E, Vanassche T, Staessen JA.
PMID: 34601965
Hypertension. 2021 Nov;78(5):1222-1231. doi: 10.1161/HYPERTENSIONAHA.121.17766. Epub 2021 Oct 04.

[Figure: see text].

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McEvoy JW, Yang WY, Thijs L, et al. Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements. Hypertension. 2021;78(5):1222-1231doi: 10.1161/HYPERTENSIONAHA.121.17766.
McEvoy, J. W., Yang, W. Y., Thijs, L., Zhang, Z. Y., Melgarejo, J. D., Boggia, J., Hansen, T. W., Asayama, K., Ohkubo, T., Dolan, E., Stolarz-Skrzypek, K., Malyutina, S., Casiglia, E., Lind, L., Filipovský, J., Maestre, G. E., Li, Y., Wang, J. G., Imai, Y., Kawecka-Jaszcz, K., Sandoya, E., Narkiewicz, K., O'Brien, E., Vanassche, T., Staessen, J. A. (2021). Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements. Hypertension (Dallas, Tex. : 1979), 78(5), 1222-1231. https://doi.org/10.1161/HYPERTENSIONAHA.121.17766
McEvoy, John W, et al. "Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements." Hypertension (Dallas, Tex. : 1979) vol. 78,5 (2021): 1222-1231. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17766
McEvoy JW, Yang WY, Thijs L, Zhang ZY, Melgarejo JD, Boggia J, Hansen TW, Asayama K, Ohkubo T, Dolan E, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Lind L, Filipovský J, Maestre GE, Li Y, Wang JG, Imai Y, Kawecka-Jaszcz K, Sandoya E, Narkiewicz K, O'Brien E, Vanassche T, Staessen JA. Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements. Hypertension. 2021 Nov;78(5):1222-1231. doi: 10.1161/HYPERTENSIONAHA.121.17766. Epub 2021 Oct 04. PMID: 34601965; PMCID: PMC8516806.
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Breba Fruits Characterization from Four Varieties (Ficus carica L.) with Important Commercial Interest in Spain.

Foods (Basel, Switzerland)

Núñez-Gómez D, Legua P, Martínez-Nicolás JJ, Melgarejo P.
PMID: 34945688
Foods. 2021 Dec 17;10(12). doi: 10.3390/foods10123138.

Although most of the published articles generalize with the fruit of the fig tree (

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Núñez-Gómez D, Legua P, Martínez-Nicolás JJ, et al. Breba Fruits Characterization from Four Varieties (Ficus carica L.) with Important Commercial Interest in Spain. Foods. 2021;10(12)doi: 10.3390/foods10123138.
Núñez-Gómez, D., Legua, P., Martínez-Nicolás, J. J., & Melgarejo, P. (2021). Breba Fruits Characterization from Four Varieties (Ficus carica L.) with Important Commercial Interest in Spain. Foods (Basel, Switzerland), 10(12), . https://doi.org/10.3390/foods10123138
Núñez-Gómez, Dámaris, et al. "Breba Fruits Characterization from Four Varieties (Ficus carica L.) with Important Commercial Interest in Spain." Foods (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/foods10123138
Núñez-Gómez D, Legua P, Martínez-Nicolás JJ, Melgarejo P. Breba Fruits Characterization from Four Varieties (Ficus carica L.) with Important Commercial Interest in Spain. Foods. 2021 Dec 17;10(12). doi: 10.3390/foods10123138. PMID: 34945688; PMCID: PMC8700890.
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17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients.

Clinical positron imaging : official journal of the Institute for Clinical P.E.T

Moya F, Gómez F, De Pedro M, Maldonado A, Melgarejo M, Gorospe E, Ruiz J, Jiménez J, Pozo M.
PMID: 11150774
Clin Positron Imaging. 2000 Jul;3(4):171. doi: 10.1016/s1095-0397(00)00083-2.

Purpose: SCC represents nearly 90% of all oral malignancies, with an increasing incidence. Accurate Tumour-Node-Metastasis staging (TNM) is mandatory for planning surgical options and chemotherapy-radiotherapy management. Positron Emission Tomography (PET) using 18F-Fluorodeoxyglucose (FDG) provides functional information about tumoral tissues...

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Moya F, Gómez F, De Pedro M, et al. 17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients. Clin Positron Imaging. 2000;3(4):171doi: 10.1016/s1095-0397(00)00083-2.
Moya, F., Gómez, F., De Pedro M, Maldonado, A., Melgarejo, M., Gorospe, E., Ruiz, J., Jiménez, J., & Pozo, M. (2000). 17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients. Clinical positron imaging : official journal of the Institute for Clinical P.E.T, 3(4), 171. https://doi.org/10.1016/s1095-0397(00)00083-2
Moya, et al. "17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients." Clinical positron imaging : official journal of the Institute for Clinical P.E.T vol. 3,4 (2000): 171. doi: https://doi.org/10.1016/s1095-0397(00)00083-2
Moya F, Gómez F, De Pedro M, Maldonado A, Melgarejo M, Gorospe E, Ruiz J, Jiménez J, Pozo M. 17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients. Clin Positron Imaging. 2000 Jul;3(4):171. doi: 10.1016/s1095-0397(00)00083-2. PMID: 11150774.
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