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Identification of glypican-3-derived long peptides activating both CD8.


Sayem MA, Tomita Y, Yuno A, Hirayama M, Irie A, Tsukamoto H, Senju S, Yuba E, Yoshikawa T, Kono K, Nakatsura T, Nishimura Y.
PMID: 26942076
Oncoimmunology. 2015 Aug 31;5(1):e1062209. doi: 10.1080/2162402X.2015.1062209. eCollection 2016.

In a recent phase I clinical trial, a vaccine consisting of glypican-3 (GPC3)-derived CTL epitopes was found to be safe and induced measurable immune and clinical responses in patients with hepatocellular carcinoma (HCC). The aim of this study was...

Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension.

Frontiers in pharmacology

Sasagawa S, Nishimura Y, Sawada H, Zhang E, Okabe S, Murakami S, Ashikawa Y, Yuge M, Kawaguchi K, Kawase R, Mitani Y, Maruyama K, Tanaka T.
PMID: 27375481
Front Pharmacol. 2016 Jun 07;7:142. doi: 10.3389/fphar.2016.00142. eCollection 2016.

Pulmonary arterial hypertension (PAH) is a heterogeneous disorder associated with a progressive increase in pulmonary artery resistance and pressure. Although various therapies have been developed, the 5-year survival rate of PAH patients remains low. There is thus an important...

Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society.

Esophagus : official journal of the Japan Esophageal Society

Kuwano H, Nishimura Y, Oyama T, Kato H, Kitagawa Y, Kusano M, Shimada H, Takiuchi H, Toh Y, Doki Y, Naomoto Y, Matsubara H, Miyazaki T, Muto M, Yanagisawa A.
PMID: 25620903
Esophagus. 2015;12:1-30. doi: 10.1007/s10388-014-0465-1. Epub 2014 Nov 11.

No abstract available.

Fatigue-related differences in erector spinae between prepubertal children and young adults using surface electromyographic power spectral analysis.

Journal of back and musculoskeletal rehabilitation

Tanina H, Nishimura Y, Tsuboi H, Sakata T, Nakamura T, Murata KY, Arakawa H, Umezu Y, Tajima F.
PMID: 27232083
J Back Musculoskelet Rehabil. 2016 May 20; doi: 10.3233/BMR-160705. Epub 2016 May 20.

BACKGROUND: The erector spinae is more resistant to fatigue in adult women than men. However, no study has reported the sex differences in back muscle fatigue in children.OBJECTIVE: The aim of this study was to evaluate the fatigability of...

Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology.

The Journal of antibiotics

Adachi H, Nakae K, Sakamoto S, Nosaka C, Atsumi S, Shibuya M, Higashi N, Nakajima M, Irimura T, Nishimura Y.
PMID: 29089599
J Antibiot (Tokyo). 2017 Nov 01; doi: 10.1038/ja.2017.138. Epub 2017 Nov 01.

Microbial metabolites have attracted increasing interest as a source of therapeutics and as probes for biological mechanisms. New microbial metabolites and derivatives targeted at inflammation and bone disease therapy have been identified by focusing on prostaglandin release, osteoblast differentiation...

Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report.

NMC case report journal

Fukuoka T, Nishimura Y, Hara M, Haimoto S, Eguchi K, Yoshikawa S, Wakabayashi T, Ginsberg HJ.
PMID: 29018653
NMC Case Rep J. 2017 Sep 12;4(4):115-120. doi: 10.2176/ eCollection 2017 Oct.

Chiari type 1 malformation (CM1) rarely causes papilloedema, which is indicative of high intracranial pressure with or without ventricular dilatation. Furthermore, concomitant brain parenchymal abnormalities have not been reported to date. In this paper, the authors report on a...

A case of panspinal epidural abscess that presented with meningeal irritation.

Acute medicine & surgery

Okada N, Nishiyama T, Kurihara M, Nishimura Y, Nishimura Y, Ando Y, Otsubo S, Yamada K, Maeda Y.
PMID: 29123892
Acute Med Surg. 2017 Jul 06;4(3):363-366. doi: 10.1002/ams2.294. eCollection 2017 Jul.

CASE: In rare cases, spinal epidural abscess involves the entire spine and can lead to neurological deficits and sepsis if treatment is delayed or suboptimal. A 65-year-old man was admitted with a diagnosis of bacterial meningitis. After admission, magnetic...

Frontiers in endocrinology

Nishimura Y, Mabuchi K, Takano A, Hara Y, Negishi H, Morimoto K, Ueno T, Uchiyama S, Takamata A.
PMID: 29097993
Front Endocrinol (Lausanne). 2017 Oct 19;8:281. doi: 10.3389/fendo.2017.00281. eCollection 2017.

Chronic estrogen replacement in ovariectomized rats attenuates food intake and enhances c-Fos expression in the suprachiasmatic nucleus (SCN), specifically during the light phase.

A high performance photothermal film with spherical shell-type metallic nanocomposites for solar thermoelectric conversion.


Kosuga A, Yamamoto Y, Miyai M, Matsuzawa M, Nishimura Y, Hidaka S, Yamamoto K, Tanaka S, Yamamoto Y, Tokonami S, Iida T.
PMID: 25869092
Nanoscale. 2015 May 07;7(17):7580-4. doi: 10.1039/c5nr00943j.

A photothermal film (PTF) with densely assembled gold nanoparticle-fixed beads on a polymer substrate is fabricated. Remarkably, a temperature rise higher than 40 °C is achieved in the PTF with only 100 seconds of artificial solar irradiation, and the...

High-precision instrument for measuring the surface tension, viscosity and surface viscoelasticity of liquids using ripplon surface laser-light scattering with tunable wavelength selection.

The Review of scientific instruments

Nishimura Y, Hasegawa A, Nagasaka Y.
PMID: 24784645
Rev Sci Instrum. 2014 Apr;85(4):044904. doi: 10.1063/1.4871992.

Here we describe our new high-precision instrument that simultaneously measures the surface tension, viscosity, and surface viscoelasticity of liquids. The instrument works on the ripplon surface-laser light scattering principle and operates with an automatically tunable selection of ripplon wavelength...

Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus.

Modern rheumatology

Morimoto S, Hashimoto H, Yamanaka K, Tokano Y, Nishimura Y, Sawada S, Kamatani N, Sumida T, Yoshizaki K, Nagasawa K, Miyasaka N.
PMID: 24383636
Mod Rheumatol. 2000 Dec;10(4):235-9. doi: 10.3109/s101650070009.

Abstract The relation between HLA class II alleles and clinical findings were examined in Japanese patients with systemic lupus erythematosus (SLE). In 284 patients with multicenter SLE, HLA class II alleles were examined using the DNA typing method, and...

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.

Frontiers in pharmacology

Nishimura Y, Sasagawa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T.
PMID: 26441656
Front Pharmacol. 2015 Sep 15;6:199. doi: 10.3389/fphar.2015.00199. eCollection 2015.

Both caloric restriction (CR) and resveratrol (RSV) have beneficial effects on obesity. However, the biochemical pathways that mediate these beneficial effects might be complex and interconnected and have not been fully elucidated. To reveal the common therapeutic mechanism of...

Showing 1 to 12 of 604 entries